JP2015504924A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015504924A5 JP2015504924A5 JP2014554892A JP2014554892A JP2015504924A5 JP 2015504924 A5 JP2015504924 A5 JP 2015504924A5 JP 2014554892 A JP2014554892 A JP 2014554892A JP 2014554892 A JP2014554892 A JP 2014554892A JP 2015504924 A5 JP2015504924 A5 JP 2015504924A5
- Authority
- JP
- Japan
- Prior art keywords
- progesterone
- drug substance
- transdermal pharmaceutical
- transdermal
- estrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 36
- 229960003387 progesterone Drugs 0.000 claims 18
- 239000000186 progesterone Substances 0.000 claims 18
- 239000008186 active pharmaceutical agent Substances 0.000 claims 14
- 229940088679 drug related substance Drugs 0.000 claims 14
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 239000000825 pharmaceutical preparation Substances 0.000 claims 11
- 229940011871 estrogen Drugs 0.000 claims 8
- 239000000262 estrogen Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 6
- 230000007812 deficiency Effects 0.000 claims 6
- 229960005309 estradiol Drugs 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 206010030247 Oestrogen deficiency Diseases 0.000 claims 4
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims 4
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 3
- -1 diglyceride Chemical compound 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 229930182833 estradiol Natural products 0.000 claims 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261590927P | 2012-01-26 | 2012-01-26 | |
| US61/590,927 | 2012-01-26 | ||
| US201261661302P | 2012-06-18 | 2012-06-18 | |
| US61/661,302 | 2012-06-18 | ||
| US201261662265P | 2012-06-20 | 2012-06-20 | |
| US61/662,265 | 2012-06-20 | ||
| US13/684,002 | 2012-11-21 | ||
| US13/684,002 US8633178B2 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
| PCT/US2013/023309 WO2013112947A1 (en) | 2012-01-26 | 2013-01-25 | Transdermal hormone replacement therapies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504924A JP2015504924A (ja) | 2015-02-16 |
| JP2015504924A5 true JP2015504924A5 (OSRAM) | 2016-03-10 |
| JP6342334B2 JP6342334B2 (ja) | 2018-06-13 |
Family
ID=48873981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554892A Expired - Fee Related JP6342334B2 (ja) | 2012-01-26 | 2013-01-25 | 経皮ホルモン補充療法 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP2806742B1 (OSRAM) |
| JP (1) | JP6342334B2 (OSRAM) |
| AU (1) | AU2013211876B2 (OSRAM) |
| BR (1) | BR112014018439A8 (OSRAM) |
| CA (1) | CA2861346C (OSRAM) |
| MX (1) | MX367596B (OSRAM) |
| WO (1) | WO2013112947A1 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| CA2856520C (en) | 2011-11-23 | 2021-04-06 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2015073177A1 (en) * | 2013-10-10 | 2015-05-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositons and methods |
| BR112016009008B8 (pt) * | 2013-10-22 | 2023-01-31 | Therapeuticsmd Inc | Uso de estradiol e/ou hemi-hidrato de estradiol e de um agente solubilizante compreendendo um óleo de cadeia média para a preparação de um pessário para o tratamento de atrofia vulvovaginal e pessário que compreende estradiol |
| AR100562A1 (es) | 2014-05-22 | 2016-10-12 | Therapeuticsmd Inc | Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal |
| AU2015296609A1 (en) * | 2014-07-29 | 2016-12-22 | Therapeuticsmd, Inc. | Transdermal cream |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| US20230414912A1 (en) * | 2020-11-12 | 2023-12-28 | Medrx Co., Ltd. | Microneedle Array Coated with Composition Containing Particles |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5145682A (en) * | 1986-05-30 | 1992-09-08 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for postmenopausal syndrome treatment and process for administration |
| CN1021196C (zh) * | 1986-12-29 | 1993-06-16 | 新泽西州州立大学(鲁杰斯) | 透皮雌激素/孕激素药剂单元、系统及方法 |
| US4788062A (en) * | 1987-02-26 | 1988-11-29 | Alza Corporation | Transdermal administration of progesterone, estradiol esters, and mixtures thereof |
| US4973468A (en) * | 1989-03-22 | 1990-11-27 | Cygnus Research Corporation | Skin permeation enhancer compositions |
| JP2910857B2 (ja) * | 1989-04-04 | 1999-06-23 | ニチバン株式会社 | プロスタグランジンｅ１経皮吸収製剤 |
| US5543150A (en) * | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
| DE19548332A1 (de) * | 1995-12-22 | 1997-07-10 | Rotta Res Bv | Hormonpflaster |
| AU3136897A (en) * | 1996-05-22 | 1997-12-09 | Diversified Pharmaceuticals, Inc. | Compositions, methods and devices for the transdermal delivery of drugs |
| DE19700913C2 (de) * | 1997-01-14 | 2001-01-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Abgabe von Hormonen |
| US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| KR100452972B1 (ko) * | 2000-05-16 | 2004-10-14 | 주식회사 삼양사 | 경피투여용 하이드로젤 조성물 |
| KR20030003769A (ko) * | 2000-05-31 | 2003-01-10 | 니찌방 가부시기가이샤 | 경피흡수형 스테로이드 외용제 |
| US20070111975A1 (en) * | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
-
2013
- 2013-01-25 WO PCT/US2013/023309 patent/WO2013112947A1/en not_active Ceased
- 2013-01-25 EP EP13741053.6A patent/EP2806742B1/en active Active
- 2013-01-25 AU AU2013211876A patent/AU2013211876B2/en not_active Ceased
- 2013-01-25 BR BR112014018439A patent/BR112014018439A8/pt not_active Application Discontinuation
- 2013-01-25 CA CA2861346A patent/CA2861346C/en active Active
- 2013-01-25 JP JP2014554892A patent/JP6342334B2/ja not_active Expired - Fee Related
- 2013-01-25 MX MX2014009093A patent/MX367596B/es active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015504924A5 (OSRAM) | ||
| EP2861233B1 (en) | Transdermal hormone replacement therapies | |
| KR102177782B1 (ko) | 천연 병용 호르몬 대체 제형 및 요법 | |
| KR101607034B1 (ko) | 경구 테스토스테론 에스테르 제형 및 이를 포함하는 테스토스테론 결핍을 치료하는 방법 | |
| JP2015520237A5 (OSRAM) | ||
| ES2885523T3 (es) | Formulaciones y terapias de reposición hormonal de combinación naturales | |
| JP6342334B2 (ja) | 経皮ホルモン補充療法 | |
| JP2015520235A5 (OSRAM) | ||
| US20170281646A1 (en) | Steroid hormone pharmaceutical composition | |
| JP2007508296A5 (OSRAM) | ||
| JP2012527484A (ja) | 哺乳動物疾患の治療におけるエンドキシフェンの方法および組成物 | |
| AU2014261009A1 (en) | Compositions of pharmaceutical actives containing Diethylene glycol monoethyl ether or other alkyl derivatives | |
| JP2017516768A (ja) | 天然の併用ホルモン補充療法剤及び療法 | |
| AR075735A1 (es) | Composiciones farmaceuticas de liberacion inmediata que comprenden oxicodona y naloxona. uso | |
| JP2016503030A5 (OSRAM) | ||
| JP2020503269A (ja) | 経口ウンデカン酸テストステロン療法 | |
| ES2983643T3 (es) | Terapia oral con tridecanoato de testosterona | |
| HRP20140204T1 (hr) | Oralni oblici doziranja bendamustina | |
| JP2022517217A (ja) | 経口薄フィルム | |
| JP2017516794A (ja) | 経口イソトレチノイン医薬組成物 | |
| CN104363899A (zh) | [(1s)-1-{[(2s,4r)-4-(7-氯-4-甲氧基异喹啉-1-基氧基)-2-({(1r,2s)-1-[(环丙基磺酰基)氨甲酰基]-2-乙烯基环丙基}氨甲酰基)吡咯烷-1-基]羰基}-2,2-二甲基丙基]氨基甲酸1,1-二甲基乙基酯的增溶的胶囊制剂 | |
| MX384683B (es) | Composición y métodos farmacéuticos. | |
| JP2019523779A5 (OSRAM) | ||
| JP2011507853A5 (OSRAM) | ||
| CN105073118A (zh) | 用于经口递送的脂平衡长链睾酮酯 |