JP2015504430A - Ｉｌ−７アンタゴニスト及びｐｓａ応答又は非応答対立遺伝子を用いた乾癬性関節炎（ｐｓａ）を治療する方法 - Google Patents
Ｉｌ−７アンタゴニスト及びｐｓａ応答又は非応答対立遺伝子を用いた乾癬性関節炎（ｐｓａ）を治療する方法 Download PDFInfo
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| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| HUE069586T2 (hu) | 2010-10-01 | 2025-03-28 | Modernatx Inc | Módosított nukleozidok, nukleotidok és nukleinsavak, valamint ezek felhasználása |
| CN104800844A (zh) | 2010-11-05 | 2015-07-29 | 诺华有限公司 | 使用il-17拮抗剂治疗类风湿性关节炎的方法 |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DK3682905T3 (da) | 2011-10-03 | 2022-02-28 | Modernatx Inc | Modificerede nukleosider, nukleotider og nukleinsyrer og anvendelser deraf |
| HRP20220717T1 (hr) | 2011-12-16 | 2022-07-22 | Modernatx, Inc. | Modificirani pripravci mrna |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| JP6189415B2 (ja) | 2012-04-02 | 2017-08-30 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | 細胞質および細胞骨格タンパク質の産生のための修飾ポリヌクレオチド |
| EP2922554B1 (en) | 2012-11-26 | 2022-02-23 | ModernaTX, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| US11548940B2 (en) | 2014-05-15 | 2023-01-10 | Rani Therapeutics, Llc | Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| CN113368233A (zh) | 2014-05-15 | 2021-09-10 | 拉尼医疗有限公司 | 包含多肽和/或蛋白质的固体块的药物组合物和该固体块的制备方法 |
| FI3191120T3 (fi) * | 2014-09-10 | 2024-07-10 | Novartis Ag | Il-17-antagonistien käyttö rakennevaurion etenemisen estämiseksi nivelpsoriaasipotilailla |
| AR103172A1 (es) * | 2014-12-22 | 2017-04-19 | Novartis Ag | Reducción selectiva de residuos de cisteina en anticuerpos il-17 |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| US20160244520A1 (en) * | 2015-01-24 | 2016-08-25 | Abbvie Inc. | Compositions and methods for treating psoriatic arthritis |
| SG11201802887PA (en) | 2015-10-27 | 2018-05-30 | Ucb Biopharma Sprl | Methods of treatment using anti-il-17a/f antibodies |
| MA55149A (fr) * | 2018-11-20 | 2021-09-29 | Janssen Biotech Inc | Procédé sûr et efficace de traitement du psoriasis avec un anticorps spécifique anti-il-23 |
| CA3142667A1 (en) * | 2019-06-04 | 2020-12-10 | Janssen Biotech, Inc. | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
| KR20220066318A (ko) * | 2019-09-20 | 2022-05-24 | 노파르티스 아게 | 인터류킨-17(il-17) 길항제를 사용한 자가면역 질환의 치료 방법 |
| EP4305062A1 (en) * | 2021-03-12 | 2024-01-17 | Janssen Biotech, Inc. | Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody |
| AU2022233792A1 (en) * | 2021-03-12 | 2023-10-26 | Janssen Biotech, Inc. | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
| CN114427001A (zh) * | 2022-01-29 | 2022-05-03 | 中日友好医院(中日友好临床医学研究所) | 基于78个snp位点评估阿达木单抗治疗银屑病有效性的试剂盒 |
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| HUE039353T2 (hu) | 2005-12-13 | 2018-12-28 | Lilly Co Eli | Anti-IL-17 ellenanyagok |
| CA2637166A1 (en) | 2006-01-31 | 2007-10-18 | Novartis Ag | Il-17 antagonistic antibodies for treating cancer |
| GB0612928D0 (en) | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
| CA2690568A1 (en) * | 2007-06-20 | 2008-12-24 | Schering Corporation | Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease |
| RU2539029C2 (ru) | 2008-09-29 | 2015-01-10 | Роше Гликарт Аг | Антитела против интерлейкина 17 (ил-17) человека и их применение |
| WO2011014349A1 (en) * | 2009-07-28 | 2011-02-03 | Centocor Ortho Biotech Inc. | Serum markers predicting clinical response to anti-tnfalpha antibodies in patients with psoriatic arthritis |
| NO2625199T3 (enExample) * | 2010-10-08 | 2018-04-21 | ||
| AR084234A1 (es) * | 2010-12-13 | 2013-05-02 | Novartis Ag | Metodos predictivos y metodos para tratar artritis usando antagonistas de interleuquina 17 (il-17) |
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| JP2008507988A (ja) * | 2004-08-05 | 2008-03-21 | ノバルティス アクチエンゲゼルシャフト | Ｉｌ−１７拮抗性抗体 |
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| JPN6016009264; ＬＡＭＢＥＲＴ Ｓ． ｅｔ ａｌ．: 'ＴＲＡＦ３ＩＰ２ ｃｏｕｐｌｅｓ ＩＬ-１７ ｔｏ ｔｈｅ ｅｐｉｄｅｒｍａｌ ｄｅｆｅｎｓｅ ｒｅｓｐｏｎｓｅ' Ｊｏｕｒｎａｌ ｏｆ Ｉｎｖｅｓｔｉｇａｔｉｖｅ Ｄｅｒｍａｔｏｌｏｇｙ Ｖｏｌ．１３１， Ｓｕｐｐｌ．２, 201109, ｐ．Ｓ１９， Ａｂｓｔｒａｃｔ Ｎｏ．１１２ * |
| JPN6016009265; ＬＡＭＢＥＲＴ Ｓ． ｅｔ ａｌ．: 'ＴＲＡＦ３ＩＰ２ ｃｏｕｐｌｅｓ ＩＬ-１７ ｔｏ ｔｈｅ ｅｐｉｄｅｒｍａｌ ｄｅｆｅｎｓｅ ｒｅｓｐｏｎｓｅ' Ｊｏｕｒｎａｌ ｏｆ Ｉｎｖｅｓｔｉｇａｔｉｖｅ Ｄｅｒｍａｔｏｌｏｇｙ Ｖｏｌ．１３１， Ｓｕｐｐｌ．１, 201104, ｐ．Ｓ６， Ａｂｓｔｒａｃｔ Ｎｏ．０３４ * |
| JPN6016009266; ＶＥＬＩＣＨＫＯ Ｓ． ｅｔ ａｌ．: 'Ｇｌｏｂａｌ ｇｅｎｅ ｅｘｐｒｅｓｓｉｏｎ ａｎａｌｙｓｉｓ ｏｆ Ａｃｔ１'ｓ ｅｆｆｅｃｔｓ ｉｎ ａｉｒｗａｙ ｅｐｉｔｈｅｌｉａｌ ｃｅｌｌｓ' Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１８６， ＭｅｅｔｉｎｇＡｂｓｔｒａｃｔｓ, 201104, Ａｂｓｔｒａｃｔ Ｎｏ．１６１．１７ * |
| JPN6016009267; ＥＬＬＩＮＧＨＡＵＳ Ｅ． ｅｔ ａｌ．: 'Ｇｅｎｏｍｅ-ｗｉｄｅ ａｓｓｏｃｉａｔｉｏｎ ｓｔｕｄｙ ｉｄｅｎｔｉｆｉｅｓ ａ ｐｓｏｒｉａｓｉｓ ｓｕｓｃｅｐｔｉｂｉｌｉｔｙ ｌｏｃｕｓ ａｔ ＴＲＡＦ３ＩＰ２' Ｎａｔｕｒｅ Ｇｅｎｅｔｉｃｓ Ｖｏｌ．４２， Ｎｏ．１１, 2010, ｐ．９９１-５ * |
| JPN6016009268; ＧＬＡＤＭＡＮ Ｄ．Ｄ． ｅｔ ａｌ．: 'ＨＬＡ-ＤＲＢ１＊０４ ａｌｌｅｌｅｓ ｉｎ ｐｓｏｒｉａｔｉｃ ａｒｔｈｒｉｔｉｓ： ｃｏｍｐａｒｉｓｏｎ ｗｉｔｈ ｒｈｅｕｍａｔｏｉｄ ａｒｔｈｒｉｔｉｓ ａｎｄ ｈｅａｌｔｈｙ ｃｏｎｔｒｏｌ' Ｈｕｍａｎ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．６２， Ｎｏ．１１, 2001, ｐ．１２３９-４４ * |
| JPN6016009269; ＭＣＩＮＮＥＳ Ｉ． ｅｔ ａｌ．: 'Ａｎｔｉ-ｉｎｔｅｒｌｅｕｋｉｎ １７Ａ ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｙ ｓｅｃｕｋｉｎｕｍａｂ ｒｅｄｕｃｅｓ ｓｉｇｎｓ ａｎｄ ｓｙｍｐｔｏｍｓ ｏｆ ｐｓｏｒｉａｔｉｃ ａｒｔｈｒｉｔ' Ａｒｔｈｒｉｔｉｓ ａｎｄ Ｒｈｅｕｍａｔｉｓｍ Ｖｏｌ．６３， Ｓｕｐｐｌ．１０, 201110, Ａｂｓｔｒａｃｔ Ｎｏ．７７９ * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013077907A1 (en) | 2013-05-30 |
| CN104011223A (zh) | 2014-08-27 |
| BR112014012101A2 (pt) | 2019-09-24 |
| CA2856252A1 (en) | 2013-05-30 |
| RU2014125071A (ru) | 2015-12-27 |
| AU2012341081A1 (en) | 2014-05-29 |
| KR20140097178A (ko) | 2014-08-06 |
| AU2012341081B2 (en) | 2015-06-04 |
| EP2783014A1 (en) | 2014-10-01 |
| MX2014006158A (es) | 2014-06-19 |
| AR086907A1 (es) | 2014-01-29 |
| US20150064193A1 (en) | 2015-03-05 |
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