JP2015522040A5 - - Google Patents

Info

Publication number

JP2015522040A5

JP2015522040A5 JP2015520705A JP2015520705A JP2015522040A5 JP 2015522040 A5 JP2015522040 A5 JP 2015522040A5 JP 2015520705 A JP2015520705 A JP 2015520705A JP 2015520705 A JP2015520705 A JP 2015520705A JP 2015522040 A5 JP2015522040 A5 JP 2015522040A5

Authority

JP

Japan

Prior art keywords

composition

kit

lactalbumin

antibiotic

kit according

Prior art date

2013-07-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 13
• 235000014113 dietary fatty acids Nutrition 0.000 claims 7
• 229930195729 fatty acid Natural products 0.000 claims 7
• 239000000194 fatty acid Substances 0.000 claims 7
• 150000004665 fatty acids Chemical class 0.000 claims 6
• 102000004407 Lactalbumin Human genes 0.000 claims 5
• 108090000942 Lactalbumin Proteins 0.000 claims 5
• 230000003115 biocidal effect Effects 0.000 claims 5
• 208000015181 infectious disease Diseases 0.000 claims 5
• 235000021241 α-lactalbumin Nutrition 0.000 claims 5
• 208000035473 Communicable disease Diseases 0.000 claims 3
• 239000003242 anti bacterial agent Substances 0.000 claims 3
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
• 208000035143 Bacterial infection Diseases 0.000 claims 2
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
• 239000005642 Oleic acid Substances 0.000 claims 2
• 229940088710 antibiotic agent Drugs 0.000 claims 2
• 208000022362 bacterial infectious disease Diseases 0.000 claims 2
• 230000015572 biosynthetic process Effects 0.000 claims 2
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
• 238000009472 formulation Methods 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 239000003865 nucleic acid synthesis inhibitor Substances 0.000 claims 2
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
• 239000007787 solid Substances 0.000 claims 2
• 238000003786 synthesis reaction Methods 0.000 claims 2
• DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 1
• -1 C20 fatty acids Chemical class 0.000 claims 1
• 108010015899 Glycopeptides Proteins 0.000 claims 1
• 102000002068 Glycopeptides Human genes 0.000 claims 1
• 241000606768 Haemophilus influenzae Species 0.000 claims 1
• OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
• 108010028921 Lipopeptides Proteins 0.000 claims 1
• 241000588655 Moraxella catarrhalis Species 0.000 claims 1
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
• 229930182555 Penicillin Natural products 0.000 claims 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
• 229940123573 Protein synthesis inhibitor Drugs 0.000 claims 1
• 229940123752 RNA synthesis inhibitor Drugs 0.000 claims 1
• 206010041925 Staphylococcal infections Diseases 0.000 claims 1
• 241000191967 Staphylococcus aureus Species 0.000 claims 1
• 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 230000000844 anti-bacterial effect Effects 0.000 claims 1
• 239000004599 antimicrobial Substances 0.000 claims 1
• 239000003782 beta lactam antibiotic agent Substances 0.000 claims 1
• 239000006185 dispersion Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229960000304 folic acid Drugs 0.000 claims 1
• 235000019152 folic acid Nutrition 0.000 claims 1
• 239000011724 folic acid Substances 0.000 claims 1
• 239000000499 gel Substances 0.000 claims 1
• 235000020778 linoleic acid Nutrition 0.000 claims 1
• OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
• 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 claims 1
• 239000006072 paste Substances 0.000 claims 1
• 229940049954 penicillin Drugs 0.000 claims 1
• 239000000007 protein synthesis inhibitor Substances 0.000 claims 1
• 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
• 239000002132 β-lactam antibiotic Substances 0.000 claims 1
• 229940124586 β-lactam antibiotics Drugs 0.000 claims 1