JP2015502401A5 - - Google Patents
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- JP2015502401A5 JP2015502401A5 JP2014548336A JP2014548336A JP2015502401A5 JP 2015502401 A5 JP2015502401 A5 JP 2015502401A5 JP 2014548336 A JP2014548336 A JP 2014548336A JP 2014548336 A JP2014548336 A JP 2014548336A JP 2015502401 A5 JP2015502401 A5 JP 2015502401A5
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- JP
- Japan
- Prior art keywords
- cells
- cell
- immature hematopoietic
- depleted
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000001744 T-lymphocyte Anatomy 0.000 claims 42
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 35
- 210000004027 cell Anatomy 0.000 claims 13
- 210000003719 b-lymphocyte Anatomy 0.000 claims 12
- 238000000034 method Methods 0.000 claims 9
- 230000037396 body weight Effects 0.000 claims 7
- 239000011159 matrix material Substances 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000002372 labelling Methods 0.000 claims 4
- 230000005291 magnetic effect Effects 0.000 claims 4
- 230000003211 malignant effect Effects 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 238000002054 transplantation Methods 0.000 claims 4
- 239000002458 cell surface marker Substances 0.000 claims 3
- 239000006249 magnetic particle Substances 0.000 claims 3
- 230000028327 secretion Effects 0.000 claims 3
- 238000000926 separation method Methods 0.000 claims 3
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 102100025946 Transforming growth factor beta activator LRRC32 Human genes 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229960004397 cyclophosphamide Drugs 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000007898 magnetic cell sorting Methods 0.000 claims 2
- 238000002826 magnetic-activated cell sorting Methods 0.000 claims 2
- 230000001400 myeloablative effect Effects 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 108090001008 Avidin Proteins 0.000 claims 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims 1
- 101710093674 Cyclic nucleotide-gated cation channel beta-1 Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101001004924 Homo sapiens Transforming growth factor beta activator LRRC32 Proteins 0.000 claims 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102100020881 Interleukin-1 alpha Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 102000013462 Interleukin-12 Human genes 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 102000004388 Interleukin-4 Human genes 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 208000024556 Mendelian disease Diseases 0.000 claims 1
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 claims 1
- 101710169732 Transforming growth factor beta activator LRRC32 Proteins 0.000 claims 1
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 230000001494 anti-thymocyte effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229960002092 busulfan Drugs 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000005294 ferromagnetic effect Effects 0.000 claims 1
- 239000003302 ferromagnetic material Substances 0.000 claims 1
- 229960000390 fludarabine Drugs 0.000 claims 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000003881 globally optimized alternating phase rectangular pulse Methods 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 208000018706 hematopoietic system disease Diseases 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 238000007885 magnetic separation Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229960001924 melphalan Drugs 0.000 claims 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 239000011325 microbead Substances 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 229960001196 thiotepa Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578917P | 2011-12-22 | 2011-12-22 | |
| US61/578,917 | 2011-12-22 | ||
| PCT/IL2012/050541 WO2013093919A2 (en) | 2011-12-22 | 2012-12-20 | A combination therapy for a stable and long term engraftment using specific protocols for t/b cell depletion |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007779A Division JP2018080201A (ja) | 2011-12-22 | 2018-01-22 | Ｔ細胞／ｂ細胞枯渇化のための特異的プロトコルを使用する安定かつ長期の生着のための併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502401A JP2015502401A (ja) | 2015-01-22 |
| JP2015502401A5 true JP2015502401A5 (enExample) | 2016-01-21 |
| JP6313219B2 JP6313219B2 (ja) | 2018-04-18 |
Family
ID=48669650
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548337A Pending JP2015504047A (ja) | 2011-12-22 | 2012-12-20 | 安定かつ長期の生着のための併用療法 |
| JP2014548336A Active JP6313219B2 (ja) | 2011-12-22 | 2012-12-20 | Ｔ細胞／ｂ細胞枯渇化のための特異的プロトコルを使用する安定かつ長期の生着のための併用療法 |
| JP2018007779A Pending JP2018080201A (ja) | 2011-12-22 | 2018-01-22 | Ｔ細胞／ｂ細胞枯渇化のための特異的プロトコルを使用する安定かつ長期の生着のための併用療法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548337A Pending JP2015504047A (ja) | 2011-12-22 | 2012-12-20 | 安定かつ長期の生着のための併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007779A Pending JP2018080201A (ja) | 2011-12-22 | 2018-01-22 | Ｔ細胞／ｂ細胞枯渇化のための特異的プロトコルを使用する安定かつ長期の生着のための併用療法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US10434121B2 (enExample) |
| EP (2) | EP2797421B1 (enExample) |
| JP (3) | JP2015504047A (enExample) |
| KR (2) | KR102109643B1 (enExample) |
| CN (2) | CN104093314A (enExample) |
| AU (3) | AU2012355990B2 (enExample) |
| BR (2) | BR112014015960A8 (enExample) |
| CA (2) | CA2859952C (enExample) |
| DK (2) | DK2797421T3 (enExample) |
| ES (2) | ES2811529T3 (enExample) |
| IN (2) | IN2014MN01468A (enExample) |
| MX (2) | MX2014007648A (enExample) |
| RU (2) | RU2648354C2 (enExample) |
| SG (3) | SG11201403459XA (enExample) |
| WO (2) | WO2013093919A2 (enExample) |
| ZA (2) | ZA201405071B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013035099A1 (en) | 2011-09-08 | 2013-03-14 | Yeda Research And Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| PT2788009T (pt) | 2011-12-08 | 2016-08-31 | Yeda Res & Dev | Células pulmonares fetais de mamíferos e uso terapêutico das mesmas |
| JP2015504047A (ja) | 2011-12-22 | 2015-02-05 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | 安定かつ長期の生着のための併用療法 |
| CA3206342A1 (en) | 2013-05-09 | 2014-11-13 | Advanced Neuroregenerative Therapies, Llc | G-csf for use in treating or preventing a disease with age and disease immune dysfunction and cellular senescence |
| EP4026563B1 (en) | 2015-06-18 | 2025-10-29 | Yeda Research and Development Co. Ltd | Conditioning protocols and use of same for tissue regeneration |
| EP3322424B1 (en) | 2015-07-16 | 2023-10-11 | Yeda Research and Development Co., Ltd. | Use of anti third party central memory t cells |
| CN108025023A (zh) * | 2015-08-25 | 2018-05-11 | Uab研究基金会 | 用于干细胞移植的方法 |
| RU2747728C2 (ru) * | 2015-12-04 | 2021-05-13 | Фред Хатчинсон Кэнсер Рисерч Сентер | Применение размноженных популяций гематопоэтических стволовых клеток/клеток-предшественников |
| EP3463402B1 (en) * | 2016-05-22 | 2021-06-23 | Yeda Research and Development Co. Ltd. | Methods of using pulmonary cells for transplantation and induction of tolerance |
| EP4011381A1 (en) * | 2016-06-03 | 2022-06-15 | Memorial Sloan-Kettering Cancer Center | Adoptive cell therapies as early treatment options |
| ES3064681T3 (en) | 2017-01-18 | 2026-04-28 | Yeda Res And Development Co Ltd | Genetically modified veto cells and use of same in immunotherapy |
| US10751368B2 (en) | 2017-01-18 | 2020-08-25 | Yeda Research And Development Co. Ltd. | Methods of transplantation and disease treatment |
| EP3571230A4 (en) | 2017-01-20 | 2020-12-16 | Magenta Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR DELETION OF CD137 + CELLS |
| EP4417210A1 (en) | 2017-03-15 | 2024-08-21 | Orca Biosystems, Inc. | Compositions and methods for hematopoietic stem cell transplants |
| IL274632B2 (en) * | 2017-11-15 | 2024-12-01 | Weird Science Llc | Methods and compositions for non-myeloablative bone marrow reconstitution |
| CN119857155A (zh) | 2017-11-29 | 2025-04-22 | 海德堡医药研究有限责任公司 | 用于耗尽cd5+细胞的组合物和方法 |
| EP3723785A1 (en) * | 2017-12-17 | 2020-10-21 | Yeda Research and Development Co. Ltd | Cop9 signalosome (csn) complex modulators and uses thereof |
| EP3749334B1 (en) | 2018-02-08 | 2024-12-11 | The Board of Trustees of the Leland Stanford Junior University | Allogenic hematopoietic stem cell transplantation |
| WO2019178106A1 (en) * | 2018-03-12 | 2019-09-19 | Medeor Therapeutics, Inc. | Methods for treating non-cancerous disorders using hematopoietic cells |
| US10842821B2 (en) * | 2018-04-05 | 2020-11-24 | Medeor Therapeutics, Inc. | Cellular compositions derived from prior organ donors and methods of manufacture and use thereof |
| US10881692B2 (en) * | 2018-04-05 | 2021-01-05 | Medeor Therapeutics, Inc. | Compositions for establishing mixed chimerism and methods of manufacture thereof |
| CA3107383A1 (en) * | 2018-07-23 | 2020-01-30 | Magenta Therapeutics, Inc. | Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy |
| US11435350B2 (en) | 2018-09-18 | 2022-09-06 | Medeor Therapeutics, Inc. | Methods of analysis of blood from deceased donors |
| US11813376B2 (en) | 2018-09-18 | 2023-11-14 | Medeor Therapeutics, Inc. | Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof |
| CA3112320A1 (en) * | 2018-09-18 | 2020-03-26 | Medeor Therapeutics, Inc. | Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof |
| CA3114292A1 (en) * | 2018-09-27 | 2020-04-02 | Phosphogam, Inc. | Methods and compositions for the expansion and use of allogeneic gamma/delta-t cells |
| US20210380946A1 (en) * | 2018-11-01 | 2021-12-09 | Children's Hospital Medical Center | Reduced intensity conditioning with melphalan |
| CN109781987B (zh) * | 2019-01-09 | 2022-04-26 | 暨南大学 | 终末效应t细胞亚群在制备辅助评估再生障碍性贫血病情程度试剂盒中的应用 |
| EP3953383A4 (en) * | 2019-04-08 | 2023-01-18 | Russell Biotech, Inc. | Improved manufacturing procedures for cell based therapies |
| NZ781538A (en) | 2019-04-24 | 2025-12-19 | Heidelberg Pharma Res Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| RU2723164C1 (ru) * | 2019-10-07 | 2020-06-09 | Федеральное государственное бюджетное учреждение науки "Кировский научно-исследовательский институт гематологии и переливания крови Федерального медико-биологического агентства" | Способ расчета дозы клеток-предшественниц гемопоэза в лейкоцитаферезном продукте путем учета изменения целостности клеточных мембран при хранении |
| JP2023500277A (ja) * | 2019-11-05 | 2023-01-05 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | Ｔ細胞媒介性自己免疫疾患の治療におけるベト細胞の使用 |
| WO2021243190A1 (en) * | 2020-05-28 | 2021-12-02 | Biomagnetic Solutions Llc | Compositions and methods for negative selection of naive t and b cells with a single antibody |
| WO2022133282A1 (en) * | 2020-12-18 | 2022-06-23 | Ossium Health, Inc. | Methods of cell therapies |
| CN112669992B (zh) * | 2020-12-30 | 2024-06-11 | 中国人民解放军总医院 | 单倍体造血干细胞移植atg个体化用药量的计算方法 |
| RU2764742C1 (ru) * | 2021-04-09 | 2022-01-20 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. академика В.И. Шумакова" Минздрава России) | Способ подбора режима иммуносупрессии детям раннего возраста в отдаленном периоде после трансплантации печени |
| US20250114360A1 (en) * | 2022-02-03 | 2025-04-10 | The Regents Of The University Of California | Novel regimen for augmenting and extending transplant tolerance |
| WO2024073751A1 (en) | 2022-09-29 | 2024-04-04 | Vor Biopharma Inc. | Methods and compositions for gene modification and enrichment |
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