JP2015505296A5 - - Google Patents
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- JP2015505296A5 JP2015505296A5 JP2014538931A JP2014538931A JP2015505296A5 JP 2015505296 A5 JP2015505296 A5 JP 2015505296A5 JP 2014538931 A JP2014538931 A JP 2014538931A JP 2014538931 A JP2014538931 A JP 2014538931A JP 2015505296 A5 JP2015505296 A5 JP 2015505296A5
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- JP
- Japan
- Prior art keywords
- compound
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- -1 peptidyl compound Chemical class 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- NSCGMRWMLGCCDO-YDALLXLXSA-N CCCC(N(C)[C@@](CC)(CCC)C(N)=O)[U] Chemical compound CCCC(N(C)[C@@](CC)(CCC)C(N)=O)[U] NSCGMRWMLGCCDO-YDALLXLXSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550782P | 2011-10-24 | 2011-10-24 | |
| US61/550,782 | 2011-10-24 | ||
| PCT/US2012/061696 WO2013063120A2 (en) | 2011-10-24 | 2012-10-24 | Nmda receptor modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015505296A JP2015505296A (ja) | 2015-02-19 |
| JP2015505296A5 true JP2015505296A5 (cg-RX-API-DMAC7.html) | 2015-11-26 |
| JP6210993B2 JP6210993B2 (ja) | 2017-10-11 |
Family
ID=48168770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014538931A Active JP6210993B2 (ja) | 2011-10-24 | 2012-10-24 | Ｎｍｄａ受容体調節剤およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US8673843B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2771021B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6210993B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101692275B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN104321071A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2012328927B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014009851A8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2853364C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2703904T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1206616A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2621049C2 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201401776WA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013063120A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010033757A1 (en) | 2008-09-18 | 2010-03-25 | Naurex, Inc. | Nmda receptor modulators and uses thereof |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| BR112012020142A2 (pt) | 2010-02-11 | 2020-08-18 | Northwestern University | moduladores do receptor de nmda com estrutura secundária estabilizada e usos dos mesmos. |
| KR101692275B1 (ko) * | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도 |
| SMT202300232T1 (it) | 2011-09-08 | 2023-09-06 | Sage Therapeutics Inc | Steroidi neuroattivi, composizioni e relativi usi |
| BR112015018094A2 (pt) | 2013-01-29 | 2017-07-18 | Naurex Inc | moduladores de receptor nmda de espiro-lactama e usos dos mesmos |
| JP6419087B2 (ja) | 2013-01-29 | 2018-11-07 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
| ES2935352T3 (es) | 2013-01-29 | 2023-03-06 | Aptinyx Inc | Moduladores de receptores NMDA de espiro-lactama y sus usos |
| MX375286B (es) | 2013-01-29 | 2025-03-06 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
| CN105026401A (zh) | 2013-01-29 | 2015-11-04 | 诺雷克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| AU2014243773B2 (en) | 2013-03-13 | 2018-12-13 | Sage Therapeutics, Inc. | Neuroactive steroids and methods of use thereof |
| CN104109189B (zh) * | 2013-04-18 | 2019-05-10 | 中国人民解放军军事医学科学院毒物药物研究所 | Thr-Pro-Pro-Thr四肽的液相合成方法 |
| JP6603668B2 (ja) * | 2013-10-28 | 2019-11-06 | ノーレックス インコーポレイテッド | Ｎｍｄａ受容体モジュレーター及びプロドラッグ、塩、並びにこれらの使用 |
| WO2015195967A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2016014982A1 (en) | 2014-07-24 | 2016-01-28 | Naurex, Inc. | N-methyl-d-aspartate receptor modulators and methods of making and using same |
| CN112121171A (zh) * | 2014-10-07 | 2020-12-25 | 萨奇治疗股份有限公司 | 神经活性化合物及其使用方法 |
| BR122021005552B1 (pt) | 2015-07-06 | 2024-01-02 | Sage Therapeutics, Inc | Compostos oxiesteróis, seus usos e composição farmacêutica |
| AU2016289971C1 (en) | 2015-07-06 | 2022-12-08 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2017007832A1 (en) | 2015-07-06 | 2017-01-12 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| KR20180102052A (ko) * | 2015-10-16 | 2018-09-14 | 노오쓰웨스턴 유니버시티 | 조현병, 양극성 장애, 인지 손상 및 주요 우울 장애의 치료를 위한 비전형적 항정신병약과 nmda 조절제의 약제학적 병용 |
| EP3436022B1 (en) | 2016-04-01 | 2022-03-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| KR102128675B1 (ko) | 2016-05-19 | 2020-06-30 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| PT3481846T (pt) | 2016-07-07 | 2021-08-13 | Sage Therapeutics Inc | 24-hidroxiesteroides 11-substituídos para utilização no tratamento de afeções relacionadas com nmda |
| KR102503590B1 (ko) | 2016-08-01 | 2023-02-24 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| SG11201900551WA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| EA201990424A1 (ru) | 2016-08-01 | 2019-08-30 | Аптиникс Инк. | Спиролактамовые модуляторы nmda-рецептора и их применение |
| CA3031563C (en) | 2016-08-01 | 2023-12-05 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
| JP2019527235A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用 |
| WO2018064649A1 (en) | 2016-09-30 | 2018-04-05 | Sage Therapeutics, Inc. | C7 substituted oxysterols and methods as nmda modulators |
| RU2019115112A (ru) | 2016-10-18 | 2020-11-24 | Сейдж Терапьютикс, Инк. | Оксистеролы и способы их применения |
| RU2019115113A (ru) | 2016-10-18 | 2020-11-24 | Сейдж Терапьютикс, Инк. | Оксистеролы и способы их применения |
| CN108148113A (zh) * | 2016-12-06 | 2018-06-12 | 深圳先进技术研究院 | 一种nmda受体调控剂四肽衍生物的固相合成方法 |
| CN107474107B (zh) * | 2017-05-18 | 2023-01-17 | 江苏恩华药业股份有限公司 | Glyx-13的制备方法及用于制备glyx-13的化合物 |
| FR3067028B1 (fr) * | 2017-06-06 | 2019-07-12 | Adpuerivitam | Modulateurs de recepteurs nmda, compositions les comprenant et utilisation de ces composes dans le traitement de maladies impliquant le systeme nerveux central |
| CA3071269C (en) * | 2017-07-28 | 2025-06-10 | Naurex Inc. | METHOD AND INTERMEDIATES FOR THE SYNTHESIS OF PEPTIDE COMPOUNDS |
| SG11202007256PA (en) | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| CN110003309B (zh) * | 2019-04-09 | 2021-09-10 | 北京广为医药科技有限公司 | 调节nmda受体活性的化合物、其药物组合物及用途 |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
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| PL2485751T3 (pl) | 2009-10-05 | 2014-10-31 | Univ Northwestern | GLYX-13 do stosowania w sposobie leczenia depresji opornej na leczenie |
| KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도 |
| BR112012020142A2 (pt) | 2010-02-11 | 2020-08-18 | Northwestern University | moduladores do receptor de nmda com estrutura secundária estabilizada e usos dos mesmos. |
| EP3679931A3 (en) | 2011-04-27 | 2020-10-14 | Northwestern University | Methods of treating alzheimer's disease, huntington's disease, autism, and other disorders |
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2011
- 2011-02-11 KR KR1020127023731A patent/KR101692275B1/ko not_active Expired - Fee Related
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2012
- 2012-06-18 US US13/525,861 patent/US8673843B2/en active Active
- 2012-10-24 WO PCT/US2012/061696 patent/WO2013063120A2/en not_active Ceased
- 2012-10-24 SG SG11201401776WA patent/SG11201401776WA/en unknown
- 2012-10-24 US US14/353,681 patent/US20150051262A1/en not_active Abandoned
- 2012-10-24 BR BR112014009851A patent/BR112014009851A8/pt not_active Application Discontinuation
- 2012-10-24 AU AU2012328927A patent/AU2012328927B2/en active Active
- 2012-10-24 JP JP2014538931A patent/JP6210993B2/ja active Active
- 2012-10-24 RU RU2014121090A patent/RU2621049C2/ru active
- 2012-10-24 CA CA2853364A patent/CA2853364C/en active Active
- 2012-10-24 ES ES12844456T patent/ES2703904T3/es active Active
- 2012-10-24 EP EP12844456.9A patent/EP2771021B1/en active Active
- 2012-10-24 KR KR1020147013898A patent/KR102038161B1/ko active Active
- 2012-10-24 CN CN201280063834.6A patent/CN104321071A/zh active Pending
- 2012-10-24 CN CN201810978925.1A patent/CN109232713A/zh active Pending
- 2012-10-24 HK HK15107208.6A patent/HK1206616A1/xx unknown
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2014
- 2014-01-23 US US14/162,328 patent/US20150315237A1/en not_active Abandoned
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2016
- 2016-08-30 US US15/252,132 patent/US20160368947A1/en not_active Abandoned
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2017
- 2017-08-14 AU AU2017213587A patent/AU2017213587A1/en not_active Abandoned
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2018
- 2018-02-14 US US15/896,662 patent/US20180237474A1/en not_active Abandoned
- 2018-07-06 US US16/028,664 patent/US20190135862A1/en not_active Abandoned
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2019
- 2019-06-11 AU AU2019204073A patent/AU2019204073B2/en active Active