JP2015506748A - 緑内障を治療するための方法、外科キット及び器具 - Google Patents
緑内障を治療するための方法、外科キット及び器具 Download PDFInfo
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
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- A—HUMAN NECESSITIES
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00885—Methods or devices for eye surgery using laser for treating a particular disease
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
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Abstract
Description
−眼球運動に障害が生じ、結果としてものが二重に見えること(複視)。
−低眼圧(網膜剥離を招くおそれのある低IOP)になること。
−結膜の侵食及び感染、並びに侵食を防止するために死体強膜を使用する高い関連コスト。さらに死体強膜は米国外で得ることが難しく、いくつかの宗教では死体組織を使用することを禁止している。
−プレートのカプセル封入が難しく、このことは適切な流体濾過を妨げ、IOP制御の不良を招く。
BAB又はABA(線状トリブロック)、
B(AB)n又はa(BA)n(線状交互ブロック)、又は
X−(AB)n又はX−(BA)n(ジブロック、トリブロック、及び他のラジアル・ブロック・コポリマーを含む)(Aはエラストマーポリオレフィンブロックであり、Bは熱可塑性ブロックであり、nは正の整数であり、そしてXは開始シード分子である)
を有している。
このような材料は、星形ブロック・コポリマー(n=3又は4以上)、又は多樹状突起状のブロック・コポリマーであってよい。ガラス状セグメントに加えて、架橋剤をポリマー中に組み込むことによりSIBSの熱硬化性バージョンを提供することができる。これらの架橋剤を組み込んだ模範的なポリマーは米国特許出願公開第20090124773号明細書に詳述されている。上記明細書はそれぞれ参照することにより本明細書中に全体的に組み込まれる。これらの材料は、SIBS材料と呼ばれる高分子材料に集合的に属する。
− ブロック・コポリマー相のうちの1つと混和可能なホモポリマーとともにブレンドを形成することができる。例えばポリフェニレンオキシドは、ポリスチレン−ポリイソブチレン−ポリスチレンコポリマーのスチレンブロックと混和可能である。これは、ポリスチレン−ポリイソブチレン−ポリスチレンコポリマーとポリフェニレンオキシドとから形成された成形部分又は被膜の強度を高めることになる。
− ブロック・コポリマーのブロックと完全には混和することのできない付加ポリマー又は他のコポリマーとともにブレンドを形成することができる。付加ポリマー又はコポリマーは、例えば別の治療薬と適合性がある点、又はブロック・コポリマー(例えばポリスチレン−ポリイソブチレン−ポリスチレンコポリマー)からの治療薬の放出を変化させる点において有利である。
− 器具201(又は器具部分)から浸出することができる糖(上記リスト参照)のような成分とともにブレンドを形成し、器具又は器具構成部分をより多孔質にし、多孔質構造を通る放出速度を制御することができる。
− ブロック・コポリマーの分子量を変える。
− ブロック・コポリマーのエラストマー部分及び熱可塑性部分のために選択される特定成分、並びにこれらの成分の相対量を変える。
− ブロック・コポリマーを処理する際に使用される溶媒のタイプ及び相対量を変える。
− ブロック・コポリマーの多孔率を変える。
− ブロック・コポリマーに境界層を被せる。
− ブロック・コポリマーと他のポリマー又はコポリマーとをブレンドする。
Claims (44)
- 眼の前房内部の上昇した眼内圧を外科治療するためのキットであって、
前記前房に接続する通路を画定すべく組織を通して挿入されるニードル本体を有する機器と、
可撓性チューブ及び組織シーリング手段を含む房水排出器具と
を含み、
前記ニードル本体はその長さに沿って第1最大断面寸法を有しており、
前記チューブは、前記前房から房水を迂回させるためのダクトを画定しており、且つ、互いに反対側の近位端及び遠位端と、前記第1最大断面寸法よりも小さな第2最大断面寸法を有する第2外面とを有しており、前記組織シーリング手段は、前記チューブの前記近位端及び前記遠位端から離間された少なくとも1つのエレメントを含み、前記少なくとも1つのエレメントは、前記チューブの第2外面を超えて半径方向外側に向かって延びていて、前記組織と該少なくとも1つのエレメントとの間にシールを形成すべく、前記第1最大断面寸法よりも大きい第3最大断面寸法を有している、眼の前房内部の上昇した眼内圧を外科治療するためのキット。 - 前記少なくとも1つのエレメントの第2最大断面寸法が、少なくとも1つの鈍い面によって画定されている、請求項1に記載のキット。
- 前記少なくとも1つのエレメントが、テーパされた遠位部分を有している、請求項1に記載のキット。
- 前記少なくとも1つのエレメントが、前記チューブの両側で前記チューブから半径方向に延びる第1タブと第2タブとを含み、前記第1タブは第1外縁部を画定し、前記第2タブは第2外縁部を画定し、前記第3最大断面寸法は、前記第1外縁部と前記第2外縁部との間の最大距離によって画定されている、請求項1に記載のキット。
- 前記第1及び第2タブが、前記チューブの中心軸の周りに反映された互いの鏡像である、請求項4に記載のキット。
- 前記第1及び第2タブが、ほぼ平面的な形状を成しており、前記チューブの中心軸に対して横方向に延びる共通平面内に位置している、請求項4に記載のキット。
- 前記1及び第2タブの最大厚が、前記チューブの第2最大断面直径以下である、請求項6に記載のキット。
- 前記1及び第2タブがそれぞれ、それぞれのテーパされた遠位部分を有している、請求項4に記載のキット。
- 前記第1最大断面寸法が0.4mm〜0.7mmである、請求項1に記載のキット。
- 前記第2最大断面寸法が0.4mm以下である、請求項9に記載のキット。
- 前記第3最大断面寸法が少なくとも0.9mmである、請求項10に記載のキット。
- 前記チューブが均質な高分子材料から実現されている、請求項1に記載のキット。
- 前記房水排出器具は、高分子材料から実現された単一の成形部分である、請求項1に記載のキット。
- 前記高分子材料が、SIBS材料、シリコーンゴム、ポリオレフィンポリマー、ポリウレタンポリマー、アクリルポリマー、フルオロポリマー、ポリアミドポリマー、ヒドロゲルポリマー、生物学に基づく構造、軟質ポリマー発泡体材料、多孔質ポリマー材料、及びこれらの組み合わせから成る群から選択される、請求項13に記載のキット。
- さらに、
前記房水排出器具のチューブを受容するようにサイズ設定された導管を含む器具を含み、前記導管は、前記房水排出器具のチューブの通過を可能にするスロットを有している、請求項1に記載のキット。 - 前記スロットが前記導管の一部に沿って延びており、前記導管を位置決めするために、前記スロットの近位端に隣接してタブが配置されている、請求項15に記載のキット。
- さらに、
前記房水排出器具を位置決めするために、前記房水排出器具のチューブ内に挿入されるようにサイズ設定されたスタイレットを含む、請求項1に記載のキット。 - 前記ニードル本体が曲げ形態を有している、請求項1に記載のキット。
- 前記機器が、前記ニードル本体から近位側に配置された平刃部分を有しており、前記平刃部分は、前記平刃部分の両側に配置された2つのカッティング面を有している、請求項1に記載のキット。
- 眼の上昇した眼内圧を外科治療する方法であって、
第1最大断面寸法をその長さに沿って有するニードル本体を、組織を通して挿入することにより、眼の前房に接続された通路を画定するステップと、
可撓性チューブ及び組織シーリング手段を含む房水排出器具を用意するステップであって、前記チューブは、前記前房から房水を迂回させるためのダクトを画定しており、且つ、互いに反対側の近位端及び遠位端と、前記第1最大断面寸法よりも小さな第2最大断面寸法を有する第2外面とを有しており、前記組織シーリング手段は、前記チューブの前記近位端及び前記遠位端から離間された少なくとも1つのエレメントを含み、前記少なくとも1つのエレメントは、前記チューブの前記第2外面を超えて半径方向外側に向かって延びていて、前記第1最大断面寸法よりも大きい第3最大断面寸法を有している、ステップと、
前記チューブの遠位端が前記眼の前房内に位置し、前記組織シーリング手段が前記通路内に配置されて前記組織と前記器具との間のシールを形成し、房水が前記前房から排出されるように、前記房水排出器具を前記通路内に挿入するステップと
を含む、眼の上昇した眼内圧を外科治療する方法。 - 前記少なくとも1つのエレメントの第2最大断面寸法が、少なくとも1つの鈍い面によって画定されている、請求項20に記載の方法。
- 前記少なくとも1つのエレメントが、前記通路内への前記組織シーリング手段の挿入を容易にする、テーパされた遠位部分を有している、請求項20に記載の方法。
- 前記少なくとも1つのエレメントが、前記チューブの両側で前記チューブから半径方向に延びる第1タブと第2タブとを含み、前記第1タブは第1外縁部を画定し、前記第2タブは第2外縁部を画定し、前記第3最大断面寸法は、前記第1外縁部と前記第2外縁部との間の最大距離によって画定されている、請求項20に記載の方法。
- 前記第1及び第2タブが、前記チューブの中心軸の周りに反映された互いの鏡像である、請求項23に記載の方法。
- 前記1及び第2タブの最大厚が、前記チューブの第2最大断面直径以下である、請求項23に記載の方法。
- 前記1及び第2タブがそれぞれ、それぞれのテーパされた遠位部分を有している、請求項23に記載の方法。
- 前記第1及び第2タブが、ほぼ平面的な形状を成しており、前記チューブの中心軸に対して横方向に延びる共通平面内に位置している、請求項23に記載の方法。
- 前記第1最大断面寸法が0.4mm〜0.7mmである、請求項20に記載の方法。
- 前記第2最大断面寸法が0.4mm以下である、請求項28に記載の方法。
- 前記第3最大断面寸法が少なくとも0.9mmである、請求項29に記載の方法。
- さらに、前記ニードル本体によって画定された前記通路の一部を広げるために平らなナイフを使用するステップを含む、請求項20に記載の方法。
- 前記ニードル本体と前記平らなナイフとが単一の外科用機器の一部である、請求項31に記載の方法。
- 前記房水排出器具は、前記房水排出器具のチューブ内に挿入されたスタイレットを使用して、前記ニードルによって画定された前記通路内に挿入される、請求項20に記載の方法。
- さらに、
前記房水排出器具のチューブを受容するようにサイズ設定されて、前記房水排出器具のチューブの通過を可能にするスロットを有する導管を含む器具を、前記ニードル本体によって画定された前記通路内に挿入するステップと、
前記房水排出器具を前記導管内に挿入するステップと、
前記房水排出器具を残しながら、前記ニードル本体によって画定された前記通路から前記導管を取り外すステップであって、この際に前記導管のスロットが前記取り外し中に前記房水排出器具のチューブの通過を可能にする、ステップと
を含む、請求項20に記載の方法。 - 前記導管は、前記ニードル本体の近位部分の周りに配置され、前記ニードル本体の遠位部分によって前記通路が画定されると、前記ニードル本体によって画定された前記通路内に挿入される、請求項34に記載の方法。
- 前記スロットが前記導管の遠位部分に沿って延びており、前記ニードル本体によって画定された前記通路内部に前記導管を位置決めするために、前記スロットの近位端に隣接してタブが配置されており、前記通路内部に前記導管の遠位部分を残したままにするために、前記器具が前記通路内部に位置決めされた状態で前記タブから遠位側で切断される、請求項34に記載の方法。
- 眼の前房内部の上昇した眼内圧を治療するための埋め込み可能な器具であって、
可撓性チューブ及び組織シーリング手段を含み、
前記チューブは、前記前房から房水を迂回させるためのダクトを画定しており、且つ、互いに反対側の近位端及び遠位端と、第1最大断面寸法を有する外面とを有しており、前記組織シーリング手段は、前記チューブの前記近位端及び前記遠位端から離間された少なくとも1つのエレメントを含み、前記少なくとも1つのエレメントは、前記チューブの外面を超えて半径方向外側に向かって延びていて、前記第1最大断面寸法よりも大きい第2最大断面寸法を有しており、前記第2最大断面寸法は少なくとも1つの鈍い面によって画定されている、眼の前房内部の上昇した眼内圧を治療するための埋め込み可能な器具。 - 前記少なくとも1つの鈍い面が長円形の断面プロフィールを有する、請求項37に記載の器具。
- 前記少なくとも1つの鈍い面が楕円形又は円形の断面プロフィールを有する、請求項37に記載の器具。
- 前記少なくとも1つのエレメントが、テーパされた遠位部分を有している、請求項37に記載の器具。
- 前記少なくとも1つのエレメントが、前記チューブの両側で前記チューブから半径方向に延びる第1タブと第2タブとを含み、前記第1タブは第1外縁部を形成し、前記第2タブは第2外縁部を形成し、前記第2最大断面寸法は、前記第1外縁部と前記第2外縁部との間の最大距離によって画定されている、請求項37に記載の器具。
- 前記第1最大断面寸法が0.4mm以下であり、前記第2最大断面寸法が少なくとも0.9mmである、請求項37に記載の器具。
- 前記器具は、SIBS材料、シリコーンゴム、ポリオレフィンポリマー、ポリウレタンポリマー、アクリルポリマー、フルオロポリマー、ポリアミドポリマー、ヒドロゲルポリマー、生物学に基づく構造、軟質ポリマー発泡体材料、多孔質ポリマー材料、及びこれらの組み合わせから成る群から選択された高分子材料から実現された単一の成形部分である、請求項37に記載の器具。
- 前記器具の少なくとも一部のための前記高分子材料に、少なくとも1種の治療薬が装填されている、請求項43に記載の器具。
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018520771A (ja) * | 2015-06-26 | 2018-08-02 | インフォーカス,インコーポレイテッド | 緑内障デバイス送達システム及び経結膜の送達方法 |
JP2023501629A (ja) * | 2019-11-19 | 2023-01-18 | マイクロト インコーポレーテッド | 容易で安全な方法で眼圧を低下させることができる眼疾患用インプラント装置 |
JP7445809B2 (ja) | 2017-06-13 | 2024-03-07 | インフォーカス,インコーポレイテッド | 緑内障の治療のためのシステム、方法及び器具 |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60042853D1 (de) | 1999-04-26 | 2009-10-08 | Glaukos Corp | Shunteinrichtung zur Glaukombehandlung |
US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
DE60225815T2 (de) | 2001-04-07 | 2009-02-05 | Glaukos Corp., Laguna Hills | Glaukom-stent für die glaukom-behandlung |
US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
US20120123316A1 (en) | 2010-11-15 | 2012-05-17 | Aquesys, Inc. | Intraocular shunts for placement in the intra-tenon's space |
US8663303B2 (en) | 2010-11-15 | 2014-03-04 | Aquesys, Inc. | Methods for deploying an intraocular shunt from a deployment device and into an eye |
US10085884B2 (en) | 2006-06-30 | 2018-10-02 | Aquesys, Inc. | Intraocular devices |
US8852256B2 (en) | 2010-11-15 | 2014-10-07 | Aquesys, Inc. | Methods for intraocular shunt placement |
US8721702B2 (en) | 2010-11-15 | 2014-05-13 | Aquesys, Inc. | Intraocular shunt deployment devices |
JP5748407B2 (ja) | 2006-11-10 | 2015-07-15 | グローコス コーポレーション | ブドウ膜強膜シャント |
US20170360609A9 (en) | 2007-09-24 | 2017-12-21 | Ivantis, Inc. | Methods and devices for increasing aqueous humor outflow |
US10842671B2 (en) | 2010-11-15 | 2020-11-24 | Aquesys, Inc. | Intraocular shunt placement in the suprachoroidal space |
US10080682B2 (en) | 2011-12-08 | 2018-09-25 | Aquesys, Inc. | Intrascleral shunt placement |
US9808373B2 (en) | 2013-06-28 | 2017-11-07 | Aquesys, Inc. | Intraocular shunt implantation |
US9610195B2 (en) | 2013-02-27 | 2017-04-04 | Aquesys, Inc. | Intraocular shunt implantation methods and devices |
US8765210B2 (en) | 2011-12-08 | 2014-07-01 | Aquesys, Inc. | Systems and methods for making gelatin shunts |
US8852136B2 (en) | 2011-12-08 | 2014-10-07 | Aquesys, Inc. | Methods for placing a shunt into the intra-scleral space |
US9101444B2 (en) | 2012-01-12 | 2015-08-11 | Innfocus, Inc. | Method, surgical kit and device for treating glaucoma |
US10342700B2 (en) * | 2012-02-22 | 2019-07-09 | Ira H. Schachar | Device and method for treatment of retinal detachment and other maladies of the eye |
US9554940B2 (en) | 2012-03-26 | 2017-01-31 | Glaukos Corporation | System and method for delivering multiple ocular implants |
US9358156B2 (en) | 2012-04-18 | 2016-06-07 | Invantis, Inc. | Ocular implants for delivery into an anterior chamber of the eye |
US10617558B2 (en) | 2012-11-28 | 2020-04-14 | Ivantis, Inc. | Apparatus for delivering ocular implants into an anterior chamber of the eye |
DE102013018008A1 (de) * | 2012-12-19 | 2014-06-26 | Ophtalmic Implants Private Limited | Trokar und integriertes Trokarnadelsystem für die Glaukomdrainagechirurgie |
US10159600B2 (en) | 2013-02-19 | 2018-12-25 | Aquesys, Inc. | Adjustable intraocular flow regulation |
US9125723B2 (en) | 2013-02-19 | 2015-09-08 | Aquesys, Inc. | Adjustable glaucoma implant |
US9592151B2 (en) | 2013-03-15 | 2017-03-14 | Glaukos Corporation | Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye |
US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
NZ719850A (en) | 2013-11-14 | 2017-03-31 | Aquesys Inc | Intraocular shunt inserter |
US9044301B1 (en) | 2013-11-25 | 2015-06-02 | Innfocus, Inc. | Methods, systems and devices for treating glaucoma |
US10010447B2 (en) * | 2013-12-18 | 2018-07-03 | Novartis Ag | Systems and methods for subretinal delivery of therapeutic agents |
CN106456364B (zh) * | 2014-02-24 | 2018-01-16 | 新加坡国立大学 | 眼睛引流装置及其制造方法 |
BR112016021477A2 (pt) | 2014-03-17 | 2017-08-15 | Arkis Biosciences | Fio-guia de tunelização |
EP3677229A1 (en) | 2014-05-29 | 2020-07-08 | Glaukos Corporation | Implants with controlled drug delivery features |
WO2016011056A1 (en) | 2014-07-14 | 2016-01-21 | Ivantis, Inc. | Ocular implant delivery system and method |
CN204050005U (zh) | 2014-09-09 | 2014-12-31 | 赵潺 | 一次性负压前房穿刺针 |
CN113208809A (zh) | 2014-12-31 | 2021-08-06 | 迈克罗欧普提克斯股份有限公司 | 青光眼治疗装置和方法 |
JP6916742B2 (ja) | 2015-06-03 | 2021-08-11 | アクエシス, インコーポレイテッド | Ab externo(眼外から眼内へ)の眼内シャント配置 |
JP6837475B2 (ja) | 2015-08-14 | 2021-03-03 | イバンティス インコーポレイテッド | 圧力センサを備えた眼用インプラントおよび送達システム |
US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
US10980667B2 (en) | 2015-09-30 | 2021-04-20 | Microoptx Inc. | Eye treatment devices and methods |
WO2017106517A1 (en) | 2015-12-15 | 2017-06-22 | Ivantis, Inc. | Ocular implant and delivery system |
USD786433S1 (en) | 2016-01-29 | 2017-05-09 | Arkis Biosciences Inc. | Trocar |
CN105997341B (zh) * | 2016-04-21 | 2019-03-08 | 温州医科大学附属眼视光医院 | 一种青光眼内引流替代仿生支架的制备及其使用方法 |
CA3024891A1 (en) | 2016-05-31 | 2017-12-07 | Qura, Inc. | Implantable intraocular pressure sensors and methods of use |
WO2017210627A1 (en) | 2016-06-02 | 2017-12-07 | Aquesys, Inc. | Intraocular drug delivery |
CN106139265A (zh) * | 2016-07-14 | 2016-11-23 | 遵义医学院附属医院 | 胸腔引流置入装置 |
TW201811280A (zh) * | 2016-09-01 | 2018-04-01 | 英福卡斯公司 | 用於插入青光眼分流器之工具 |
USD835777S1 (en) | 2016-10-27 | 2018-12-11 | Arkis Biosciences Inc. | Guidewire stylette |
US11523940B2 (en) * | 2017-03-17 | 2022-12-13 | W. L. Gore & Associates, Inc. | Delivery aids for glaucoma shunts |
USD822830S1 (en) | 2017-04-20 | 2018-07-10 | Arkis Biosciences Inc. | Catheter retention device |
US11116625B2 (en) | 2017-09-28 | 2021-09-14 | Glaukos Corporation | Apparatus and method for controlling placement of intraocular implants |
CN110573117B (zh) | 2017-10-06 | 2021-10-26 | 格劳科斯公司 | 用于递送多个眼部植入物的系统和方法 |
USD846738S1 (en) | 2017-10-27 | 2019-04-23 | Glaukos Corporation | Implant delivery apparatus |
US11246753B2 (en) | 2017-11-08 | 2022-02-15 | Aquesys, Inc. | Manually adjustable intraocular flow regulation |
CN111867532B (zh) * | 2018-02-19 | 2024-01-05 | 新加坡保健服务集团有限公司 | 在靶外科手术部位处剪切组织的方法和设备 |
CN112351755A (zh) * | 2018-02-22 | 2021-02-09 | 伊万提斯公司 | 眼部植入物和输送系统 |
US11135089B2 (en) | 2018-03-09 | 2021-10-05 | Aquesys, Inc. | Intraocular shunt inserter |
US10952898B2 (en) | 2018-03-09 | 2021-03-23 | Aquesys, Inc. | Intraocular shunt inserter |
CN108433748A (zh) * | 2018-04-11 | 2018-08-24 | 中山大学中山眼科中心 | 带阀门的液态标本的采集装置 |
CN110711075A (zh) * | 2018-07-11 | 2020-01-21 | 吴坚 | 一种泪小管栓塞 |
US11173067B2 (en) | 2018-09-07 | 2021-11-16 | Vialase, Inc. | Surgical system and procedure for precise intraocular pressure reduction |
US11986424B2 (en) | 2018-07-16 | 2024-05-21 | Vialase, Inc. | Method, system, and apparatus for imaging and surgical scanning of the irido-corneal angle for laser surgery of glaucoma |
US11246754B2 (en) | 2018-07-16 | 2022-02-15 | Vialase, Inc. | Surgical system and procedure for treatment of the trabecular meshwork and Schlemm's canal using a femtosecond laser |
US11110006B2 (en) | 2018-09-07 | 2021-09-07 | Vialase, Inc. | Non-invasive and minimally invasive laser surgery for the reduction of intraocular pressure in the eye |
US10821024B2 (en) | 2018-07-16 | 2020-11-03 | Vialase, Inc. | System and method for angled optical access to the irido-corneal angle of the eye |
JP7022030B2 (ja) | 2018-08-08 | 2022-02-17 | Kddi株式会社 | コンテンツ配信ネットワークの転送装置 |
CN109172129A (zh) * | 2018-09-29 | 2019-01-11 | 王丽强 | 青光眼阀引流装置 |
EP3666236B1 (en) | 2018-12-12 | 2021-05-05 | AJL Ophthalmic, S.A. | Glaucoma implant device |
WO2020176315A1 (en) | 2019-02-27 | 2020-09-03 | Innfocus, Inc. | Glaucoma device inserter |
US11234866B2 (en) * | 2019-04-19 | 2022-02-01 | Elios Vision, Inc. | Personalization of excimer laser fibers |
WO2021000255A1 (zh) * | 2019-07-02 | 2021-01-07 | 北京华视诺维医疗科技有限公司 | 房水采集装置 |
WO2021072315A1 (en) | 2019-10-10 | 2021-04-15 | Shifamed Holdings, Llc | Adjustable flow glaucoma shunts and associated systems and methods |
WO2021151007A1 (en) | 2020-01-23 | 2021-07-29 | Shifamed Holdings, Llc | Adjustable flow glaucoma shunts and associated systems and methods |
US11564567B2 (en) | 2020-02-04 | 2023-01-31 | Vialase, Inc. | System and method for locating a surface of ocular tissue for glaucoma surgery based on dual aiming beams |
US11291585B2 (en) | 2020-02-14 | 2022-04-05 | Shifamed Holdings, Llc | Shunting systems with rotation-based flow control assemblies, and associated systems and methods |
US11737920B2 (en) | 2020-02-18 | 2023-08-29 | Shifamed Holdings, Llc | Adjustable flow glaucoma shunts having non-linearly arranged flow control elements, and associated systems and methods |
EP4120978A4 (en) | 2020-03-19 | 2024-04-17 | Shifamed Holdings Llc | INTRAOCULAR LEADS WITH TRAIL-FLAT ACTUATION ELEMENTS AND ASSOCIATED SYSTEMS AND METHODS |
US11612315B2 (en) | 2020-04-09 | 2023-03-28 | Vialase, Inc. | Alignment and diagnostic device and methods for imaging and surgery at the irido-corneal angle of the eye |
WO2021212007A2 (en) | 2020-04-16 | 2021-10-21 | Shifamed Holdings, Llc | Adjustable glaucoma treatment devices and associated systems and methods |
WO2022150684A1 (en) | 2021-01-11 | 2022-07-14 | Ivantis, Inc. | Systems and methods for viscoelastic delivery |
US11865283B2 (en) | 2021-01-22 | 2024-01-09 | Shifamed Holdings, Llc | Adjustable shunting systems with plate assemblies, and associated systems and methods |
CA3231671A1 (en) * | 2021-09-10 | 2023-03-16 | Iantrek, Inc. | Methods and devices for increasing aqueous drainage of the eye |
WO2023135549A1 (en) * | 2022-01-14 | 2023-07-20 | Liqid Medical Proprietary Limited | Surgical kit and method for treating glaucoma |
WO2023178379A1 (en) * | 2022-03-21 | 2023-09-28 | Molteno Ophthalmic Ltd | Ophthalmic implant with restriction mechanism on a drainage tube for treating glaucoma |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08508181A (ja) * | 1993-03-19 | 1996-09-03 | ユニバーシティ オブ マイアミ | 緑内症外科手術における人口網を移植するための方法及び器具 |
WO2010065970A1 (en) * | 2008-12-05 | 2010-06-10 | Ivantis, Inc. | Methods and apparatus for delivering ocular implants into the eye |
JP2010533565A (ja) * | 2007-07-17 | 2010-10-28 | トランセンド・メディカル・インコーポレイテッド | ヒドロゲルの拡張能力を備えた眼内植込み体 |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3726284A (en) * | 1971-04-05 | 1973-04-10 | R Parker | Replacement tube for the lacrimal drainage ducts |
US4011870A (en) * | 1976-03-05 | 1977-03-15 | Michael Goldstein | Needle instrument |
US4342849A (en) | 1979-09-10 | 1982-08-03 | The University Of Akron | Novel telechelic polymers and processes for the preparation thereof |
US4276394A (en) | 1979-09-10 | 1981-06-30 | The University Of Akron | Novel telechelic polymers, block copolymers and processes for the preparation thereof |
US4316973A (en) | 1979-09-10 | 1982-02-23 | The University Of Akron | Novel telechelic polymers and processes for the preparation thereof |
US4554918A (en) | 1982-07-28 | 1985-11-26 | White Thomas C | Ocular pressure relief device |
US4787885A (en) | 1984-04-06 | 1988-11-29 | Binder Perry S | Hydrogel seton |
US4897255A (en) | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US5122572A (en) | 1985-06-20 | 1992-06-16 | Kennedy Joseph P | Living catalysts, complexes and polymers therefrom |
US4910321A (en) | 1985-06-20 | 1990-03-20 | University Of Akron | Living catalysts, complexes and polymers therefrom |
DE3628006A1 (de) * | 1986-08-18 | 1988-02-25 | Frimberger Erintrud | Vorrichtung zum plazieren eines ernaehrungs-schlauches am magen des menschlichen oder tierischen koerpers |
US4929683A (en) | 1986-08-25 | 1990-05-29 | University Of Akron | Living polymerization of olefin to end-functionalized polymers |
US5066730A (en) | 1986-08-25 | 1991-11-19 | The University Of Akron | Living polymerization of olefins to end-functionalized polymers |
US4946899A (en) | 1988-12-16 | 1990-08-07 | The University Of Akron | Thermoplastic elastomers of isobutylene and process of preparation |
US4946436A (en) | 1989-11-17 | 1990-08-07 | Smith Stewart G | Pressure-relieving device and process for implanting |
US6007511A (en) * | 1991-05-08 | 1999-12-28 | Prywes; Arnold S. | Shunt valve and therapeutic delivery system for treatment of glaucoma and methods and apparatus for its installation |
US5300020A (en) * | 1991-05-31 | 1994-04-05 | Medflex Corporation | Surgically implantable device for glaucoma relief |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5968058A (en) | 1996-03-27 | 1999-10-19 | Optonol Ltd. | Device for and method of implanting an intraocular implant |
US5741331A (en) | 1996-07-29 | 1998-04-21 | Corvita Corporation | Biostable elastomeric polymers having quaternary carbons |
US6007510A (en) | 1996-10-25 | 1999-12-28 | Anamed, Inc. | Implantable devices and methods for controlling the flow of fluids within the body |
US6050970A (en) | 1997-05-08 | 2000-04-18 | Pharmacia & Upjohn Company | Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye |
US6203513B1 (en) | 1997-11-20 | 2001-03-20 | Optonol Ltd. | Flow regulating implant, method of manufacture, and delivery device |
US6010461A (en) | 1998-09-01 | 2000-01-04 | Sitek, Inc. | Monolithic silicon intra-ocular pressure sensor and method therefor |
US6558342B1 (en) * | 1999-06-02 | 2003-05-06 | Optonol Ltd. | Flow control device, introducer and method of implanting |
US7708711B2 (en) | 2000-04-14 | 2010-05-04 | Glaukos Corporation | Ocular implant with therapeutic agents and methods thereof |
US6545097B2 (en) | 2000-12-12 | 2003-04-08 | Scimed Life Systems, Inc. | Drug delivery compositions and medical devices containing block copolymer |
US6881198B2 (en) | 2001-01-09 | 2005-04-19 | J. David Brown | Glaucoma treatment device and method |
US6666841B2 (en) | 2001-05-02 | 2003-12-23 | Glaukos Corporation | Bifurcatable trabecular shunt for glaucoma treatment |
US6966888B2 (en) | 2002-01-13 | 2005-11-22 | Eagle Vision, Inc. | Sinus valved glaucoma shunt |
US20040147870A1 (en) | 2002-04-08 | 2004-07-29 | Burns Thomas W. | Glaucoma treatment kit |
AU2003256657A1 (en) | 2002-07-19 | 2004-02-09 | Yale University | Uveoscleral drainage device |
AU2004296205B2 (en) | 2003-12-05 | 2009-11-12 | Innfocus, Llc | Glaucoma implant device |
US7594899B2 (en) | 2004-12-03 | 2009-09-29 | Innfocus, Llc | Glaucoma implant device |
US20070118065A1 (en) * | 2004-12-03 | 2007-05-24 | Leonard Pinchuk | Glaucoma Implant Device |
US7837644B2 (en) | 2004-12-03 | 2010-11-23 | Innfocus, Llc | Glaucoma implant device |
US7559952B2 (en) * | 2004-12-17 | 2009-07-14 | Innovia, Llc | Elastomeric polymer filament cosmetic implant |
US20070027470A1 (en) * | 2005-07-07 | 2007-02-01 | Dodick Jack M | Surgical instrument |
EP3005996B1 (en) * | 2006-01-17 | 2019-12-04 | Novartis Ag | Glaucoma treatment device |
CN101505683B (zh) * | 2006-03-31 | 2013-08-28 | 玛提治疗有限公司 | 用于鼻泪系统的药物释放方法、结构及组合物 |
US7909789B2 (en) * | 2006-06-26 | 2011-03-22 | Sight Sciences, Inc. | Intraocular implants and methods and kits therefor |
US8469987B2 (en) * | 2007-08-09 | 2013-06-25 | Senorx, Inc. | Split sheath for trocar assembly |
US8765895B2 (en) | 2007-11-08 | 2014-07-01 | Innolene Llc | Crosslinked polyolefins for biomedical applications and method of making same |
US20090177219A1 (en) * | 2008-01-03 | 2009-07-09 | Conlon Sean P | Flexible tissue-penetration instrument with blunt tip assembly and methods for penetrating tissue |
US9101444B2 (en) | 2012-01-12 | 2015-08-11 | Innfocus, Inc. | Method, surgical kit and device for treating glaucoma |
-
2012
- 2012-01-12 US US13/348,931 patent/US9101444B2/en active Active
-
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08508181A (ja) * | 1993-03-19 | 1996-09-03 | ユニバーシティ オブ マイアミ | 緑内症外科手術における人口網を移植するための方法及び器具 |
JP2010533565A (ja) * | 2007-07-17 | 2010-10-28 | トランセンド・メディカル・インコーポレイテッド | ヒドロゲルの拡張能力を備えた眼内植込み体 |
WO2010065970A1 (en) * | 2008-12-05 | 2010-06-10 | Ivantis, Inc. | Methods and apparatus for delivering ocular implants into the eye |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018520771A (ja) * | 2015-06-26 | 2018-08-02 | インフォーカス,インコーポレイテッド | 緑内障デバイス送達システム及び経結膜の送達方法 |
JP7445809B2 (ja) | 2017-06-13 | 2024-03-07 | インフォーカス,インコーポレイテッド | 緑内障の治療のためのシステム、方法及び器具 |
JP2023501629A (ja) * | 2019-11-19 | 2023-01-18 | マイクロト インコーポレーテッド | 容易で安全な方法で眼圧を低下させることができる眼疾患用インプラント装置 |
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