JP2015516387A5 - - Google Patents
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- Publication number
- JP2015516387A5 JP2015516387A5 JP2015504823A JP2015504823A JP2015516387A5 JP 2015516387 A5 JP2015516387 A5 JP 2015516387A5 JP 2015504823 A JP2015504823 A JP 2015504823A JP 2015504823 A JP2015504823 A JP 2015504823A JP 2015516387 A5 JP2015516387 A5 JP 2015516387A5
- Authority
- JP
- Japan
- Prior art keywords
- growth factor
- period
- carrier
- particles
- delivery vehicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 10
- 210000000988 bone and bone Anatomy 0.000 claims description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 4
- 239000001506 calcium phosphate Substances 0.000 claims description 4
- 235000011010 calcium phosphates Nutrition 0.000 claims description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 239000000969 carrier Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims 29
- 239000002245 particle Substances 0.000 claims 13
- PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 230000000921 morphogenic effect Effects 0.000 claims 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 2
- 229920001992 poloxamer 407 Polymers 0.000 claims 2
- 229940044476 poloxamer 407 Drugs 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 102000008143 Bone Morphogenetic Protein 2 Human genes 0.000 claims 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CA2012/050234 WO2012139223A1 (en) | 2011-04-11 | 2012-04-11 | System and method for multiphasic release of growth factors |
| CAPCT/CA2012/050234 | 2012-04-11 | ||
| PCT/CA2012/050738 WO2013152418A1 (en) | 2012-04-11 | 2012-10-17 | System and method for multiphasic release of growth factors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516387A JP2015516387A (ja) | 2015-06-11 |
| JP2015516387A5 true JP2015516387A5 (https=) | 2015-12-10 |
| JP6318143B2 JP6318143B2 (ja) | 2018-04-25 |
Family
ID=49328692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504823A Active JP6318143B2 (ja) | 2012-04-11 | 2012-10-17 | 成長因子の多相性放出のためのシステムおよび方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2836195B1 (https=) |
| JP (1) | JP6318143B2 (https=) |
| CN (2) | CN104220046A (https=) |
| AU (1) | AU2012376780B2 (https=) |
| CA (1) | CA2868992C (https=) |
| ES (1) | ES2873098T3 (https=) |
| IN (1) | IN2014DN08829A (https=) |
| RU (1) | RU2014145234A (https=) |
| WO (1) | WO2013152418A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10130678B2 (en) | 2014-12-29 | 2018-11-20 | Bioventus, LLC. | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
| CA3002565A1 (en) | 2015-10-30 | 2017-05-04 | Bioventus, Llc | Matrix for enhanced delivery of osteoinductive molecules in bone repair |
| EP3468626A1 (en) | 2016-06-10 | 2019-04-17 | Bioventus LLC | Protein delivery with porous metallic structure |
| US10351437B2 (en) | 2016-10-17 | 2019-07-16 | Lidds Ab | Method for producing calcium sulphate hemihydrate with unique properties |
| ES2935170T3 (es) * | 2017-10-19 | 2023-03-02 | Genera Istrazivanja D O O | Sustituto de injerto óseo autólogo |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4789732A (en) | 1980-08-04 | 1988-12-06 | Regents Of The University Of California | Bone morphogenetic protein composition |
| US4761471A (en) | 1980-08-04 | 1988-08-02 | The Regents Of The University Of California | Bone morphogenetic protein composition |
| US4795804A (en) | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
| US4857456A (en) | 1985-04-30 | 1989-08-15 | The Regents Of The University Of California | Assay of Bone morphogenetic protein (BMP) and anti-BMP antibody for the diagnosis of bone disorders |
| US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| US5631142A (en) | 1986-07-01 | 1997-05-20 | Genetics Institute, Inc. | Compositions comprising bone morphogenetic protein-2 (BMP-2) |
| ATE238417T1 (de) | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| US5385887A (en) | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| CA2360938C (en) * | 1999-02-02 | 2008-01-08 | Warren Oliver Haggard | Controlled release composite |
| US20070190102A1 (en) * | 2000-06-30 | 2007-08-16 | Ping Luo | Method of preparing hydroxyapatite based drug delivery implant for infection and cancer treatment |
| US6503109B1 (en) | 2000-07-19 | 2003-01-07 | Marshall D. Duffield | Swivel drive assembly |
| US6770695B2 (en) * | 2000-08-07 | 2004-08-03 | John L. Ricci | Time release calcium sulfate matrix for bone augmentation |
| US20080233165A1 (en) | 2000-08-07 | 2008-09-25 | Biolok International, Inc. | Time release calcium sulfate and growth factor matrix for bone augmentation |
| US7671012B2 (en) * | 2004-02-10 | 2010-03-02 | Biosurface Engineering Technologies, Inc. | Formulations and methods for delivery of growth factor analogs |
| EP1893174A2 (en) * | 2005-05-10 | 2008-03-05 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
| US20070248675A1 (en) * | 2005-09-08 | 2007-10-25 | Gwangju Institute Of Science And Technology | Composite comprising polysaccharide-functionalized nanoparticle and hydrogel matrix, a drug delivery system and a bone defect replacement matrix for sustained release comprising the same, and the preparation method thereof |
| US20070255422A1 (en) * | 2006-04-25 | 2007-11-01 | Mei Wei | Calcium phosphate polymer composite and method |
| AU2009200540A1 (en) * | 2008-07-03 | 2010-01-21 | Induce Biologics Inc. | Use of immobilized antagonists for enhancing growth factor containing bioimplant effectiveness |
| US9492375B2 (en) * | 2008-07-23 | 2016-11-15 | Warsaw Orthopedic, Inc. | Foam carrier for bone grafting |
| WO2010017288A1 (en) | 2008-08-05 | 2010-02-11 | The University Of Miami | Composite bone grafts, particulate bone-calcium sulfate constructs, and methods of treating joint injuries |
-
2012
- 2012-10-17 JP JP2015504823A patent/JP6318143B2/ja active Active
- 2012-10-17 EP EP12874355.6A patent/EP2836195B1/en active Active
- 2012-10-17 ES ES12874355T patent/ES2873098T3/es active Active
- 2012-10-17 IN IN8829DEN2014 patent/IN2014DN08829A/en unknown
- 2012-10-17 CA CA2868992A patent/CA2868992C/en active Active
- 2012-10-17 WO PCT/CA2012/050738 patent/WO2013152418A1/en not_active Ceased
- 2012-10-17 AU AU2012376780A patent/AU2012376780B2/en active Active
- 2012-10-17 CN CN201280072332.XA patent/CN104220046A/zh active Pending
- 2012-10-17 RU RU2014145234A patent/RU2014145234A/ru not_active Application Discontinuation
- 2012-10-17 CN CN201910739023.7A patent/CN110464701A/zh active Pending
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