JP2015171359A5 - - Google Patents

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Publication number

JP2015171359A5

JP2015171359A5 JP2015033801A JP2015033801A JP2015171359A5 JP 2015171359 A5 JP2015171359 A5 JP 2015171359A5 JP 2015033801 A JP2015033801 A JP 2015033801A JP 2015033801 A JP2015033801 A JP 2015033801A JP 2015171359 A5 JP2015171359 A5 JP 2015171359A5

Authority

JP

Japan

Prior art keywords

amino acid

acid sequence

pyranose

modified

seq

Prior art date

2015-02-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001413 amino acids Chemical group 0.000 claims 23
• 108010001816 pyranose oxidase Proteins 0.000 claims 13
• 235000001014 amino acid Nutrition 0.000 claims 10
• 229940024606 amino acid Drugs 0.000 claims 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 9
• 230000000694 effects Effects 0.000 claims 8
• 235000018102 proteins Nutrition 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 150000003214 pyranose derivatives Chemical class 0.000 claims 4
• 108090000790 Enzymes Proteins 0.000 claims 2
• 102000004190 Enzymes Human genes 0.000 claims 2
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
• 101710193171 Pyranose dehydrogenase Proteins 0.000 claims 2
• 235000004279 alanine Nutrition 0.000 claims 2
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 238000012986 modification Methods 0.000 claims 2
• 230000004048 modification Effects 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
• 229960000310 isoleucine Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000003647 oxidation Effects 0.000 claims 1
• 238000007254 oxidation reaction Methods 0.000 claims 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1