EA024105B1 - Liquid antimicrobial hard surface cleaning composition - Google Patents

Abstract

The invention relates to a liquid hard surface cleaning and disinfection composition that provides relatively fast antimicrobial action. An aqueous composition with a pH in the range of 9 to 12 comprising selective amounts of benzalkonium chloride; a salt of di- or tricarboxylic acid; and sodium tripolyphosphate are claimed. The invention also relates to the use of this composition as an antimicrobial composition.

Description

FIELD OF THE INVENTION

The invention relates to a liquid composition for cleaning and disinfecting a hard surface. More specifically, the invention relates to a composition for disinfecting a solid surface that provides synergistic antibacterial effectiveness.

State of the art

Liquid compositions for the disinfection and cleaning of hard surfaces such as floors, walls, windows, doors, furniture and countertops in various indoor and outdoor locations are known. Toilets and bathrooms are other places where pathogenic microorganisms breed and compositions for disinfection and cleaning in liquid form are widely used. Other types of hard surfaces that are cleaned with such compositions include dishes and other items found in households, offices and other public places.

Two popular classes of disinfecting / disinfecting active ingredients are (I) whitening and (II) phenolic substances. Halogen and active oxygen are the two most effective whitening agents. Bleaching agents are compounds that release oxidizing agents such as chlorine, bromine, fluorine, oxygen evolution or other oxidizing agents that disrupt the cell walls of microbes such as bacteria and viruses, thus disinfecting the treated surfaces. Phenolic substances are another class of antimicrobial agents, often derived from essential oils extracted from natural sources, which are formed into an emulsified form and sold as floor and toilet cleaners.

These compounds are sometimes considered either aggressive or requiring a long time to achieve antimicrobial action. Very often, these compositions include surfactants in order to form an emulsion of the oil components present in it, or in order to provide a cleaning action with a detergent action. To remove residual surfactants, surfaces treated or cleaned are soon washed or wiped so that they are substantially free of the disinfecting / cleaning composition. This provides very little time for a disinfecting effect.

Thus, there is a need for a composition that provides a relatively more effective antimicrobial effect when the purification period is relatively short, typically about 5 minutes or less, preferably less than 2 minutes, and in many cases less than 1 minute, and sometimes such as low as 15 s or less. The inventors of the present invention unexpectedly found that compositions containing selected ingredients, namely individual salts of dicarboxylic or tricarboxylic acids and sodium tripolyphosphate (BTPP) in benzalkonium chloride (BAC), provide synergistic, antimicrobial efficacy that is not provided by each of these compounds individually or due to any of the binary combinations of these agents, in a very short time period of less than 15 s. In addition, the inclusion of essential oil agents such as terpineol and / or thymol provides additional increased antibacterial efficacy.

In addition, the authors of the present invention found that the use of a composition containing benzalkonium chloride and individual salts of dicarboxylic or tricarboxylic acid provides increased antimicrobial efficacy, the effect of which was also not known until now.

Liquid compositions for cleaning hard surfaces having a pH of from 9 to 12, including a cationic surfactant, such as benzalkonium chloride (BAC), are known. It is also known to include an alkaline agent, such as BTRP, in such compositions.

UO 09128012 (EcoLaB) discloses detergent concentrates, related detergents and related methods that are capable of removing fresh, greasy and polymerized dirt from surfaces and include one or more alkalinity sources, one or more chelating agents, one or more surfactants and water as the rest.

OV 1395839 (Hessb! And Vspsksg. 1975) discloses detergent compositions with a reduced phosphate content, which include: (a) from 2 to 40 parts by weight of a mixture of sodium tripolyphosphate and trisodium citrate in a ratio of 99: 1 to 54:55 and (b) 1 part by weight of at least one nonionic surfactant, wherein said composition in a 1% aqueous solution has a pH of not more than 10.

IB 2009176887 (Blerai) discloses a biocidal composition that contains an effective amount of a biocidal agent, such as a quaternary ammonium compound or a mixture of quaternary ammonium compounds and an effective amount of a cell membrane disintegrant. The synergy index of the biocidal agent and the cell membrane disintegrant is less than 1.

None of the patent publications mentioned above address the problem of the slow action of the antimicrobial composition, disclose a synergistic combination of the active components described and claimed in the present invention to provide a fast antimicrobial action in the disinfection of hard surfaces.

An object of the present invention is to overcome or mitigate at least one of

- 1,024,105 disadvantages of the prior art or providing a useful alternative.

Another objective of the present invention is to provide a liquid composition for cleaning and disinfecting a hard surface, which has a relatively rapid antimicrobial effect.

SUMMARY OF THE INVENTION

In accordance with a first aspect of the present invention, there is provided a liquid antimicrobial cleansing composition for a solid surface with a pH of from 9 to 12, including:

(a) 0.5 to 4 wt.% benzalkonium chloride;

(b) 0.25 to 3 wt.% salt of di- or tricarboxylic acid;

(c) 0.25 to 3 wt.% sodium tripolyphosphate;

(ά) 87 to 97 wt.% water.

In accordance with another aspect of the present invention, a method for cleaning and disinfecting a hard surface, comprising applying to the specified hard surface the composition according to the first aspect, diluted with water in a mass ratio of from 1:20 to 1: 200.

DETAILED DESCRIPTION OF THE INVENTION

These and other aspects, features and advantages will become apparent to those of ordinary skill in the art upon reading the following detailed description and the appended claims. For the avoidance of doubt, any feature of one aspect of the present invention may be used in any other aspect of the present invention. The word containing is intended to mean including, but not necessarily, consisting of or composed of. In other words, the steps or options listed do not have to be exhaustive. It should be noted that the examples described in the description below are intended to illustrate the invention and are not intended to limit the invention to these examples as such. Similarly, all percentages are mass / mass percent, unless otherwise indicated.

With the exception of working and comparative examples, or where otherwise expressly indicated, all numbers in this description indicating the quantities of the material or the reaction conditions, the physical properties of the materials and / or use, should be understood as modified by the word approximately. Unless otherwise indicated, numerical ranges expressed in a format from x to y are understood to include x and y. When several preferred ranges are described in a format from x to y for a particular feature, it should be understood that all ranges combining different endpoints are also considered.

The first aspect of the present invention provides a liquid antimicrobial composition for cleaning a solid surface with a pH of from 9 to 12. The composition contains from 0.5 to 4 wt.% Benzalkonium chloride; 0.25 to 3 wt.% salt of di- or tricarboxylic acid; 0.25 to 3 wt.% sodium tripolyphosphate and 87 to 97 wt.% water.

The composition contains from 0.5 to 4%, more preferably from 1 to 2%, even more preferably from 1.25 to 1.75% of a cationic surfactant benzalkonium chloride.

The composition contains from 0.25 to 3%, preferably from 0.5 to 2%, more preferably from 0.5 to 1.5% by weight of the composition of the salt of di- or tricarboxylic acid. The di- or tricarboxylic acid salt is preferably selected from oxalate, fumarate, phthalate, maleate, malate, malonate or citrate. The di- or tricarboxylic acid salt is most preferably phthalate, malate, malonate or citrate. Alkali metal or alkaline earth metal salts are preferred, alkali metal salts are more preferred, of which sodium salt is most preferred. The salt structures of some carboxylic acids are given below:

- 2 024105

It should be noted that the inclusion of di- or tricarboxylates in the compositions of the invention provides the desired antimicrobial efficacy, while monocarboxylates do not show equally good efficacy.

The composition contains from 0.25 to 3%, preferably from 0.5 to 2%, more preferably from 1.25 to 1.75% by weight of the composition of sodium tripolyphosphate.

The composition according to the invention contains water as a preferred carrier. Water is present in an amount of from 87 to 97%, preferably from 90 to 95%, by weight of the composition.

The composition optionally contains an antimicrobial active substance selected from the active component of an essential oil. If present, the antimicrobial component of the essential oil is present in an amount of from 0.01 to 2% by weight of the composition. Preferred active ingredients of the essential oil are thymol, terpineol, eugenol, or mixtures thereof. The most preferred active ingredient of the essential oil is a mixture of thymol and terpineol. If present, thymol and terpineol are present in an amount of from 0.05 to 1%, more preferably from 0.08 to 0.3% by weight of the composition. The most useful antimicrobial compositions of the present invention preferably contain thymol greater than 0.05 and less than 0.3% by weight of the composition. Thymol can be added to the antimicrobial composition in purified form. In addition, thyme oil or thyme extract containing thymol can be added to the antimicrobial composition, while ensuring the presence of thymol in the desired concentration in the composition of the present invention. Thyme oil or thyme extract is obtained from the thyme plant. Thyme plant refers to a plant belonging to the genus Tyutik and includes, but is not limited to, the following types: Tyutik uydat18, Tyutik kyteoyek, Tyutik takyyutia, Tyutik tygikut, Tyuytikut .

Most useful high-speed antimicrobial compositions of the present invention preferably contain terpineol of more than 0.05 and less than 1% by weight of the composition. Terpineol is preferably selected from alpha-terpineol, beta-terpineol, gamma-terpineol, or a mixture thereof. It is particularly preferred that terpineol is alpha terpineol. Terpineol can be added to the antimicrobial composition in purified form. Alternatively, a pine oil containing terpineol may be added to the antimicrobial composition.

It should be noted that in addition to the synergistic antimicrobial interaction of benzalkonium chloride, salt of di- or tricarboxylic acid and sodium tripolyphosphate, the inclusion of the active components of essential oils in the composition further increases the antimicrobial effectiveness.

The composition of the present invention optionally contains a surfactant. A preferred surfactant is a nonionic surfactant. The nonionic surfactant is preferably present in an amount of from 2 to 10% by weight of the composition. Particularly preferred nonionic surfactants are fatty alcohol ethoxylates, preferably C ₈ -C ₂₂ , more preferably C ₈ -Ci, fatty alcohol ethoxylates containing from 1 to 8 ethylene oxide groups. Suitable concentrations of surfactants in liquid applications for cleaning a solid surface are preferably from 1 to 5% by weight of the composition.

The composition of the invention has a pH of from 9 to 12, preferably from 10.5 to 11.5. This can be achieved by incorporating the necessary ingredients of the invention in selected amounts, and can still be achieved by incorporating an alkaline agent. The alkaline agent is preferably sodium carbonate or sodium hydroxide. The alkaline agent is preferably present in an amount of 0.1 to 1% by weight of the composition.

The inventors of the present invention have found that a highly effective antimicrobial effect of the composition according to the invention can be achieved in the absence of conventional disinfectants, such as bleaching agents, for example halogens, halogenated compounds and active oxygen bleaches. However, a small amount of such bleaches may

- 3 024105 to be present in the composition, for example less than 1%, preferably less than 0.5%, more preferably less than 0.1%, and the effectiveness of the composition is achieved even in the absence of a bleaching agent in the composition.

The composition may further comprise various additional ingredients known to those skilled in the art. Such additional ingredients include, but are not limited to, perfumes, colorants, preservatives, emollients, sunscreens, emulsifiers, gelling agents or thickeners.

The antimicrobial composition may be in the form of a liquid, but the liquid composition may be further compacted into a gel or paste. The antimicrobial composition of the present invention can be used to clean and care for hard surfaces such as glass, metal, plastic, wood, ceramics, and the like.

In accordance with another aspect of the present invention, there is provided a method for cleaning and disinfecting a hard surface, comprising applying to said hard surface a composition of the invention diluted with water in a weight ratio of from 1:20 to 1: 200, preferably in a ratio of from 1:40 to 1:80 .

The method preferably includes the step of washing the surface with a suitable solvent, preferably water, or the surface may be wiped with a suitable cloth.

The inventors have found that the composition of the present invention provides an antimicrobial effect, where the contact time of antimicrobial active substances with the surface is low, i.e. less than 5 minutes, preferably less than 2 minutes, even more preferably less than 1 minute, and in many cases less than 15 seconds.

According to another aspect of the present invention, there is provided the use of a composition comprising benzalkonium chloride and a salt of a di- or tricarboxylic acid to provide an antimicrobial effect. The use of antimicrobial components is preferably non-therapeutic. The composition for use in antimicrobial activity preferably contains benzalkonium chloride in a concentration of from 0.001 to 4% and a salt of di- or tricarboxylic acid in a concentration of from 0.001 to 3% at the site of disinfection.

The invention will now be demonstrated by the following non-limiting examples.

Examples

Examples 1-3. Antimicrobial efficacy of the composition of the invention.

Were obtained antibacterial compositions for cleaning a hard surface, as shown in the table. 1. The compositions were tested for antibacterial efficacy using the Βδ ΕΝ1276 European Suspension Test (European Test Protocol Suspension Test), which is briefly described below.

A bacterial suspension test (1 ml) was added to a product sample under a specific dilution condition (8 ml) along with a specific contamination (1 ml). The mixture was kept at 20 ° C for 5 minutes. After this contact time period, an aliquot is taken and immediately neutralized by a proven method. The number of bacteria in each sample is determined by plating on agar ΤδΑ and the decrease in the number of viable microorganisms is calculated after incubation for 48 hours.

In the table. 1 below: the organism used was R. aetidshock bacteria ATCC 15442 (at a concentration of 10 ⁷ CFU / ml); the dilution was 1:70 of the product (sexual cleaner) in hard water. The pH of the samples was 11.0. The contamination used was bovine serum albumin (ΒδΑ) 0.03%.

The decrease in bacterial od in the above test is presented in table. one.

Table 1

Ingredients Example 1 (wt.%) Example 2 (wt.%) Example 3 (wt.%) Neodol (C12EO9) 3.0 3.0 3.0 Benzalkonium chloride 1,5 1,5 1,5 8TRP (sodium tripolyphosphate) 1,5 1,5 1,5 Sodium carbonate 0.3 0.3 0.3 Di / tricarboxylate - Sodium malonate 1,0 Sodium Citrate 1.0 Decrease Lob bacteria 3.8 7.3 7.3

The data in the table. 1 show that the compositions as such in accordance with the invention (examples 2 and 3) provide significantly improved antibacterial efficacy compared with the composition outside the invention (example 1).

Examples 4-6. Examples with low contact times.

Experiments were carried out similar to Examples 1 to 3, except that the dilution was 1:40 and the contact time of the product with bacteria was 30 s instead of 5 minutes. The data are presented in Table 4 024105. 2.

table 2

Ingredients Example 4 (wt.%) Example 5 (May,%) Example 6 (wt.%) Neodol (C12EO9) 3.0 3.0 3.0 Benzalkonium chloride 1,5 1,5 1,5 8TRP 1,5 1,5 1,5 Sodium carbonate 0.3 0.3 0.3 Di / tricarboxylate - Sodium malonate 1,0 Sodium Citrate 1.0 Decrease L0 £ bacteria 2,5 6.2 7.2

The data in the table. 2 show that the antibacterial compositions of the invention (Examples 5 and 6) are effective even at short contact times, about 30 seconds.

Examples 7-15. The effectiveness of the compositions of the invention on various other bacteria. Compositions similar to examples 1 to 3 were prepared and tested against various other types of bacteria, as shown in table. 3. The contact time was 5 minutes and the dilution of the product with water was 1: 200. The contamination used was bovine serum albumin (ΒδΑ) in 0.3%.

Compositions and reduction of 1 od of various bacteria are given in table. 3.

Table 3

Example Product sample Bacteria Decrease L0 £ 7 Example 1 E. SOI ATCC 10536 2,5 8 Example 1 ,5. Ageich ATCC 6538 3,5 nine Example 1 E. Mgae ATCC 10541 2,8 10 Example 2 E. SOI ATCC 10536 5.8 eleven Example 2 8. aigeeiz ATCC 6538 6.5 12 Example 2 E. Mgae ATCC 10541 6.0 thirteen Example 3 E. SOI ATCC 10536 7.2 14 Example 3 8. aigeeiz ATCC 6538 7.2 fifteen Example 3 | E. Mgae ATCC 10541 7.2

The data in the table. 3 show that the samples according to the invention (examples 10 to 15) are significantly superior to samples outside the invention (examples 7 to 9) in terms of antibacterial efficacy against various types of bacteria.

Examples 16-21. Antibacterial efficacy of the compositions of the invention, optionally containing the active components of the essential oil.

Compositions as shown in the table. 4 were tested for antibacterial efficacy when diluted 1:60 with hard water, using contamination, which is used in examples 9-15 with a contact time of 5 minutes. The bacteria used were R. aetzdshoka ATCC 15442 (at a density of 10 ⁷ CFU / ml cell). The pH of the compositions was 11. The data are shown in table. 4.

Table 4

Ingredients Example sixteen (wt.%) Example 17 (wt.%) Example eighteen (wt.%) Example nineteen (wt.%) Example twenty (wt.%) Example 21 (wt.%) Neodol (C12EO9) 3.0 3.0 3.0 3.0 3.0 3.0 Benzalkonium chloride 1,5 1,5 1,5 1,5 1,5 1,5 8TRP 1,5 1,5 1,5 1,5 1,5 1,5 Sodium carbonate 0.3 0.3 0.3 0.3 0.3 0.3 Di / tricarboxylate - Fumarate sodium 1,0 Phthalate sodium 1,0 Malat sodium 1,0 Malonate sodium 1,0 Citrate sodium 1,0 Thymol 0.125 0.125 0.125 0.125 0.125 0.125 Terpineol 0.25 0.25 0.25 0.25 0.25 0.25 Decrease in bacteria 4.3 5.2 7.3 5.9 7.3 7.3

The data in the table. 4 show that various other di / tricarboxylates can be used in the composition of the present invention in the presence of the active components of the essential oil, and these samples (examples 17 to 21) give significantly better antibacterial efficacy compared to the sample outside the invention (example 16) .

Examples 22-24. Synergistic interaction between benzalkonium chloride and di / tricarboxylates.

Various compositions were prepared, indicated in the table. 5, and antimicrobial efficacy was measured using the procedure used in example 1 (except that in this

- 5 024105 case used 1:10 dilution). Data on the reduction of 1od bacteria are shown in table. 5.

Table 5

Ingredients Example 22 (wt.%) Example 24 (wt.%) Example 24 (wt.%) Neodol (C12EO9) 3.0 3.0 3.0 Benzalkonium chloride 1,5 - 1,5 Sodium carbonate 0.3 0.3 0.3 Di / tricarboxylate - Sodium citrate 1,0 Sodium Citrate 1.0 Decreased Lob bacteria 3.2 No reduction 7.3

The data in the table. 5 show the synergistic interaction between benzalkonium chloride and citric acid for antimicrobial efficacy.

Thus, the invention provides a composition for disinfecting a solid surface that interacts synergistically to provide conditions for antibacterial action in short times.

Claims (9)

CLAIM 1. A liquid antimicrobial composition for cleaning a solid surface with a pH of from 9 to 12, containing: (a) from 0.5 to 4 wt.% benzalkonium chloride; (b) 0.25 to 3 wt.% salt of di- or tricarboxylic acid; (c) 0.25 to 3 wt.% sodium tripolyphosphate; (ά) from 87 to 97 wt.% water. 2. The composition according to claim 1, characterized in that the said salt of di- or tricarboxylic acid is selected from oxalate, fumarate, phthalate, maleate, malate, malonate or citrate. 3. The composition according to claim 2, characterized in that said salt of di- or tricarboxylic acid is selected from phthalate, malate, malonate or citrate. 4. The composition according to any one of the preceding paragraphs, additionally containing a non-ionic surfactant. 5. The composition according to claim 4, characterized in that said non-ionic surfactant is present in an amount of from 2 to 10 wt.% Of the composition. 6. The composition according to claim 4 or 5, characterized in that the non-ionic surfactant contains fatty alcohol ethoxylate. 7. The composition according to one of the preceding paragraphs, additionally containing an alkaline agent selected from sodium carbonate or sodium hydroxide. 8. The composition according to claim 7, characterized in that said alkaline agent is present in an amount of from 0.1 to 1 wt.% Of the composition. 9. A method of cleaning and disinfecting a solid surface, comprising applying to the specified solid surface of the composition according to any one of the preceding paragraphs, diluted with water in a mass ratio of from 1:20 to 1: 200.