JP2015512412A5 - - Google Patents
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- Publication number
- JP2015512412A5 JP2015512412A5 JP2015503545A JP2015503545A JP2015512412A5 JP 2015512412 A5 JP2015512412 A5 JP 2015512412A5 JP 2015503545 A JP2015503545 A JP 2015503545A JP 2015503545 A JP2015503545 A JP 2015503545A JP 2015512412 A5 JP2015512412 A5 JP 2015512412A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- composition
- trail
- binding
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 24
- 230000027455 binding Effects 0.000 claims 11
- 108700012411 TNFSF10 Proteins 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 9
- 108010000449 TNF-Related Apoptosis-Inducing Ligand Receptors Proteins 0.000 claims 5
- 102000002259 TNF-Related Apoptosis-Inducing Ligand Receptors Human genes 0.000 claims 5
- 230000006907 apoptotic process Effects 0.000 claims 5
- 230000009870 specific binding Effects 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 2
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616929P | 2012-03-28 | 2012-03-28 | |
| US61/616,929 | 2012-03-28 | ||
| PCT/US2013/034163 WO2013148877A1 (en) | 2012-03-28 | 2013-03-27 | Dr5 receptor agonist combinations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512412A JP2015512412A (ja) | 2015-04-27 |
| JP2015512412A5 true JP2015512412A5 (https=) | 2016-04-28 |
| JP6219923B2 JP6219923B2 (ja) | 2017-10-25 |
Family
ID=48087754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503545A Expired - Fee Related JP6219923B2 (ja) | 2012-03-28 | 2013-03-27 | Ｄｒ５受容体アゴニストの組み合わせ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20150056204A1 (https=) |
| EP (1) | EP2831116A1 (https=) |
| JP (1) | JP6219923B2 (https=) |
| AU (1) | AU2013239682B2 (https=) |
| CA (1) | CA2867631C (https=) |
| HK (1) | HK1206760A1 (https=) |
| MX (1) | MX350202B (https=) |
| WO (1) | WO2013148877A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015138638A1 (en) | 2014-03-11 | 2015-09-17 | Theraly Pharmaceuticals, Inc. | Long acting trail receptor agonists for treatment of autoimmune diseases |
| EP3048116A1 (en) * | 2015-01-23 | 2016-07-27 | International-Drug-Development-Biotech | Anti-dr5 antibodies with enhanced apoptosis potency |
| RU2017129236A (ru) * | 2015-01-26 | 2019-03-07 | Макродженикс, Инк. | Мультивалентные молекулы, содержащие dr5-связывающие домены |
| US20180333491A1 (en) * | 2015-08-19 | 2018-11-22 | Sinotau Pharmaceuticals Group | Trail receptor-binding agents and uses of same |
| US11007251B2 (en) | 2015-12-17 | 2021-05-18 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
| EA201892260A1 (ru) | 2016-04-07 | 2019-03-29 | Дзе Джонс Хопкинс Юниверсити | Композиции и способы для лечения панкреатита и боли с применением агонистов рецептора смерти |
| KR101926834B1 (ko) | 2017-03-21 | 2018-12-07 | 동아에스티 주식회사 | 항-dr5 항체 및 그의 용도 |
| US20210363265A1 (en) * | 2017-08-24 | 2021-11-25 | Invenra Inc. | Multivalent receptor-clustering agonist antibody constructs |
| EP4277706A1 (en) * | 2021-01-15 | 2023-11-22 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Inducers of senescence, in combination with a selective death receptor 5 (dr5) agonist, for use in a method of treating cancer |
| TW202528350A (zh) * | 2023-11-10 | 2025-07-16 | 大陸商信達生物製藥（蘇州）有限公司 | 抗ｄｒ５和ｃｅａｃａｍ５的雙特異性抗體及其用途 |
| WO2025193146A1 (en) * | 2024-03-13 | 2025-09-18 | Berg Thoren Fredrik | Trail receptor binding molecules |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4289872A (en) | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
| US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
| WO1993021259A1 (en) | 1992-04-14 | 1993-10-28 | Cornell Research Foundation Inc. | Dendritic based macromolecules and method of production |
| US6284236B1 (en) | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
| US6998116B1 (en) | 1996-01-09 | 2006-02-14 | Genentech, Inc. | Apo-2 ligand |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| PT1012274E (pt) | 1997-01-28 | 2007-08-14 | Craig A Rosen | Receptor 4 contendo um domínio de morte (dm4; receptor de morte 4), membro da super-família do ftn e ligação a liart (ap02) |
| US7528239B1 (en) | 1997-02-13 | 2009-05-05 | Immunex Corporation | Receptor that binds trail |
| US6872568B1 (en) * | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| US6100082A (en) | 1997-09-23 | 2000-08-08 | Hassanein; Waleed H. | Perfusion apparatus and method including chemical compositions for maintaining an organ |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| JP2002543151A (ja) * | 1999-05-04 | 2002-12-17 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 死ドメイン含有レセプター５ |
| US7279160B2 (en) * | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7662925B2 (en) | 2002-03-01 | 2010-02-16 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
| EP2500032A1 (en) | 2002-06-24 | 2012-09-19 | Genentech, Inc. | APO-2 ligand/trail variants and uses thereof |
| GB0328261D0 (en) | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
| US8029783B2 (en) * | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| EP1853294A4 (en) | 2005-03-03 | 2010-01-27 | Covx Technologies Ireland Ltd | ANTIANGIOGENIC COMPOUNDS |
| PE20071101A1 (es) * | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| EP2368908A3 (en) | 2006-11-10 | 2011-10-12 | CovX Technologies Ireland Limited | Anti- angiogenic compounds |
| GB0704651D0 (en) * | 2007-03-09 | 2007-04-18 | Ucl Business Plc | Composition |
| US9120855B2 (en) * | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
| MX2012013144A (es) * | 2010-05-14 | 2012-11-30 | Amgen Inc | Agonistas mejorados de receptor de muerte. |
-
2013
- 2013-03-27 JP JP2015503545A patent/JP6219923B2/ja not_active Expired - Fee Related
- 2013-03-27 US US14/388,762 patent/US20150056204A1/en not_active Abandoned
- 2013-03-27 HK HK15107435.1A patent/HK1206760A1/xx unknown
- 2013-03-27 WO PCT/US2013/034163 patent/WO2013148877A1/en not_active Ceased
- 2013-03-27 EP EP13715858.0A patent/EP2831116A1/en not_active Withdrawn
- 2013-03-27 AU AU2013239682A patent/AU2013239682B2/en not_active Ceased
- 2013-03-27 MX MX2014011540A patent/MX350202B/es active IP Right Grant
- 2013-03-27 CA CA2867631A patent/CA2867631C/en not_active Expired - Fee Related
-
2018
- 2018-10-31 US US16/176,343 patent/US20190284290A1/en not_active Abandoned
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