JP2015510946A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015510946A5 JP2015510946A5 JP2015501862A JP2015501862A JP2015510946A5 JP 2015510946 A5 JP2015510946 A5 JP 2015510946A5 JP 2015501862 A JP2015501862 A JP 2015501862A JP 2015501862 A JP2015501862 A JP 2015501862A JP 2015510946 A5 JP2015510946 A5 JP 2015510946A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- substituted
- group
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 75
- 125000000217 alkyl group Chemical group 0.000 claims 64
- 229910052739 hydrogen Inorganic materials 0.000 claims 52
- 239000001257 hydrogen Substances 0.000 claims 52
- 150000002431 hydrogen Chemical class 0.000 claims 27
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 25
- -1 substituted Chemical class 0.000 claims 23
- 229940024606 amino acid Drugs 0.000 claims 22
- 235000001014 amino acid Nutrition 0.000 claims 22
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 19
- 125000003342 alkenyl group Chemical group 0.000 claims 18
- 125000003107 substituted aryl group Chemical group 0.000 claims 18
- 125000000304 alkynyl group Chemical group 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 241000700605 Viruses Species 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- 229960003767 alanine Drugs 0.000 claims 8
- 235000004279 alanine Nutrition 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 6
- 229960004295 valine Drugs 0.000 claims 6
- 239000004474 valine Substances 0.000 claims 6
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 4
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 4
- 241001113283 Respirovirus Species 0.000 claims 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 4
- 229960002449 glycine Drugs 0.000 claims 4
- 229960003136 leucine Drugs 0.000 claims 4
- 229930182817 methionine Natural products 0.000 claims 4
- 229960004452 methionine Drugs 0.000 claims 4
- 229960005190 phenylalanine Drugs 0.000 claims 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 4
- 229960002429 proline Drugs 0.000 claims 4
- 229960004799 tryptophan Drugs 0.000 claims 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
- 241000035314 Henipavirus Species 0.000 claims 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- 241000351643 Metapneumovirus Species 0.000 claims 3
- 241000712045 Morbillivirus Species 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 239000004473 Threonine Substances 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 229960003121 arginine Drugs 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- 229960005261 aspartic acid Drugs 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- 229960002433 cysteine Drugs 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- 229960002989 glutamic acid Drugs 0.000 claims 3
- 235000013922 glutamic acid Nutrition 0.000 claims 3
- 239000004220 glutamic acid Substances 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 229960002743 glutamine Drugs 0.000 claims 3
- 235000004554 glutamine Nutrition 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 229960002885 histidine Drugs 0.000 claims 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- 229960003646 lysine Drugs 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229960001153 serine Drugs 0.000 claims 3
- 229960002898 threonine Drugs 0.000 claims 3
- 229960004441 tyrosine Drugs 0.000 claims 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 2
- 102220495689 Putative uncharacterized protein FLJ43944_R40A_mutation Human genes 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical class O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- GCFAUZGWPDYAJN-UHFFFAOYSA-N cyclohexyl 3-phenylprop-2-enoate Chemical compound C=1C=CC=CC=1C=CC(=O)OC1CCCCC1 GCFAUZGWPDYAJN-UHFFFAOYSA-N 0.000 claims 2
- 229940104302 cytosine Drugs 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000011574 phosphorus Substances 0.000 claims 2
- KDESEECZHLTGMH-QMMMGPOBSA-N propan-2-yl (2s)-2-amino-4-methylpentanoate Chemical compound CC(C)C[C@H](N)C(=O)OC(C)C KDESEECZHLTGMH-QMMMGPOBSA-N 0.000 claims 2
- QDQVXVRZVCTVHE-YFKPBYRVSA-N propan-2-yl (2s)-2-aminopropanoate Chemical compound CC(C)OC(=O)[C@H](C)N QDQVXVRZVCTVHE-YFKPBYRVSA-N 0.000 claims 2
- 125000004646 sulfenyl group Chemical group S(*)* 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims 1
- RMSGQZDGSZOJMU-UHFFFAOYSA-N 1-butyl-2-phenylbenzene Chemical group CCCCC1=CC=CC=C1C1=CC=CC=C1 RMSGQZDGSZOJMU-UHFFFAOYSA-N 0.000 claims 1
- 241000342334 Human metapneumovirus Species 0.000 claims 1
- 241000726041 Human respirovirus 1 Species 0.000 claims 1
- 241000712003 Human respirovirus 3 Species 0.000 claims 1
- 241001559187 Human rubulavirus 2 Species 0.000 claims 1
- 241001559186 Human rubulavirus 4 Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000711386 Mumps virus Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005282 allenyl group Chemical group 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 102220481543 eIF5-mimic protein 2_R39A_mutation Human genes 0.000 claims 1
- 102220481542 eIF5-mimic protein 2_R41A_mutation Human genes 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 150000004702 methyl esters Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 102220596570 tRNA-splicing endonuclease subunit Sen15_R43A_mutation Human genes 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 C*(C)*CC[n]1c(nc(*)nc2*)c2nc1 Chemical compound C*(C)*CC[n]1c(nc(*)nc2*)c2nc1 0.000 description 1
- XBCXJKGHPABGSD-UHFFFAOYSA-N CN(C=CC(N1)=O)C1=O Chemical compound CN(C=CC(N1)=O)C1=O XBCXJKGHPABGSD-UHFFFAOYSA-N 0.000 description 1
- OXKBOESOCFIGTH-UHFFFAOYSA-N CN1[I]=NC2=C1N=CNC2=O Chemical compound CN1[I]=NC2=C1N=CNC2=O OXKBOESOCFIGTH-UHFFFAOYSA-N 0.000 description 1
- UUWJNBOCAPUTBK-UHFFFAOYSA-N C[n]1c(N=C(N)NC2=O)c2nc1 Chemical compound C[n]1c(N=C(N)NC2=O)c2nc1 UUWJNBOCAPUTBK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613836P | 2012-03-21 | 2012-03-21 | |
| US61/613,836 | 2012-03-21 | ||
| US13/721,988 US9073960B2 (en) | 2011-12-22 | 2012-12-20 | Substituted nucleosides, nucleotides and analogs thereof |
| US13/721,988 | 2012-12-20 | ||
| PCT/US2013/033018 WO2013142525A1 (en) | 2012-03-21 | 2013-03-19 | Substituted nucleosides, nucleotides and analogs thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510946A JP2015510946A (ja) | 2015-04-13 |
| JP2015510946A5 true JP2015510946A5 (https=) | 2016-05-19 |
| JP6430364B2 JP6430364B2 (ja) | 2018-11-28 |
Family
ID=49223309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501862A Expired - Fee Related JP6430364B2 (ja) | 2012-03-21 | 2013-03-19 | 置換されたヌクレオシド、ヌクレオチドおよびそのアナログ |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US20190381081A1 (https=) |
| EP (1) | EP2827875B1 (https=) |
| JP (1) | JP6430364B2 (https=) |
| KR (1) | KR102172040B1 (https=) |
| CN (2) | CN110917205A (https=) |
| AP (1) | AP2014007943A0 (https=) |
| AU (2) | AU2013235220C1 (https=) |
| CA (1) | CA2866901C (https=) |
| CL (1) | CL2014002392A1 (https=) |
| CY (1) | CY1122125T1 (https=) |
| DK (1) | DK2827875T3 (https=) |
| EA (1) | EA035159B1 (https=) |
| ES (1) | ES2710506T3 (https=) |
| GE (1) | GEP201706721B (https=) |
| HK (1) | HK1203142A1 (https=) |
| HR (1) | HRP20182030T1 (https=) |
| HU (1) | HUE043054T2 (https=) |
| IL (1) | IL234546B (https=) |
| LT (1) | LT2827875T (https=) |
| ME (1) | ME03502B (https=) |
| MX (2) | MX361460B (https=) |
| NZ (1) | NZ629428A (https=) |
| PH (1) | PH12014502094B1 (https=) |
| PL (1) | PL2827875T3 (https=) |
| PT (1) | PT2827875T (https=) |
| RS (1) | RS58437B1 (https=) |
| SG (2) | SG11201405351RA (https=) |
| SI (1) | SI2827875T1 (https=) |
| SM (1) | SMT201900070T1 (https=) |
| TW (2) | TWI663978B (https=) |
| UA (1) | UA113980C2 (https=) |
| WO (1) | WO2013142525A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2619215B1 (en) | 2010-09-22 | 2018-09-05 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| BR112013005872A2 (pt) | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compostos, composição farmacêutica e respectivos usos |
| AU2011349278C1 (en) | 2010-12-22 | 2017-01-19 | Alios Biopharma, Inc. | Cyclic nucleotide analogs |
| EP2794630A4 (en) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE |
| UA117095C2 (uk) | 2011-12-22 | 2018-06-25 | Аліос Біофарма, Інк. | Нуклеозидна сполука або її фармацевтично прийнятна сіль |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| NZ630800A (en) | 2012-03-21 | 2016-06-24 | Alios Biopharma Inc | Methods of preparing substituted nucleotide analogs |
| US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| SG11201407336PA (en) | 2012-05-25 | 2015-03-30 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
| CN104955458A (zh) | 2012-11-07 | 2015-09-30 | Z·索 | 取代的吉西他滨芳基酰胺类似物和使用所述类似物的治疗方法 |
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2014100498A1 (en) | 2012-12-21 | 2014-06-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9504705B2 (en) | 2013-04-05 | 2016-11-29 | Alios Biopharma, Inc. | Hepatitis C viral infection treatment using a combination of compounds |
| HK1224229A1 (zh) | 2013-06-26 | 2017-08-18 | Alios Biopharma, Inc. | 取代的核苷，核苷酸及其类似物 |
| WO2014209983A1 (en) | 2013-06-26 | 2014-12-31 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP3055319A4 (en) | 2013-10-11 | 2018-01-10 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2015106128A2 (en) | 2014-01-09 | 2015-07-16 | Alnylam Pharmaceuticals, Inc. | MODIFIED RNAi AGENTS |
| JP6581100B2 (ja) * | 2014-02-06 | 2019-09-25 | リボサイエンス・エルエルシー | インフルエンザｒｎａ複製の阻害剤としての４’−ジフルオロメチル置換ヌクレオシド誘導体 |
| WO2015134334A1 (en) * | 2014-03-03 | 2015-09-11 | Suo Zucai | Gemcitabine analogs |
| TN2016000566A1 (en) * | 2014-06-24 | 2018-04-04 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| LT3160476T (lt) | 2014-06-24 | 2021-04-12 | Janssen Biopharma, Inc. | Pakeistieji nukleozidai, nukleotidai ir jų analogai, skirti naudoti virusinių infekcijų gydyme |
| CA2955604A1 (en) * | 2014-07-22 | 2016-01-28 | Alios Biopharma, Inc. | Methods for treating paramyxoviruses |
| TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
| SG11201700851WA (en) * | 2014-08-05 | 2017-03-30 | Alios Biopharma Inc | Combination therapy for treating a paramyxovirus |
| TWI673283B (zh) * | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | ２’－氯胺基嘧啶酮及嘧啶二酮核苷類 |
| MX381291B (es) | 2014-09-26 | 2025-03-12 | Riboscience Llc | Derivados de nucleósidos sustituidos con 4'-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial. |
| WO2016069489A1 (en) | 2014-10-28 | 2016-05-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| DK3236972T3 (en) | 2014-12-26 | 2021-10-04 | Univ Emory | Antivirale N4-hydroxycytidin-derivativer |
| WO2016145103A1 (en) | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
| WO2018081449A1 (en) | 2016-10-27 | 2018-05-03 | Alios Biopharma, Inc. | Methods for treating respiratory syncytial virus infection |
| US10435429B2 (en) | 2017-10-03 | 2019-10-08 | Nucorion Pharmaceuticals, Inc. | 5-fluorouridine monophosphate cyclic triester compounds |
| JP6804790B1 (ja) | 2017-12-07 | 2020-12-23 | エモリー ユニバーシティー | Ｎ４−ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
| EP3752511A4 (en) | 2018-01-10 | 2021-12-29 | Nucorion Pharmaceuticals, Inc. | Phosphor(n)amidatacetal and phosph(on)atalcetal compounds |
| US11427550B2 (en) | 2018-01-19 | 2022-08-30 | Nucorion Pharmaceuticals, Inc. | 5-fluorouracil compounds |
| AU2020231934B2 (en) | 2019-03-06 | 2023-04-20 | Glaxosmithkline Intellectual Property (No.2) Limited | Compounds useful in HIV therapy |
| CN114206896B (zh) | 2019-07-17 | 2024-12-17 | 纽科利制药公司 | 环状脱氧核糖核苷酸化合物 |
| AU2021224588B2 (en) | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| US11718637B2 (en) | 2020-03-20 | 2023-08-08 | Gilead Sciences, Inc. | Prodrugs of 4′-C-substituted-2-halo-2′- deoxyadenosine nucleosides and methods of making and using the same |
| CN115605492B (zh) | 2020-04-21 | 2025-09-16 | 配体制药股份有限公司 | 核苷酸前药化合物 |
| US12552820B2 (en) | 2020-04-21 | 2026-02-17 | Ligand Pharmaceuticals Incorporated | Benzyloxy phosph(on)ate compounds |
| CN111892636A (zh) * | 2020-08-07 | 2020-11-06 | 山东大学 | 一种阿兹夫定的合成方法 |
| EP4323362B1 (en) | 2021-04-16 | 2025-05-07 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| AU2022328698B2 (en) | 2021-08-18 | 2025-02-20 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| TW202400134A (zh) * | 2022-03-15 | 2024-01-01 | 美商羅米醫療公司 | 用於治療疾病之化合物及方法 |
| WO2024103016A1 (en) * | 2022-11-11 | 2024-05-16 | Rome Therapeutics, Inc. | 4'-halomethyl-cytidine phosphoramidates and related compounds and their use in treating medical conditions |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| JP4076114B2 (ja) * | 1999-05-12 | 2008-04-16 | ヤマサ醤油株式会社 | ４’−ｃ−エチニルプリンヌクレオシド化合物 |
| KR20090089922A (ko) * | 2000-10-18 | 2009-08-24 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| WO2002057425A2 (en) | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2003062255A2 (en) * | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | Sugar modified nucleosides as viral replication inhibitors |
| RU2004128943A (ru) * | 2002-02-28 | 2005-04-20 | Байота, Инк. (Us) | Средства, имитирующие нуклеотиды, и их пролекарственные формы |
| CN100532388C (zh) * | 2007-07-16 | 2009-08-26 | 郑州大学 | 2’-氟-4’-取代-核苷类似物、其制备方法及应用 |
| US8445669B2 (en) * | 2008-04-10 | 2013-05-21 | Hamari Chemicals, Ltd. | Production process of ethynylthymidine compounds from 5-methyluridine as a starting material |
| GB0815968D0 (en) * | 2008-09-03 | 2008-10-08 | Angeletti P Ist Richerche Bio | Antiviral agents |
| US8163707B2 (en) * | 2008-09-15 | 2012-04-24 | Enanta Pharmaceuticals, Inc. | 4′-allene-substituted nucleoside derivatives |
| BR122020020745B8 (pt) * | 2010-07-22 | 2023-10-31 | Gilead Sciences Inc | Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende |
| EP2619215B1 (en) * | 2010-09-22 | 2018-09-05 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| BR112013005872A2 (pt) * | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compostos, composição farmacêutica e respectivos usos |
| UA117095C2 (uk) * | 2011-12-22 | 2018-06-25 | Аліос Біофарма, Інк. | Нуклеозидна сполука або її фармацевтично прийнятна сіль |
| CN106749272B (zh) * | 2012-03-13 | 2019-08-30 | 吉利德科学公司 | 用于抗病毒治疗的2’-取代的卡巴-核苷类似物 |
-
2013
- 2013-03-19 AU AU2013235220A patent/AU2013235220C1/en not_active Ceased
- 2013-03-19 AP AP2014007943A patent/AP2014007943A0/xx unknown
- 2013-03-19 ES ES13763460T patent/ES2710506T3/es active Active
- 2013-03-19 DK DK13763460.6T patent/DK2827875T3/en active
- 2013-03-19 EP EP13763460.6A patent/EP2827875B1/en active Active
- 2013-03-19 GE GEAP201313603A patent/GEP201706721B/en unknown
- 2013-03-19 HR HRP20182030TT patent/HRP20182030T1/hr unknown
- 2013-03-19 UA UAA201411297A patent/UA113980C2/uk unknown
- 2013-03-19 SM SM20190070T patent/SMT201900070T1/it unknown
- 2013-03-19 CN CN201911178884.9A patent/CN110917205A/zh active Pending
- 2013-03-19 NZ NZ629428A patent/NZ629428A/en not_active IP Right Cessation
- 2013-03-19 PL PL13763460T patent/PL2827875T3/pl unknown
- 2013-03-19 KR KR1020147029092A patent/KR102172040B1/ko not_active Expired - Fee Related
- 2013-03-19 HK HK15103627.8A patent/HK1203142A1/xx unknown
- 2013-03-19 WO PCT/US2013/033018 patent/WO2013142525A1/en not_active Ceased
- 2013-03-19 ME MEP-2019-36A patent/ME03502B/me unknown
- 2013-03-19 HU HUE13763460A patent/HUE043054T2/hu unknown
- 2013-03-19 MX MX2014011238A patent/MX361460B/es active IP Right Grant
- 2013-03-19 SG SG11201405351RA patent/SG11201405351RA/en unknown
- 2013-03-19 JP JP2015501862A patent/JP6430364B2/ja not_active Expired - Fee Related
- 2013-03-19 LT LTEP13763460.6T patent/LT2827875T/lt unknown
- 2013-03-19 CN CN201380015428.7A patent/CN104203253A/zh active Pending
- 2013-03-19 PT PT13763460T patent/PT2827875T/pt unknown
- 2013-03-19 RS RS20190171A patent/RS58437B1/sr unknown
- 2013-03-19 SI SI201331282T patent/SI2827875T1/sl unknown
- 2013-03-19 CA CA2866901A patent/CA2866901C/en active Active
- 2013-03-19 EA EA201491493A patent/EA035159B1/ru not_active IP Right Cessation
- 2013-03-19 SG SG10201804571TA patent/SG10201804571TA/en unknown
- 2013-03-21 TW TW107105463A patent/TWI663978B/zh not_active IP Right Cessation
- 2013-03-21 TW TW102110129A patent/TWI639612B/zh not_active IP Right Cessation
-
2014
- 2014-09-09 IL IL234546A patent/IL234546B/en active IP Right Grant
- 2014-09-10 CL CL2014002392A patent/CL2014002392A1/es unknown
- 2014-09-19 MX MX2018015050A patent/MX2018015050A/es unknown
- 2014-09-22 PH PH12014502094A patent/PH12014502094B1/en unknown
-
2018
- 2018-06-07 AU AU2018204024A patent/AU2018204024A1/en not_active Abandoned
-
2019
- 2019-02-06 CY CY20191100160T patent/CY1122125T1/el unknown
- 2019-06-21 US US16/449,164 patent/US20190381081A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015510946A5 (https=) | ||
| JP2015503506A5 (https=) | ||
| JP2012521359A5 (https=) | ||
| JP2016523906A5 (https=) | ||
| JP2016536288A5 (https=) | ||
| JP2018188468A5 (https=) | ||
| JP2017519784A5 (https=) | ||
| CY1124469T1 (el) | Παραγωγα πυριμιδινης για τη θεραπευτικη αντιμετωπιση ιογενων λοιμωξεων | |
| IL274901B2 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| JP2013521295A5 (https=) | ||
| NZ629428A (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| EA201291301A1 (ru) | Производные 2-хинолинилуксусной кислоты в качестве противовирусных соединений против вич | |
| AR089408A1 (es) | Nucleosidos sustituidos, nucleotidos y analogos de los mismos para ser empleados en el tratamiento de enfermedades virales | |
| BR112014006840A2 (pt) | derivados de pirrolopirimidina e purina | |
| NZ716822A (en) | Antiviral compounds | |
| SG179445A1 (en) | Nucleoside phosphoramidate prodrugs | |
| SI2906563T1 (en) | Derivatives of pyrrolo (3,2-d) pyrimidine for the treatment of viral infections and other diseases | |
| UA108221C2 (uk) | Похідні тіофен-2-карбонової кислоти як інгібітори вірусів flaviviridae | |
| JP2017538722A5 (https=) | ||
| HK1200812A1 (en) | Rod -like hepatitis c virus inhibitors containing the fragement {2- [4- (bi phenyl - 4 - yl) - 1h - imidazo - 2 - yl] pyrrolidine - 1 - carbonlymethyl} amine | |
| EA201290053A1 (ru) | Ингибиторы вирусов flaviviridae | |
| NZ627036A (en) | Piperidino-pyrimidine derivatives for the treatment of viral infections | |
| NZ609487A (en) | Indoles as respiratory syncytial virus antiviral agents | |
| HRP20171720T1 (hr) | Derivati pirolo [3,2-d] pirimidina za liječenje virusnih infekcija i drugih bolesti | |
| JP2014500265A5 (https=) |