JP2015224230A - Liquid composition and external preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a liquid composition which hardly causes a precipitation of glycyrrhetic acid, while comprising glycyrrhetic acid and being low in oil content, and has an excellent feeling of use without stickiness.SOLUTION: The invention provides a liquid composition containing 0.0001-1.0 mass% of glycyrrhetic acid, 60-97.4 mass% of water, 0.5-3 mass% of a surfactant, and 2-6 mass% of lower alcohol. In such a liquid composition, glycyrrhetic acid is preferred to be dispersed in an aqueous medium containing water, a surfactant, and lower alcohol.

Description

  The present invention relates to a liquid composition and an external preparation. More specifically, the present invention relates to a liquid composition containing glycyrrhetinic acid and suitably used for liquid cosmetics, and an external preparation blended with the liquid composition.

  β-Glycyrrhetinic acid (hereinafter simply referred to as “glycyrrhetinic acid”) is an aglycone of glycyrrhizic acid obtained from the rhizome of licorice and is a compound obtained by hydrolyzing glycyrrhizic acid. Glycyrrhetinic acid is known to have useful actions such as an anti-inflammatory action and a whitening action, and has been incorporated into many skin cosmetics using such actions.

  Since oil-soluble glycyrrhetinic acid is insoluble in water, it cannot be stably dissolved even if it is contained in a liquid composition containing water as a main component, and glycyrrhetinic acid is precipitated. Therefore, liquid cosmetics containing glycyrrhetinic acid have been limited to oily cosmetics, water-in-oil emulsified cosmetics, and the like. However, since oily cosmetics and emulsified cosmetics contain a large amount of oily components, there is a problem in feeling of use such as stickiness and the like, and the provision of aqueous cosmetics containing glycyrrhetinic acid has been awaited.

  Among these, glycyrrhetinic acid 0.05-3.0 mass%, purified water 30-60 mass%, glycols 10-50 mass%, lower alcohol 10-40 mass%, and carboxyvinyl polymer 0.5-5 A water-soluble gel external preparation containing 0.0% by mass has been proposed (see Patent Document 1).

JP-A-5-148146

  Patent Document 1 is intended to solubilize glycyrrhetinic acid in water. However, the composition of Patent Document 1 is added with a carboxyvinyl polymer as a gelling agent and feels sticky. There was a problem. For this reason, it has been difficult to use it in cosmetics such as lotions and cosmetic liquids that require a non-sticky feel.

  The present invention has been made in view of the above problems, and a liquid composition containing glycyrrhetinic acid and having a low oil content, hardly causing precipitation of glycyrrhetinic acid, having no stickiness, and having an excellent feeling in use, and blended with the same It aims at providing an external preparation.

  In order to achieve the above object, first, the present invention provides 0.0001 to 1.0% by mass of glycyrrhetinic acid, 60 to 97.4% by mass of water, and 0.5 to 3% by mass of surface activity. A liquid composition comprising an agent and 2 to 6% by mass of a lower alcohol is provided (Invention 1).

  The liquid composition according to the above invention (Invention 1) can effectively disperse glycyrrhetic acid by containing the surfactant in the above range, and further contains glycyrrhetin in the above range by containing the lower alcohol. The dispersibility of the acid is further increased. Furthermore, since water is contained in the above range, it becomes excellent in use feeling such as stickiness. Therefore, the liquid composition according to the above invention (Invention 1) is less likely to cause precipitation of glycyrrhetinic acid even with a low oil content, and does not feel sticky and has excellent usability.

  In the said invention (invention 1), it is preferable that the said glycyrrhetic acid is disperse | distributing to the aqueous medium containing the said water, the said surfactant, and the said lower alcohol (invention 2).

  2ndly, this invention provides the external preparation characterized by containing the liquid composition which concerns on the said invention (invention 1 and 2) (invention 3).

  The external preparation according to the above invention (Invention 3) contains the above-mentioned liquid composition (Invention 1 and 2), and therefore contains glycyrrhetinic acid, and does not feel sticky or the like and has excellent usability. It becomes.

  Although the liquid composition of the present invention contains glycyrrhetic acid, it has a low oil content and hardly precipitates glycyrrhetic acid. Moreover, the external preparation which mix | blended the liquid composition of this invention does not have stickiness, and becomes the thing excellent in the usability | use_condition.

2 is a photograph showing the results of Test Example 1 in Examples 1 and 5 and Comparative Example 1. FIG.

Embodiments of the present invention will be described below.
[Liquid composition]
The liquid composition according to this embodiment (hereinafter sometimes referred to as “liquid composition L”) contains glycyrrhetinic acid, water, a surfactant, and a lower alcohol.

  The liquid composition L contains 0.0001 to 1.0% by mass of glycyrrhetinic acid, preferably 0.001 to 0.75% by mass, and particularly preferably 0.01 to 0.5% by mass. By containing 0.0001% by mass or more of glycyrrhetic acid, the liquid composition L can be provided with a preferable physiological action of glycyrrhetic acid. Further, when the content of glycyrrhetinic acid is 1.0% by mass or less, precipitation of glycyrrhetic acid in the liquid composition L hardly occurs.

  The liquid composition L contains water as an essential component. Here, the water used in the present embodiment includes pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, and the like and those subjected to various treatments. Examples of the treatment applied to water include purification, heating, sterilization, filtration, ion exchange, osmotic pressure adjustment, buffering, and the like. Therefore, the water used in the present embodiment includes purified water, hot water, ion exchange water, physiological saline, phosphate buffer, phosphate buffered saline, and the like.

  The liquid composition L contains 60 to 97.4% by mass of water, preferably 65 to 95% by mass, and particularly preferably 66 to 94% by mass. By containing 60% by mass or more of water, the liquid composition L contains glycyrrhetinic acid but does not feel sticky and has excellent usability, that is, exhibits a dosage form very close to water. It becomes. Further, when the water content is 97.4% by mass or less, precipitation of glycyrrhetic acid in the liquid composition L is difficult to occur.

  Here, conventionally, since glycyrrhetinic acid is insoluble in water even when trying to contain glycyrrhetinic acid in a low oil liquid composition mainly composed of water, such a composition, for example, lotion or cosmetic liquid, etc. It was difficult to provide. However, the liquid composition L according to the present embodiment contains a predetermined amount of a surfactant and a lower alcohol as described later, so that water is contained at a relatively high rate (that is, 60% by mass or more). Also, precipitation of glycyrrhetinic acid is difficult to occur.

  In the present specification, the term “low oil” means that the content of the oily component described below is low enough that the liquid composition L can be used in skin lotion or cosmetic liquid, and preferably the oily component described below. It means that the content of is 2% by mass or less.

  The liquid composition L contains a surfactant as an essential component. When the liquid composition L contains a surfactant, precipitation of glycyrrhetic acid can hardly occur.

  Surfactants used in the present embodiment are those generally used in cosmetics, for example, anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants and the like. Although it can select suitably from inside, a nonionic surfactant is preferable from viewpoints, such as hypoallergenicity. Among the nonionic surfactants preferably used, nonionic surfactants include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez. (Polyoxyethylene behenyl ether) and other polyoxyethylene alkyl ethers; castor oil and hydrogenated castor oil derivatives; sugars and sugar alcohol esters; sugars and sugar alcohol ethers, and the like. By using the above in combination, glycyrrhetinic acid can be effectively dispersed in the liquid composition L. Among these, laureth-9, PEG-60 hydrogenated castor oil, sucrose distearate and behenez-30 are preferable from the viewpoint of the molecular structure and hydrophilicity.

  In the liquid composition L, the content of the surfactant is 0.5 to 3% by mass, preferably 0.7 to 2.8% by mass, and particularly preferably 0.9 to 2.6. % By mass. The liquid composition L contains 0.5% by mass or more of the surfactant, whereby glycyrrhetic acid is easily dispersed in the liquid composition L, and as a result, precipitation of glycyrrhetic acid is difficult to occur. On the other hand, when the content of the surfactant is 3% by mass or less, when the liquid composition L is used as an external preparation (for example, cosmetics, quasi-drugs, etc.), it is more excellent in usability and safety. It will be.

  The liquid composition L further contains a lower alcohol as an essential component. Here, in the present specification, the “lower alcohol” is an alcohol having 1 to 6 carbon atoms, and includes a lower monohydric alcohol and a lower polyhydric alcohol.

  Examples of such lower alcohol include lower monohydric alcohols such as ethanol, 1-propanol, 2-propanol, and n-butanol; ethylene glycol, propylene glycol (1,2-propanediol), 1,3-propanediol. Lower polyhydric alcohols such as 1,2-butylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2,4-butanetriol, and diethylene glycol; These can be used alone or in combination of two or more. In the present embodiment, from the viewpoints of dispersibility of glycyrrhetinic acid, safety when used as a liquid cosmetic, and feeling of use, among these, ethanol, 1,3-butylene glycol, diethylene glycol, 1,2-pentanediol 1,2-hexanediol is preferred.

  In the liquid composition L, the content of the lower alcohol is 2 to 6% by mass, preferably 2.5 to 5.5% by mass, and particularly preferably 3 to 5% by mass. When the content of the lower alcohol is 2% by mass or more, the dispersibility of glycyrrhetic acid by the surfactant described above is further increased, and as a result, precipitation of glycyrrhetic acid in the liquid composition L is difficult to occur. Further, when the content of the lower alcohol is 6% by mass or less, it becomes difficult to feel the feel of the lower alcohol such as stickiness, and the usability is excellent.

  In the liquid composition L, glycyrrhetinic acid is preferably dispersed in an aqueous medium containing water, a surfactant and a lower alcohol. When glycyrrhetinic acid is dispersed in the aqueous medium, precipitation of glycyrrhetic acid in the liquid composition L is less likely to occur. Here, in the liquid composition L, it is considered that by using a surfactant or a lower alcohol in a content within the above range, the solubility of glycyrrhetinic acid in water is improved and the dispersibility is efficiently increased. It is done. However, this embodiment is not limited to these molecular mechanisms.

  The liquid composition L may further contain an oil component. In the liquid composition L according to the present embodiment, glycyrrhetinic acid is dispersed even if the oil content is low, and precipitation thereof is difficult to occur. However, by containing a small amount of an oily component, precipitation of glycyrrhetic acid is more likely to occur. It will be difficult.

  Examples of oily components that can be used in the present embodiment include hydrocarbons such as liquid paraffin, squalane and petrolatum; fats and oils such as owl, olive oil, castor oil, mink oil and macadamian nut oil; beeswax and gay wax Waxes; jojoba oil, glyceryl trioctanoate, triethylhexanoin, cholesterol fatty acid ester, phytosterol fatty acid ester, triglyceride, etc .; fatty acids; higher alcohols; silicones such as dimethicone; fluorinated oils; lanolin and its derivatives These can be used, and these can be used alone or in combination of two or more. Among these, triethylhexanoin, squalane, and dimethicone are particularly suitable for maintaining the dispersibility of glycyrrhetic acid, and are particularly preferable.

  When the liquid composition L contains an oil component, the content is preferably 0.01 to 2% by mass, more preferably 0.025 to 1.75% by mass, and 0.05 to It is particularly preferably 1.5% by mass. By containing 0.01% by mass or more of the oil component, the dispersibility of glycyrrhetinic acid can be further improved. Moreover, when the liquid composition L contains an oily component, when the liquid composition L is applied to the skin as an external preparation for skin, an effect that the moisturizing effect of the skin can be maintained is also achieved. Moreover, since content of an oil-based component is 2 mass% or less, the liquid composition L will not feel stickiness, and it will be excellent in usability.

  In addition, the liquid composition L includes other components such as humectants, antiseptics, antibacterial agents, enzymes, and other functional components, as well as fragrances, pigments, pH adjusters, and the like in a range that does not impair the effects of the present embodiment. You may mix with.

  Here, it is preferable that the liquid composition L reduce the content of the gelling agent, more preferably not contain it at an effective concentration (for example, 0.5% by mass or more) that exerts a gelling action, and it is contained at all. It is particularly preferred not to do so. When the content of the gelling agent is large, when the liquid composition L is used as a cosmetic, the effect of this embodiment that there is no stickiness and excellent usability may be impaired.

  The liquid composition L preferably has a pH of 4 to 11. When the pH is in such a range, when the liquid composition L is used as a cosmetic, the irritation is small and the safety is excellent.

  When the liquid composition L is centrifuged at 1,500 × g for 10 minutes, it is preferable that precipitation does not occur, and even if centrifugation is performed at 2,300 × g for 10 minutes, precipitation does not occur. Preferably, it is particularly preferable that no precipitation occurs even after centrifugation at 3,300 × g for 10 minutes. Here, when precipitation does not occur after centrifugation, 10 mL of liquid composition L is collected in a 15 mL centrifuge tube, centrifuged under the above conditions, and then observed with the naked eye. This means that no difference in light transmittance is observed between the upper and lower liquid phases.

  Here, the conventional low oil glycyrrhetinic acid-containing composition was very difficult to prevent precipitation under the above centrifugation conditions, but the liquid composition L according to this embodiment is By having the composition described above, precipitation does not occur even under the above-mentioned centrifugal separation conditions. As a result, when the liquid composition L is used as a cosmetic, no stickiness is felt, and the feeling of use is extremely excellent. It becomes.

  Liquid composition L contains glycyrrhetinic acid, which is an active ingredient, but does not easily precipitate glycyrrhetinic acid, and therefore does not feel sticky when applied to the skin. Therefore, cosmetics, pharmaceuticals, quasi drugs, etc. Can be suitably used.

  The liquid composition L can be produced by a conventionally known method except that a predetermined amount of glycyrrhetinic acid, a surfactant, a lower alcohol and water is contained.

  For example, glycyrrhetinic acid and a surfactant and, if desired, an oil component are mixed and stirred to prepare a glycyrrhetic acid-containing mixed solution. Here, the glycyrrhetinic acid-containing mixed solution may further contain a part of the lower alcohol which is an essential component of the liquid composition L. Moreover, it is preferable to perform the operation of mixing and stirring mentioned above on the conditions whose temperature is 60-80 degreeC. Furthermore, it is preferable that glycyrrhetinic acid is completely dispersed in the glycyrrhetic acid-containing mixed solution.

  To the resulting glycyrrhetinic acid-containing mixture, a mixed solution of water and lower alcohol is added and mixed and stirred. Here, the water and lower alcohol mixed solution may further contain a part of the surfactant, which is an essential component of the liquid composition L, and, if desired, other components (for example, various functionalities). Components, pH adjusters, and the like). In mixing and stirring the glycyrrhetinic acid-containing mixed solution and the mixed solution of water and lower alcohol, the temperature is preferably 60 to 80 ° C. In this way, the liquid composition L can be obtained.

  The liquid composition L according to the present embodiment described above contains glycyrrhetinic acid that is insoluble in water, and does not easily precipitate even though it is low in oil content, and therefore has excellent usability.

[External preparation]
Since the liquid composition L described above is a low oil composition containing glycyrrhetinic acid and does not easily precipitate, it is suitable for blending in an external preparation for treating the skin or the like. The external preparation according to the present embodiment is excellent in feeling of use while containing glycyrrhetinic acid by blending the liquid composition L.

  As an external preparation according to the present embodiment, liquid cosmetics requiring a low oil content, such as lotions, cosmetic liquids, lotions, hair tonics, hair liquids, liquid sunscreen agents, antiperspirants, etc. Preferred examples include external preparations including skin cosmetics. When used in these external preparations, glycyrrhetinic acid is not easily precipitated, and the liquid composition L is excellent in usability.

  When the liquid composition L is blended in the external preparation, the blending amount can be appropriately adjusted according to the type of the external preparation, but the preferred blending ratio is about 0.0001 to the glycyrrhetic acid content. 1 mass%, and a particularly suitable blending ratio is about 0.001 to 0.5 mass%.

  As long as the external preparation according to the present embodiment does not impair the physiological function of glycyrrhetinic acid and the effect of the liquid composition L, the main agent, auxiliary agent or other components used in the production of normal external preparations, for example, astringents , Disinfectant / antibacterial agent, whitening agent, UV absorber, moisturizer, cell activator, anti-inflammatory / antiallergic agent, antioxidant / active oxygen remover, hydrocarbons, fatty acids, esters, fragrances, etc. Can do. When used in this way, the product becomes more general, and a synergistic effect with other components used in combination may produce a superior effect than would normally be expected.

  The external preparation according to the present embodiment described above is blended with the liquid composition L which is low in oil content and hardly precipitates glycyrrhetinic acid, so that it contains glycyrrhetinic acid but does not feel sticky. The feeling is excellent.

  The embodiment described above is described for facilitating understanding of the present invention, and is not described for limiting the present invention. Therefore, each element disclosed in the above embodiment is intended to include all design changes and equivalents belonging to the technical scope of the present invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to each following example at all.

[Example 1]
The components shown in item A of Table 1 were mixed and stirred and mixed until completely dispersed under conditions of 60 to 80 ° C. to obtain a mixed solution A. On the other hand, the components shown in item B of Table 1 were mixed and completely dissolved to obtain a mixed solution B. Subsequently, while adding the mixed solution A to the mixed solution B little by little, the mixture was stirred and mixed under conditions of 60 to 80 ° C. and completely dispersed, thereby obtaining a liquid composition.

[Examples 2-6, Comparative Examples 1-5, Blank]
A liquid composition was produced in the same manner as in Example 1 except that the formulation shown in Table 1 was changed.

Details of the abbreviations described in Table 1 are as follows.
[Glycyrrhetinic acid]
・ Glycyrrhetinic acid: manufactured by Maruzen Pharmaceutical Co., Ltd. [Surfactant]
・ Laureth-9: Polyoxyethylene (9) lauryl ether, manufactured by Nikko Chemicals, NIKKOL BL-9EX
PEG-60 hydrogenated castor oil: polyoxyethylene (60) hydrogenated castor oil, manufactured by Nikko Chemicals, NIKKOL HCO-60
・ Sucrose distearate: Mitsubishi Chemical Foods, Surf Hope SE COSME C-1807
・ Behenes-30: Polyoxyethylene (30) behenyl ether, manufactured by Nikko Chemicals, NIKKOL BB-30
[Lower alcohol]
・ 1,2-Pentanediol: manufactured by Simrise ・ 1,3-butylene glycol: manufactured by Higher Alcohol [Oil component]
Triethylhexanoin: glyceryl tri-2-ethylhexanoate, manufactured by Nikko Chemicals, NIKKOL Trifat S-308
・ Squalane: Plant-based squalane, manufactured by Higher Alcohol Industry Co., Ltd., trade name “Olive Squalane”
・ Dimethicone: MOMENTIVE, Element 14 * PDMS 10-JC
[Others]
・ (Acrylates / alkyl acrylate (C10-30)) crosspolymer: Nikko Chemicals, PEMULEN TR-2
・ NaOH: Wako Pure Chemical Industries

[Test Example 1] Evaluation of dispersibility The liquid compositions of Examples 1 to 6 and Comparative Examples 1 to 5 were allowed to stand at 5 ° C for 7 days, and then the presence or absence of precipitation was observed. The results are shown in Table 1. The results of Example 1, Example 5, and Comparative Example 1 are shown in FIG.

  In addition, the blank shown in FIG. 1 is purified water and emulsion (containing no glycyrrhetinic acid), and is left as a control test for 7 days at 5 ° C. as in the examples and comparative examples.

[Test Example 2] Evaluation of feeling of use The liquid compositions of Examples 1 to 6 and Comparative Examples 1 to 5 were used by a cosmetic evaluation specialist panelist to evaluate the presence or absence of stickiness. The results are shown in Table 1.

  As shown in Table 1, the liquid composition of the present invention had a stable dosage form without causing precipitation of glycyrrhetinic acid, and did not feel sticky and had a good feel.

  The liquid composition of the present invention is suitably used for liquid cosmetics such as skin lotions and cosmetic liquids, particularly low oil content.

Claims (3)

0.0001-1.0% by weight of glycyrrhetinic acid,
60-97.4 wt% water,
0.5 to 3% by weight surfactant and 2 to 6% by weight lower alcohol,
A liquid composition comprising:   The liquid composition according to claim 1, wherein the glycyrrhetinic acid is dispersed in an aqueous medium containing the water, the surfactant, and the lower alcohol.   An external preparation comprising the liquid composition according to claim 1.