JP2015502135A5 - - Google Patents

Info

Publication number

JP2015502135A5

JP2015502135A5 JP2014532366A JP2014532366A JP2015502135A5 JP 2015502135 A5 JP2015502135 A5 JP 2015502135A5 JP 2014532366 A JP2014532366 A JP 2014532366A JP 2014532366 A JP2014532366 A JP 2014532366A JP 2015502135 A5 JP2015502135 A5 JP 2015502135A5

Authority

JP

Japan

Prior art keywords

cell

nucleic acid

acid molecule

protein

virus

Prior art date

2012-09-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims 11
• 210000004443 dendritic cell Anatomy 0.000 claims 11
• 239000003814 drug Substances 0.000 claims 10
• 102000039446 nucleic acids Human genes 0.000 claims 10
• 108020004707 nucleic acids Proteins 0.000 claims 10
• 150000007523 nucleic acids Chemical class 0.000 claims 10
• 102000003839 Human Proteins Human genes 0.000 claims 8
• 108090000144 Human Proteins Proteins 0.000 claims 8
• 241000700605 Viruses Species 0.000 claims 8
• 208000016192 Demyelinating disease Diseases 0.000 claims 5
• KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 4
• 102000047918 Myelin Basic Human genes 0.000 claims 4
• 101710107068 Myelin basic protein Proteins 0.000 claims 4
• 102000016202 Proteolipids Human genes 0.000 claims 4
• 108010010974 Proteolipids Proteins 0.000 claims 4
• 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
• 241000713666 Lentivirus Species 0.000 claims 3
• 201000006417 multiple sclerosis Diseases 0.000 claims 3
• 102000003886 Glycoproteins Human genes 0.000 claims 2
• 108090000288 Glycoproteins Proteins 0.000 claims 2
• 102000006386 Myelin Proteins Human genes 0.000 claims 2
• 108010083674 Myelin Proteins Proteins 0.000 claims 2
• 102000002233 Myelin-Oligodendrocyte Glycoprotein Human genes 0.000 claims 2
• 108010000123 Myelin-Oligodendrocyte Glycoprotein Proteins 0.000 claims 2
• 108700026244 Open Reading Frames Proteins 0.000 claims 2
• 210000001185 bone marrow Anatomy 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 210000005012 myelin Anatomy 0.000 claims 2
• 210000004248 oligodendroglia Anatomy 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims 1
• 102100024230 Dendritic cell-specific transmembrane protein Human genes 0.000 claims 1
• 101710190014 Dendritic cell-specific transmembrane protein Proteins 0.000 claims 1
• 208000034189 Sclerosis Diseases 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 229960002092 busulfan Drugs 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 230000006378 damage Effects 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000001400 myeloablative effect Effects 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 1