JP2015504430A - Ｉｌ−７アンタゴニスト及びｐｓａ応答又は非応答対立遺伝子を用いた乾癬性関節炎（ｐｓａ）を治療する方法 - Google Patents

Ｉｌ−７アンタゴニスト及びｐｓａ応答又は非応答対立遺伝子を用いた乾癬性関節炎（ｐｓａ）を治療する方法 Download PDF

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JP2015504430A
JP2015504430A JP2014542299A JP2014542299A JP2015504430A JP 2015504430 A JP2015504430 A JP 2015504430A JP 2014542299 A JP2014542299 A JP 2014542299A JP 2014542299 A JP2014542299 A JP 2014542299A JP 2015504430 A JP2015504430 A JP 2015504430A
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ノバルティス アーゲー
ノバルティス アーゲー
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JP2014542299A 2011-11-21 2012-06-07 Ｉｌ−７アンタゴニスト及びｐｓａ応答又は非応答対立遺伝子を用いた乾癬性関節炎（ｐｓａ）を治療する方法 Pending JP2015504430A (ja)

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IQ3702011 2011-11-21
IQ370/2011 2011-11-21
US201261624564P 2012-04-16 2012-04-16
US61/624,564 2012-04-16
PCT/US2012/041310 WO2013077907A1 (en) 2011-11-21 2012-06-07 Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non- response alleles

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JP2015504430A true JP2015504430A (ja) 2015-02-12
JP2015504430A5 JP2015504430A5 (https=) 2015-07-23

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US (1) US20150064193A1 (https=)
EP (1) EP2783014A1 (https=)
JP (1) JP2015504430A (https=)
KR (1) KR20140097178A (https=)
CN (1) CN104011223A (https=)
AR (1) AR086907A1 (https=)
AU (1) AU2012341081B2 (https=)
BR (1) BR112014012101A2 (https=)
CA (1) CA2856252A1 (https=)
MX (1) MX2014006158A (https=)
RU (1) RU2014125071A (https=)
WO (1) WO2013077907A1 (https=)

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PH12013500660B1 (en) 2010-10-08 2017-10-27 Novartis Ag Methods of treating psoriasis using il-17 antagonists
MX362591B (es) 2010-11-05 2019-01-25 Novartis Ag Uso de antagonistas de il-17.
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
WO2014081507A1 (en) 2012-11-26 2014-05-30 Moderna Therapeutics, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
EP3142645A4 (en) 2014-05-15 2017-12-27 Rani Therapeutics, LLC Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
US11548940B2 (en) 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
MX2017003216A (es) 2014-09-10 2017-05-23 Novartis Ag Uso de antagonistas de il-17 para inhibir la progresion del daño estructural en pacientes con artritis psoriasica.
AR103172A1 (es) * 2014-12-22 2017-04-19 Novartis Ag Reducción selectiva de residuos de cisteina en anticuerpos il-17
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
US20160244520A1 (en) * 2015-01-24 2016-08-25 Abbvie Inc. Compositions and methods for treating psoriatic arthritis
MY206805A (en) 2015-10-27 2025-01-08 UCB Biopharma SRL Methods of treatment using anti-il-17a/f antibodies
MA55149A (fr) * 2018-11-20 2021-09-29 Janssen Biotech Inc Procédé sûr et efficace de traitement du psoriasis avec un anticorps spécifique anti-il-23
MX2021014953A (es) * 2019-06-04 2022-01-24 Janssen Biotech Inc Metodo seguro y eficaz para tratar la artritis psoriasica con el anticuerpo especifico anti-il23.
US12497449B2 (en) * 2019-09-20 2025-12-16 Novartis Ag Methods of treating autoimmune diseases using interleukin-17 (IL-17) antagonists
BR112023018400A2 (pt) * 2021-03-12 2023-12-12 Janssen Biotech Inc Método para tratamento de pacientes de artrite psoriática com resposta inadequada à terapia de tnf com anticorpo específico anti-il23
MX2023010705A (es) * 2021-03-12 2023-11-22 Janssen Biotech Inc Método seguro y eficaz para tratar la artritis psoriásica con el anticuerpo específico anti-il23.
CN114427001A (zh) * 2022-01-29 2022-05-03 中日友好医院(中日友好临床医学研究所) 基于78个snp位点评估阿达木单抗治疗银屑病有效性的试剂盒

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JPN6016009266; ＶＥＬＩＣＨＫＯ　Ｓ．　ｅｔ　ａｌ．: 'Ｇｌｏｂａｌ　ｇｅｎｅ　ｅｘｐｒｅｓｓｉｏｎ　ａｎａｌｙｓｉｓ　ｏｆ　Ａｃｔ１'ｓ　ｅｆｆｅｃｔｓ　ｉｎ　ａｉｒｗａｙ　ｅｐｉｔｈｅｌｉａｌ　ｃｅｌｌｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１８６，　ＭｅｅｔｉｎｇＡｂｓｔｒａｃｔｓ, 201104, Ａｂｓｔｒａｃｔ　Ｎｏ．１６１．１７ *
JPN6016009267; ＥＬＬＩＮＧＨＡＵＳ　Ｅ．　ｅｔ　ａｌ．: 'Ｇｅｎｏｍｅ-ｗｉｄｅ　ａｓｓｏｃｉａｔｉｏｎ　ｓｔｕｄｙ　ｉｄｅｎｔｉｆｉｅｓ　ａ　ｐｓｏｒｉａｓｉｓ　ｓｕｓｃｅｐｔｉｂｉｌｉｔｙ　ｌｏｃｕｓ　ａｔ　ＴＲＡＦ３ＩＰ２' Ｎａｔｕｒｅ　Ｇｅｎｅｔｉｃｓ Ｖｏｌ．４２，　Ｎｏ．１１, 2010, ｐ．９９１-５ *
JPN6016009268; ＧＬＡＤＭＡＮ　Ｄ．Ｄ．　ｅｔ　ａｌ．: 'ＨＬＡ-ＤＲＢ１＊０４　ａｌｌｅｌｅｓ　ｉｎ　ｐｓｏｒｉａｔｉｃ　ａｒｔｈｒｉｔｉｓ：　ｃｏｍｐａｒｉｓｏｎ　ｗｉｔｈ　ｒｈｅｕｍａｔｏｉｄ　ａｒｔｈｒｉｔｉｓ　ａｎｄ　ｈｅａｌｔｈｙ　ｃｏｎｔｒｏｌ' Ｈｕｍａｎ　Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．６２，　Ｎｏ．１１, 2001, ｐ．１２３９-４４ *
JPN6016009269; ＭＣＩＮＮＥＳ　Ｉ．　ｅｔ　ａｌ．: 'Ａｎｔｉ-ｉｎｔｅｒｌｅｕｋｉｎ　１７Ａ　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｙ　ｓｅｃｕｋｉｎｕｍａｂ　ｒｅｄｕｃｅｓ　ｓｉｇｎｓ　ａｎｄ　ｓｙｍｐｔｏｍｓ　ｏｆ　ｐｓｏｒｉａｔｉｃ　ａｒｔｈｒｉｔ' Ａｒｔｈｒｉｔｉｓ　ａｎｄ　Ｒｈｅｕｍａｔｉｓｍ Ｖｏｌ．６３，　Ｓｕｐｐｌ．１０, 201110, Ａｂｓｔｒａｃｔ　Ｎｏ．７７９ *

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RU2014125071A (ru) 2015-12-27
AU2012341081B2 (en) 2015-06-04
AU2012341081A1 (en) 2014-05-29
CN104011223A (zh) 2014-08-27
EP2783014A1 (en) 2014-10-01
BR112014012101A2 (pt) 2019-09-24
US20150064193A1 (en) 2015-03-05
CA2856252A1 (en) 2013-05-30
MX2014006158A (es) 2014-06-19
AR086907A1 (es) 2014-01-29
WO2013077907A1 (en) 2013-05-30
KR20140097178A (ko) 2014-08-06

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