JP2015517520A5 - - Google Patents
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- JP2015517520A5 JP2015517520A5 JP2015512636A JP2015512636A JP2015517520A5 JP 2015517520 A5 JP2015517520 A5 JP 2015517520A5 JP 2015512636 A JP2015512636 A JP 2015512636A JP 2015512636 A JP2015512636 A JP 2015512636A JP 2015517520 A5 JP2015517520 A5 JP 2015517520A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- subject
- cells
- cell
- brain injury
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 33
- 102000040430 polynucleotide Human genes 0.000 claims description 21
- 108091033319 polynucleotide Proteins 0.000 claims description 21
- 239000002157 polynucleotide Substances 0.000 claims description 21
- 230000001272 neurogenic effect Effects 0.000 claims description 15
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 13
- 208000029028 brain injury Diseases 0.000 claims description 13
- 230000009529 traumatic brain injury Effects 0.000 claims description 13
- 210000004556 brain Anatomy 0.000 claims description 12
- 102400000552 Notch 1 intracellular domain Human genes 0.000 claims description 11
- 101800001628 Notch 1 intracellular domain Proteins 0.000 claims description 11
- 102000005650 Notch Receptors Human genes 0.000 claims description 7
- 108010070047 Notch Receptors Proteins 0.000 claims description 7
- 238000004113 cell culture Methods 0.000 claims description 7
- 238000012258 culturing Methods 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 5
- 230000005012 migration Effects 0.000 claims description 3
- 238000013508 migration Methods 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims description 3
- 238000002054 transplantation Methods 0.000 claims description 3
- 230000006931 brain damage Effects 0.000 claims 1
- 231100000874 brain damage Toxicity 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 38
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 12
- 230000035755 proliferation Effects 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261647893P | 2012-05-16 | 2012-05-16 | |
| US61/647,893 | 2012-05-16 | ||
| PCT/US2013/030895 WO2013172944A1 (en) | 2012-05-16 | 2013-03-13 | Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016184086A Division JP2016220694A (ja) | 2012-05-16 | 2016-09-21 | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517520A JP2015517520A (ja) | 2015-06-22 |
| JP2015517520A5 true JP2015517520A5 (OSRAM) | 2015-10-29 |
| JP6134783B2 JP6134783B2 (ja) | 2017-05-24 |
Family
ID=48040424
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512636A Active JP6134783B2 (ja) | 2012-05-16 | 2013-03-13 | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
| JP2016184086A Pending JP2016220694A (ja) | 2012-05-16 | 2016-09-21 | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
| JP2018082259A Pending JP2018111733A (ja) | 2012-05-16 | 2018-04-23 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2021038508A Pending JP2021098738A (ja) | 2012-05-16 | 2021-03-10 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2023078339A Pending JP2023099213A (ja) | 2012-05-16 | 2023-05-11 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2025030492A Pending JP2025098021A (ja) | 2012-05-16 | 2025-02-27 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016184086A Pending JP2016220694A (ja) | 2012-05-16 | 2016-09-21 | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
| JP2018082259A Pending JP2018111733A (ja) | 2012-05-16 | 2018-04-23 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2021038508A Pending JP2021098738A (ja) | 2012-05-16 | 2021-03-10 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2023078339A Pending JP2023099213A (ja) | 2012-05-16 | 2023-05-11 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2025030492A Pending JP2025098021A (ja) | 2012-05-16 | 2025-02-27 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9828593B2 (OSRAM) |
| EP (1) | EP2849766B1 (OSRAM) |
| JP (6) | JP6134783B2 (OSRAM) |
| CN (3) | CN104519891B (OSRAM) |
| AU (2) | AU2013263417B2 (OSRAM) |
| CA (1) | CA2872188C (OSRAM) |
| WO (1) | WO2013172944A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6134783B2 (ja) * | 2012-05-16 | 2017-05-24 | サンバイオ，インコーポレイティド | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
| KR20150075082A (ko) | 2012-10-09 | 2015-07-02 | 산바이오 인코포레이티드 | 망막 변성의 치료 방법 및 치료용 조성물 |
| EP3104708A4 (en) * | 2014-02-10 | 2017-08-09 | Cytori Therapeutics, Inc. | Regenerative cell therapy for central nervous system (cns) disorders and ptsd |
| CN107427536B (zh) | 2015-04-01 | 2022-02-08 | 桑比欧公司 | 用于刺激细胞增殖和提供fgf2同种型的生物活性混合物的方法和组合物 |
| US10555972B2 (en) * | 2016-02-26 | 2020-02-11 | Innopeutics Corporation | Therapeutic effects of NURR1 and FOXA2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells |
| WO2017152035A1 (en) * | 2016-03-03 | 2017-09-08 | Henry Ford Health System | 3-d collagen scaffold-generated exosomes and uses thereof |
| CN110382020A (zh) | 2016-12-28 | 2019-10-25 | 桑比欧公司 | 细胞递送系统及操作细胞递送系统的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US20030003090A1 (en) | 2001-05-31 | 2003-01-02 | Prockop Darwin J. | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors |
| JP3886346B2 (ja) | 2001-06-22 | 2007-02-28 | サンバイオ，インコーポレイティド | 骨髄間質細胞由来Ｓｃｈｗａｎｎ細胞を含む神経再生用医薬組成物 |
| PT1479767E (pt) * | 2002-02-06 | 2013-11-07 | Sanbio Inc | Processo de diferenciação/indução de células intersticiais da medula óssea em células nervosas e células de músculo esquelético por transferência do gene notch |
| EP1644026A4 (en) * | 2003-06-12 | 2007-10-24 | Ms Science Corp | SIGMA LIGANDS FOR NEURONAL REGENERATION AND FUNCTIONAL RECREATION |
| ES2372501T3 (es) | 2004-04-12 | 2012-01-20 | Sanbio, Inc. | Células que presentan características de células neuronales progenitoras. |
| CA2599971C (en) * | 2005-03-07 | 2012-12-18 | Sanbio Inc. | Use of neuronal precursor cells for treatment of central nervous system lesions |
| CN101008033A (zh) * | 2006-01-27 | 2007-08-01 | 陈云 | 功能性中枢神经损伤诊断检测用基因芯片及其制造方法 |
| WO2008102460A1 (en) | 2007-02-23 | 2008-08-28 | Sanbio Inc. | Transplantation of bone marrow stromal cell-induced neural stem cells for promoting fuctional recovery after spinal cord injury |
| CN101801396B (zh) * | 2007-08-15 | 2013-10-30 | 桑比欧公司 | 治疗神经变性的方法和组合物 |
| EP2222839B1 (en) | 2007-12-03 | 2015-09-16 | SanBio, Inc. | Methods and compositions for modulating differentiation of pluripotential cells |
| US10702554B2 (en) | 2007-12-03 | 2020-07-07 | Sanbio, Inc. | Extracellular matrix from pluripotent cells |
| CN102027118B (zh) | 2008-04-30 | 2014-07-30 | 桑比欧公司 | 含有dna甲基化状态改变的神经再生细胞 |
| US8785190B2 (en) | 2011-04-06 | 2014-07-22 | Sanbio, Inc. | Methods and compositions for modulating peripheral immune function |
| US20120263681A1 (en) | 2011-04-12 | 2012-10-18 | Fujifilm Corporation | Composition comprising cell and biocompatible polymer |
| JP6306506B2 (ja) | 2011-08-19 | 2018-04-04 | サンバイオ，インコーポレイティド | 神経原生及びグリア原生因子及びそれらについてのアッセイ |
| EP4218727A3 (en) | 2012-01-27 | 2023-08-30 | SanBio, Inc. | Methods and compositions for modulating angiogenesis and vasculogenesis |
| JP6134783B2 (ja) * | 2012-05-16 | 2017-05-24 | サンバイオ，インコーポレイティド | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
-
2013
- 2013-03-13 JP JP2015512636A patent/JP6134783B2/ja active Active
- 2013-03-13 US US13/800,585 patent/US9828593B2/en active Active
- 2013-03-13 EP EP13713286.6A patent/EP2849766B1/en active Active
- 2013-03-13 CN CN201380025599.8A patent/CN104519891B/zh active Active
- 2013-03-13 AU AU2013263417A patent/AU2013263417B2/en active Active
- 2013-03-13 CA CA2872188A patent/CA2872188C/en active Active
- 2013-03-13 WO PCT/US2013/030895 patent/WO2013172944A1/en not_active Ceased
- 2013-03-13 CN CN201910165600.6A patent/CN109718250B/zh active Active
- 2013-03-13 CN CN202211044392.2A patent/CN115381855A/zh active Pending
-
2014
- 2014-09-18 US US14/489,934 patent/US20150197741A1/en not_active Abandoned
-
2016
- 2016-07-13 AU AU2016204910A patent/AU2016204910B2/en active Active
- 2016-09-21 JP JP2016184086A patent/JP2016220694A/ja active Pending
-
2018
- 2018-04-23 JP JP2018082259A patent/JP2018111733A/ja active Pending
-
2019
- 2019-02-26 US US16/285,700 patent/US10626389B2/en active Active
-
2020
- 2020-03-05 US US16/809,852 patent/US20200354709A1/en active Pending
-
2021
- 2021-03-10 JP JP2021038508A patent/JP2021098738A/ja active Pending
-
2023
- 2023-05-11 JP JP2023078339A patent/JP2023099213A/ja active Pending
-
2025
- 2025-02-27 JP JP2025030492A patent/JP2025098021A/ja active Pending
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