JP2015504514A5 - - Google Patents
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- JP2015504514A5 JP2015504514A5 JP2014541200A JP2014541200A JP2015504514A5 JP 2015504514 A5 JP2015504514 A5 JP 2015504514A5 JP 2014541200 A JP2014541200 A JP 2014541200A JP 2014541200 A JP2014541200 A JP 2014541200A JP 2015504514 A5 JP2015504514 A5 JP 2015504514A5
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- JP
- Japan
- Prior art keywords
- level
- item
- treatment
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- syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 90
- 239000000090 biomarker Substances 0.000 claims description 63
- 238000011282 treatment Methods 0.000 claims description 35
- 208000011580 syndromic disease Diseases 0.000 claims description 32
- 239000000523 sample Substances 0.000 claims description 21
- 210000004556 brain Anatomy 0.000 claims description 16
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 14
- 108010089932 heparan sulfate sulfatase Proteins 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 7
- 239000013068 control sample Substances 0.000 claims description 6
- 238000002641 enzyme replacement therapy Methods 0.000 claims description 6
- 239000003550 marker Substances 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims description 3
- 238000007913 intrathecal administration Methods 0.000 claims description 3
- 230000001272 neurogenic effect Effects 0.000 claims description 3
- 210000005259 peripheral blood Anatomy 0.000 claims description 3
- 239000011886 peripheral blood Substances 0.000 claims description 3
- 210000002381 plasma Anatomy 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 230000004797 therapeutic response Effects 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 claims description 3
- 210000001638 cerebellum Anatomy 0.000 claims description 2
- 230000001054 cortical effect Effects 0.000 claims description 2
- 210000004884 grey matter Anatomy 0.000 claims description 2
- 230000004766 neurogenesis Effects 0.000 claims description 2
- 210000004885 white matter Anatomy 0.000 claims description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 11
- 208000005340 mucopolysaccharidosis III Diseases 0.000 claims 6
- 208000011045 mucopolysaccharidosis type 3 Diseases 0.000 claims 6
- 238000002716 delivery method Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 description 10
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 10
- 102000016838 Calbindin 1 Human genes 0.000 description 8
- 108010028310 Calbindin 1 Proteins 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 210000004381 amniotic fluid Anatomy 0.000 description 2
- 210000004252 chorionic villi Anatomy 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 108010009254 Lysosomal-Associated Membrane Protein 1 Proteins 0.000 description 1
- 108010009491 Lysosomal-Associated Membrane Protein 2 Proteins 0.000 description 1
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 description 1
- 102100038225 Lysosome-associated membrane glycoprotein 2 Human genes 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 102000007478 beta-N-Acetylhexosaminidases Human genes 0.000 description 1
- 108010085377 beta-N-Acetylhexosaminidases Proteins 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161556810P | 2011-11-07 | 2011-11-07 | |
| US61/556,810 | 2011-11-07 | ||
| US201261584165P | 2012-01-06 | 2012-01-06 | |
| US61/584,165 | 2012-01-06 | ||
| PCT/US2012/063935 WO2013070760A1 (en) | 2011-11-07 | 2012-11-07 | Biomarkers for sanfilippo syndrome and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015504514A JP2015504514A (ja) | 2015-02-12 |
| JP2015504514A5 true JP2015504514A5 (https=) | 2015-12-24 |
Family
ID=48280853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541200A Pending JP2015504514A (ja) | 2011-11-07 | 2012-11-07 | サンフィリポ症候群のためのバイオマーカーおよびそれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20130121984A1 (https=) |
| EP (1) | EP2776553B1 (https=) |
| JP (1) | JP2015504514A (https=) |
| CN (1) | CN104114686A (https=) |
| AU (1) | AU2012335890A1 (https=) |
| CA (1) | CA2854333A1 (https=) |
| WO (1) | WO2013070760A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201590582A1 (ru) * | 2012-12-07 | 2016-01-29 | Шир Хьюман Дженетик Терапис, Инк. | Способы и композиции для лечения мукополисахаридоза типа iiia с использованием интратекального введения |
| US10413597B2 (en) | 2014-09-29 | 2019-09-17 | Alexion Pharmaceuticals, Inc. | Methods of treating Mucopolysaccharidosis IIIB (MPSIIIB) |
| MA40954A (fr) * | 2014-11-14 | 2017-09-19 | Shire Human Genetic Therapies | Détermination de niveaux de glycosaminoglycane par spectrométrie de masse |
| WO2017132675A1 (en) * | 2016-01-29 | 2017-08-03 | Alexion Pharmaceuticals, Inc. | Enzyme replacement therapy in mucopolysaccharidosis iiib patients |
| EP3684463B1 (en) | 2017-09-19 | 2025-05-14 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US11478603B2 (en) | 2017-12-31 | 2022-10-25 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| CN113382683A (zh) | 2018-09-14 | 2021-09-10 | 纽罗因恒思蒙特实验有限责任公司 | 改善睡眠的系统和方法 |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| WO2021057985A1 (zh) * | 2019-09-27 | 2021-04-01 | 成都中医药大学 | 检测粪钙卫蛋白含量的试剂在制备子宫病变筛查试剂盒中的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| WO2003004514A1 (en) * | 2001-07-06 | 2003-01-16 | Origene Technologies, Inc | Small intestine and colon genes |
| AU2003231220A1 (en) * | 2002-04-30 | 2003-11-17 | Saint Louis University | A method for detecting lysosomal storage diseases |
| AUPS293002A0 (en) * | 2002-06-14 | 2002-07-04 | Women's And Children's Hospital | Identification of oligosaccharides and their use in the diagnosis and evaluation of mucopolysaccharidoses and other related disorders |
| US20050026823A1 (en) * | 2003-06-20 | 2005-02-03 | Biomarin Pharmaceutical Inc. | Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues |
| US7442372B2 (en) * | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| WO2007065273A1 (en) * | 2005-12-08 | 2007-06-14 | The University Of British Columbia | Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith |
| US20070161074A1 (en) * | 2005-12-27 | 2007-07-12 | Daiichi Pharmaceutical Co., Ltd. | Diagnostic method of mucopolysaccharidoses |
| WO2010078515A2 (en) * | 2009-01-02 | 2010-07-08 | Zacharon Pharmaceuticals, Inc. | Polymer end group detection |
| US9029530B2 (en) * | 2009-01-02 | 2015-05-12 | Biomarin Pharmaceutical Inc. | Detection of oligosaccharides |
-
2012
- 2012-11-07 US US13/671,302 patent/US20130121984A1/en not_active Abandoned
- 2012-11-07 EP EP12847544.9A patent/EP2776553B1/en active Active
- 2012-11-07 CA CA2854333A patent/CA2854333A1/en not_active Abandoned
- 2012-11-07 JP JP2014541200A patent/JP2015504514A/ja active Pending
- 2012-11-07 WO PCT/US2012/063935 patent/WO2013070760A1/en not_active Ceased
- 2012-11-07 CN CN201280065796.8A patent/CN104114686A/zh active Pending
- 2012-11-07 AU AU2012335890A patent/AU2012335890A1/en not_active Abandoned
-
2016
- 2016-06-16 US US15/184,731 patent/US20170131293A1/en not_active Abandoned
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