JP2015519049A5 - - Google Patents
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- JP2015519049A5 JP2015519049A5 JP2015510631A JP2015510631A JP2015519049A5 JP 2015519049 A5 JP2015519049 A5 JP 2015519049A5 JP 2015510631 A JP2015510631 A JP 2015510631A JP 2015510631 A JP2015510631 A JP 2015510631A JP 2015519049 A5 JP2015519049 A5 JP 2015519049A5
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- JP
- Japan
- Prior art keywords
- substance
- side chain
- alicyclic
- peptide
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000126 substance Substances 0.000 description 9
- 125000002723 alicyclic group Chemical group 0.000 description 4
- 125000004122 cyclic group Chemical group 0.000 description 2
- 101700049451 lppL Proteins 0.000 description 2
- 102000019632 Acyl transferases Human genes 0.000 description 1
- 108091022082 Acyl transferases Proteins 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000004442 acylamino group Chemical group 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000000843 anti-fungal Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- FAUOJMHVEYMQQG-HVYQDZECSA-N echinocandin B Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@@H](C)O)=CC=C(O)C=C1 FAUOJMHVEYMQQG-HVYQDZECSA-N 0.000 description 1
- 108010062092 echinocandin B Proteins 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
Description
本発明における「環状リポペプチド物質」または「脂環式ペプチド」とは、ポリペプチド環を含有し、この環にある側鎖が「アシルアミノ基」を含有する物質を指すが、この物質はほかの側鎖を有してもよい。
この「環状リポペプチド物質」の代表は、FR901379、echinocandin B(エキノカンジンB)で、このような物質は抗真菌活性を有する既知のものである。
当該発明の固定化脂環式ペプチドアシルトランスフェラーゼは、脂環式ペプチド物質の側鎖の「アミド基」を脱アシル化して「アミノ基」を形成することができ、具体的に、物質FR901379またはその塩のパルミトイル側鎖または物質FR901379を含む、式Ｉで表される化合物のアシル側鎖を脱アシル化し、式ＩＩで表される脂環式ペプチド物質を得ることができる。
この「環状リポペプチド物質」の代表は、FR901379、echinocandin B(エキノカンジンB)で、このような物質は抗真菌活性を有する既知のものである。
当該発明の固定化脂環式ペプチドアシルトランスフェラーゼは、脂環式ペプチド物質の側鎖の「アミド基」を脱アシル化して「アミノ基」を形成することができ、具体的に、物質FR901379またはその塩のパルミトイル側鎖または物質FR901379を含む、式Ｉで表される化合物のアシル側鎖を脱アシル化し、式ＩＩで表される脂環式ペプチド物質を得ることができる。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101483927A CN103387975A (zh) | 2012-05-11 | 2012-05-11 | 一种固定化环脂肽酰基转移酶及其制备方法和用途 |
| CN201210148392.7 | 2012-05-11 | ||
| PCT/CN2013/075508 WO2013166993A1 (zh) | 2012-05-11 | 2013-05-10 | 一种固定化环脂肽酰基转移酶及其制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015519049A JP2015519049A (ja) | 2015-07-09 |
| JP2015519049A5 true JP2015519049A5 (ja) | 2016-06-30 |
Family
ID=49532397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510631A Pending JP2015519049A (ja) | 2012-05-11 | 2013-05-10 | 固定化脂環式ペプチドアシルトランスフェラーゼ及びその製造方法と用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20150140604A1 (ja) |
| EP (1) | EP2848685B1 (ja) |
| JP (1) | JP2015519049A (ja) |
| KR (1) | KR20150013726A (ja) |
| CN (1) | CN103387975A (ja) |
| AU (1) | AU2013258683A1 (ja) |
| CA (1) | CA2873090C (ja) |
| RU (1) | RU2014149304A (ja) |
| WO (1) | WO2013166993A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105154424B (zh) * | 2015-09-28 | 2018-10-16 | 杭州华东医药集团新药研究院有限公司 | 一种固定化环脂肽脱酰酶的制备方法及其应用 |
| CN115786379A (zh) * | 2023-01-06 | 2023-03-14 | 成都雅途生物技术有限公司 | 固定化酶与制备方法以及固定化酶转化fr901379的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3892580A (en) * | 1973-03-26 | 1975-07-01 | Corning Glass Works | Method of making porous inorganic bodies |
| US3930951A (en) | 1974-05-28 | 1976-01-06 | Corning Glass Works | Bonding enzymes to porous inorganic carriers |
| JPS5548392A (en) * | 1978-02-17 | 1980-04-07 | Toyo Jozo Co Ltd | Novel immobilizing material combined with biologically active substance, its preparation, device comprising it, method, and preparation of support |
| US4288549A (en) | 1979-06-08 | 1981-09-08 | Eli Lilly And Company | Method of producing the A-30912 antibiotics |
| US4320053A (en) | 1979-12-13 | 1982-03-16 | Eli Lilly And Company | Derivatives of A-30912D nucleus |
| JPS6322802A (ja) * | 1987-03-31 | 1988-01-30 | Toyo Jozo Co Ltd | 新規なアミノ化アクリロニトリル系ポリマ−の製造法 |
| DE3880273T2 (de) * | 1987-11-27 | 1993-07-29 | Ecc Int Ltd | Poroese anorganische materialien. |
| GB8925593D0 (en) | 1989-11-13 | 1990-01-04 | Fujisawa Pharmaceutical Co | Fr901379 substance and preparation thereof |
| FI912873A (fi) * | 1990-06-18 | 1991-12-19 | Fujisawa Pharmaceutical Co | Ny polypeptidfoerening och foerfarande foer dess framstaellning. |
| DE69739532D1 (de) * | 1996-03-08 | 2009-09-24 | Astellas Pharma Inc | Prozess für die deacylierung von zyklischen lipopeptiden. |
| WO1997047738A1 (fr) | 1996-06-13 | 1997-12-18 | Fujisawa Pharmaceutical Co., Ltd. | Acylase des lipopeptides cycliques |
| BR122016015076B1 (pt) * | 2003-01-17 | 2017-05-16 | Dupont Nutrition Biosci Aps | método de produção de um éster de carboidrato e uso de uma enzima lipídio aciltransferase para produzir um éster de carboidrato |
| US7378261B2 (en) * | 2003-04-14 | 2008-05-27 | E.I. Du Pont De Nemours And Company | Method for preparing para-hydroxystyrene by biocatalytic decarboxylation of para-hydroxycinnamic acid in a biphasic reaction medium |
| US9303256B2 (en) | 2005-09-30 | 2016-04-05 | Novozymes A/S | Immobilization of enzymes |
| EP2592140A4 (en) * | 2010-06-09 | 2014-08-13 | Jgc Corp | SUPPORT FOR IMMOBILIZATION OF A PROTEIN, IMMOBILIZED PROTEIN AND PRODUCTION METHOD THEREOF |
| US8877777B2 (en) * | 2010-09-30 | 2014-11-04 | Shanghai Techwell Biopharmaceutical Co., Ltd. | Process for purifying cyclolipopeptide compounds or the salts thereof |
-
2012
- 2012-05-11 CN CN2012101483927A patent/CN103387975A/zh active Pending
-
2013
- 2013-05-10 AU AU2013258683A patent/AU2013258683A1/en not_active Abandoned
- 2013-05-10 JP JP2015510631A patent/JP2015519049A/ja active Pending
- 2013-05-10 WO PCT/CN2013/075508 patent/WO2013166993A1/zh active Application Filing
- 2013-05-10 RU RU2014149304A patent/RU2014149304A/ru not_active Application Discontinuation
- 2013-05-10 KR KR1020147034431A patent/KR20150013726A/ko active Search and Examination
- 2013-05-10 US US14/400,473 patent/US20150140604A1/en not_active Abandoned
- 2013-05-10 EP EP13788659.4A patent/EP2848685B1/en active Active
- 2013-05-10 CA CA2873090A patent/CA2873090C/en active Active
-
2020
- 2020-01-13 US US16/741,460 patent/US11518990B2/en active Active
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