CA2867348A1 - Treatment of cancer with tor kinase inhibitors - Google Patents
Treatment of cancer with tor kinase inhibitors Download PDFInfo
- Publication number
- CA2867348A1 CA2867348A1 CA2867348A CA2867348A CA2867348A1 CA 2867348 A1 CA2867348 A1 CA 2867348A1 CA 2867348 A CA2867348 A CA 2867348A CA 2867348 A CA2867348 A CA 2867348A CA 2867348 A1 CA2867348 A1 CA 2867348A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- pyrazin
- unsubstituted
- tor kinase
- breast cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261611374P | 2012-03-15 | 2012-03-15 | |
| US61/611,374 | 2012-03-15 | ||
| US201261715331P | 2012-10-18 | 2012-10-18 | |
| US61/715,331 | 2012-10-18 | ||
| PCT/US2013/031185 WO2013138553A1 (en) | 2012-03-15 | 2013-03-14 | Treatment of cancer with tor kinase inhibitors |
Publications (1)
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|---|---|
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|---|---|---|---|---|
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| EP3549940A1 (en) | 2013-04-17 | 2019-10-09 | Signal Pharmaceuticals, LLC | Pharmaceutical formulations, of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one |
| MY189663A (en) | 2013-04-17 | 2022-02-23 | Signal Pharm Llc | Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer |
| HK1221168A1 (zh) | 2013-04-17 | 2017-05-26 | 西格诺药品有限公司 | 用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法 |
| WO2014172436A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer |
| JP6382946B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ，エルエルシー | ジヒドロピラジノ−ピラジンによる癌治療 |
| CA2908742C (en) * | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
| WO2014172425A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| CN107474051B (zh) | 2013-05-29 | 2020-10-30 | 西格诺药品有限公司 | 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| EP3131552B1 (en) | 2014-04-16 | 2020-07-15 | Signal Pharmaceuticals, LLC | Methods for treating cancer using tor kinase inhibitor combination therapy |
| WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
| IL271491B2 (en) | 2017-06-22 | 2023-09-01 | Celgene Corp | Treatment of carcinoma of the liver characterized by hepatitis b virus infection |
| CN112933088B (zh) * | 2021-02-03 | 2022-02-22 | 南华大学附属第一医院 | Y041-5921在制备抗肿瘤药物中的应用 |
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| ES2627352T3 (es) | 2006-10-19 | 2017-07-27 | Signal Pharmaceuticals, Llc | Compuestos heteroarilo, sus composiciones y su uso como inhibidores de proteínas quinasas |
| RU2474582C2 (ru) | 2006-10-19 | 2013-02-10 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Гетероарильные соединения, их композиции и их применение в качестве ингибиторов протеинкиназы |
| CA2721072A1 (en) * | 2008-04-11 | 2009-10-15 | Bionovo, Inc. | Anticancer methods employing extracts of gleditsia sinensis lam |
| WO2010022243A1 (en) * | 2008-08-20 | 2010-02-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chemoprevention of head and neck squamous cell carcinomas |
| US8110578B2 (en) * | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| NZ599549A (en) | 2009-10-26 | 2013-11-29 | Signal Pharm Llc | Methods of synthesis and purification of heteroaryl compounds |
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2013
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- 2013-03-14 MY MYPI2014702602A patent/MY178012A/en unknown
- 2013-03-14 WO PCT/US2013/031185 patent/WO2013138553A1/en not_active Ceased
- 2013-03-14 MX MX2014011118A patent/MX360880B/es active IP Right Grant
- 2013-03-14 KR KR1020147028898A patent/KR102057359B1/ko active Active
- 2013-03-14 BR BR112014022707-1A patent/BR112014022707A2/pt not_active IP Right Cessation
- 2013-03-14 TW TW102109151A patent/TWI635862B/zh active
- 2013-03-14 JP JP2015500593A patent/JP2015511963A/ja active Pending
- 2013-03-14 AU AU2013202993A patent/AU2013202993B2/en not_active Ceased
- 2013-03-14 SG SG11201405724RA patent/SG11201405724RA/en unknown
- 2013-03-14 CN CN201380024241.3A patent/CN104271139A/zh active Pending
- 2013-03-14 CA CA2867348A patent/CA2867348A1/en not_active Abandoned
- 2013-03-14 ES ES13713003.5T patent/ES2678250T3/es active Active
- 2013-03-14 US US13/803,305 patent/US20130245027A1/en not_active Abandoned
- 2013-03-14 NZ NZ628407A patent/NZ628407A/en not_active IP Right Cessation
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2014
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- 2014-09-15 PH PH12014502046A patent/PH12014502046B1/en unknown
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2017
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2022
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| SG11201405724RA (en) | 2014-10-30 |
| US20130245027A1 (en) | 2013-09-19 |
| KR20140138951A (ko) | 2014-12-04 |
| NI201400112A (es) | 2015-01-15 |
| WO2013138553A1 (en) | 2013-09-19 |
| JP6470820B2 (ja) | 2019-02-13 |
| PH12014502046A1 (en) | 2014-12-10 |
| BR112014022707A2 (pt) | 2020-10-27 |
| KR102057359B1 (ko) | 2019-12-18 |
| IL234641A0 (en) | 2014-11-30 |
| IL234641B (en) | 2020-04-30 |
| JP2015511963A (ja) | 2015-04-23 |
| ES2678250T3 (es) | 2018-08-09 |
| EP2825169A1 (en) | 2015-01-21 |
| MX360880B (es) | 2018-11-21 |
| MX2014011118A (es) | 2015-04-08 |
| JP2018052963A (ja) | 2018-04-05 |
| ZA201406701B (en) | 2016-05-25 |
| TWI635862B (zh) | 2018-09-21 |
| PH12014502046B1 (en) | 2020-10-16 |
| AU2013202993A1 (en) | 2013-10-03 |
| MY178012A (en) | 2020-09-29 |
| NZ628407A (en) | 2016-04-29 |
| TW201343165A (zh) | 2013-11-01 |
| CN104271139A (zh) | 2015-01-07 |
| US20230338370A1 (en) | 2023-10-26 |
| AU2013202993B2 (en) | 2015-09-03 |
| EP2825169B1 (en) | 2018-05-09 |
| HK1201753A1 (en) | 2015-09-11 |
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