CN104011223A - 使用il-17拮抗剂及psa应答或非应答等位基因治疗银屑病性关节炎(psa)的方法 - Google Patents

使用il-17拮抗剂及psa应答或非应答等位基因治疗银屑病性关节炎(psa)的方法 Download PDF

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Publication number
CN104011223A
CN104011223A CN201280057295.5A CN201280057295A CN104011223A CN 104011223 A CN104011223 A CN 104011223A CN 201280057295 A CN201280057295 A CN 201280057295A CN 104011223 A CN104011223 A CN 104011223A
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psa
patient
allelotrope
antagonist
seq
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汪盈
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Novartis AG
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Novartis AG
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
CN201280057295.5A 2011-11-21 2012-06-07 使用il-17拮抗剂及psa应答或非应答等位基因治疗银屑病性关节炎(psa)的方法 Pending CN104011223A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IQ3702011 2011-11-21
IQ370/2011 2011-11-21
US201261624564P 2012-04-16 2012-04-16
US61/624,564 2012-04-16
PCT/US2012/041310 WO2013077907A1 (en) 2011-11-21 2012-06-07 Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non- response alleles

Publications (1)

Publication Number Publication Date
CN104011223A true CN104011223A (zh) 2014-08-27

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CN201280057295.5A Pending CN104011223A (zh) 2011-11-21 2012-06-07 使用il-17拮抗剂及psa应答或非应答等位基因治疗银屑病性关节炎(psa)的方法

Country Status (12)

Country Link
US (1) US20150064193A1 (https=)
EP (1) EP2783014A1 (https=)
JP (1) JP2015504430A (https=)
KR (1) KR20140097178A (https=)
CN (1) CN104011223A (https=)
AR (1) AR086907A1 (https=)
AU (1) AU2012341081B2 (https=)
BR (1) BR112014012101A2 (https=)
CA (1) CA2856252A1 (https=)
MX (1) MX2014006158A (https=)
RU (1) RU2014125071A (https=)
WO (1) WO2013077907A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001460A (zh) * 2014-12-22 2017-08-01 诺华股份有限公司 Il‑17抗体中半胱氨酸残基的选择性还原
CN107073110A (zh) * 2014-09-10 2017-08-18 诺华股份有限公司 使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN113395979A (zh) * 2018-11-20 2021-09-14 詹森生物科技公司 用抗il-23特异性抗体治疗银屑病的安全且有效的方法
CN113855800A (zh) * 2014-12-22 2021-12-31 诺华股份有限公司 Il-17抗体的药物产品和稳定液体组合物

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WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2013120302A (ru) 2010-10-01 2014-11-20 Модерна Терапьютикс, Инк. Сконструированные нуклеиновые кислоты и способы их применения
PH12013500660B1 (en) 2010-10-08 2017-10-27 Novartis Ag Methods of treating psoriasis using il-17 antagonists
MX362591B (es) 2010-11-05 2019-01-25 Novartis Ag Uso de antagonistas de il-17.
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
WO2014081507A1 (en) 2012-11-26 2014-05-30 Moderna Therapeutics, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
EP3142645A4 (en) 2014-05-15 2017-12-27 Rani Therapeutics, LLC Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
US11548940B2 (en) 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US20160244520A1 (en) * 2015-01-24 2016-08-25 Abbvie Inc. Compositions and methods for treating psoriatic arthritis
MY206805A (en) 2015-10-27 2025-01-08 UCB Biopharma SRL Methods of treatment using anti-il-17a/f antibodies
MX2021014953A (es) * 2019-06-04 2022-01-24 Janssen Biotech Inc Metodo seguro y eficaz para tratar la artritis psoriasica con el anticuerpo especifico anti-il23.
US12497449B2 (en) * 2019-09-20 2025-12-16 Novartis Ag Methods of treating autoimmune diseases using interleukin-17 (IL-17) antagonists
BR112023018400A2 (pt) * 2021-03-12 2023-12-12 Janssen Biotech Inc Método para tratamento de pacientes de artrite psoriática com resposta inadequada à terapia de tnf com anticorpo específico anti-il23
MX2023010705A (es) * 2021-03-12 2023-11-22 Janssen Biotech Inc Método seguro y eficaz para tratar la artritis psoriásica con el anticuerpo específico anti-il23.
CN114427001A (zh) * 2022-01-29 2022-05-03 中日友好医院(中日友好临床医学研究所) 基于78个snp位点评估阿达木单抗治疗银屑病有效性的试剂盒

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115957326A (zh) * 2014-09-10 2023-04-14 诺华股份有限公司 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN107073110A (zh) * 2014-09-10 2017-08-18 诺华股份有限公司 使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN114452380A (zh) * 2014-12-22 2022-05-10 诺华股份有限公司 Il-17抗体的药物产品和稳定液体组合物
CN113855800A (zh) * 2014-12-22 2021-12-31 诺华股份有限公司 Il-17抗体的药物产品和稳定液体组合物
CN114010780A (zh) * 2014-12-22 2022-02-08 诺华股份有限公司 Il-17抗体中半胱氨酸残基的选择性还原
US11292833B2 (en) 2014-12-22 2022-04-05 Novartis Ag Selective reduction of cysteine residues in IL-17 antibodies
CN107001460A (zh) * 2014-12-22 2017-08-01 诺华股份有限公司 Il‑17抗体中半胱氨酸残基的选择性还原
US12296008B2 (en) 2014-12-22 2025-05-13 Novartis Ag Pharmaceutical products and stable liquid compositions of IL-17 antibodies
US12485172B2 (en) 2014-12-22 2025-12-02 Novartis Ag Pharmaceutical products and stable liquid compositions of IL-17 antibodies
US12485173B2 (en) 2014-12-22 2025-12-02 Novartis Ag Pharmaceutical products and stable liquid compositions of IL-17 antibodies
US12544438B2 (en) 2014-12-22 2026-02-10 Novartis Ag Pharmaceutical products and stable liquid compositions of IL-17 antibodies
US12599664B2 (en) 2014-12-22 2026-04-14 Novartis Ag Pharmaceutical products and stable liquid compositions of IL-17 antibodies
CN113395979A (zh) * 2018-11-20 2021-09-14 詹森生物科技公司 用抗il-23特异性抗体治疗银屑病的安全且有效的方法

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RU2014125071A (ru) 2015-12-27
AU2012341081B2 (en) 2015-06-04
AU2012341081A1 (en) 2014-05-29
EP2783014A1 (en) 2014-10-01
BR112014012101A2 (pt) 2019-09-24
US20150064193A1 (en) 2015-03-05
CA2856252A1 (en) 2013-05-30
JP2015504430A (ja) 2015-02-12
MX2014006158A (es) 2014-06-19
AR086907A1 (es) 2014-01-29
WO2013077907A1 (en) 2013-05-30
KR20140097178A (ko) 2014-08-06

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Application publication date: 20140827