JP2015226493A - 目元の肌状態の推定方法 - Google Patents
目元の肌状態の推定方法 Download PDFInfo
- Publication number
- JP2015226493A JP2015226493A JP2014113161A JP2014113161A JP2015226493A JP 2015226493 A JP2015226493 A JP 2015226493A JP 2014113161 A JP2014113161 A JP 2014113161A JP 2014113161 A JP2014113161 A JP 2014113161A JP 2015226493 A JP2015226493 A JP 2015226493A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- enzyme
- eyes
- activity
- skin condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 54
- 102000004190 Enzymes Human genes 0.000 claims abstract description 114
- 108090000790 Enzymes Proteins 0.000 claims abstract description 114
- 230000000694 effects Effects 0.000 claims abstract description 97
- 238000002360 preparation method Methods 0.000 claims abstract description 35
- 239000000126 substance Substances 0.000 claims abstract description 18
- 210000003491 skin Anatomy 0.000 claims description 146
- 210000000434 stratum corneum Anatomy 0.000 claims description 37
- 102000004958 Caspase-14 Human genes 0.000 claims description 36
- 108090001132 Caspase-14 Proteins 0.000 claims description 36
- 238000011156 evaluation Methods 0.000 claims description 20
- 230000037303 wrinkles Effects 0.000 claims description 19
- 239000002537 cosmetic Substances 0.000 claims description 14
- 230000009471 action Effects 0.000 claims description 13
- 238000007665 sagging Methods 0.000 claims description 9
- 230000006872 improvement Effects 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 238000000491 multivariate analysis Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 18
- 229940041514 candida albicans extract Drugs 0.000 description 16
- 239000012138 yeast extract Substances 0.000 description 16
- 239000000284 extract Substances 0.000 description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 241000196324 Embryophyta Species 0.000 description 10
- 230000000007 visual effect Effects 0.000 description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 102000006746 NADH Dehydrogenase Human genes 0.000 description 5
- 108010086428 NADH Dehydrogenase Proteins 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
- 102000016938 Catalase Human genes 0.000 description 4
- 108010053835 Catalase Proteins 0.000 description 4
- 102100034868 Kallikrein-5 Human genes 0.000 description 4
- 101710176223 Kallikrein-5 Proteins 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- -1 Chaps Chemical compound 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000007995 HEPES buffer Substances 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 239000012131 assay buffer Substances 0.000 description 3
- 238000009223 counseling Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 241001340526 Chrysoclista linneella Species 0.000 description 2
- 102000030789 Histidine Ammonia-Lyase Human genes 0.000 description 2
- 108700006308 Histidine ammonia-lyases Proteins 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 108060008539 Transglutaminase Proteins 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000010219 correlation analysis Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000002559 palpation Methods 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 102000003601 transglutaminase Human genes 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- CCBICDLNWJRFPO-UHFFFAOYSA-N 2,6-dichloroindophenol Chemical compound C1=CC(O)=CC=C1N=C1C=C(Cl)C(=O)C(Cl)=C1 CCBICDLNWJRFPO-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000012850 discrimination method Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000003028 enzyme activity measurement method Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000008921 facial expression Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 108010021648 semen liquefaction factor Proteins 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 150000003410 sphingosines Chemical class 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014113161A JP2015226493A (ja) | 2014-05-30 | 2014-05-30 | 目元の肌状態の推定方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014113161A JP2015226493A (ja) | 2014-05-30 | 2014-05-30 | 目元の肌状態の推定方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015226493A true JP2015226493A (ja) | 2015-12-17 |
| JP2015226493A5 JP2015226493A5 (enExample) | 2017-06-08 |
Family
ID=54884462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014113161A Pending JP2015226493A (ja) | 2014-05-30 | 2014-05-30 | 目元の肌状態の推定方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2015226493A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017093599A (ja) * | 2015-11-19 | 2017-06-01 | 株式会社ニューギン | 遊技機 |
| JP2022144014A (ja) * | 2021-03-18 | 2022-10-03 | 丸善製薬株式会社 | カスパーゼ-14発現促進剤 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0868791A (ja) * | 1994-08-31 | 1996-03-12 | Shiseido Co Ltd | デスモソーム機能の評価方法 |
| WO2004058991A1 (de) * | 2002-12-20 | 2004-07-15 | Henkel Kommanditgesellschaft Auf Aktien | Verfahren zur bestimmung des enzymatischen status humaner haut in vitro |
| WO2009142268A1 (ja) * | 2008-05-23 | 2009-11-26 | 株式会社資生堂 | ブレオマイシン水解酵素の活性を指標とした天然保湿因子による皮膚バリアー機能状態の評価方法 |
-
2014
- 2014-05-30 JP JP2014113161A patent/JP2015226493A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0868791A (ja) * | 1994-08-31 | 1996-03-12 | Shiseido Co Ltd | デスモソーム機能の評価方法 |
| WO2004058991A1 (de) * | 2002-12-20 | 2004-07-15 | Henkel Kommanditgesellschaft Auf Aktien | Verfahren zur bestimmung des enzymatischen status humaner haut in vitro |
| WO2009142268A1 (ja) * | 2008-05-23 | 2009-11-26 | 株式会社資生堂 | ブレオマイシン水解酵素の活性を指標とした天然保湿因子による皮膚バリアー機能状態の評価方法 |
Non-Patent Citations (1)
| Title |
|---|
| 「肌の見た目の美しさと角層中の酵素活性の高さに関係性があることを発見〜美しい肌ほど酵素活性が高い結果, JPN6018005392, ISSN: 0003864375 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017093599A (ja) * | 2015-11-19 | 2017-06-01 | 株式会社ニューギン | 遊技機 |
| JP2022144014A (ja) * | 2021-03-18 | 2022-10-03 | 丸善製薬株式会社 | カスパーゼ-14発現促進剤 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6033435B2 (ja) | 天然物由来のフィロバシディウム抑制物質を含む抗菌用組成物 | |
| US10620189B2 (en) | Surface isotropy as a marker for epidermal maturation | |
| Iglesia et al. | A multi‐functional anti‐aging moisturizer maintains a diverse and balanced facial skin microbiome | |
| KR101500191B1 (ko) | 피부 케어용 조성물 및 이의 제조 방법 | |
| CN111686048B (zh) | 一种抗衰老精华及其制备方法 | |
| CN113876633A (zh) | 一种仿人体皮脂脂质构成的天然植物油脂复合物及其制备方法和用途 | |
| CN117180143A (zh) | 一种乳木果油发酵物及其制备方法和应用 | |
| JP5275898B2 (ja) | 皮膚状態の評価方法 | |
| Awad et al. | Phenotypic Identification and Molecular Characterization of Malassezia spp. isolated from Pityriasis versicolor patients with special emphasis to risk factors in Diyala province, Iraq | |
| CN101674841B (zh) | 抗组胺物质及其制备方法 | |
| US9192791B2 (en) | Topical composition containing theanine derivatives for use on skin | |
| JP2015226493A (ja) | 目元の肌状態の推定方法 | |
| JP2017009426A (ja) | 発毛の状態及び頭皮の圧縮応力の評価方法 | |
| CN114099388B (zh) | 一种抗皱组合物其制备方法及其应用 | |
| EP2763652A2 (fr) | Utilisation de glucanes obtenus a partir de prunus persica comme agent cosmetique anti-age | |
| JP6185372B2 (ja) | 皮膚外用剤 | |
| JP2015101541A (ja) | 皮膚関連酵素活性化剤 | |
| TWI777096B (zh) | 銀杏癒傷組織的萃取物用於改善肌膚泛紅的用途 | |
| JP2007008912A (ja) | 生活リズム恒常性維持のための美容施術方法 | |
| Wojciechowska et al. | New Insights into Common Bean (Phaseolus vulgaris L.) Sprouts: Pilot Studies on the Formulation of a Cosmeceutical Based on Micellar Extracts Bean Sprouts | |
| TWI674107B (zh) | 白茅根發酵物用於提升皮膚細胞角蛋白基因、聚角蛋白微絲基因與玻尿酸合成酶基因表現量、促進膠原蛋白與彈力蛋白增生、及提升抗氧化能力的用途 | |
| TW202012925A (zh) | 改善因老化或缺氧所致的皮膚狀態之成分篩選方法、以及以皮下組織之黏彈性作爲指標之皮下組織之氧量或皮下脂肪細胞之纖維化程度之估算方法 | |
| JP7625409B2 (ja) | 角層水分量が低下した脂性肌に対する肌荒れ改善剤 | |
| JP2024132905A (ja) | Qsox1遺伝子発現亢進剤 | |
| Berna et al. | LB727 Using a machine learning approach to identify rare and low-frequency filaggrin variants associated with remission of Atopic Dermatitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170413 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170413 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20180214 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180220 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180327 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20180828 |