JP2015514227A5 - - Google Patents
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- Publication number
- JP2015514227A5 JP2015514227A5 JP2015505956A JP2015505956A JP2015514227A5 JP 2015514227 A5 JP2015514227 A5 JP 2015514227A5 JP 2015505956 A JP2015505956 A JP 2015505956A JP 2015505956 A JP2015505956 A JP 2015505956A JP 2015514227 A5 JP2015514227 A5 JP 2015514227A5
- Authority
- JP
- Japan
- Prior art keywords
- biomarker
- individual
- biological sample
- tuberculosis infection
- differential expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000090 biomarker Substances 0.000 claims 40
- 238000000034 method Methods 0.000 claims 38
- 201000008827 tuberculosis Diseases 0.000 claims 20
- 239000012472 biological sample Substances 0.000 claims 12
- 208000015181 infectious disease Diseases 0.000 claims 11
- -1 MRC-2 Proteins 0.000 claims 8
- 238000003556 assay Methods 0.000 claims 6
- 206010036790 Productive cough Diseases 0.000 claims 5
- 210000003802 sputum Anatomy 0.000 claims 5
- 208000024794 sputum Diseases 0.000 claims 5
- 108091023037 Aptamer Proteins 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 230000002380 cytological effect Effects 0.000 claims 3
- 238000000099 in vitro assay Methods 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102100021834 3-hydroxyacyl-CoA dehydrogenase Human genes 0.000 claims 2
- 102100035991 Alpha-2-antiplasmin Human genes 0.000 claims 2
- 102000004411 Antithrombin III Human genes 0.000 claims 2
- 108090000935 Antithrombin III Proteins 0.000 claims 2
- 101710163595 Chaperone protein DnaK Proteins 0.000 claims 2
- 102100037529 Coagulation factor V Human genes 0.000 claims 2
- 102100031051 Cysteine and glycine-rich protein 1 Human genes 0.000 claims 2
- 101100208245 Danio rerio thbs4b gene Proteins 0.000 claims 2
- 102100031758 Extracellular matrix protein 1 Human genes 0.000 claims 2
- 108010014172 Factor V Proteins 0.000 claims 2
- 102000044445 Galectin-8 Human genes 0.000 claims 2
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims 2
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims 2
- 102100036284 Hepcidin Human genes 0.000 claims 2
- 101000866526 Homo sapiens Extracellular matrix protein 1 Proteins 0.000 claims 2
- 101000608769 Homo sapiens Galectin-8 Proteins 0.000 claims 2
- 101001021253 Homo sapiens Hepcidin Proteins 0.000 claims 2
- 101000983161 Homo sapiens Phospholipase A2, membrane associated Proteins 0.000 claims 2
- 101000705756 Homo sapiens Proteasome activator complex subunit 1 Proteins 0.000 claims 2
- 101000666502 Homo sapiens Xaa-Pro aminopeptidase 1 Proteins 0.000 claims 2
- 102000004375 Insulin-like growth factor-binding protein 1 Human genes 0.000 claims 2
- 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 claims 2
- 102000003815 Interleukin-11 Human genes 0.000 claims 2
- 108090000177 Interleukin-11 Proteins 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
- 101710089435 Lipopolysaccharide-binding protein Proteins 0.000 claims 2
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims 2
- 101100078144 Mus musculus Msrb1 gene Proteins 0.000 claims 2
- 102100026831 Phospholipase A2, membrane associated Human genes 0.000 claims 2
- 102100031300 Proteasome activator complex subunit 1 Human genes 0.000 claims 2
- 101710190759 Serum amyloid A protein Proteins 0.000 claims 2
- 102100032277 Serum amyloid A-1 protein Human genes 0.000 claims 2
- 101150053966 THBS4 gene Proteins 0.000 claims 2
- 102100029219 Thrombospondin-4 Human genes 0.000 claims 2
- 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 claims 2
- 102100038365 Xaa-Pro aminopeptidase 1 Human genes 0.000 claims 2
- 108090000183 alpha-2-Antiplasmin Proteins 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 229960005348 antithrombin iii Drugs 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 108091006374 cAMP receptor proteins Proteins 0.000 claims 2
- 238000004590 computer program Methods 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 230000007420 reactivation Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261623732P | 2012-04-13 | 2012-04-13 | |
| US61/623,732 | 2012-04-13 | ||
| PCT/US2013/036447 WO2013155460A1 (en) | 2012-04-13 | 2013-04-12 | Tuberculosis biomarkers and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015514227A JP2015514227A (ja) | 2015-05-18 |
| JP2015514227A5 true JP2015514227A5 (cg-RX-API-DMAC10.html) | 2016-06-09 |
Family
ID=49328218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505956A Pending JP2015514227A (ja) | 2012-04-13 | 2013-04-12 | 結核バイオマーカーおよびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20140155411A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2836608A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2015514227A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2867481A1 (cg-RX-API-DMAC10.html) |
| HK (1) | HK1205764A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2013155460A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140155411A1 (en) | 2012-04-13 | 2014-06-05 | Somalogic, Inc. | Tuberculosis Biomarkers and Uses Thereof |
| WO2015164616A1 (en) * | 2014-04-24 | 2015-10-29 | Somalogic, Inc. | Biomarkers for detection of tuberculosis |
| US20180356419A1 (en) * | 2015-05-08 | 2018-12-13 | Somalogic, Inc. | Biomarkers for detection of tuberculosis risk |
| GB201519872D0 (en) | 2015-11-11 | 2015-12-23 | Univ Cape Town And Ct For Infectious Disease Res | Biomarkers for prospective determination of risk for development of active tuberculosis |
| GB201602305D0 (en) * | 2016-02-09 | 2016-03-23 | Medical Res Council And Imp Innovations Ltd | TB Biomarkers |
| EP3443356B1 (en) * | 2016-04-15 | 2024-06-05 | Stellenbosch University | Host biomarkers for immunodiagnosis and monitoring of tuberculosis disease |
| US10607228B1 (en) * | 2016-08-24 | 2020-03-31 | Jpmorgan Chase Bank, N.A. | Dynamic rule strategy and fraud detection system and method |
| KR20180048420A (ko) * | 2016-11-02 | 2018-05-10 | 김성천 | 차세대서열결정법을 이용한 표적 단백질의 집단적 정량 방법과 그 용도 |
| US20190392952A1 (en) * | 2016-12-09 | 2019-12-26 | Basil Leaf Technologies, Llc | Computer-implemented methods, systems, and computer-readable media for diagnosing a condition |
| JP6812789B2 (ja) * | 2016-12-28 | 2021-01-13 | 富士通株式会社 | 情報処理装置、情報処理プログラム、および情報処理方法 |
| WO2019202448A1 (en) * | 2018-04-16 | 2019-10-24 | University Of Cape Town | A three-protein proteomic biomarker for prospective determination of risk for development of active tuberculosis |
| JPWO2020162441A1 (cg-RX-API-DMAC10.html) * | 2019-02-04 | 2020-08-13 | ||
| JP7607950B2 (ja) * | 2019-09-30 | 2025-01-06 | ユニバーシティ・オブ・ケープ・タウン | 尿サンプル中において結核の診断を行なうための方法 |
| CN112034176B (zh) * | 2020-07-09 | 2022-08-30 | 中国工程物理研究院材料研究所 | Cntn1作为长期低剂量电离辐射暴露诊断的分子标记物的用途 |
| US20220026417A1 (en) * | 2020-07-21 | 2022-01-27 | Industry-University Cooperation Foundation, Catholic University of Pusan | Method of simultaneously diagnosing active tuberculosis and latent tuberculosis infection using human whole blood sample-derived biomarker |
| CN112481369A (zh) * | 2020-12-03 | 2021-03-12 | 中国医学科学院病原生物学研究所 | Msrb1作为结核病诊断分子标识的用途 |
| US11676726B2 (en) * | 2021-06-22 | 2023-06-13 | David Haase | Apparatus and method for generating a treatment plan for salutogenesis |
| WO2023021262A1 (en) * | 2021-08-17 | 2023-02-23 | Scotland's Rural College | Methods of determining animal phenotypes |
| CZ309154B6 (cs) * | 2021-08-20 | 2022-03-16 | GeneSpector Innovations s.r.o. | Způsob predikce závažnosti průběhu infekčního onemocnění a biomarker pro použití při provádění tohoto způsobu a monitoringu terapie infekčního onemocnění |
| CN114250310B (zh) * | 2021-11-15 | 2023-12-08 | 四川大学华西医院 | 用于检测结核病的dna甲基化标志物、诊断模型、甲基化探针及试剂盒 |
| CN115466797A (zh) * | 2022-06-06 | 2022-12-13 | 四川大学华西第二医院 | 用于检测rs4770965和rs9507713的试剂在制备结核筛查试剂盒中的用途 |
| EP4608557A1 (en) * | 2022-10-24 | 2025-09-03 | Inflammatix, Inc. | A fluidic device and methods for characterization of an infection or other condition |
| CN116106556B (zh) * | 2022-12-29 | 2026-04-03 | 梅州市人民医院(梅州市医学科学院) | 一种量子点荧光微球定量检测胎球蛋白b的免疫层析试纸条及其制备方法 |
| JP2024104962A (ja) * | 2023-01-25 | 2024-08-06 | オリンパスメディカルシステムズ株式会社 | 機械学習方法および判定装置 |
| EP4467662A1 (en) | 2023-05-26 | 2024-11-27 | Forschungszentrum Borstel, Leibniz Lungenzentrum | Method for predicting the time point of culture conversion in individuals |
| CN119689002B (zh) * | 2025-02-25 | 2025-06-06 | 山东大学 | 用于预测胚胎反复种植失败的生物标志物组合、试剂盒及其应用和联合药物及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143506A (en) * | 1998-08-13 | 2000-11-07 | The Research Foundation Of State Of Ny | Diagnostic method for detection of periodontitis or peri-implantitis |
| WO2004001070A1 (en) * | 2002-06-20 | 2003-12-31 | Glaxo Group Limited | Surrogate markers for the determination of the disease status of an individual infected by mycobacterium tuberculosis |
| US20060009378A1 (en) * | 2002-11-14 | 2006-01-12 | Itshak Golan | Novel galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases |
| KR20060015646A (ko) * | 2003-06-13 | 2006-02-17 | 유니버시티 오브 피츠버그 | 면역, 혈액 및 염증성 질환의 모니터링 방법 |
| GB0510511D0 (en) * | 2005-05-23 | 2005-06-29 | St Georges Entpr Ltd | Diagnosis of tuberculosis |
| JP2007024631A (ja) | 2005-07-14 | 2007-02-01 | Human Science Shinko Zaidan | 同位体標識法 |
| CA2623530C (en) * | 2005-09-26 | 2015-02-03 | Apotech Corporation | Antibodies against april as biomarkers for early prognosis of lymphoma patients |
| US20070292869A1 (en) * | 2006-03-02 | 2007-12-20 | Ppd Biomarker Discovery Sciences, Llc | Compositions and Methods for Analyzing Renal Cancer |
| US20080085524A1 (en) | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| KR100961926B1 (ko) * | 2007-08-30 | 2010-06-10 | 서울대학교산학협력단 | 당뇨병성 망막병증 검출용 바이오 마커 조성물 및 진단키트 |
| AT505727B1 (de) * | 2007-09-04 | 2009-06-15 | Univ Innsbruck | Verfahren zur diagnose des metabolischen syndroms |
| KR20110036590A (ko) * | 2008-06-25 | 2011-04-07 | 베일러 리서치 인스티튜트 | 결핵균 감염의 혈액 전사 시그너처 |
| US20110129817A1 (en) * | 2009-11-30 | 2011-06-02 | Baylor Research Institute | Blood transcriptional signature of active versus latent mycobacterium tuberculosis infection |
| WO2010133967A1 (en) * | 2009-05-14 | 2010-11-25 | University Of Oxford | Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers |
| ES2488828T3 (es) * | 2010-03-31 | 2014-08-29 | Firmenich Sa | Preparación de cápsulas sólidas que comprenden aromas |
| NZ602618A (en) * | 2010-04-12 | 2013-12-20 | Somalogic Inc | Aptamers to beta-ngf and their use in treating beta-ngf mediated diseases and disorders |
| US20140155411A1 (en) | 2012-04-13 | 2014-06-05 | Somalogic, Inc. | Tuberculosis Biomarkers and Uses Thereof |
| CN103065065A (zh) * | 2012-11-18 | 2013-04-24 | 浙江大学 | 一种活动性肺结核蛋白表达差异质谱模型及构建方法 |
-
2013
- 2013-04-12 US US13/862,177 patent/US20140155411A1/en not_active Abandoned
- 2013-04-12 WO PCT/US2013/036447 patent/WO2013155460A1/en not_active Ceased
- 2013-04-12 EP EP13774934.7A patent/EP2836608A4/en not_active Withdrawn
- 2013-04-12 CA CA2867481A patent/CA2867481A1/en not_active Abandoned
- 2013-04-12 HK HK15106261.2A patent/HK1205764A1/xx unknown
- 2013-04-12 JP JP2015505956A patent/JP2015514227A/ja active Pending
-
2015
- 2015-12-14 US US14/968,276 patent/US20160109462A1/en not_active Abandoned
-
2017
- 2017-09-20 US US15/709,880 patent/US10408847B2/en active Active
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