JP2015508500A5 - - Google Patents

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JP2015508500A5
JP2015508500A5 JP2014551418A JP2014551418A JP2015508500A5 JP 2015508500 A5 JP2015508500 A5 JP 2015508500A5 JP 2014551418 A JP2014551418 A JP 2014551418A JP 2014551418 A JP2014551418 A JP 2014551418A JP 2015508500 A5 JP2015508500 A5 JP 2015508500A5
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Japan
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peroxide
enzyme
eam
binding ligand
complex
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JP2014551418A
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JP6276706B2 (ja
JP2015508500A (ja
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Priority claimed from PCT/US2013/020836 external-priority patent/WO2013106434A1/en
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Publication of JP2015508500A5 publication Critical patent/JP2015508500A5/ja
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JP2014551418A 2012-01-09 2013-01-09 Ｅ−ｔｒａｃｅアッセイシグナル増幅の酵素カスケード方法 Expired - Fee Related JP6276706B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261584563P 2012-01-09 2012-01-09
US61/584,563 2012-01-09
PCT/US2013/020836 WO2013106434A1 (en) 2012-01-09 2013-01-09 Enzyme cascade methods for e-trace assay signal amplification

Publications (3)

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JP2015508500A JP2015508500A (ja) 2015-03-19
JP2015508500A5 true JP2015508500A5 (US20080131398A1-20080605-C00009.png) 2016-02-25
JP6276706B2 JP6276706B2 (ja) 2018-02-07

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JP2014551418A Expired - Fee Related JP6276706B2 (ja) 2012-01-09 2013-01-09 Ｅ−ｔｒａｃｅアッセイシグナル増幅の酵素カスケード方法

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US (2) US9250203B2 (US20080131398A1-20080605-C00009.png)
EP (1) EP2802669A1 (US20080131398A1-20080605-C00009.png)
JP (1) JP6276706B2 (US20080131398A1-20080605-C00009.png)
CA (1) CA2860739A1 (US20080131398A1-20080605-C00009.png)
WO (1) WO2013106434A1 (US20080131398A1-20080605-C00009.png)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8951400B2 (en) 2007-10-17 2015-02-10 Ohmx Corporation Chemistry used in biosensors
EP2462238B1 (en) 2009-08-07 2013-07-17 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immunoassay
WO2012100078A1 (en) 2011-01-19 2012-07-26 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay
WO2013059293A1 (en) 2011-10-17 2013-04-25 Ohmx Corporation Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
EP2773650A1 (en) 2011-11-04 2014-09-10 Ohmx Corporation Novel chemistry used in biosensors
JP6199387B2 (ja) 2012-07-27 2017-09-20 オームクス コーポレイション 構成要素の均一反応後の単分子層の電子測定
EP2877851A1 (en) 2012-07-27 2015-06-03 Ohmx Corporation Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US407828A (en) 1889-07-30 Tire-tightener
US332565A (en) 1885-12-15 Self-binding grain-harvester
US4247533A (en) 1978-05-01 1981-01-27 The Rockefeller University Hemoglobin A1c radioimmunoassay
DE3061860D1 (en) 1979-04-24 1983-03-17 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4727036A (en) 1985-08-08 1988-02-23 Molecular Diagnostics, Inc. Antibodies for use in determining hemoglobin A1c
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5206144A (en) 1985-03-29 1993-04-27 Novo Industri A/S Determination of glycated (glycosylated) hemoglobin in blood
US4806468A (en) 1987-02-05 1989-02-21 Becton, Dickinson And Company Measurement of glycosylated hemoglobin by immunoassay
JPS63254998A (ja) * 1987-04-10 1988-10-21 Imuno Baion:Kk 微量のピリジンヌクレオチド補酵素分析法
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
DE68910828T2 (de) 1988-08-02 1994-05-11 London Biotechnology Ltd Ein verstärkungs-testverfahren für hydrolase-enzyme.
US5173373A (en) 1989-09-14 1992-12-22 Yamaha Hatsudoki Kabushiki Kaisha Gasket for fuel cell
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
DK0533838T3 (da) 1990-06-11 1998-02-23 Nexstar Pharmaceuticals Inc Nukleinsyreligander
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
DE69228817T2 (de) 1991-07-26 1999-09-23 Dade Chemistry Systems Inc Signalerkennungspruefung in der anwesenheit von einem suspendierten festen träger
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
DE4430023A1 (de) 1994-08-24 1996-02-29 Boehringer Mannheim Gmbh Elektrochemischer Sensor
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
CA2245664A1 (en) 1996-02-08 1997-08-14 Australian Membrane And Biotechnology Research Institute Enzyme detection biosensors
JP4072206B2 (ja) 1996-11-05 2008-04-09 クリニカル・マイクロ・センサーズ・インコーポレイテッド 導電性オリゴマーを介して核酸に連結させた電極
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6162645A (en) 1997-03-13 2000-12-19 Abbott Laboratories Determination of % glycated hemoglobin
JP4124830B2 (ja) 1997-06-12 2008-07-23 クリニカル・マイクロ・センサーズ・インコーポレイテッド 分析物の検出のための電気的方法
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
AU763494B2 (en) 1998-05-06 2003-07-24 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes utilizing monolayers
RU2161653C2 (ru) 1998-08-24 2001-01-10 ФАРМАКОВСКИЙ Дмитрий Александрович Способ количественного электрохимического анализа биомолекул
US6281006B1 (en) 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
EP1157029B1 (de) 1999-02-23 2005-12-28 Pentapharm AG Oligopeptidderivate zur elektrochemischen messung der aktivität von proteasen
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US7234414B2 (en) 1999-11-18 2007-06-26 Sensortec Limited Mastitis detection
GB0002201D0 (en) 2000-01-31 2000-03-22 Imperial College Process
US6753143B2 (en) * 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
DE10024314A1 (de) 2000-05-17 2001-11-22 Basf Ag Verfahren, umfassend die indirekte elektrochemische Regeneration von NAD(P)H
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
JP4567333B2 (ja) 2001-08-24 2010-10-20 センサーテック・リミテッド 高感度電位差測定センサを製造する方法
US6562581B2 (en) 2001-08-31 2003-05-13 Portascience Method for quantitative determination of glycated hemoglobin
KR100407822B1 (ko) 2001-12-04 2003-12-01 한국전자통신연구원 전기화학식 면역 센서와 이를 이용한 생화학 시료검출장치 및 방법
WO2004043493A1 (en) 2002-11-14 2004-05-27 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
US7214528B1 (en) 2002-12-31 2007-05-08 Oregon Health & Sciences University Device for direct electrical detection of molecules and molecule-molecule interactions
US8425745B2 (en) 2006-10-06 2013-04-23 Nanomix, Inc. Electrochemical nanosensors for biomolecule detection
AU2003903504A0 (en) 2003-07-08 2003-07-24 Johnson, Daniel Improvements in sensor chips
GB0316075D0 (en) 2003-07-09 2003-08-13 Molecular Sensing Plc Protease detection assay
FR2859524B1 (fr) * 2003-09-04 2005-12-16 Jaubjaub Consulting Gabarit de controle demontable de la geometrie d'un profile forme
AU2005216251B2 (en) 2004-02-23 2011-03-10 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
TWI245894B (en) 2004-02-26 2005-12-21 Univ Tamkang Method and chemical sensor for determining concentrations of hydrogen peroxide and its precursor in a solution
US7511142B2 (en) 2004-07-28 2009-03-31 Agency For Science, Technology And Research Mediator-modified redox biomolecules for use in electrochemical determination of analyte
CA2574046A1 (en) 2004-08-13 2006-02-16 Egomedical Technologies Ag Analyte test system for determining the concentration of an analyte in a physiological or aqueous fluid
GB2420180A (en) 2004-11-11 2006-05-17 Sensor Tech Ltd Method of electrochemical analysis of an analyte
US20070111226A1 (en) 2005-08-24 2007-05-17 Applera Corporation Method to Quantify siRNAs, miRNAs and Polymorphic miRNAs
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
US8951400B2 (en) 2007-10-17 2015-02-10 Ohmx Corporation Chemistry used in biosensors
AU2008311820A1 (en) 2007-10-17 2009-04-23 Ohmx Corporation Novel chemistry used in biosensors
CN102076867A (zh) 2008-05-13 2011-05-25 通用原子公司 用于直接测定糖化血红蛋白百分比的电化学生物传感器
EP2440911A4 (en) 2009-06-08 2013-02-13 Univ Western Ontario ELECTROCHEMICAL PROCESS AND DEVICE FOR IDENTIFYING THE PRESENCE OF A TARGET
EP2462238B1 (en) 2009-08-07 2013-07-17 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immunoassay
WO2011041586A1 (en) 2009-09-30 2011-04-07 Virogenomics, Inc. Electromagnetic detection of analytes
US20140134658A1 (en) 2010-05-21 2014-05-15 Notrhwestern University, An Illinois Not For Profit Corporation Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness
WO2011146143A2 (en) 2010-05-21 2011-11-24 Ohmx Corporation Detection of cancer by assaying psa enzymatic activity
US8945943B2 (en) 2010-05-26 2015-02-03 The Board Of Trustees Of The University Of Illinois Personal glucose meters for detection and quantification of a broad range of analytes
WO2012100078A1 (en) 2011-01-19 2012-07-26 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay
WO2013059293A1 (en) 2011-10-17 2013-04-25 Ohmx Corporation Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
EP2773650A1 (en) 2011-11-04 2014-09-10 Ohmx Corporation Novel chemistry used in biosensors
EP2877851A1 (en) 2012-07-27 2015-06-03 Ohmx Corporation Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes
JP6199387B2 (ja) 2012-07-27 2017-09-20 オームクス コーポレイション 構成要素の均一反応後の単分子層の電子測定
US9659398B2 (en) 2013-03-15 2017-05-23 Dreamworks Animation Llc Multiple visual representations of lighting effects in a computer animation scene

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