JP2015508892A - 慢性ｂ型肝炎患者の応答予測及び治療観察のためのｂ型肝炎ウイルス免疫複合体 - Google Patents
慢性ｂ型肝炎患者の応答予測及び治療観察のためのｂ型肝炎ウイルス免疫複合体 Download PDFInfo
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- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010972 statistical evaluation Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/02—Hepadnaviridae, e.g. hepatitis B virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
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- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
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- Medicinal Chemistry (AREA)
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- Analytical Chemistry (AREA)
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- Rheumatology (AREA)
- Rehabilitation Therapy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP12156192.2A EP2629096A1 (en) | 2012-02-20 | 2012-02-20 | HBV immunocomplexes for response prediction and therapy monitoring of chronic HBV patients |
| EP12156192.2 | 2012-02-20 | ||
| PCT/EP2013/053150 WO2013124229A1 (en) | 2012-02-20 | 2013-02-18 | Hbv immunocomplexes for response prediction and therapy monitoring of chronic hbv patients |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015508892A true JP2015508892A (ja) | 2015-03-23 |
| JP2015508892A5 JP2015508892A5 (enExample) | 2016-04-07 |
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| JP2014557064A Pending JP2015508892A (ja) | 2012-02-20 | 2013-02-18 | 慢性ｂ型肝炎患者の応答予測及び治療観察のためのｂ型肝炎ウイルス免疫複合体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150192583A1 (enExample) |
| EP (2) | EP2629096A1 (enExample) |
| JP (1) | JP2015508892A (enExample) |
| CN (1) | CN104126124A (enExample) |
| CA (1) | CA2863106A1 (enExample) |
| HK (1) | HK1203616A1 (enExample) |
| WO (1) | WO2013124229A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016159178A1 (ja) * | 2015-03-30 | 2016-10-06 | 雅史 溝上 | インターフェロン治療効果予測方法及びそれを用いたｂ型肝炎患者の治療用医薬組成物 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1250744A1 (zh) * | 2015-07-15 | 2019-01-11 | F. Hoffmann-La Roche Ag | Hbv治疗应答的生物标志物 |
| US20190339275A1 (en) * | 2016-11-11 | 2019-11-07 | Melbourne Health | Assay for determining hepatitis b clearance |
| CN111465703A (zh) * | 2017-12-21 | 2020-07-28 | 新西兰健康创新中心管理有限公司 | 分析乙型肝炎病毒突变的方法及其用途 |
| EP3788377A1 (en) * | 2018-05-04 | 2021-03-10 | Abbott Laboratories | Hbv diagnostic, prognostic, and therapeutic methods and products |
| CN110564894B (zh) * | 2019-09-10 | 2023-04-07 | 深圳市罗湖区人民医院 | 干扰物对荧光定量pcr检测hbv dna的干扰评价方法 |
| CN111474187A (zh) * | 2020-04-09 | 2020-07-31 | 三峡大学 | 一种免疫电镜免疫反应盒 |
| CN115466802B (zh) * | 2022-10-28 | 2023-12-12 | 北京大学 | Tp53bp2在调控干扰素信号通路及抗病毒中的用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09511577A (ja) * | 1994-03-31 | 1997-11-18 | ザ スクリップス リサーチ インスティチュート | 慢性肝炎ｂ型ウイルス感染の診断方法 |
| JP2010526307A (ja) * | 2007-05-08 | 2010-07-29 | エフ．ホフマン−ラ ロシュ アーゲー | 特異的免疫グロブリンクラスｇ抗体の検出方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003502384A (ja) * | 1999-06-22 | 2003-01-21 | カイロン コーポレイション | 慢性ｈｂｖ感染を処置するための方法 |
| CN1261455C (zh) * | 2002-07-19 | 2006-06-28 | 余宙耀 | 一种重组人源性抗乙肝表面抗原（HBsAg）Fab抗体及其制取方法 |
| DE10339927A1 (de) * | 2003-08-29 | 2005-03-24 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | Zusammensetzung zur Prophylaxe/Therapie von HBV-Infektionen und HBV-vermittelten Erkrankungen |
| GB0326416D0 (en) * | 2003-11-12 | 2003-12-17 | Karolinska Innovations Ab | Methods and means relating to hepatitis B infection |
| US20090170926A1 (en) * | 2004-03-31 | 2009-07-02 | Monash Univeristy | Antiviral agents |
| EP2419727A1 (en) * | 2009-04-14 | 2012-02-22 | Schering Corporation | Interferon-alfa sensitivity biomarkers |
-
2012
- 2012-02-20 EP EP12156192.2A patent/EP2629096A1/en not_active Ceased
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2013
- 2013-02-18 CN CN201380010278.0A patent/CN104126124A/zh active Pending
- 2013-02-18 CA CA2863106A patent/CA2863106A1/en not_active Abandoned
- 2013-02-18 WO PCT/EP2013/053150 patent/WO2013124229A1/en not_active Ceased
- 2013-02-18 JP JP2014557064A patent/JP2015508892A/ja active Pending
- 2013-02-18 HK HK15104040.5A patent/HK1203616A1/xx unknown
- 2013-02-18 EP EP13706944.9A patent/EP2817631A1/en not_active Ceased
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2014
- 2014-08-19 US US14/462,802 patent/US20150192583A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09511577A (ja) * | 1994-03-31 | 1997-11-18 | ザ スクリップス リサーチ インスティチュート | 慢性肝炎ｂ型ウイルス感染の診断方法 |
| JP2010526307A (ja) * | 2007-05-08 | 2010-07-29 | エフ．ホフマン−ラ ロシュ アーゲー | 特異的免疫グロブリンクラスｇ抗体の検出方法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016159178A1 (ja) * | 2015-03-30 | 2016-10-06 | 雅史 溝上 | インターフェロン治療効果予測方法及びそれを用いたｂ型肝炎患者の治療用医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104126124A (zh) | 2014-10-29 |
| HK1203616A1 (en) | 2015-10-30 |
| EP2629096A1 (en) | 2013-08-21 |
| EP2817631A1 (en) | 2014-12-31 |
| CA2863106A1 (en) | 2013-08-29 |
| US20150192583A1 (en) | 2015-07-09 |
| WO2013124229A1 (en) | 2013-08-29 |
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