IN2014MN01467A - - Google Patents
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- Publication number
- IN2014MN01467A IN2014MN01467A IN1467MUN2014A IN2014MN01467A IN 2014MN01467 A IN2014MN01467 A IN 2014MN01467A IN 1467MUN2014 A IN1467MUN2014 A IN 1467MUN2014A IN 2014MN01467 A IN2014MN01467 A IN 2014MN01467A
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- IN
- India
- Prior art keywords
- subject
- cells
- immature hematopoietic
- hematopoietic cells
- body weight
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A—HUMAN NECESSITIES
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- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A61K2121/00—Preparations for use in therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
Abstract
A method of treating a subject in need of a non syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells wherein the T cell depleted immature hematopoietic cells comprise less than 5 x 105 CD3+ T cells per kilogram body weight of the subject and wherein the dose comprises at least about 5 x 106 CD34+ cells per kilogram body weight of the subject and wherein the T cell depleted immature hematopoietic cells are obtained by separating the T cells from the immature hematopoietic cells by magnetic cell sorting and (b) administering to the subject a therapeutically effective amount of cyclophosphamide wherein the therapeutically effective amount comprises 25 200 mg per kilogram body weight thereby treating the subject.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161578917P | 2011-12-22 | 2011-12-22 | |
PCT/IL2012/050541 WO2013093919A2 (en) | 2011-12-22 | 2012-12-20 | A combination therapy for a stable and long term engraftment using specific protocols for t/b cell depletion |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014MN01467A true IN2014MN01467A (en) | 2015-05-01 |
Family
ID=48669650
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1468MUN2014 IN2014MN01468A (en) | 2011-12-22 | 2012-12-20 | |
IN1467MUN2014 IN2014MN01467A (en) | 2011-12-22 | 2012-12-20 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1468MUN2014 IN2014MN01468A (en) | 2011-12-22 | 2012-12-20 |
Country Status (17)
Country | Link |
---|---|
US (5) | US10369172B2 (en) |
EP (2) | EP2797421B1 (en) |
JP (3) | JP2015504047A (en) |
KR (2) | KR20140105848A (en) |
CN (2) | CN104470542A (en) |
AU (3) | AU2012355989B2 (en) |
BR (2) | BR112014015960A8 (en) |
CA (2) | CA2859953A1 (en) |
DK (2) | DK2797421T3 (en) |
ES (2) | ES2864323T3 (en) |
HK (2) | HK1202810A1 (en) |
IN (2) | IN2014MN01468A (en) |
MX (2) | MX2014007648A (en) |
RU (2) | RU2648354C2 (en) |
SG (3) | SG11201403459XA (en) |
WO (2) | WO2013093920A2 (en) |
ZA (2) | ZA201405071B (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201400513PA (en) | 2011-09-08 | 2014-06-27 | Yeda Res & Dev | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
RU2014127338A (en) | 2011-12-08 | 2016-02-10 | Иеда Рисерч Энд Девелопмент Ко., Лтд. | NURSEY PULMONIC CELLS OF MAMMALS AND THEIR THERAPEUTIC APPLICATION |
BR112014015960A8 (en) | 2011-12-22 | 2017-07-04 | Yeda Res & Dev | method for treating an individual in need of a non-syngeneic cell or tissue graft, method for treating an individual in need of a hematopoietic transplant, method for treating an individual in need of a non-syngeneic cell or tissue graft, method for treating an individual in need of an immature hematopoietic cell transplantation, and method for inducing specific donor tolerance in an individual in need of a non-congenital cell or tissue graft |
CN105407900A (en) | 2013-05-09 | 2016-03-16 | 先进神经变性疗法有限公司 | G-CSF for use in treating or preventing disease associated with aging in a patient, for administration with stem-cell containing composition and/or an electromagnetic signal |
US10668109B2 (en) | 2015-06-18 | 2020-06-02 | Yeda Research And Development Co. Ltd. | Conditioning protocols and use of same for tissue regeneration |
WO2017009852A1 (en) * | 2015-07-16 | 2017-01-19 | Yeda Research And Development Co. Ltd. | Use of anti third party central memory t cells |
AU2016364934A1 (en) * | 2015-12-04 | 2018-06-07 | Fred Hutchinson Cancer Center | Uses of expanded populations of hematopoietic stem/progenitor cells |
WO2017203520A1 (en) | 2016-05-22 | 2017-11-30 | Yeda Research And Development Co. Ltd. | Methods of using pulmonary cells for transplantation and induction of tolerance |
JP2019517518A (en) * | 2016-06-03 | 2019-06-24 | メモリアル スローン ケタリング キャンサー センター | Adoptive cell therapy as an early treatment option |
US10751368B2 (en) | 2017-01-18 | 2020-08-25 | Yeda Research And Development Co. Ltd. | Methods of transplantation and disease treatment |
WO2018134824A1 (en) | 2017-01-18 | 2018-07-26 | Yeda Research And Development Co. Ltd. | Genetically modified veto cells and use of same in immunotherapy |
MX2019008205A (en) | 2017-01-20 | 2020-01-23 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd137+ cells. |
CA3056406A1 (en) | 2017-03-15 | 2018-09-20 | Orca Biosystems Inc. | Compositions and methods for hematopoietic stem cell transplants |
JP2021503015A (en) * | 2017-11-15 | 2021-02-04 | ウィヤード・サイエンス・エルエルシー | Methods and Compositions for Nonmyeloablative Bone Marrow Reconstruction |
WO2019116376A1 (en) * | 2017-12-17 | 2019-06-20 | Yeda Research And Development Co. Ltd. | Cop9 signalosome (csn) complex modulators and uses thereof |
US11952588B2 (en) | 2018-02-08 | 2024-04-09 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for allogenic hematopoietic stem cell transplantation |
US11273179B2 (en) | 2018-03-12 | 2022-03-15 | Medeor Therapeutics, Inc. | Methods for treating non-cancerous disorders using hematopoietic cells |
US10842821B2 (en) | 2018-04-05 | 2020-11-24 | Medeor Therapeutics, Inc. | Cellular compositions derived from prior organ donors and methods of manufacture and use thereof |
US10881692B2 (en) * | 2018-04-05 | 2021-01-05 | Medeor Therapeutics, Inc. | Compositions for establishing mixed chimerism and methods of manufacture thereof |
AU2019311077A1 (en) * | 2018-07-23 | 2021-02-25 | Heidelberg Pharma Research Gmbh | Use of anti-CD5 antibody drug conjugate (ADC) in allogeneic cell therapy |
US11435350B2 (en) | 2018-09-18 | 2022-09-06 | Medeor Therapeutics, Inc. | Methods of analysis of blood from deceased donors |
US11813376B2 (en) | 2018-09-18 | 2023-11-14 | Medeor Therapeutics, Inc. | Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof |
WO2020061180A1 (en) * | 2018-09-18 | 2020-03-26 | Medeor Therapeutics, Inc. | Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof |
CN109781987B (en) * | 2019-01-09 | 2022-04-26 | 暨南大学 | Application of terminal effector T cell subset in preparation of kit for auxiliary evaluation of aplastic anemia disease degree |
SG11202110287QA (en) | 2019-04-24 | 2021-10-28 | Heidelberg Pharma Res Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
RU2723164C1 (en) * | 2019-10-07 | 2020-06-09 | Федеральное государственное бюджетное учреждение науки "Кировский научно-исследовательский институт гематологии и переливания крови Федерального медико-биологического агентства" | Method for calculating the dose of haematopoiesis precursor cells in a leukocytapheresis product by taking into account the change in the integrity of cell membranes during storage |
WO2022133282A1 (en) * | 2020-12-18 | 2022-06-23 | Ossium Health, Inc. | Methods of cell therapies |
CN112669992A (en) * | 2020-12-30 | 2021-04-16 | 中国人民解放军总医院 | Method for calculating individual dosage of ATG (Atg transfer) for haploid hematopoietic stem cell transplantation |
RU2764742C1 (en) * | 2021-04-09 | 2022-01-20 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. академика В.И. Шумакова" Минздрава России) | Method for selecting an immunosuppression regimen for young children in the long-term period after liver transplantation |
WO2023150512A1 (en) * | 2022-02-03 | 2023-08-10 | The Regents Of The University Of California | A novel regimen for augmenting and extending transplant tolerance |
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