MX2014005412A - A liquid hard surface antimicrobial cleaning composition. - Google Patents

Abstract

The invention relates to a liquid hard surface cleaning and disinfection composition that provides relatively fast antimicrobial action. A aqueous composition with a pH in the range of 9 to 12 comprising selective amounts of benzalkonium chloride; a salt of di or tri carboxylic acid; and sodium tripolyphosphate is claimed.

Description

A LIQUID ANTI MICROBIAL CLEANSING COMPOSITION HARD SURFACE Technical field The invention relates to a liquid hard surface cleaning and disinfecting composition. The invention relates more particularly to a hard surface disinfection composition that provides synergistic antibacterial efficacy.

BACKGROUND OF THE INVENTION Liquid compositions are known for disinfecting and cleaning hard surfaces such as floors, walls, windows, doors, furniture and table tops in various interior and exterior locations. Toilets and toilets are other places where germs proliferate and liquid disinfection and cleaning compositions are widely used. Other types of hard surfaces that are cleaned by such compositions include utensils and other items found in homes, offices and other public places.

Two of the popular classes of disinfectant / sanitizing assets are (i) bleach, and (ii) phenolic. Halogen and active oxygen are two most effective bleaches. Bleaches are compounds that release oxidizing agents such as chlorine, bromine, fluorine, nascent oxygen or other oxidizing agents that break the cell walls of microbes such as bacteria and viruses, thereby disinfecting the surfaces thus treated. Phenolics are another class of antimicrobials frequently derived from essential oils extracted from natural sources, which are formulated in an emulsified form and sold as floor and toilet cleaner.

These compounds are sometimes considered either hard or take a long time for the antimicrobial action to take place. Very often, these compositions include surfactants either to emulsify the oily components present therein or to allow cleaning via detergency action. To remove the residual surfactants, the surfaces being treated or cleaned are shortly after rinsed or cleaned to be substantially free of the disinfection / cleaning composition. This allows very little time for the disinfection action to take place.

Therefore, there is a need to provide a composition that provides relatively more effective antimicrobial action, when the cleaning period is relatively small, typically about 5 minutes or less, preferably less than 2 minutes and in many cases less than one minute or less. sometimes as low as 1 5 seconds or less. The present inventors have surprisingly found that the compositions comprising selected ingredients viz. Select salts of dicarboxylic or tricarboxylic acids and sodium tripolyphosphate (STPP) in a composition containing benzalkonium chloride (BAC) provides synergistic antimicrobial efficacy not provided by each alone or by any of the binary combinations of these agents, on time scales very short of less than 15 seconds. Additionally, the inclusion of essential oil agents such as terpineol and / or thymol, provides additional intensified antibacterial efficacy.

In addition, the present inventors have found that the use of a composition comprising benzalkonium chloride and select salts of dicarboxylic or tricarboxylic acid, provides enhanced antimicrobial efficacy, said action was also not known until now.

Liquid hard surface cleaning compositions having a pH of 9 to 12 comprising cationic surfactant such as benzalkonium chloride (BAC) are known. It is also known to include alkaline agent such as STPP in such compositions.

WO09128012 (Ecolab) discloses cleaner concentrates, associated cleansers, and associated methods that are capable of removing greasy, fresh stains and polymerized stains from surfaces and include one or more alkalinity sources, one or more chelators, one or more surfactants, and as a rest, water.

GB1395839 (Hoechst &Benckiser, 1975) describes detergent compositions with reduced phosphate content, which comprises (a) 2 to 40 parts by weight of a mixture of sodium tripolyphosphate and trisodium citrate in a ratio between 99: 1 and 54: 55, and (b) 1 part by weight of at least one nonionic surfactant, said composition having 1 percent aqueous solution having a pH of at most 1 0.

US20091 76887 (Stepan) describes a biocidal composition, which comprises an effective amount of a biocidal agent, such as a quaternary ammonium compound or a mixture of quaternary ammonium and an effective amount of a cell membrane disrupter. The synergy index of the biocidal agent and the cell membrane disrupter is less than 1.

None of the patent publications cited above solves the problem of slow-acting antimicrobial composition, nor does it describe the synergistic combination of active ingredients described and claimed in the present invention to provide the fast-acting antimicrobial action to disinfect hard surfaces.

An objective of the present invention is to overcome or improve at least one of the disadvantages of the prior art, or to provide a useful alternative.

Another object of the present invention is to provide a liquid hard surface cleaning and disinfecting composition, which has relatively rapid antimicrobial action.

BRIEF DESCRIPTION OF THE INVENTION According to the first aspect of the invention, there is provided a liquid hard surface antimicrobial cleaning composition with a pH in the range of 9 to 12, comprising (a) 0.5 to 4% by weight of benzalkonium chloride; (b) 0.25 to 3% by weight of di or tricarboxylic acid salt; (c) 0.25 to 3% by weight of sodium tripolyphosphate; Y (d) 87 to 97% by weight of water.

According to another aspect of the invention, there is provided a method for cleaning and disinfecting a hard surface comprising applying to said hard surface a composition of the first aspect diluted with water in a weight ratio of 1: 20 to 1: 200.

Detailed description of the invention These and other aspects, features and advantages will become apparent to those of ordinary skill in the art from a reading of the following detailed description and the appended claims. So that there is no doubt, any characteristic of an aspect of the present invention can be used in any other aspect of the invention. The word "comprises" is intended to mean "includes", but not necessarily "consists of" or "composed of". In other words, the steps or options listed need not be exhaustive. It is noted that the examples given in the description below are intended to clarify the invention and are not intended to limit the invention to those examples per se. Similarly, all percentages are weight / weight percentages unless otherwise indicated.

Except in the operation and comparison examples, or where explicitly stated otherwise, all figures in this description that indicate material quantities or reaction conditions, physical properties of materials and / or use, will be understood as modified by the word "approximately". Unless otherwise specified, the numerical ranges expressed in the format "from x to y" are understood to include x and y. When multiple preferred ranges are described for a specific characteristic format "from x to y", it is understood that all the ranges that combine the different endpoints are also contemplated.

The first aspect of the invention provides a liquid hard surface antimicrobial cleaning composition with a pH in the range of 9 to 12. The composition comprises 0.5 to 4% by weight of benzalkonium chloride; 0.25 to 3% by weight of di or tricarboxylic acid salt; 0.25 to 3% by weight of sodium tripolyphosphate; and 87 to 97% by weight of water.

The composition comprises 0.5 to 4%, more preferably 1 to 2%, more preferably 1.25 to 1.75% of cationic benzalkonium chloride surfactant.

The composition comprises 0.25 to 3%, preferably 0.5 to 2%, more preferably 0.5 to 1.5% by weight of the di or tricarboxylic acid salt composition. The di or tricarboxylic acid salt is preferably chosen from an oxalate, fumarate, phthalate, maleate, malate, malonate or citrate. The di or tricarboxylic acid salt is most preferably a phthalate, malate, malonate or citrate. Alkali metal or alkaline earth metal salts are preferred, more preferably alkali metal salts of which the sodium salt is highly preferred. The structure of salts of some of the carboxylic acids is given below: Sodium oxalate Sodium fumarate Sodium phthalate Sodium maleate Sodium malate Sodium malonate It is noted that the inclusion of di or tricarboxylates in the composition of the invention provides the desired antimicrobial efficacy, while the monocarboxylates do not demonstrate such good efficacy.

The composition comprises 0.25 to 3%, preferably 0.5 to 2%, more preferably 1.25 to 1.7% by weight of the sodium tripolyphosphate composition.

The composition of the invention comprises water as a carrier favorite. The water is present in 87 to 97%, preferably 90 to 95% by weight of the composition.

The composition optionally comprises an antimicrobial active selected from an essential oil active. When present, the antimicrobial active of essential oil is present at 0.01 to 2% by weight of the composition. Preferred essential oil actives are thymol, terpineol, eugenol or mixtures thereof. The most preferred essential oil active is a mixture of thymol and terpineol. When the thymol and terpineol present are present at 0.05 to 1%, more preferably 0.08 to 0.3% by weight of the composition. Most useful antimicrobial positions of the present invention preferably have thymol greater than 0.05 and less than 0.3% by weight of the composition. Thymol can be added to the antimicrobial composition in purified form. Alternatively, thyme oil or extract of tomillo comprising thymol can be added to the antimicrobial composition, while ensuring that thymol is present at the desired concentration in the composition of the present invention. The oil of tomillo or extract of tomillo is obtained from the thyme plant. The tomillo plant refers to a plant belonging to the genus Thymus and includes but is not limited to the following species: Thymus vulgaris, Thymus zygis, Thymus satureoides, Thymus mastichina, Thymus broussonetti, Thymus maoccanus, Thymus pallidus, Thymus algeriensis, Thymus. serpyllum, Thymus pulegoide and Thymus citriodorus.

Most antimicrobial compositions of quick action useful of the present invention, preferably have terpineol greater than 0.05 and less than 1% by weight of the composition. Terpineol is preferably selected from alpha-terpineol, beta-terpineol, gamma-terpineol or mixtures thereof. It is particularly preferred that terpineol is alpha-terpineol. Terpineol can be added to the antimicrobial composition in purified form. Alternatively, the pine oil comprising terpineol can be added to the antimicrobial composition.

It is observed that in addition to the antimicrobial synergy interaction of benzalkonium chloride, the salt of di or tricarboxylic acid and sodium tripolyphosphate, inclusion of active essential oils further intensifies the antimicrobial efficacy.

A composition of the invention optionally comprises a surfactant. The preferred surfactant is a nonionic surfactant. The nonionic surfactant is preferably present in an amount of 2 to 10% by weight of the composition. Particularly preferred nonionic surfactants are fatty alcohol ethoxylates, preferably C8-C22, more preferably C8C 16 fatty alcohol ethoxylates, comprising between 1 and 8 ethylene oxide groups. The concentrations of suitable surfactants in liquid hard surface cleaning application forms are preferably from 1 to 5% by weight of the composition.

The composition of the invention has a pH in the range of 9 to 12, preferably in the range of 10.5 to 1 1 .5. This could be achieved by incorporating the essential ingredients of the invention in amounts selected, can also be achieved by incorporating an alkaline agent. The alkaline agent is preferably sodium carbonate or sodium hydroxide. The alkaline agent is preferably present in 0.1 to 1% by weight of the composition.

The present inventors have determined that the highly effective antimicrobial action of the composition of the invention can be achieved in the absence of conventional disinfectants such as bleaches, for example, halogens, halogen compounds and bleach based on active oxygen. However a small amount of such bleaches may be present in the composition, for example, less than 1%, preferably less than 0.5%, more preferably less than 0.1% and the effectiveness of the composition is achievable even with the bleaches being absent of the composition. The composition may further comprise several additional ingredients known to a person skilled in the art. Such additional ingredients include but are not limited to: perfumes, pigments, preservatives, emollients, sunscreens, emulsifiers, gelling agents or thickening agents.

The antimicrobial composition can be in the form of a liquid, but the liquid composition can be further thickened to a gel or a paste. The antimicrobial composition of the present invention can be used for cleaning and care of hard surfaces, such as glass, metal, plastic, wood, ceramics and the like.

According to another aspect of the present invention, a method for cleaning and disinfecting a hard surface is provided. comprising applying to said hard surface a composition of the invention diluted with water in a weight ratio of 1: 20 to 1: 200, preferably in a ratio of 1: 40 to 1: 80.

The method preferably comprises a step for rinsing the surface with a suitable solvent, preferably water or the surface can be cleaned with a suitable cleanser.

The inventors have determined that the composition of the invention provides an antimicrobial action, where the contact time of the antimicrobial actives with the surface is low, that is, of the order of less than 5 minutes, preferably less than 2 minutes, more preferably less one minute and in many cases less than 1 5 seconds.

In accordance with yet another aspect of the present invention, there is provided the use of a compound comprising benzalkonium chloride and a di or tricarboxylic acid salt to provide antimicrobial benefit. The antimicrobial use is preferably non-therapeutic. The composition for use in antimicrobial activity preferably has benzalkonium chloride at a concentration in the range of 0.001 to 4% and di or tricarboxylic acid salt at a concentration in the range of 0.001 to 3% at the disinfection site.

The invention will now be demonstrated with the aid of the following non-limiting examples.

Examples Examples 1 to 3: Antibacterial efficacy of the composition of the invention Antibacterial compositions for hard surface cleaning were prepared as shown in Table 1. The compositions were tested for antibacterial efficacy using the European Suspension Test BS EN1276, which is briefly described below: A test suspension of bacteria (1 ml) was added to a sample of the product under a certain dilution condition (8 ml) together with a specific soil (1 ml). The mixture was maintained at 20 ° C for 5 minutes. After this period of contact time, an aliquot was taken and neutralized immediately by a validated method. The number of bacteria in each sample is determined by placing on TSA agar cultures and the reduction in viable count is calculated after incubation for 48 hours.

In Table 1 below the organism used was P. aeruginosa bacterium ATCC 15442 (at 107 cfu / ml concentration); the dilution was 1:70 of the product (a floor cleaner) in hard water. The pH of the samples was 11.0. The dirt used was bovine serum albumin (BSA) at 0.03%.

The logarithmic reduction of bacteria in the previous test is summarized in Table 1.

Table 1 The data in Table 1 indicate that the compositions according to the invention (Examples 2 and 3) provide a greatly improved antibacterial efficacy as compared to a composition outside the invention (Example 1).

Examples 4 to 6: Examples in low contact times Experiments similar to Examples 1 to 3 were performed, except that the dilution was 1: 40 and the contact time of the product with the bacteria was 30 followed instead of 5 minutes.

The data are summarized in Table 2.

Table 2 The data in Table 2 indicate that the antibacterial compositions of the invention (Examples 5 and 6) are effective even in short contact times of about 30 seconds.

Examples 7 to 15: Efficacy of the compositions of the invention in other various bacteria Compositions similar to Examples 1 to 3 were prepared and tested against various other types of bacteria as shown in Table 3. The contact time was 5 minutes and the dilution of the product with water was 1: 200. The dirt used was bovine serum albumin (BSA) at 0.3%.

The compositions and the logarithmic reduction of the various Bacteria are shown in Table 3.

Table 3 The data in Table 3 indicate that the samples according to the invention (Examples 1 to 1 5) are greatly larger than the samples outside the invention (Examples 7 to 9) in terms of antibacterial efficacy against various types of bacteria. .

Examples 1 6 to 21: Antibacterial efficacy of compositions of the invention additionally comprising essential oil actives The compositions as shown in Table 4, were tested for antibacterial efficacy at a dilution of 1: 60 with hard water using the dirt as used in Examples 9 to 15 in a 5 minutes contact time. The bacteria used was P. aeruginosa ATCC 15442 (at 107 cfu / ml of cell density). The pH of the compositions was 11. The data are shown in Table 4.

Table 4 The data in Table 4 indicate that various other di / tricarboxylates can be used in the composition of the invention in the presence of essential oil actives and these samples (Examples 17 to 21) give an enormously superior antibacterial efficacy as compared to a shows outside the invention (Example 16).

Examples 22 to 24: Synergistic interaction between benzalkonium chloride and di / tricarboxylates Various compositions as shown in Table 5 were prepared and the antimicrobial efficacy was measured using the procedure used for Example 1 (except that in the present case, the dilution used was 1: 60). The data on the logarithmic reduction of bacteria are shown in Table 5.

Table 5 The data in Table 5 indicate that the synergistic interaction between benzalkonium chloride and citric acid for antimicrobial efficacy.

The invention thus provides a composition for hard surface disinfection that interacts synergistically to allow antibacterial action in fasting times.

Claims (12)

1. REIVIN DICACIONES 1 . A liquid, antimicrobial cleaning composition of hard surfaces, with a pH in the range of 9 to 1 2, including (a) 0.5 to 4% by weight of benzalkonium chloride; (b) 0.25 to 3% by weight of a di or tricarboxylic acid salt; (c) 0.25 to 3% by weight of sodium tripolyphosphate; Y (d) 87 to 97% by weight of water. 2. A composition as claimed in claim 1, wherein a di or tricarboxylic acid salt is chosen from an oxalate, fumarate, phthalate, maleate, malate, malonate or citrate. 3. A composition as claimed in claim 2, wherein d or tricarboxylic acid salt is selected from a phthalate, malate, malonate or citrate. 4. A composition as claimed in any of the preceding claims, comprising an antimicrobial active of essential oil selected from thymol or terpineol. 5. A composition as claimed in claim 4, wherein said antimicrobial active is present at 0.01 to 2% by weight of the composition. 6. A com position as claimed in claim 4 or 5 comprising thymol or terpineol. 7. A com position as claimed in any of the preceding claims comprising a non-ionic surfactant. 8. A composition as claimed in claim 7, in wherein said nonionic surfactant is present in an amount of 2 to 10% by weight of the composition. 9. A composition as claimed in claim 7 or 8, wherein said nonionic surfactant comprises fatty alcohol ethoxylate. 10. A composition as claimed in any of the preceding claims that an alkaline agent selected from sodium carbonate or sodium hydroxide. eleven . A composition as claimed in claim 10, wherein said alkaline agent is present in 0.1 to 1% by weight of the composition. 12. A method for cleaning and disinfecting a hard surface comprising applying to said hard surface a composition as claimed in any of the preceding claims, diluted in water in a weight ratio of 1: 20 to 1: 200. SUMMARY The invention relates to a liquid composition for cleaning and disinfecting hard surfaces that provides relatively fast antimicrobial action. An aqueous composition with a pH in the range of 9 to 12 comprising selective amounts of benzalkonium chloride is claimed; a di or tricarboxylic acid salt; and sodium tripolyphosphate.