JP2015501644A5 - - Google Patents
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- Publication number
- JP2015501644A5 JP2015501644A5 JP2014546158A JP2014546158A JP2015501644A5 JP 2015501644 A5 JP2015501644 A5 JP 2015501644A5 JP 2014546158 A JP2014546158 A JP 2014546158A JP 2014546158 A JP2014546158 A JP 2014546158A JP 2015501644 A5 JP2015501644 A5 JP 2015501644A5
- Authority
- JP
- Japan
- Prior art keywords
- individual
- cell receptor
- gene segment
- profile
- immune activation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101150111062 C gene Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 108091008875 B cell receptors Proteins 0.000 claims 6
- 230000005934 immune activation Effects 0.000 claims 5
- 108091093088 Amplicon Proteins 0.000 claims 4
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568850P | 2011-12-09 | 2011-12-09 | |
| US61/568,850 | 2011-12-09 | ||
| PCT/US2012/068631 WO2013086462A1 (en) | 2011-12-09 | 2012-12-07 | Method of measuring immune activation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015501644A JP2015501644A (ja) | 2015-01-19 |
| JP2015501644A5 true JP2015501644A5 (OSRAM) | 2017-01-26 |
Family
ID=48574963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546158A Pending JP2015501644A (ja) | 2011-12-09 | 2012-12-07 | 免疫活性化を測定する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20140342360A1 (OSRAM) |
| EP (1) | EP2788507A4 (OSRAM) |
| JP (1) | JP2015501644A (OSRAM) |
| WO (1) | WO2013086462A1 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| GB2467704B (en) | 2008-11-07 | 2011-08-24 | Mlc Dx Inc | A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| US9394567B2 (en) | 2008-11-07 | 2016-07-19 | Adaptive Biotechnologies Corporation | Detection and quantification of sample contamination in immune repertoire analysis |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| PL2387627T3 (pl) | 2009-01-15 | 2016-10-31 | Profilowanie odporności adaptacyjnej i wytwarzanie przeciwciał monoklonalnych | |
| KR20120044941A (ko) | 2009-06-25 | 2012-05-08 | 프레드 헛친슨 켄서 리서치 센터 | 적응 면역의 측정방법 |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| CA2853088C (en) | 2011-10-21 | 2018-03-13 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| ES2867924T3 (es) | 2011-12-09 | 2021-10-21 | Adaptive Biotechnologies Corp | Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| ES2662128T3 (es) | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
| JP5756247B1 (ja) | 2012-05-08 | 2015-07-29 | アダプティブ バイオテクノロジーズ コーポレイション | マルチプレックスｐｃｒ反応における増幅バイアスを測定し校正する組成物及び方法 |
| ES2660027T3 (es) | 2012-10-01 | 2018-03-20 | Adaptive Biotechnologies Corporation | Evaluación de la inmunocompetencia por la diversidad de los receptores de inmunidad adaptativa y caracterización de la clonalidad |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| EP3114240B1 (en) | 2014-03-05 | 2019-07-24 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| AU2015339191A1 (en) | 2014-10-29 | 2017-05-18 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| AU2015353581A1 (en) | 2014-11-25 | 2017-06-15 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| EP3277294B1 (en) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| US11137385B2 (en) | 2019-05-31 | 2021-10-05 | Illumina, Inc. | Obtaining information from a biological sample in a flow cell |
| JP2023553890A (ja) * | 2020-12-07 | 2023-12-26 | アブサイ コーポレーション | 疾患関連タンパク質組成物を産生するためのシステム及び方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4416189A (en) * | 1988-10-06 | 1990-05-01 | T Cell Sciences, Inc. | Therapeutic and diagnostic methods using soluble t cell surface molecules |
| WO1997046706A1 (en) * | 1996-06-03 | 1997-12-11 | University Of Alberta | Methods for detection of rearranged dna |
| US20020136722A1 (en) * | 1997-06-18 | 2002-09-26 | Heath Andrew William | Vaccination method |
| WO2005115449A1 (en) * | 2004-05-28 | 2005-12-08 | Alk-Abelló A/S | Method of treating allergy and infection by eliciting an iga antibody response |
| US20060100264A1 (en) * | 2004-11-06 | 2006-05-11 | Bjeldanes Leonard F | 3,3'-Diindolylmethane immune activating compositions |
| WO2008026927A2 (en) * | 2006-08-30 | 2008-03-06 | Academisch Medisch Centrum | Process for displaying t- and b-cell receptor repertoires |
| US8748103B2 (en) * | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| GB2467704B (en) * | 2008-11-07 | 2011-08-24 | Mlc Dx Inc | A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells |
-
2012
- 2012-12-07 US US14/363,956 patent/US20140342360A1/en not_active Abandoned
- 2012-12-07 JP JP2014546158A patent/JP2015501644A/ja active Pending
- 2012-12-07 EP EP12854963.1A patent/EP2788507A4/en not_active Withdrawn
- 2012-12-07 WO PCT/US2012/068631 patent/WO2013086462A1/en not_active Ceased
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