JP2015516449A5 - - Google Patents
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- Publication number
- JP2015516449A5 JP2015516449A5 JP2015511955A JP2015511955A JP2015516449A5 JP 2015516449 A5 JP2015516449 A5 JP 2015516449A5 JP 2015511955 A JP2015511955 A JP 2015511955A JP 2015511955 A JP2015511955 A JP 2015511955A JP 2015516449 A5 JP2015516449 A5 JP 2015516449A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- weeks
- refers
- treated
- therapeutically effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002193 Pain Diseases 0.000 description 6
- 208000005298 acute pain Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000002831 pharmacologic agent Substances 0.000 description 2
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003897 | 2012-05-18 | ||
| EP12003897.1 | 2012-05-18 | ||
| PCT/EP2013/001468 WO2013170969A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516449A JP2015516449A (ja) | 2015-06-11 |
| JP2015516449A5 true JP2015516449A5 (cg-RX-API-DMAC7.html) | 2017-03-23 |
| JP6116676B2 JP6116676B2 (ja) | 2017-04-19 |
Family
ID=48468208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511955A Active JP6116676B2 (ja) | 2012-05-18 | 2013-05-16 | （１ｒ，４ｒ）−６’−フルオロ−Ｎ，Ｎ−ジメチル−４−フェニル−４’，９’−ジヒドロ−３’Ｈ−スピロ［シクロヘキサン−１，１’−ピラノ［３，４，ｂ］インドール］−４−アミンおよびパラセタモールまたはプロパセタモールを含む医薬組成物 |
Country Status (22)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2974578C (en) | 2015-01-23 | 2020-11-17 | Grunenthal Gmbh | Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function |
| CN118286209A (zh) | 2016-02-29 | 2024-07-05 | 帕克治疗公司 | 西博帕多的滴定 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS584720A (ja) | 1981-06-26 | 1983-01-11 | ザ・アツプジヨン・カンパニ− | 鎮痛用医薬組成物 |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4404208A (en) | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| IE55189B1 (en) | 1982-07-08 | 1990-06-20 | Wyeth John & Brother Ltd | Pharmaceutical compositions |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| DE3665538D1 (en) | 1985-01-23 | 1989-10-19 | Asta Pharma Ag | Synergistic combination of flupirtin and non-steroidal anti-phlogistics |
| IE81142B1 (en) | 1989-05-22 | 2000-04-19 | Biochemical Veterinary Res | Divalent metal salts of indomethacin |
| EP0661050A1 (en) | 1991-07-04 | 1995-07-05 | Taisho Pharmaceutical Co. Ltd | Analgesic |
| JPH05221857A (ja) * | 1992-02-14 | 1993-08-31 | Arakusu:Kk | 配合解熱鎮痛剤 |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| CA2163995A1 (en) | 1993-06-07 | 1994-12-22 | Malcolm Maccoss | Spiro-substituted azacycles as neurokinin antagonists |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| JP5026635B2 (ja) | 1998-09-10 | 2012-09-12 | ニュコメデ ダンマルク アンパーツセルスカブ | 医薬物質の迅速放出医薬組成物 |
| CA2350531A1 (en) | 1998-11-13 | 2000-05-25 | Smriti Iyengar | Method for treating pain |
| DE50104197D1 (de) | 2000-12-28 | 2004-11-25 | Fresenius Kabi Austria Gmbh Gr | Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung |
| WO2003064425A1 (en) | 2002-01-28 | 2003-08-07 | Pfizer Japan Inc. | N-substituted spiropiperidine compounds as ligands for orl-1 receptor |
| SI1374906T1 (sl) | 2002-06-17 | 2007-10-31 | Chiesi Farma Spa | Postopek za pripravo inkluzijskih spojin piroksakama: beta-ciklodekstrina |
| DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| WO2006134486A2 (en) | 2005-06-17 | 2006-12-21 | Pfizer Japan Inc. | Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists |
| PT2012764E (pt) * | 2006-04-28 | 2011-02-02 | Gruenenthal Gmbh | Combinação farmacêutica que compreende 3-(3-dimetilamino-1- etil-2-metilpropil)fenol e paracetamol |
| WO2007128412A1 (en) | 2006-04-28 | 2007-11-15 | Grünenthal GmbH | Pharmaceutical combination comprising 3- (3-dimethylamin0-1-ethyl-2-methyl-pr0pyl) -phenol and an nsaid |
| CN101147735A (zh) * | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DE102006056458A1 (de) * | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| WO2009046801A1 (en) | 2007-10-09 | 2009-04-16 | Merck Patent Gmbh | Pharmaceutical compositions containing benfotiamine and one or one more pharmaceutically active agents for the treatment of pain conditions of neuropathic origin |
| CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| JP5731387B2 (ja) | 2008-09-05 | 2015-06-10 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 医薬配合剤 |
| US20100069501A1 (en) | 2008-09-05 | 2010-03-18 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and Paracetamol |
| AU2009289736A1 (en) | 2008-09-05 | 2010-03-11 | Grunenthal Gmbh | Pharmaceutical combination comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and an NSAID |
| DK2600851T3 (en) * | 2010-08-04 | 2018-06-25 | Gruenenthal Gmbh | PHARMACEUTICAL DOSAGE FORM CONTAINING 6'-FLUORO- (N-METHYL OR N, N-DIMETHYL -) - 4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO [CYCLOHEXAN-1,1'-PYRANO [3,4, B] INDOL] -4-AMINE FOR TREATMENT OF NEUROPATHIC PAIN |
| PE20131108A1 (es) * | 2010-08-04 | 2013-10-17 | Gruenenthal Chemie | Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil- o n,n-dimetil)-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano[3,4,b]indol]-4-amina |
| EP2600846B1 (en) * | 2010-08-04 | 2015-11-25 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cylohexane-1,1'-pyrano[3,4,b]indol]-4-amine |
| US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
-
2013
- 2013-05-13 US US13/892,969 patent/US20130310435A1/en not_active Abandoned
- 2013-05-16 EA EA201401272A patent/EA026949B1/ru not_active IP Right Cessation
- 2013-05-16 RS RS20171229A patent/RS56617B1/sr unknown
- 2013-05-16 HU HUE13723674A patent/HUE034676T2/hu unknown
- 2013-05-16 CA CA2873644A patent/CA2873644A1/en not_active Abandoned
- 2013-05-16 SI SI201330870T patent/SI2849740T1/en unknown
- 2013-05-16 MX MX2014012723A patent/MX352596B/es active IP Right Grant
- 2013-05-16 AU AU2013262075A patent/AU2013262075B2/en not_active Ceased
- 2013-05-16 NO NO13723674A patent/NO2849740T3/no unknown
- 2013-05-16 DK DK13723674.1T patent/DK2849740T3/da active
- 2013-05-16 JP JP2015511955A patent/JP6116676B2/ja active Active
- 2013-05-16 BR BR112014028561A patent/BR112014028561A2/pt not_active IP Right Cessation
- 2013-05-16 CN CN201810706944.9A patent/CN108524498A/zh active Pending
- 2013-05-16 ES ES13723674.1T patent/ES2650441T3/es active Active
- 2013-05-16 CN CN201380025683.XA patent/CN104302282A/zh active Pending
- 2013-05-16 EP EP13723674.1A patent/EP2849740B1/en not_active Not-in-force
- 2013-05-16 HR HRP20171438TT patent/HRP20171438T1/hr unknown
- 2013-05-16 PL PL13723674T patent/PL2849740T3/pl unknown
- 2013-05-16 WO PCT/EP2013/001468 patent/WO2013170969A1/en not_active Ceased
- 2013-05-16 LT LTEP13723674.1T patent/LT2849740T/lt unknown
- 2013-05-16 PT PT137236741T patent/PT2849740T/pt unknown
-
2014
- 2014-11-12 IL IL235651A patent/IL235651B/en active IP Right Grant
-
2017
- 2017-10-06 US US15/726,761 patent/US20180092867A1/en not_active Abandoned
- 2017-11-20 CY CY20171101212T patent/CY1119610T1/el unknown
-
2019
- 2019-07-03 US US16/502,651 patent/US11311504B2/en active Active
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