JP2015231365A5 - - Google Patents
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- Publication number
- JP2015231365A5 JP2015231365A5 JP2015098423A JP2015098423A JP2015231365A5 JP 2015231365 A5 JP2015231365 A5 JP 2015231365A5 JP 2015098423 A JP2015098423 A JP 2015098423A JP 2015098423 A JP2015098423 A JP 2015098423A JP 2015231365 A5 JP2015231365 A5 JP 2015231365A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- culturing
- stem cells
- inner ear
- pluripotent stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 238000012258 culturing Methods 0.000 claims 10
- 210000003027 ear inner Anatomy 0.000 claims 8
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 8
- 210000000130 stem cell Anatomy 0.000 claims 7
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 6
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 6
- 230000001939 inductive effect Effects 0.000 claims 6
- 230000006698 induction Effects 0.000 claims 5
- 230000002792 vascular Effects 0.000 claims 4
- 102100028412 Fibroblast growth factor 10 Human genes 0.000 claims 2
- 102100028043 Fibroblast growth factor 3 Human genes 0.000 claims 2
- 101000917237 Homo sapiens Fibroblast growth factor 10 Proteins 0.000 claims 2
- 101001060280 Homo sapiens Fibroblast growth factor 3 Proteins 0.000 claims 2
- 102000011384 Pendrin Human genes 0.000 claims 2
- 108050001616 Pendrin Proteins 0.000 claims 2
- 239000000835 fiber Substances 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000011435 rock Substances 0.000 claims 2
- 239000012679 serum free medium Substances 0.000 claims 2
- 238000004114 suspension culture Methods 0.000 claims 2
- 102100031734 Fibroblast growth factor 19 Human genes 0.000 claims 1
- 102100031361 Fibroblast growth factor 20 Human genes 0.000 claims 1
- 102100037665 Fibroblast growth factor 9 Human genes 0.000 claims 1
- 208000003098 Ganglion Cysts Diseases 0.000 claims 1
- 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 claims 1
- 101000846532 Homo sapiens Fibroblast growth factor 20 Proteins 0.000 claims 1
- 101001027380 Homo sapiens Fibroblast growth factor 9 Proteins 0.000 claims 1
- 208000005400 Synovial Cyst Diseases 0.000 claims 1
- 210000000270 basal cell Anatomy 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000002768 hair cell Anatomy 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 210000004498 neuroglial cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 210000005167 vascular cell Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015098423A JP6218152B2 (ja) | 2014-05-13 | 2015-05-13 | 内耳細胞誘導方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014100017 | 2014-05-13 | ||
| JP2014100017 | 2014-05-13 | ||
| JP2015098423A JP6218152B2 (ja) | 2014-05-13 | 2015-05-13 | 内耳細胞誘導方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015231365A JP2015231365A (ja) | 2015-12-24 |
| JP2015231365A5 true JP2015231365A5 (cg-RX-API-DMAC10.html) | 2017-06-01 |
| JP6218152B2 JP6218152B2 (ja) | 2017-10-25 |
Family
ID=54933292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015098423A Active JP6218152B2 (ja) | 2014-05-13 | 2015-05-13 | 内耳細胞誘導方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6218152B2 (cg-RX-API-DMAC10.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017146035A1 (ja) * | 2016-02-22 | 2017-08-31 | 学校法人順天堂 | 内耳細胞の製造法 |
| JP2023106640A (ja) * | 2020-06-09 | 2023-08-02 | 株式会社オトリンク | 内耳有毛細胞の製造方法、薬剤の評価方法、及び細胞分化誘導用組成物 |
| JP2023106639A (ja) * | 2020-06-09 | 2023-08-02 | 株式会社オトリンク | 内耳前駆細胞の製造方法、内耳有毛細胞の製造方法、薬剤の評価方法、及び内耳細胞分化誘導用組成物 |
| JP7893496B2 (ja) * | 2021-09-03 | 2026-07-22 | 学校法人北里研究所 | 内耳血管条辺縁細胞の製造方法、薬剤の評価方法、及び薬剤評価用細胞培養物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2464723B1 (en) * | 2009-08-12 | 2016-06-22 | Kyoto University | Method for inducing differentiation of pluripotent stem cells into neural precursor cells |
| WO2013166488A1 (en) * | 2012-05-04 | 2013-11-07 | Indiana University Research & Technology Corporation | Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells |
| WO2013187416A1 (ja) * | 2012-06-12 | 2013-12-19 | 学校法人 慶應義塾 | 神経系分化に適したiPS細胞の増幅方法、及び神経幹細胞の誘導方法 |
-
2015
- 2015-05-13 JP JP2015098423A patent/JP6218152B2/ja active Active
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