JP2015520188A - Ｈｇｈ−ｘｔｅｎ融合タンパク質および成長ホルモン欠乏症の処置におけるその使用 - Google Patents

Ｈｇｈ−ｘｔｅｎ融合タンパク質および成長ホルモン欠乏症の処置におけるその使用 Download PDF

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JP2015520188A
JP2015520188A JP2015516010A JP2015516010A JP2015520188A JP 2015520188 A JP2015520188 A JP 2015520188A JP 2015516010 A JP2015516010 A JP 2015516010A JP 2015516010 A JP2015516010 A JP 2015516010A JP 2015520188 A JP2015520188 A JP 2015520188A
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JP
Japan
Prior art keywords
hgh
xten
fusion protein
bolus dose
sequence
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JP2015516010A
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Japanese (ja)
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JP2015520188A5 (OSRAM
Inventor
ジェフリー エル． クリーランド，
ジェフリー エル． クリーランド，
ジョージ エム． ブライト，
ジョージ エム． ブライト，
エリック ハンフリーズ，
エリック ハンフリーズ，
フォルカー シェレンバーガー，
フォルカー シェレンバーガー，
ジョシュア シルバーマン，
ジョシュア シルバーマン，
ウィレム ピー． ステマー，
ウィレム ピー． ステマー，
チア−ウェイ ワン，
チア−ウェイ ワン，
ネイサン ギーティング，
ネイサン ギーティング，
ベンジャミン スピンク，
ベンジャミン スピンク，
Original Assignee
アムニクス オペレーティング インコーポレイテッド
アムニクス オペレーティング インコーポレイテッド
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Publication of JP2015520188A publication Critical patent/JP2015520188A/ja
Publication of JP2015520188A5 publication Critical patent/JP2015520188A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015516010A 2012-06-05 2013-03-14 Ｈｇｈ−ｘｔｅｎ融合タンパク質および成長ホルモン欠乏症の処置におけるその使用 Pending JP2015520188A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261689390P 2012-06-05 2012-06-05
US61/689,390 2012-06-05
US201261663475P 2012-06-22 2012-06-22
US61/663,475 2012-06-22
US201361763753P 2013-02-12 2013-02-12
US61/763,753 2013-02-12
PCT/US2013/031673 WO2013184216A1 (en) 2012-06-05 2013-03-14 Hgh-xten fusion protein and its use in the treatment of growth hormone deficiency

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017043512A Division JP2017125051A (ja) 2012-06-05 2017-03-08 Ｈｇｈ−ｘｔｅｎ融合タンパク質および成長ホルモン欠乏症の処置におけるその使用

Publications (2)

Publication Number Publication Date
JP2015520188A true JP2015520188A (ja) 2015-07-16
JP2015520188A5 JP2015520188A5 (OSRAM) 2016-05-12

Family

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JP2015516010A Pending JP2015520188A (ja) 2012-06-05 2013-03-14 Ｈｇｈ−ｘｔｅｎ融合タンパク質および成長ホルモン欠乏症の処置におけるその使用
JP2017043512A Pending JP2017125051A (ja) 2012-06-05 2017-03-08 Ｈｇｈ−ｘｔｅｎ融合タンパク質および成長ホルモン欠乏症の処置におけるその使用

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JP2017043512A Pending JP2017125051A (ja) 2012-06-05 2017-03-08 Ｈｇｈ−ｘｔｅｎ融合タンパク質および成長ホルモン欠乏症の処置におけるその使用

Country Status (17)

Country Link
US (2) US20140162949A1 (OSRAM)
EP (1) EP2858664B1 (OSRAM)
JP (2) JP2015520188A (OSRAM)
KR (1) KR20150021072A (OSRAM)
CN (2) CN104519903A (OSRAM)
AU (1) AU2013272220A1 (OSRAM)
BR (1) BR112014030404A2 (OSRAM)
CA (1) CA2875827A1 (OSRAM)
DK (1) DK2858664T3 (OSRAM)
ES (1) ES2733220T3 (OSRAM)
HK (1) HK1208629A1 (OSRAM)
IL (1) IL236070A0 (OSRAM)
MX (1) MX2014014927A (OSRAM)
NZ (1) NZ702557A (OSRAM)
PH (1) PH12014502738A1 (OSRAM)
SG (1) SG11201408152VA (OSRAM)
WO (1) WO2013184216A1 (OSRAM)

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US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
WO2010091122A1 (en) 2009-02-03 2010-08-12 Amunix, Inc. Extended recombinant polypeptides and compositions comprising same
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
BR112015022257A8 (pt) * 2013-03-11 2018-01-23 Amunix Operating Inc tratamento de deficiência do hormônio do crescimento pediátrica com análogos de hormônio do crescimento humano
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
WO2017136583A1 (en) 2016-02-02 2017-08-10 Versartis, Inc. Growth hormone treatment adherence system
WO2017142331A1 (en) * 2016-02-17 2017-08-24 Genexine, Inc. Pharmaceutical composition comprising recombinant hgh for the treatment of growth hormone deficiency
US12233113B2 (en) * 2016-02-17 2025-02-25 Genexine, Inc. Pharmaceutical composition comprising recombinant hGH for the treatment of growth hormone deficiency
EP3491012A4 (en) * 2016-07-27 2020-07-01 Amunix Operating Inc. TREATING ADULT GROWTH HORMONE WITH ANALOGUE OF HUMAN GROWTH HORMONE
JOP20190019A1 (ar) 2016-08-30 2019-02-12 Genexine Inc تركيبة صيدلانية لعلاج نقص في هرمون نمو يحتوي على بروتين اندماجي لهرمون نمو بشري (hGH)
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
WO2019126576A1 (en) 2017-12-21 2019-06-27 Amunix Pharmaceuticals, Inc. Release segments and binding compositions comprising same
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
CN116925237A (zh) 2019-12-31 2023-10-24 北京质肽生物医药科技有限公司 Glp-1和gdf15的融合蛋白以及其缀合物
WO2021139744A1 (en) 2020-01-11 2021-07-15 Beijing Ql Biopharmaceutical Co., Ltd. Conjugates of fusion proteins of glp-1 and fgf21
JP2023545684A (ja) 2020-09-30 2023-10-31 ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド ポリペプチドコンジュゲートおよび使用の方法
CN116554343B (zh) * 2022-01-30 2024-07-12 领诺(上海)医药科技有限公司 一种长效重组人生长激素及其应用
CA3252113A1 (en) 2022-03-30 2023-10-05 Beijing Ql Biopharmaceutical Co Ltd Liquid pharmaceutical compositions of polypeptide conjugates and their methods of use
CN116003632A (zh) * 2022-12-07 2023-04-25 北京大学 长效缓释型人重组生长激素融合蛋白及其药物组合物和应用

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WO2010144502A2 (en) * 2009-06-08 2010-12-16 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same

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WO2010091122A1 (en) * 2009-02-03 2010-08-12 Amunix, Inc. Extended recombinant polypeptides and compositions comprising same

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CLELAND JL: "A NOVEL HUMAN GROWTH HORMONE XTEN CONSTRUCT (VRS-317) FOR ONCE-A-MONTH SUBCUTANEOUS 以下備考", ENDOCR REV. [ONLINE], vol. V32, JPN5015007477, June 2011 (2011-06-01), ISSN: 0003457504 *
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Also Published As

Publication number Publication date
CN104519903A (zh) 2015-04-15
WO2013184216A1 (en) 2013-12-12
SG11201408152VA (en) 2015-01-29
US20180051063A1 (en) 2018-02-22
AU2013272220A1 (en) 2015-01-15
EP2858664B1 (en) 2019-05-08
US20140162949A1 (en) 2014-06-12
HK1208629A1 (en) 2016-03-11
ES2733220T3 (es) 2019-11-28
IL236070A0 (en) 2015-01-29
CN107320719A (zh) 2017-11-07
CA2875827A1 (en) 2013-12-12
PH12014502738A1 (en) 2015-02-02
DK2858664T3 (da) 2019-07-08
MX2014014927A (es) 2015-05-15
EP2858664A1 (en) 2015-04-15
NZ702557A (en) 2017-06-30
KR20150021072A (ko) 2015-02-27
BR112014030404A2 (pt) 2017-06-27
JP2017125051A (ja) 2017-07-20

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