JP2015514792A5 - - Google Patents

Info

Publication number

JP2015514792A5

JP2015514792A5 JP2015507484A JP2015507484A JP2015514792A5 JP 2015514792 A5 JP2015514792 A5 JP 2015514792A5 JP 2015507484 A JP2015507484 A JP 2015507484A JP 2015507484 A JP2015507484 A JP 2015507484A JP 2015514792 A5 JP2015514792 A5 JP 2015514792A5

Authority

JP

Japan

Prior art keywords

chloro

methyl

pharmaceutical composition

ethyl

amino

Prior art date

2013-04-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000008194 pharmaceutical composition Substances 0.000 claims description 24
• 150000003839 salts Chemical class 0.000 claims description 22
• 208000017520 skin disease Diseases 0.000 claims description 22
• 150000003431 steroids Chemical class 0.000 claims description 22
• -1 4-chloro-1-methyl-1H-pyrazol-5-yl Chemical group 0.000 claims description 21
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
• 241000124008 Mammalia Species 0.000 claims description 14
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 11
• 150000001875 compounds Chemical class 0.000 claims description 10
• 201000004624 Dermatitis Diseases 0.000 claims description 8
• 239000003814 drug Substances 0.000 claims description 8
• 201000004681 Psoriasis Diseases 0.000 claims description 6
• TVFIYRKPCACCNL-UHFFFAOYSA-N furan-2-carboxamide Chemical compound NC(=O)C1=CC=CO1 TVFIYRKPCACCNL-UHFFFAOYSA-N 0.000 claims description 6
• 238000004519 manufacturing process Methods 0.000 claims description 6
• 206010037844 rash Diseases 0.000 claims description 6
• 208000010201 Exanthema Diseases 0.000 claims description 4
• AFJRDFWMXUECEW-LBPRGKRZSA-N N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methyl-3-pyrazolyl)-2-thiophenecarboxamide Chemical compound CN1N=CC(Cl)=C1C1=C(Cl)SC(C(=O)N[C@H](CN)CC=2C=C(F)C=CC=2)=C1 AFJRDFWMXUECEW-LBPRGKRZSA-N 0.000 claims description 4
• 208000010668 atopic eczema Diseases 0.000 claims description 4
• 201000005884 exanthem Diseases 0.000 claims description 4
• AXTAPYRUEKNRBA-JTQLQIEISA-N n-[(2s)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide Chemical compound CN1N=CC(Cl)=C1C1=C(Cl)OC(C(=O)N[C@H](CN)CC=2C=C(F)C(F)=CC=2)=C1 AXTAPYRUEKNRBA-JTQLQIEISA-N 0.000 claims description 4
• 238000002560 therapeutic procedure Methods 0.000 claims description 4
• 238000011200 topical administration Methods 0.000 claims description 4
• YNSCKPCDFIDINW-UHFFFAOYSA-N 3-[[2-[[1-[2-(dimethylamino)acetyl]-6-methoxy-4,4-dimethyl-2,3-dihydroquinolin-7-yl]amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino]thiophene-2-carboxamide Chemical compound COC1=CC(C(CCN2C(=O)CN(C)C)(C)C)=C2C=C1NC(N=C1NC=CC1=1)=NC=1NC=1C=CSC=1C(N)=O YNSCKPCDFIDINW-UHFFFAOYSA-N 0.000 claims description 3
• 206010063409 Acarodermatitis Diseases 0.000 claims description 2
• 241001480043 Arthrodermataceae Species 0.000 claims description 2
• 241000222122 Candida albicans Species 0.000 claims description 2
• 206010007134 Candida infections Diseases 0.000 claims description 2
• 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
• 206010012442 Dermatitis contact Diseases 0.000 claims description 2
• 206010048768 Dermatosis Diseases 0.000 claims description 2
• 206010015150 Erythema Diseases 0.000 claims description 2
• 206010062639 Herpes dermatitis Diseases 0.000 claims description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
• 201000009053 Neurodermatitis Diseases 0.000 claims description 2
• 206010034277 Pemphigoid Diseases 0.000 claims description 2
• 208000003251 Pruritus Diseases 0.000 claims description 2
• 241000220317 Rosa Species 0.000 claims description 2
• 241000447727 Scabies Species 0.000 claims description 2
• 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 2
• 206010041955 Stasis dermatitis Diseases 0.000 claims description 2
• 230000001154 acute effect Effects 0.000 claims description 2
• 201000008937 atopic dermatitis Diseases 0.000 claims description 2
• 208000000594 bullous pemphigoid Diseases 0.000 claims description 2
• 201000003984 candidiasis Diseases 0.000 claims description 2
• 230000001684 chronic effect Effects 0.000 claims description 2
• 208000010247 contact dermatitis Diseases 0.000 claims description 2
• 230000037304 dermatophytes Effects 0.000 claims description 2
• 231100000321 erythema Toxicity 0.000 claims description 2
• 206010021198 ichthyosis Diseases 0.000 claims description 2
• 201000011486 lichen planus Diseases 0.000 claims description 2
• 206010025135 lupus erythematosus Diseases 0.000 claims description 2
• 239000011148 porous material Substances 0.000 claims description 2
• 208000005687 scabies Diseases 0.000 claims description 2
• 208000008742 seborrheic dermatitis Diseases 0.000 claims description 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 238000000034 method Methods 0.000 description 15
• PGNUBDXGTOZIHC-UHFFFAOYSA-N 4-chloro-1-methylpyrazole Chemical compound CN1C=C(Cl)C=N1 PGNUBDXGTOZIHC-UHFFFAOYSA-N 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• RPOIGCDOZLDYQF-UHFFFAOYSA-N 3-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide Chemical compound CN1N=CC(Cl)=C1C1=C(C(N)=O)OC=C1 RPOIGCDOZLDYQF-UHFFFAOYSA-N 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1