JP2015514760A - 胚性幹細胞微小胞を用いる眼科治療法 - Google Patents

胚性幹細胞微小胞を用いる眼科治療法 Download PDF

Info

Publication number
JP2015514760A
JP2015514760A JP2015506995A JP2015506995A JP2015514760A JP 2015514760 A JP2015514760 A JP 2015514760A JP 2015506995 A JP2015506995 A JP 2015506995A JP 2015506995 A JP2015506995 A JP 2015506995A JP 2015514760 A JP2015514760 A JP 2015514760A
Authority
JP
Japan
Prior art keywords
cells
esmv
retinal
cell
muller
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015506995A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015514760A5 (https=
Inventor
スティーブン ディー. シュワルツ
スティーブン ディー. シュワルツ
デボラ ビー. ファーバー
デボラ ビー. ファーバー
ダイアナ カッツマン
ダイアナ カッツマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Los Angeles UCLA
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of JP2015514760A publication Critical patent/JP2015514760A/ja
Publication of JP2015514760A5 publication Critical patent/JP2015514760A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0621Eye cells, e.g. cornea, iris pigmented cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0622Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/02Coculture with; Conditioned medium produced by embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/45Artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2015506995A 2012-04-16 2013-03-13 胚性幹細胞微小胞を用いる眼科治療法 Pending JP2015514760A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261624701P 2012-04-16 2012-04-16
US61/624,701 2012-04-16
PCT/US2013/030733 WO2013158258A1 (en) 2012-04-16 2013-03-13 Ocular therapeutics using embryonic system cell microvesicles

Publications (2)

Publication Number Publication Date
JP2015514760A true JP2015514760A (ja) 2015-05-21
JP2015514760A5 JP2015514760A5 (https=) 2016-06-16

Family

ID=49383920

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015506995A Pending JP2015514760A (ja) 2012-04-16 2013-03-13 胚性幹細胞微小胞を用いる眼科治療法

Country Status (8)

Country Link
US (1) US20150079047A1 (https=)
EP (1) EP2838995A4 (https=)
JP (1) JP2015514760A (https=)
KR (1) KR20150009541A (https=)
AU (1) AU2013249786A1 (https=)
CA (1) CA2870466A1 (https=)
IL (1) IL235126A0 (https=)
WO (1) WO2013158258A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7007770B1 (ja) 2021-06-21 2022-02-10 パナジー株式会社 眼症状改善剤および眼症状の改善方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101334404B1 (ko) * 2011-04-28 2013-12-12 포항공과대학교 산학협력단 배아줄기세포 유래의 인공 마이크로베시클을 이용한 역분화 유도만능줄기세포의 제조방법
CN109890964A (zh) * 2016-09-09 2019-06-14 康奈尔大学 核酸、蛋白和小分子在玻璃体囊泡体中的递送
US11653636B2 (en) * 2019-11-15 2023-05-23 University Of Ulsan Foundation For Industry Cooperation Method of making a rat model of retinal degeneration and rat model made thereby
KR20230129828A (ko) 2022-03-02 2023-09-11 포항공과대학교 산학협력단 안구 후방 질환 또는 손상의 예방 또는 치료용 조성물

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045666A1 (ja) * 2002-11-15 2004-06-03 Kyushu Tlo Company, Limited. 臓器の再生方法
JP2008536804A (ja) * 2005-02-24 2008-09-11 ザ・スクリプス・リサーチ・インステイチユート 未熟児網膜症及び関連網膜症疾患の治療のための方法
JP2009507770A (ja) * 2005-07-27 2009-02-26 ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インコーポレイティド 眼性疾患の治療への、熱ショックの使用
JP2009528834A (ja) * 2006-03-07 2009-08-13 ギータ シュロフ ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法
JP2010285434A (ja) * 2002-07-25 2010-12-24 Scripps Research Inst 造血幹細胞及び該細胞を使用して眼の新生血管の疾患を治療する方法
JP2011502142A (ja) * 2007-10-29 2011-01-20 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 損傷しまたは傷害を受けた組織または臓器の内皮/上皮再生用医薬の製造のための、幹細胞由来微小胞(mv)の使用ならびにインビトロおよびインビボでの関連した方法
WO2012020307A2 (en) * 2010-08-13 2012-02-16 The University Court Of The University Of Glasgow Therapeutic uses of microvesicles and related micrornas
JP2014524437A (ja) * 2011-08-16 2014-09-22 サムスン ライフ パブリック ウェルフェア ファンデーション 幹細胞由来微小胞を含む神経生成促進用組成物
JP2015520174A (ja) * 2012-05-31 2015-07-16 ネオステム,インコーポレイティド 眼疾患を治療するためのヒト極小胚様(vsel)幹細胞

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824685A (en) * 1995-02-01 1998-10-20 The Johns Hopkins University School Of Medicine Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists
CA2711218C (en) * 2008-01-04 2019-08-06 Lydac Neuroscience Limited A method of producing a population of differentiated cells
KR101268741B1 (ko) * 2009-10-06 2013-06-04 김지연 줄기세포를 망막세포로 분화시키는 방법

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010285434A (ja) * 2002-07-25 2010-12-24 Scripps Research Inst 造血幹細胞及び該細胞を使用して眼の新生血管の疾患を治療する方法
WO2004045666A1 (ja) * 2002-11-15 2004-06-03 Kyushu Tlo Company, Limited. 臓器の再生方法
JP2008536804A (ja) * 2005-02-24 2008-09-11 ザ・スクリプス・リサーチ・インステイチユート 未熟児網膜症及び関連網膜症疾患の治療のための方法
JP2009507770A (ja) * 2005-07-27 2009-02-26 ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インコーポレイティド 眼性疾患の治療への、熱ショックの使用
JP2009528834A (ja) * 2006-03-07 2009-08-13 ギータ シュロフ ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法
JP2011502142A (ja) * 2007-10-29 2011-01-20 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 損傷しまたは傷害を受けた組織または臓器の内皮/上皮再生用医薬の製造のための、幹細胞由来微小胞(mv)の使用ならびにインビトロおよびインビボでの関連した方法
WO2012020307A2 (en) * 2010-08-13 2012-02-16 The University Court Of The University Of Glasgow Therapeutic uses of microvesicles and related micrornas
JP2014524437A (ja) * 2011-08-16 2014-09-22 サムスン ライフ パブリック ウェルフェア ファンデーション 幹細胞由来微小胞を含む神経生成促進用組成物
JP2015520174A (ja) * 2012-05-31 2015-07-16 ネオステム,インコーポレイティド 眼疾患を治療するためのヒト極小胚様(vsel)幹細胞

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EXPERIMENTAL HEMATOLOGY, vol. 32,7,Suppl.1, JPN6016049510, 2004, pages 57 - 58, ISSN: 0003467351 *
PLOS ONE, vol. 7(11), JPN6016049514, November 2012 (2012-11-01), pages 50417, ISSN: 0003467353 *
PROC.AMER.ASSOC.CANCER RES., vol. 45, JPN6016049512, 2004, pages 644 - 2792, ISSN: 0003467352 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7007770B1 (ja) 2021-06-21 2022-02-10 パナジー株式会社 眼症状改善剤および眼症状の改善方法
WO2022269973A1 (ja) * 2021-06-21 2022-12-29 パナジー株式会社 眼症状改善剤および眼症状の改善方法
JP2023001664A (ja) * 2021-06-21 2023-01-06 パナジー株式会社 眼症状改善剤および眼症状の改善方法

Also Published As

Publication number Publication date
EP2838995A4 (en) 2016-01-06
WO2013158258A8 (en) 2014-09-04
KR20150009541A (ko) 2015-01-26
WO2013158258A1 (en) 2013-10-24
CA2870466A1 (en) 2013-10-24
US20150079047A1 (en) 2015-03-19
EP2838995A1 (en) 2015-02-25
AU2013249786A1 (en) 2014-11-06
IL235126A0 (en) 2014-12-31

Similar Documents

Publication Publication Date Title
Gabriel et al. Human brain organoids assemble functionally integrated bilateral optic vesicles
Katsman et al. Embryonic stem cell-derived microvesicles induce gene expression changes in Müller cells of the retina
TR201903889T4 (tr) Korneal endotelyal hücreler üreten yönlendirilmiş diferansiyasyona yönelik yöntem.
Li et al. Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells
Li et al. Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide
WO2017005136A1 (en) Compositions and methods for reprograming non-neuronal cells into neuron-like cells
Su et al. Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces
KR101870240B1 (ko) 지방줄기세포에서 신경줄기세포, 신경세포 및 가바성 신경세포로의 분화 유도 방법
JP2015514760A (ja) 胚性幹細胞微小胞を用いる眼科治療法
Parsons et al. Genome-scale mapping of microRNA signatures in human embryonic stem cell neurogenesis
US8927276B2 (en) Ex vivo progenitor and stem cell expansion and differentiation for use in the treatment of disease of the nervous system
Rennie et al. Therapeutic potential of amniotic fluid-derived cells for treating the injured nervous system
Durmaz et al. R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma
Yuan et al. Primary culture of germ cells that portray stem cell characteristics and recipient preparation for autologous transplantation in the rhesus monkey
JP2025111573A (ja) 高増殖性細胞の製造方法、高増殖性細胞およびその用途
CN112154203B (zh) 高效分离和培养神经干细胞的方法
US20240254440A1 (en) Methods to generate glial restricted neural progenitor cells and uses thereof
Chen et al. Adult limbal neurosphere cells: a potential autologous cell resource for retinal cell generation
Hills et al. Functional recovery from human induced pluripotent stem cell-derived dopamine neuron grafts is dependent on neurite outgrowth
Xu et al. Reversing abnormal neural development by inhibiting OLIG2 in down syndrome human iPSC brain organoids and neuronal mouse chimeras
Guloglu et al. Adipocytes derived from PA6 cells reliably promote the differentiation of dopaminergic neurons from human embryonic stem cells
Hou et al. and Hung-Chih Kuo
Rümmele Exploring the regulation of human neural stem cells quiescence using a CRISPR/Cas9 approach
JP4791675B2 (ja) 中枢神経組織の再生方法
Upadhyay et al. Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141224

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150625

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160311

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160421

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161222

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170321

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170810