JP2015500033A - 連続灌流用濾過装置 - Google Patents

連続灌流用濾過装置 Download PDF

Info

Publication number
JP2015500033A
JP2015500033A JP2014546134A JP2014546134A JP2015500033A JP 2015500033 A JP2015500033 A JP 2015500033A JP 2014546134 A JP2014546134 A JP 2014546134A JP 2014546134 A JP2014546134 A JP 2014546134A JP 2015500033 A JP2015500033 A JP 2015500033A
Authority
JP
Japan
Prior art keywords
liquid
filter
container
stirrer
shaft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014546134A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015500033A5 (cg-RX-API-DMAC7.html
Inventor
ゴンザレス，ホセ，アントニオ カスティロ
ゴンザレス，ホセ，アントニオ カスティロ
ペセ，ビシュワズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pall Artelis BVBA
Pall Technology UK Ltd
Original Assignee
Pall Artelis BVBA
Pall Technology UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pall Artelis BVBA, Pall Technology UK Ltd filed Critical Pall Artelis BVBA
Publication of JP2015500033A publication Critical patent/JP2015500033A/ja
Publication of JP2015500033A5 publication Critical patent/JP2015500033A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/051—Stirrers characterised by their elements, materials or mechanical properties
    • B01F27/054—Deformable stirrers, e.g. deformed by a centrifugal force applied during operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
    • B01F27/191—Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/91—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with propellers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/42—Mixers with shaking, oscillating, or vibrating mechanisms with pendulum stirrers, i.e. with stirrers suspended so as to oscillate about fixed points or axes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/445—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing an oscillatory movement about an axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4534—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using a rod for supporting the stirring element, e.g. stirrer sliding on a rod or mounted on a rod sliding in a tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C12M27/06—Stirrer or mobile mixing elements with horizontal or inclined stirrer shaft or axis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2014546134A 2011-12-09 2012-12-07 連続灌流用濾過装置 Pending JP2015500033A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161568872P 2011-12-09 2011-12-09
US61/568,872 2011-12-09
PCT/US2012/068513 WO2013086371A1 (en) 2011-12-09 2012-12-07 Filtration apparatus for continuous perfusion

Publications (2)

Publication Number Publication Date
JP2015500033A true JP2015500033A (ja) 2015-01-05
JP2015500033A5 JP2015500033A5 (cg-RX-API-DMAC7.html) 2016-01-14

Family

ID=48574930

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014546134A Pending JP2015500033A (ja) 2011-12-09 2012-12-07 連続灌流用濾過装置

Country Status (7)

Country Link
US (1) US20140370588A1 (cg-RX-API-DMAC7.html)
EP (1) EP2788468A4 (cg-RX-API-DMAC7.html)
JP (1) JP2015500033A (cg-RX-API-DMAC7.html)
CN (1) CN104619827A (cg-RX-API-DMAC7.html)
CA (1) CA2861519A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201402997QA (cg-RX-API-DMAC7.html)
WO (1) WO2013086371A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019505240A (ja) * 2016-02-23 2019-02-28 コーニング インコーポレイテッド 灌流バイオリアクタおよび連続細胞培養を実施するためのその使用方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9839886B2 (en) 2012-04-06 2017-12-12 Life Tehnologies Corporation Fluid mixing system with flexible drive line and foldable impeller
US9248420B2 (en) * 2013-12-16 2016-02-02 Pall Corporation High turndown impeller
EP2944372A1 (en) * 2014-05-17 2015-11-18 Miltenyi Biotec GmbH Method and device for suspending cells
US10092888B2 (en) 2014-11-07 2018-10-09 Genesis Technologies, Llc Linear reciprocating actuator
EP3240884B1 (en) * 2014-12-31 2018-12-19 GE Healthcare Bio-Sciences Corp. Shaft-mounted fluid transfer assembly for a disposable bioreactor
ITUB20154901A1 (it) * 2015-10-22 2017-04-22 Paolo Gobbi Frattini S R L Nuova sacca per la preparazione di innesti di tessuto adiposo
CN113975988B (zh) * 2015-12-29 2024-09-03 生命科技股份有限公司 具有侧向移位的柔性驱动线的流体混合系统及使用方法
JP7223012B2 (ja) 2018-01-17 2023-02-15 ライフ テクノロジーズ コーポレーション インペラアタッチメントを備えた、らせん状混合アセンブリを含む流体混合システムおよび使用方法
CN113522132B (zh) * 2021-07-19 2023-05-26 山东农业工程学院 一种农业滴灌用水肥药均混装置
FR3141686B1 (fr) * 2022-11-03 2024-12-13 Gary Kane Concept Bouchon pour distributeur d’échantillons fluides.

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4184916A (en) * 1977-11-14 1980-01-22 Monsanto Company Continuous cell culture system
JPH04252175A (ja) * 1991-01-28 1992-09-08 Teijin Ltd 細胞培養槽
US20090027997A1 (en) * 2005-10-03 2009-01-29 Zeta Ag Bioprocess Systems Single-Use Container With Stirring Device
JP2009513140A (ja) * 2005-10-26 2009-04-02 リーブテック，インコーポレイテッド ミキサーとスパージャーを備えたバイオリアクター
US20100015696A1 (en) * 2006-05-13 2010-01-21 Tom Claes Disposable bioreactor
WO2011005773A2 (en) * 2009-07-06 2011-01-13 Genentech, Inc. Method of culturing eukaryotic cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596779A (en) * 1983-03-23 1986-06-24 Bellco Glass, Inc. Culture vessel with agitator
US4649118A (en) * 1984-04-05 1987-03-10 The Virtis Company, Inc. Cell culturing apparatus with improved stirring and filter means
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US6670171B2 (en) * 2001-07-09 2003-12-30 Wheaton Usa, Inc. Disposable vessel
US7249880B2 (en) * 2003-10-14 2007-07-31 Advanced Technology Materials, Inc. Flexible mixing bag for mixing solids, liquids and gases
US7875448B2 (en) * 2004-01-12 2011-01-25 Single Use Brx, Llc Bioreactor systems and disposable bioreactor
US9109193B2 (en) * 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
US7832922B2 (en) * 2007-11-30 2010-11-16 Levitronix Gmbh Mixing apparatus and container for such

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4184916A (en) * 1977-11-14 1980-01-22 Monsanto Company Continuous cell culture system
JPH04252175A (ja) * 1991-01-28 1992-09-08 Teijin Ltd 細胞培養槽
US20090027997A1 (en) * 2005-10-03 2009-01-29 Zeta Ag Bioprocess Systems Single-Use Container With Stirring Device
JP2009513140A (ja) * 2005-10-26 2009-04-02 リーブテック，インコーポレイテッド ミキサーとスパージャーを備えたバイオリアクター
US20100015696A1 (en) * 2006-05-13 2010-01-21 Tom Claes Disposable bioreactor
WO2011005773A2 (en) * 2009-07-06 2011-01-13 Genentech, Inc. Method of culturing eukaryotic cells

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019505240A (ja) * 2016-02-23 2019-02-28 コーニング インコーポレイテッド 灌流バイオリアクタおよび連続細胞培養を実施するためのその使用方法
US11136542B2 (en) 2016-02-23 2021-10-05 Corning Incorporated Perfusion bioreactor and method for using same to perform a continuous cell culture

Also Published As

Publication number Publication date
EP2788468A1 (en) 2014-10-15
CA2861519A1 (en) 2013-06-13
SG11201402997QA (en) 2014-07-30
WO2013086371A1 (en) 2013-06-13
EP2788468A4 (en) 2015-09-16
US20140370588A1 (en) 2014-12-18
CN104619827A (zh) 2015-05-13

Similar Documents

Publication Publication Date Title
JP2015500033A (ja) 連続灌流用濾過装置
CN101466466B (zh) 反应器
CN101460605B (zh) 一次性生物反应器
CN101300338B (zh) 具有混合器和喷射器的生物反应器
US6670171B2 (en) Disposable vessel
JP6605251B2 (ja) シングルユース細胞培養装置および培養バッグ
JP2019512270A (ja) バイオリアクタシステム及びその方法
JP2007534335A (ja) 攪拌タンク反応器システム
JP6739273B2 (ja) シングルユース培養装置及び培養方法
WO2008040567A1 (en) Flexible mixing bag, mixing device and mixing system
AU2002346088A1 (en) Disposable vessel
JP2002512109A (ja) 流通型内側部材を備えた回転濾過装置
CN107438478B (zh) 生物处理混合器
CN102648044A (zh) 用于培养细胞和/或微生物的装置
JP2021517817A (ja) チャネルを有する折り畳み式バッフルを含む一回使用の容器
US20080261299A1 (en) Pneumatic Bioreactor
JP2018161115A (ja) 細胞培養装置及び細胞培養方法
JP4561192B2 (ja) 細胞培養装置及び細胞培養方法
JP6744161B2 (ja) 分離装置、培養装置および分離方法
WO2010063845A1 (en) Liquid substance circulation device comprising a compartment for an impeller having a sloped upper portion
CN208898901U (zh) 固定床和悬浮两用生物反应器
US20220315880A1 (en) Bioreactors and methods of use
JP2002045173A (ja) 細胞塊の培養方法およびバイオリアクター
JP7580871B2 (ja) バイオプロセスシステムのための羽根車組立体
JPH05304943A (ja) 生物培養装置

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151119

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151119

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160715

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160802

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170228