JP2015511963A - Ｔｏｒキナーゼ阻害剤を用いた癌の治療 - Google Patents

Ｔｏｒキナーゼ阻害剤を用いた癌の治療 Download PDF

Info

Publication number
JP2015511963A
JP2015511963A JP2015500593A JP2015500593A JP2015511963A JP 2015511963 A JP2015511963 A JP 2015511963A JP 2015500593 A JP2015500593 A JP 2015500593A JP 2015500593 A JP2015500593 A JP 2015500593A JP 2015511963 A JP2015511963 A JP 2015511963A
Authority
JP
Japan
Prior art keywords
substituted
unsubstituted
pyrazin
breast cancer
tor kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015500593A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015511963A5 (cg-RX-API-DMAC7.html
Inventor
シュ，スイチャン
ヘゲ，クリステン，マエ
レイモン，ヘザー
ナーラ，ラマ，ケイ．
Original Assignee
シグナル ファーマシューティカルズ，エルエルシー
シグナル ファーマシューティカルズ，エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シグナル ファーマシューティカルズ，エルエルシー, シグナル ファーマシューティカルズ，エルエルシー filed Critical シグナル ファーマシューティカルズ，エルエルシー
Publication of JP2015511963A publication Critical patent/JP2015511963A/ja
Publication of JP2015511963A5 publication Critical patent/JP2015511963A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2015500593A 2012-03-15 2013-03-14 Ｔｏｒキナーゼ阻害剤を用いた癌の治療 Pending JP2015511963A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261611374P 2012-03-15 2012-03-15
US61/611,374 2012-03-15
US201261715331P 2012-10-18 2012-10-18
US61/715,331 2012-10-18
PCT/US2013/031185 WO2013138553A1 (en) 2012-03-15 2013-03-14 Treatment of cancer with tor kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017218014A Division JP6470820B2 (ja) 2012-03-15 2017-11-13 Ｔｏｒキナーゼ阻害剤を用いた癌の治療

Publications (2)

Publication Number Publication Date
JP2015511963A true JP2015511963A (ja) 2015-04-23
JP2015511963A5 JP2015511963A5 (cg-RX-API-DMAC7.html) 2016-04-21

Family

ID=48014333

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015500593A Pending JP2015511963A (ja) 2012-03-15 2013-03-14 Ｔｏｒキナーゼ阻害剤を用いた癌の治療
JP2017218014A Active JP6470820B2 (ja) 2012-03-15 2017-11-13 Ｔｏｒキナーゼ阻害剤を用いた癌の治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017218014A Active JP6470820B2 (ja) 2012-03-15 2017-11-13 Ｔｏｒキナーゼ阻害剤を用いた癌の治療

Country Status (19)

Country Link
US (2) US20130245027A1 (cg-RX-API-DMAC7.html)
EP (1) EP2825169B1 (cg-RX-API-DMAC7.html)
JP (2) JP2015511963A (cg-RX-API-DMAC7.html)
KR (1) KR102057359B1 (cg-RX-API-DMAC7.html)
CN (1) CN104271139A (cg-RX-API-DMAC7.html)
AU (1) AU2013202993B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014022707A2 (cg-RX-API-DMAC7.html)
CA (1) CA2867348A1 (cg-RX-API-DMAC7.html)
ES (1) ES2678250T3 (cg-RX-API-DMAC7.html)
IL (1) IL234641B (cg-RX-API-DMAC7.html)
MX (1) MX360880B (cg-RX-API-DMAC7.html)
MY (1) MY178012A (cg-RX-API-DMAC7.html)
NI (1) NI201400112A (cg-RX-API-DMAC7.html)
NZ (1) NZ628407A (cg-RX-API-DMAC7.html)
PH (1) PH12014502046B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201405724RA (cg-RX-API-DMAC7.html)
TW (1) TWI635862B (cg-RX-API-DMAC7.html)
WO (1) WO2013138553A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201406701B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
EP3549940A1 (en) 2013-04-17 2019-10-09 Signal Pharmaceuticals, LLC Pharmaceutical formulations, of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
MY189663A (en) 2013-04-17 2022-02-23 Signal Pharm Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
HK1221168A1 (zh) 2013-04-17 2017-05-26 西格诺药品有限公司 用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法
WO2014172436A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
JP6382946B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
CA2908742C (en) * 2013-04-17 2021-06-01 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
WO2014172425A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Treatment of cancer with dihydropyrazino-pyrazines
CN107474051B (zh) 2013-05-29 2020-10-30 西格诺药品有限公司 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
EP3131552B1 (en) 2014-04-16 2020-07-15 Signal Pharmaceuticals, LLC Methods for treating cancer using tor kinase inhibitor combination therapy
WO2015160880A1 (en) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
US9718824B2 (en) 2014-04-16 2017-08-01 Signal Pharmaceuticals, Llc Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof
IL271491B2 (en) 2017-06-22 2023-09-01 Celgene Corp Treatment of carcinoma of the liver characterized by hepatitis b virus infection
CN112933088B (zh) * 2021-02-03 2022-02-22 南华大学附属第一医院 Y041-5921在制备抗肿瘤药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2627352T3 (es) 2006-10-19 2017-07-27 Signal Pharmaceuticals, Llc Compuestos heteroarilo, sus composiciones y su uso como inhibidores de proteínas quinasas
RU2474582C2 (ru) 2006-10-19 2013-02-10 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Гетероарильные соединения, их композиции и их применение в качестве ингибиторов протеинкиназы
CA2721072A1 (en) * 2008-04-11 2009-10-15 Bionovo, Inc. Anticancer methods employing extracts of gleditsia sinensis lam
WO2010022243A1 (en) * 2008-08-20 2010-02-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chemoprevention of head and neck squamous cell carcinomas
NZ599549A (en) 2009-10-26 2013-11-29 Signal Pharm Llc Methods of synthesis and purification of heteroaryl compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BERK L, ET AL.: "Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 69, no. 5, JPN6016045369, 10 January 2012 (2012-01-10), pages 1369 - 1377, ISSN: 0003446555 *
CHANG SB, ET AL.: "Rapamycin inhibits proliferation of estrogen-receptor-positive breast cancer cells", JOURNAL OF SURGICAL RESEARCH, vol. 138, no. 1, JPN6016045363, 2007, pages 37 - 44, ISSN: 0003446553 *
DEY N, ET AL.: "Preclinical efficacy of a dual PI3K-mTOR inhibitor, BEZ235 in triple negative breast cancer", EUROPEAN JOURNAL OF CANCER, vol. Vol.47, Suppl.4, JPN6016045371, 2011, pages 17, ISSN: 0003446548 *
LEHMANN BD, ET AL.: "Identification of human triple-negative breast cancer subtypes and preclinical models for selection", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 121, no. 7, JPN6016045362, July 2011 (2011-07-01), pages 2750 - 2767, ISSN: 0003446552 *
LIU T, ET AL.: "Combinatorial effects of lapatinib and rapamycin in triple-negative breast cancer cells", MOLECULAR CANCER THERAPEUTICS, vol. 10, no. 8, JPN6016045356, August 2011 (2011-08-01), pages 1460 - 1469, ISSN: 0003446550 *
YU K, ET AL.: "mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical mode", ENDOCRINE-RELATED CANCER, vol. 8, no. 3, JPN6016045366, 2001, pages 249 - 258, ISSN: 0003446554 *
ZENG Q, ET AL.: "Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in viv", EUROPEAN JOURNAL OF CANCER, vol. 46, no. 6, JPN6016045359, 2010, pages 1132 - 1143, ISSN: 0003446551 *
ZHAO H, ET AL.: "The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo", BREAST CANCER RESEARCH AND TREATMENT, vol. 131, no. 2, JPN6016045353, 11 March 2012 (2012-03-11), pages 425 - 436, ISSN: 0003446549 *

Also Published As

Publication number Publication date
SG11201405724RA (en) 2014-10-30
US20130245027A1 (en) 2013-09-19
KR20140138951A (ko) 2014-12-04
NI201400112A (es) 2015-01-15
WO2013138553A1 (en) 2013-09-19
JP6470820B2 (ja) 2019-02-13
PH12014502046A1 (en) 2014-12-10
BR112014022707A2 (pt) 2020-10-27
KR102057359B1 (ko) 2019-12-18
IL234641A0 (en) 2014-11-30
IL234641B (en) 2020-04-30
ES2678250T3 (es) 2018-08-09
EP2825169A1 (en) 2015-01-21
MX360880B (es) 2018-11-21
MX2014011118A (es) 2015-04-08
JP2018052963A (ja) 2018-04-05
ZA201406701B (en) 2016-05-25
TWI635862B (zh) 2018-09-21
PH12014502046B1 (en) 2020-10-16
CA2867348A1 (en) 2013-09-19
AU2013202993A1 (en) 2013-10-03
MY178012A (en) 2020-09-29
NZ628407A (en) 2016-04-29
TW201343165A (zh) 2013-11-01
CN104271139A (zh) 2015-01-07
US20230338370A1 (en) 2023-10-26
AU2013202993B2 (en) 2015-09-03
EP2825169B1 (en) 2018-05-09
HK1201753A1 (en) 2015-09-11

Similar Documents

Publication Publication Date Title
JP6470822B2 (ja) Ｔｏｒキナーゼ阻害剤を用いた癌の治療
JP6470820B2 (ja) Ｔｏｒキナーゼ阻害剤を用いた癌の治療
JP6470821B2 (ja) Ｔｏｒキナーゼ阻害剤を用いた癌の治療
JP6360136B2 (ja) Ｔｏｒキナーゼ阻害剤を用いたがんの処置
JP6114317B2 (ja) Ｔｏｒキナーゼ阻害剤の組合せ療法を用いて、非小細胞肺がんを処置する方法
JP6114554B2 (ja) Ｔｏｒキナーゼ阻害剤に対する感受性についての予測的なバイオマーカーとしてのｌｋｂ１変異の同定
JP2021102637A (ja) Ｔｏｒキナーゼ阻害剤を用いた癌の治療
JP2016516671A (ja) Ｔｏｒキナーゼ阻害剤を用いたがんの治療
JP2015534981A (ja) Ｔｏｒキナーゼ阻害剤を用いた癌の治療
AU2015201138B2 (en) Treatment of cancer with TOR kinase inhibitors
HK1243919B (en) Treatment of cancer with tor kinase inhibitors
HK1201750B (en) Treatment of cancer with tor kinase inhibitors
HK1201753B (en) Treatment of cancer with tor kinase inhibitors
HK1202247B (en) Treatment of cancer with tor kinase inhibitors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160229

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160229

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161129

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170227

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170711