JP2015140331A - Bactericidal composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a bactericidal composition exhibiting bactericidal effects on various microorganism existing in living environment such as a bathroom.SOLUTION: There is provided the bactericidal composition containing: aromatic alcohol such as benzyl alcohol (a component), glycol ether ((b1 component) represented by RO-(CH-O)-H, where R represents an aliphatic hydrocarbon group having 3 to 8 carbon atoms or the like and n1 represents an integer of 1 to 8; glycol ether (b2 component) represented by RO-(CH-CH(CH)-O)-H, where R represents an aliphatic hydrocarbon group having 1 to 8 carbon atoms and n2 represents an integer of 1 to 8; water (c component); and a surfactant (d component). In the bactericidal composition, the total content of the (a) component and the (b) component which is selected from the (b1) and (b2) components is 1.6 mass% or more, the mass ratio of the total content of the (a) component and the (b) component and the content of the (d) component, (d)/[(a)+(b)] is 0.8 or less, and the total content of the (a) component, the (b) component and the (c) component is 80 mass% or more.

Description

  The present invention relates to a microbicidal composition.

  There are many facilities where a sanitary environment is desired, such as food manufacturing plants, pharmaceutical manufacturing plants, hospitals, nursing homes, kitchens, toilets, and bathrooms. In these, in order to maintain a hygienic environment, frequent sterilization treatments such as floors, walls and used tools are indispensable. For sterilization and cleaning of these hard surfaces, liquid or powder cleaning agents, sterilizing agents, and sterilizing cleaning agents containing surfactants and sterilizing agents are mainly used.

  Patent Document 1 discloses a low-residue antibacterial cleaning composition containing a specific organic carboxylic acid and a hardly soluble monovalent solvent selected from aliphatic alcohols and glycol ethers under predetermined conditions.

  Patent Document 2 discloses a bactericide containing 1- (2-ethylhexyl) glycerol ether and a specific aromatic alcohol.

  Patent Document 3 discloses a pesticide composition comprising a specific emulsion stabilizer, 2- (thiazol-4-yne) benzimidazole, a mixed solvent containing a glycol-based solvent and benzyl alcohol, and a surfactant. It is disclosed.

JP-T-2004-523616 JP 2011-6434 A JP 2009-120549 A

  The present invention provides a microbicidal composition capable of exerting an excellent bactericidal effect against various microorganisms present in living environments such as bathrooms.

In the present invention, (a) a compound represented by the general formula (a1) [hereinafter referred to as the component (a)] is 0.5% by mass or more and 5% by mass or less, and (b) a compound represented by the general formula (b1). And at least one compound selected from the compounds represented by formula (b2) [hereinafter referred to as component (b)] is 0.01% by mass or more and 10% by mass or less, (c) water [hereinafter, (c ) Component], and optionally (d) a surfactant (excluding (a) component and (b) component) [hereinafter referred to as (d) component],
The total content of the component (a) and the component (b) is 1.6% by mass or more,
The mass ratio of the total content of the component (a) and the component (b) and the content of the component (d) is (d) / [(a) + (b)] and is 0.8 or less,
The total content of the component (a), the component (b) and the component (c) is 80% by mass or more.
The present invention relates to a microbicidal composition.

_{RO- (C 2 H 4 -O)} n1 -H (b1)
(In the formula, R is an aliphatic hydrocarbon group having 3 to 8 carbon atoms or a cyclic hydrocarbon group having 3 to 8 carbon atoms, and n1 is an integer of 1 to 8)
_{RO- (CH 2 -CH (CH 3} ) -O) n2 -H (b2)
(In the formula, R is an aliphatic hydrocarbon group having 1 to 8 carbon atoms or a cyclic hydrocarbon group having 3 to 8 carbon atoms, and n2 is an integer of 1 to 8)

  ADVANTAGE OF THE INVENTION According to this invention, the composition for microbicides which can exhibit the outstanding bactericidal effect with respect to various microorganisms which exist in living environments, such as a bathroom, is provided.

  The component (a) is a compound represented by the following general formula (a1).

  In general formula (a1), m is preferably 1 or 2, and more preferably 1. Therefore, the component (a) is preferably a compound selected from benzyl alcohol and phenethyl alcohol, and more preferably benzyl alcohol.

  In the composition for microbicide of the present invention, the component (a) is 0.5% by mass or more, preferably 0.8% by mass or more, more preferably 1% by mass or more, and 5% by mass or less, preferably 4%. It is contained by mass% or less, more preferably 3% by mass or less. When the content of the component (a) is in the above range, a uniform composition capable of exhibiting an excellent bactericidal effect against microorganisms can be obtained.

The component (b) is one or more compounds selected from the compound represented by the following general formula (b1) and the compound represented by the general formula (b2).
_{RO- (C 2 H 4 -O)} n1 -H (b1)
(In the formula, R is an aliphatic hydrocarbon group having 3 to 8 carbon atoms or a cyclic hydrocarbon group having 3 to 8 carbon atoms, and n1 is an integer of 1 to 8)
_{RO- (CH 2 -CH (CH 3} ) -O) n2 -H (b2)
(In the formula, R is an aliphatic hydrocarbon group having 1 to 8 carbon atoms or a cyclic hydrocarbon group having 3 to 8 carbon atoms, and n2 is an integer of 1 to 8)

  In general formula (b1), R is preferably an alkyl group having 3 or more carbon atoms, preferably 4 or more, and 8 or less, preferably 6 or less. The alkyl group is preferably a linear alkyl group. In general formula (b1), n1 is 1 or more, preferably 2 or more, and 8 or less, preferably 6 or less, preferably 3 or less.

  Examples of the compound represented by the general formula (b1) include diethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, diethylene glycol monobutyl ether, triethylene glycol monobutyl ether, ethylene glycol monoisobutyl ether, diethylene glycol monoisobutyl ether, diethylene glycol monophenyl ether, penta 1 or more types chosen from ethylene glycol monophenyl ether, hexaethylene glycol monophenyl ether, ethylene glycol monobenzyl ether, and diethylene glycol monobenzyl ether are mentioned. The compound represented by the general formula (b1) is preferably one or more compounds selected from diethylene glycol monobutyl ether, ethylene glycol monoisobutyl ether, diethylene glycol monophenyl ether, ethylene glycol monobenzyl ether, and diethylene glycol monobenzyl ether, More preferred is diethylene glycol monobutyl ether.

  In general formula (b2), R is preferably an alkyl group having 1 or more carbon atoms, preferably 4 or more, and 8 or less, preferably 6 or less. The alkyl group is preferably a linear alkyl group. In general formula (b2), n2 is 1 or more and 8 or less, preferably 5 or less, preferably 3 or less, preferably 2 or less.

  The compound represented by the general formula (b2) is selected from propylene glycol monomethyl ether, dipropylene glycol monomethyl ether, tripropylene glycol monomethyl ether, propylene glycol monopropyl ether, dipropylene glycol monopropyl ether and propylene glycol monobutyl ether. 1 or more types are mentioned. The compound represented by the general formula (b2) is preferably at least one selected from propylene glycol monobutyl ether, propylene glycol monopropyl ether, and tripropylene glycol monomethyl ether, more preferably propylene glycol monobutyl ether. .

  Component (b) is diethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, diethylene glycol monobutyl ether, triethylene glycol monobutyl ether, ethylene glycol monoisobutyl ether, diethylene glycol monoisobutyl ether, diethylene glycol monophenyl ether, pentaethylene glycol monophenyl ether, hexa Ethylene glycol monophenyl ether, ethylene glycol monobenzyl ether, diethylene glycol monobenzyl ether, propylene glycol monomethyl ether, dipropylene glycol monomethyl ether, tripropylene glycol monomethyl ether, propylene glycol monopropyl ether, dipropylene glycol One or more selected from over mono propyl ether and propylene glycol monobutyl ether is preferred.

  The component (b) is more preferably at least one selected from diethylene glycol monobutyl ether, ethylene glycol monoisobutyl ether, diethylene glycol monophenyl ether, ethylene glycol monobenzyl ether, diethylene glycol monobenzyl ether and propylene glycol monobutyl ether.

  The component (b) is more preferably diethylene glycol monobutyl ether.

  In the composition for microbicide of the present invention, the component (b) is 0.01% by mass or more, preferably 0.1% by mass or more, more preferably 1% by mass or more, and 10% by mass or less, preferably 8%. It is contained by mass% or less, more preferably 5 mass% or less. When the content of the component (b) is in the above range, a uniform composition capable of exhibiting an excellent bactericidal effect against microorganisms can be obtained.

  In the microbicidal composition of the present invention, from the viewpoint of bactericidal properties, the total content of the component (a) and the component (b) is 1.6% by mass or more, preferably 1.8% by mass or more, preferably It is 2.0% by mass or more, preferably 2.3% by mass or more, more preferably 2.5% by mass or more, and preferably 12% by mass or less, more preferably 11% by mass or less. When the total content of the component (a) and the component (b) is within the above range, a uniform composition capable of exhibiting an excellent bactericidal effect against microorganisms can be obtained.

  From the viewpoint of obtaining a uniform composition capable of exhibiting an excellent bactericidal effect against microorganisms, the composition for microbicides of the present invention has a mass ratio of (a) component to (b) component of (a) / ( b), preferably 0.05 or more, more preferably 0.1 or more, still more preferably 0.15 or more, even more preferably 0.2 or more, and preferably 500 or less, more Preferably it is 300 or less, more preferably 200 or less, even more preferably 20 or less, and even more preferably 2 or less.

  The component (c) is water. Water is used in an amount such that the total composition is 100% by weight. The water content of the component (c) is preferably 80% by mass or more, more preferably 90% by mass or more, and 98% by mass or less, preferably 97% by mass or less in the microbicidal composition of the present invention. is there.

  From the viewpoint of obtaining a uniform liquid composition capable of exhibiting an excellent bactericidal effect against microorganisms, the microbicidal composition of the present invention has a total content of (a) component, (b) component and (c) component. 80% by mass or more, preferably 90% by mass or more, preferably 95% by mass or more, more preferably 98% by mass or more, and 100% by mass or less, more preferably 100% by mass.

  The microbicidal composition of the present invention can optionally contain (d) a surfactant (excluding the components (a) and (b)) [hereinafter referred to as component (d)]. However, in the present invention, the mass ratio of the total content of the component (a) and the component (b) and the content of the component (d) is (d) / [(a) + (b)], 0.8 It is as follows. The mass ratio (d) / [(a) + (b)] of the total content of the component (a) and the component (b) and the content of the component (d) is preferably 0.7 or less, preferably 0.8. 5 or less, preferably 0.3 or less. The lower limit of this mass ratio is 0 or more, and may be 0. By containing the component (d), cleaning performance can be imparted.

  When the component (d) is contained, the mass ratio (d) / [(a) + (b)] of the total content of the component (a) and the component (b) and the content of the component (d) is the lower limit value. However, it is preferably 0.1 or more, more preferably 0.2 or more.

  In the composition for microbicide of the present invention, the content of the component (d) is preferably 3% by mass or less from the viewpoint of achieving both an excellent bactericidal effect and a cleaning effect against microorganisms. (D) Content of a component is more preferably 2 mass% or less in the composition for microbicides of this invention, More preferably, it is 1.5 mass% or less.

  Examples of the component (d) include surfactants selected from nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

  Examples of the nonionic surfactant include polyoxyalkylene alkyl ethers having an alkyl group having 10 to 18 carbon atoms, polyoxyalkylene alkenyl ethers having an alkenyl group having 10 to 18 carbon atoms, 10 to 18 carbon atoms, Polyoxyalkylene sorbitan fatty acid ester having the following fatty acid group, alkyl polyglycoside having an alkyl group having 8 to 18 carbon atoms, sucrose fatty acid ester having a fatty acid group having 8 to 18 carbon atoms, 8 or more carbon atoms And alkyl polyglyceryl ethers having 18 or less alkyl groups. Among these, from the viewpoint of detergency, polyoxyethylene alkyl ether having an alkyl group having 10 to 16 carbon atoms and having an average added mole number of ethylene oxide of 1 to 15 is preferable.

  Examples of the anionic surfactant include an anionic surfactant having one or more hydrocarbon groups and one or more groups selected from the group consisting of sulfonic acid groups, sulfate ester groups, and carboxylic acid groups. . Examples of the anionic surfactant include alkyl or alkenyl benzene sulfonic acid or a salt thereof, polyoxyalkylene alkyl or alkenyl ether sulfate or a salt thereof, alkyl or alkenyl sulfate or a salt thereof, and a fatty acid or a salt thereof. From the viewpoint of detergency, the anionic surfactant is preferably one or more selected from the group consisting of polyoxyalkylene alkyl or alkenyl ether sulfates or salts thereof and fatty acids or salts thereof. The oxyalkylene group of the polyoxyalkylene alkyl or alkenyl ether sulfate or a salt thereof is preferably an oxyethylene group. Moreover, the average addition mole number of the oxyalkylene group of polyoxyalkylene alkyl or alkenyl ether sulfate ester salt is preferably 1 or more and 10 or less. Examples of fatty acids or salts thereof include fatty acids having 10 to 18 carbon atoms and salts thereof. The alkyl group or alkenyl group of the anionic surfactant preferably has 10 to 18 carbon atoms. The salt is preferably an alkali metal salt such as sodium salt or potassium salt.

  Examples of the cationic surfactant include quaternary ammonium salt type cationic surfactants. As the quaternary ammonium salt type cationic surfactant, one or two of the groups bonded to the nitrogen atom is a hydrocarbon group having 8 to 16 carbon atoms, and the remainder is 1 to 3 carbon atoms. Examples thereof include quaternary ammonium salt type cationic surfactants, which are groups selected from the group consisting of the following alkyl groups, hydroxyalkyl groups having 1 to 3 carbon atoms, and arylalkyl groups (such as benzyl groups). Among these, a quaternary ammonium salt type cationic surfactant having a bactericidal performance is preferable, and a quaternary ammonium salt type cationic surfactant having a benzyl group is preferable from the viewpoint of bactericidal performance.

  As the amphoteric surfactant, an amphoteric surfactant having an alkyl group having 8 to 22 carbon atoms is preferable from the viewpoint of foaming. Furthermore, in this amphoteric surfactant, the carbon number of the alkyl group is preferably 10 or more, more preferably 11 or more, and is preferably 18 or less, more preferably 13 or less. As the amphoteric surfactant, it is possible to use one or more amphoteric surfactants selected from the group consisting of alkylbetaines, alkylamidobetaines, alkylsulfobetaines, alkylhydroxysulfobetaines, alkylamidohydroxysulfobetaines, and alkylamino fatty acid salts. It is preferable from the point of detergency and foaming. Among them, amphoteric surfactants selected from the group consisting of alkyl (C8 or more and 22 or less) amidopropyl betaine and alkyl (C8 or more and 22 or less) hydroxysulfobetaine are preferable, and (3-lauramidopropyl is more preferable. ) An amphoteric surfactant selected from the group consisting of dimethylbetaine and lauryldimethylhydroxysulfobetaine is more preferred. Further, two or more amphoteric surfactants listed here may be mixed and used.

From the viewpoint of imparting a cleaning effect, the component (d) is preferably at least one selected from a nonionic surfactant, an anionic surfactant, and an amphoteric surfactant, and includes a nonionic surfactant and an anionic surfactant. One or more selected from ionic surfactants are more preferable, and nonionic surfactants are more preferable.

  From the viewpoint of achieving both an excellent sterilizing effect and a cleaning effect on microorganisms, the ratio of the nonionic surfactant in the component (d) is preferably 50% by mass or more, and preferably 70% by mass or more. More preferably, it is more preferably 90% by mass or more, and still more preferably 100% by mass.

  The composition for microbicidal use of the present invention has a pH of 20 ° C. of preferably 3 or more, more preferably 4 or more, preferably 11 or less, preferably 9 or less, more preferably 7 or less.

  In order to increase the added value of the product, a fragrance, a pigment, a preservative, an antioxidant and the like can be arbitrarily added to the composition for microbicide of the present invention.

  The composition for microbicidal use of the present invention is suitably used for cleaning hard surfaces such as bathrooms, bathtubs, washbasins, tiles, restrooms, washstands, mirrors, sinks around kitchens, countertops, and taps. It is suitably used for bathrooms. Here, the term “for bathroom” is intended not only for bathrooms but also for articles having other hard surfaces such as bathtubs and washbasins that exist in the bathroom.

  According to the present invention, there is provided a method for sterilizing and cleaning a hard surface, which comprises washing the hard surface with the microbicidal composition of the present invention and rinsing the hard surface after washing with water. In this invention, after spraying the composition for microbicides of this invention on a hard surface, this hard surface can be wash | cleaned. Moreover, in this invention, a hard surface can be wash | cleaned with the cleaning article which carry | supported the microbicidal composition of this invention on the base | substrate.

  As an example, there is provided a method for sterilizing and cleaning a hard surface in which the microbicidal composition of the present invention is applied to a hard surface and then wiped and cleaned. In the wiping cleaning, it is preferable to remove the composition applied to the hard surface from the hard surface using a cloth, a cloth, a nonwoven fabric or the like.

  Further, the microbicidal composition of the present invention can be used as a cleaning article by impregnating a substrate. The cleaning article in which the substrate is impregnated with the microbicidal composition of the present invention is preferable from the viewpoint of workability of the cleaning work.

  The substrate used in the cleaning article impregnated with the microbicidal composition of the present invention is flexible and can be impregnated with the microbicidal composition, and has sufficient strength during use. Those that do not generate waste are used. It is preferable to use a substrate that can be impregnated with an amount of the microbicidal composition described below under no load.

  Examples of such a substrate include fiber structures composed of fibrous materials, such as various papers, nonwoven fabrics, woven fabrics, and knitted fabrics. Examples of fibrous materials constituting these fiber structures include cellulosic fibers, modified cellulosic fibers, synthetic fibers, and mixtures of two or more thereof.

  A porous structure (for example, a sponge-like structure) obtained by dispersing bubbles in a resin can also be used as the substrate.

  Moreover, the sterilization washing | cleaning method which wipes a hard surface using the cleaning article impregnated with the microbicidal composition of this invention is preferable for the light sterilization washing | cleaning of a hard surface from a viewpoint of workability | operativity of a cleaning operation. The cleaning article impregnated with the microbicidal composition of the present invention is a product obtained by impregnating a substrate with a microbicidal composition in advance, or a dried substrate with a microbicidal composition just before use by spraying or the like. Any of these may be used. Alternatively, the surface to be cleaned may be cleaned using a sprayed cleaning article. The cleaning article impregnated with the microbicidal composition of the present invention may be used by being mounted on a mop-shaped cleaning tool, or may be directly held and used for wiping.

When the microbicidal composition of the present invention is impregnated in advance, the impregnation rate of the microbicidal composition is based on the mass of the substrate [that is, based on the mass of the unimpregnated (dried) substrate) from the viewpoint of cleaning properties. 100% by mass or more, more preferably 150% by mass or more, and preferably 1000% by mass or less, more preferably 400% by mass or less, and 350% by mass or less. More preferably it is. If the impregnation rate is 100% by mass or more, sufficient cleaning performance against stains and dirt is obtained. If the amount is 1000% by mass or less, the amount of the microbicidal composition released onto the surface to be cleaned is appropriate, and no dirt or dirt remains on the surface to be cleaned, and the cleaning surface is made of various materials such as wood-based materials. Can be used without any effect. When the substrate is a sheet from the standpoint of further improving the cleanability, the basis weight before impregnation of the microbicidal composition is the retention of the microbicidal composition necessary for sterilization cleaning of a certain area and the operation of the sheet. From the viewpoint of property and cost, it is preferably 40 g / m ² or more, more preferably 50 g / m ² or more, and preferably 200 g / m ² or less, and 150 g / m ² or less. More preferably.

  When using the cleaning article impregnated with the microbicidal composition of the present invention, the microbicidal composition of the present invention may be separately used while spraying the article to be cleaned or the cleaning article. A larger area is cleaned by the method of use.

<Bactericidal evaluation method>
Escherichia coli (strain NBRC3982) and Staphylococcus aureus (strain NBRC12732) were each cultured twice on a nutrient agar medium (prepared according to Nutrient Agar reagent manufactured by Difco) at 37 ° C. for 24 hours. Is suspended and dispersed in 1/2 Nutrient liquid medium (Difco's Nutrient Broth reagent prepared at 1/2 concentration of Nohsho), and bacteria are used using 1/2 Nutrient liquid medium. The concentration was adjusted to 2.5 to 13 × 10 ⁸ cfu / mL to obtain a test bacterial solution.

Using the microbicidal composition shown in Tables 1 to 3 as a test solution, 1 μL of a test solution of pH 7 was mixed with 10 μL of a test bacterial solution in which the concentration of Escherichia coli or Staphylococcus aureus was adjusted to 10 ⁸ cfu / mL. After contacting for 5 minutes at 25 ° C., 100 μL of the sample was taken and suspended in 900 μL of LP diluent (prepared by Nissui Pharmaceutical Co., Ltd. according to Noh). Inactivated. After further diluting this with LP diluent, the diluted product was diluted with lecithin polysorbate-80 added soybean casein digest (Soybean-Casein Digest Agar with Lecithin & Polysorbate 80 "DAIGO 'manufactured by Wako Pure Chemical Industries, Ltd.). 'Preparation of reagents according to the certificate) The number of surviving bacteria was calculated from the number of colonies obtained by applying the reagent to an agar medium and culturing at 37 ° C overnight.

  In addition, the same operation using physiological saline instead of the test solution (microbicidal composition) (10 μL of the test bacterial solution was mixed with 1 mL of the test solution, contacted for 5 minutes, and then mixed with the LP diluted solution) As a control operation, the logarithmic difference between the number of surviving bacteria after the control operation and the number of surviving bacteria after contact with the test solution was calculated and used as an indicator of the sterilization performance.

The components in the table are as follows.
・ Polyoxyethylene lauryl ether: Ethylene oxide average addition mole number 6
・ Polyoxyethylene lauryl ether sodium sulfate: ethylene oxide average addition mole number 4

Claims (6)

(A) A compound represented by the general formula (a1) [hereinafter referred to as the component (a)] is 0.5 mass% or more and 5 mass% or less, (b) a compound represented by the general formula (b1) and the general formula ( One or more compounds selected from the compounds represented by b2) [hereinafter referred to as component (b)] are 0.01% by mass or more and 10% by mass or less, (c) water (hereinafter referred to as component (c)) And optionally (d) a surfactant (excluding the components (a) and (b)) [hereinafter referred to as the component (d)],
The total content of the component (a) and the component (b) is 1.6% by mass or more,
The mass ratio of the total content of the component (a) and the component (b) and the content of the component (d) is (d) / [(a) + (b)] and is 0.8 or less,
The total content of the component (a), the component (b) and the component (c) is 80% by mass or more.
Microbicidal composition.

_{RO- (C 2 H 4 -O)} n1 -H (b1)
(In the formula, R is an aliphatic hydrocarbon group having 3 to 8 carbon atoms or a cyclic hydrocarbon group having 3 to 8 carbon atoms, and n1 is an integer of 1 to 8)
_{RO- (CH 2 -CH (CH 3} ) -O) n2 -H (b2)
(In the formula, R is an aliphatic hydrocarbon group having 1 to 8 carbon atoms or a cyclic hydrocarbon group having 3 to 8 carbon atoms, and n2 is an integer of 1 to 8)   The composition for microbicidal treatment according to claim 1, wherein the mass ratio of the component (a) to the component (b) is (a) / (b) and is 0.05 or more and 500 or less.   (D) Microbicidal composition of Claim 1 or 2 whose content of a component is 3 mass% or less.   The microbicidal composition according to any one of claims 1 to 3, wherein the component (a) is a compound selected from benzyl alcohol and phenethyl alcohol.   Component (b) is diethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, diethylene glycol monobutyl ether, triethylene glycol monobutyl ether, ethylene glycol monoisobutyl ether, diethylene glycol monoisobutyl ether, diethylene glycol monophenyl ether, pentaethylene glycol monophenyl ether, hexa Ethylene glycol monophenyl ether, ethylene glycol monobenzyl ether, diethylene glycol monobenzyl ether, propylene glycol monomethyl ether, dipropylene glycol monomethyl ether, tripropylene glycol monomethyl ether, propylene glycol monopropyl ether, dipropylene glycol Is one or more compounds selected from over mono propyl ether and propylene glycol monobutyl ether, any one microbial composition killing according to claims 1-4.   The microbicidal composition according to any one of claims 1 to 5, which is used for cleaning a hard surface.