JP2015124150A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a dentifrice composition that has excellent effect of giving a comfortable massage effect feeling and warm feeling to an oral cavity, particularly gums.SOLUTION: A dentifrice composition comprises a coloration granule (A) comprising a dye having an absorption maximum value in the range of 400-559 nm when dissolved in solvent and measured in terms of an absorption spectrum in 400-800 nm and an excipient, and a warm feeling agent (B).

Description

  The present invention relates to a dentifrice composition in which colored granules are dispersed and blended, which is excellent in a pleasant massage effect and warmth-imparting effect in the oral cavity, particularly the gums.

  In a dentifrice composition, imparting an appropriate massage effect, warmth, and the like to the oral cavity during brushing is effective for making toothbrushing habits and expressing its effects.

  In Patent Document 1 (Japanese Patent Laid-Open No. 10-152424), granular salt is blended in a dentifrice composition, and granular erythritol is blended in a dentifrice composition in Patent Document 2 (Japanese Patent Laid-Open No. 2007-70256). Directing.

  On the other hand, the use of a warming agent as a means for giving a warming effect to the oral cavity has been conventionally known, and various substances such as chili and ginger-derived materials, vanillin derivatives, etc. are used as a warming agent. It is known as a composition component of the composition.

In Patent Documents 3 to 5 (JP 2008-266251 A, JP 8-104615 A, JP 4-124123 A), oral compositions and dentifrice compositions containing particulate substances are proposed, and ginger. Patent Document 6 (Japanese Patent Application Laid-Open No. 2013-147431) discloses that dentifrice granules containing a dentifrice composition can improve taste by using a component such as ethyl vanillin as a masking agent. Although it is disclosed that ginger or the like may be further blended as a fragrance component, there is no mention of a massage effect feeling and a warm feeling.
In addition, the above-mentioned patent document does not indicate a colored granule particularly colored to a specific color and its specific use.

Japanese Patent Laid-Open No. 10-152424 JP 2007-70256 A JP 2008-266251 A JP-A-8-104615 JP-A-4-124123 JP 2013-147431 A

  However, according to the conventional technology, a sufficient massage effect and warm feeling cannot be obtained in the dentifrice composition, and both effects cannot be simultaneously and satisfactorily provided.

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition excellent in the effect of imparting a pleasant massage effect and warmth to the oral cavity, particularly to the gums.

  As a result of intensive studies to achieve the above object, the inventors of the present invention have developed a dye having an absorption maximum in the range of 400 to 559 nm and an excipient when it is dissolved in a solvent and measured for an absorption spectrum of 400 to 800 nm. A dentifrice composition excellent in the effect of imparting a pleasant massage effect and warmth to the oral cavity, particularly to the gums, by blending the colored granules (A) containing the warming agent and the warming agent (B) I found out that I can do it.

  That is, as shown in the comparative examples and examples described later, in the dentifrice composition, the massage effect by the granular material is not sufficient, and even the colored granule does not provide a sufficient massage effect, and the blue granule or white granule is warm. When the sensitizer is used in combination, the massage effect and warmth imparting effect are low and do not improve, but when the colored granules (A) and warmth sensation (B) of the present invention are used in combination, the massage effect and warmth imparting effect are achieved. Can be improved and a comfortable and moderate massage effect and warm feeling can be imparted to the gums. Moreover, a favorable formulation appearance can be imparted.

Accordingly, the present invention provides the following dentifrice composition.
[1]:
A colored granule (A) containing a pigment and an excipient having an absorption maximum in the range of 400 to 559 nm when dissolved in a solvent and measuring an absorption spectrum of 400 to 800 nm, a warming agent (B), A dentifrice composition comprising:
[2]:
The dentifrice composition according to [1], wherein the pigment contained in the colored granule (A) is one or two or more pigments selected from red, orange and yellow.
[3]:
The dentifrice composition according to [1] or [2], wherein the excipient contained in the colored granules (A) is one or more water-insoluble materials selected from zeolite, silica, calcium carbonate, and aluminum oxide object.
[4]:
The colored granule (A) is a granulated product colored with a pigment, obtained by heating a raw material containing a pigment and an excipient at 90 to 150 ° C. after granulation [1], [2] or [3] The dentifrice composition according to [3].
[5]:
The dentifrice composition according to any one of [1] to [4], wherein the warming agent (B) is one or more selected from spirantol, chili extract, and ginger oil.
[6]:
In a white dentifrice base, 0.3 to 3% by mass of colored granules (A) and 0.003 to 0.5% by mass of warming agent (B) are dispersed and blended. ) Is a toothpaste composition according to any one of [1] to [5], wherein the toothpaste composition has an average particle size of 150 to 800 μm and an average disintegration strength of 10 to 100 g / piece.

  ADVANTAGE OF THE INVENTION According to this invention, the dentifrice composition by which the coloring granule was disperse-blended which is excellent in the comfortable massage effect and warmth provision effect in the oral cavity, especially a gum can be provided. Furthermore, a good formulation appearance can be imparted to the dentifrice composition.

  The present invention will be described in further detail below. The dentifrice composition of the present invention comprises a colored granule (A) containing a pigment and an excipient having an absorption maximum in the range of 400 to 559 nm when the absorption spectrum of 400 to 800 nm is measured by dissolving in a solvent. And a warming sensation agent (B).

<Colored granules (A)>
The colored granule (A) contains a dye having an absorption maximum in the range of 400 to 559 nm and an excipient when dissolved in a solvent and measured for an absorption spectrum of 400 to 800 nm, and is shaped by the dye. Granules containing the agent as a constituent component are colored granules.
This colored granule (A) gives a pleasant massage effect and warmth imparting effect by being dispersed and blended into the dentifrice composition. It can also give an aesthetic effect to the composition and give a good formulation appearance.

  As a pigment for coloring the granules, a pigment having an absorption maximum in the range of 400 to 559 nm when dissolved in an appropriate solvent and measured in the range of 400 to 800 nm in accordance with the visible absorption spectrum method is used. Can do.

  Here, the visible part absorption spectrum method may be under normal conditions, and the solvent used in the visible part absorption spectrum measurement may be selected from solvents suitable for the measurement according to the dye used. For example, acidic dilute ethanol, 0.02N ammonium acetate / ethanol (1: 1, mass ratio) mixture, dimethyl sulfoxide / ethylene glycol (2: 1, mass ratio) mixture, chloroform, 1-chloronaphthalene, etc. are widely used. Yes. Specifically, acidic dilute ethanol is generally used for red Nos. 202 and 205, 1-chloronaphthalene is used for red No. 226, and chloroform is generally used for orange No. 203 and yellow No. 205.

The dye having the absorption maximum value is preferably an organic dye selected from red, orange, and yellow, and more preferably a red organic dye.
Specific examples of such a dye include Red No. 202, Red No. 205, Red No. 226, Orange No. 203, Yellow No. 205 and the like, and Red No. 226 is particularly preferable.
The above dyes may be used alone or in combination of two or more in terms of effect expression.

  The amount of the pigment used is preferably 0.01 to 0.5% (mass%, the same applies hereinafter), more preferably 0.02 to 0.2%, based on the whole granule (the whole granulated granule). It is. A content of 0.01% or more is effective for manifesting the effects of the present invention, and 0.5% or less is preferable for giving a good appearance of the preparation.

  In addition, if the colored granule (A) is colored with the said pigment | dye, the aspect of the color can be adjusted suitably. The color of the colored granule (A) is, for example, red, pink, orange, brown, yellow, etc., particularly red, orange, yellow, and more preferably red. Such a color appearance is preferable from the viewpoint of massaging effect and warmth.

The colored granule (A) is a granulated product containing an excipient as a component as described above, and contains a water-insoluble material as an excipient.
As a structural component of the colored granules (A), one or more appropriate water-insoluble materials that can be blended in the dentifrice composition can be used. For example, zeolite, silica, calcium carbonate, aluminum oxide, etc. are suitable for imparting a massage effect, more preferably zeolite, silica, calcium carbonate, and the combined use of zeolite and silica is particularly preferred. A granulated product as a constituent component is preferable.

  The colored granule (A) can further contain an organic binder such as a water-soluble binder such as methylcellulose or carboxymethylcellulose or a water-insoluble binder such as wax as an excipient.

  Furthermore, in addition to the above-mentioned materials, the colored granules (A) may be added with known components that can be usually blended in the granules, and specifically include fragrance ingredients, medicinal ingredients, and the like. These optional components can be added within a range that does not interfere with the effects of the present invention.

The colored granules (A) according to the present invention are preferably disintegrant granules, and the average disintegration strength is preferably 10 to 100 g / piece, more preferably 15 to 50 g / piece. The greater the average disintegration strength, the more effective massage effect can be imparted during tooth brushing, but the amount of 100 g / piece or less is more suitable because it does not give a sense of discomfort due to granules during tooth brushing.
In addition, the average disintegration strength of the colored granules (A) was determined by measuring automatically the breaking strength (one granule at 10 nm / min) one by one for 30 granules using a rheometer (Sun Rheometer CR-200D manufactured by Sun Science Co., Ltd.). (The load when the granules disintegrate when compressed at a speed of 2)) is the average value of the values measured (the same applies hereinafter).

Moreover, it is preferable that the thing of the range of 106-850 micrometers (140-18mesh: JIS standard) is 80-100%, and, as for the particle size of a colored granule (A), More preferably, it is 90-100%. The average particle size is preferably 150 to 800 μm, more preferably 200 to 500 μm. The larger the average particle size, the better the massage effect can be imparted during brushing, and it is more suitable for visualizing the granules, but it is more preferable that the particle size is 800 μm or less because it can suppress the feeling of discomfort due to the granules and can be brushed. is there.
The average particle size of the colored granules (A) is obtained by sieving with a JIS sieve (30, 42, 50, 60, 83 mesh), and then measuring the mass of the granules remaining on each sieve. This is a value calculated from a 50% particle size.

The colored granules (A) can be prepared by a usual method. For example, it can be obtained by granulating the raw material powder containing the dye and the excipient and then heating, and in particular, it can be obtained by heating, drying and baking for about 15 to 30 minutes at 90 to 150 ° C. desirable. The granulation may be either dry or wet, but is preferably granulated by dry granulation.
Moreover, as a colored granule (A), if it can mix | blend with a dentifrice composition, a commercial item can also be used.

  In the present invention, the blending amount of the granule (A) is preferably 0.3 to 3%, more preferably 0.5 to 2% of the entire composition. Mixing 0.3% or more is suitable for enhancing the massage effect and warmth effect. Moreover, it is preferable that it is 3% or less to give a favorable formulation external appearance. If too much is added, problems may occur in the appearance of the preparation.

<Warm sensation agent (B)>
In the present invention, examples of the warming agent (B) include the following compounds, which can be used alone or in combination of two or more in terms of effect.
Spirantol, linalool oxide, pepper oleoresin, chili powder, chili tincture, chili extract, capsaicin, homocapsaicin, homodihydrocapsaicin, nonanoic acid vanillyl amide, nonanoic acid vanillyl ether, vanillyl ethyl ether, vanillyl butyl ether, vanillyl pentyl ether Vanillyl alcohol alkyl ether derivatives such as vanillyl hexyl ether, substituted benzyl alcohol derivatives, substituted benzyl alcohol alkyl ethers, vanillin propylene glycol acetal, ginger extract, ginger oil, gingerol, gingerone and the like.
Among these, spirantol, chili or ginger-derived ones, particularly spirantol, chili extract and ginger oil are preferred, and spirantol is more preferred.

  The blending amount of the warming agent (B) is preferably 0.003 to 0.5% of the entire composition from the viewpoint of manifesting the effects of the present invention. Although the warming effect and the massage effect can be imparted as the blending amount is large, 0.5% or less is more preferable for imparting an appropriate warming effect.

  Furthermore, the optimum use amount of these warming sensates (B) varies slightly depending on the type, and the use amount can be adjusted according to the compound used within the range of the above blending amount. For example, it is more preferable to use 0.01 to 0.05% spiranthol, 0.003 to 0.008% chili extract, and 0.005 to 0.015% ginger oil.

In addition, although water is mix | blended with a dentifrice composition, when the compounding quantity of water is small (for example, the water content in a composition is 10% or less), it is also possible to use polyethyleneglycol as a warming agent. . When polyethylene glycol is used in addition to the compound exemplified as the warming agent (B), the effect of the present invention is more excellent.
In addition, polyethylene glycol can use what is generally used for a dentifrice composition, and can use the thing of the average molecular weight described in the quasi-drug raw material specification 190-2,500, for example, polyethylene Examples include glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 600, polyethylene glycol 1000, polyethylene glycol 1500, polyethylene glycol 1540, and polyethylene glycol 2000. Moreover, when using polyethyleneglycol, the addition amount is 20 to 60% of the whole composition.

The dentifrice composition of the present invention can be prepared in the form of a paste, gel, etc., and can be prepared as a dosage form such as a toothpaste, a liquid dentifrice, a moisturizing dentifrice, particularly a toothpaste. As the production method, a conventional method corresponding to the dosage form can be adopted.
In this case, according to the purpose of the composition, the dosage form, and the like, appropriate known components can be blended in addition to the colored granules, the warming agent and the above components. For example, in the case of a toothpaste, an abrasive, a binder such as a cellulose (for example, carboxymethylcellulose), a thickener such as a polyhydric alcohol, an anionic such as sodium lauryl sulfate, a nonionic, a cationic, etc. Surfactants, preservatives, sweeteners such as sodium saccharin, colorants, fragrances, various active ingredients, and the like can be blended, and these ingredients can be mixed with water for production. In addition, what is necessary is just to mix | blend these arbitrary components in a normal quantity as needed.

  Moreover, the preparation method of a dentifrice composition will not be restrict | limited especially if a coloring granule and a warming agent can be disperse-blended, A well-known method is employable.

  Here, as the abrasive, silica-based abrasive such as silica gel, precipitated silica, zirconosilicate, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, phosphoric acid abrasive such as calcium pyrophosphate, water Examples thereof include aluminum oxide, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tertiary magnesium phosphate, zirconium silicate, hydroxyapatite, and synthetic resin abrasive. The average particle diameter of the abrasive is usually 30 μm or less, preferably 3 to 20 μm, as measured by the microtrack method. The compounding quantity of an abrasive | polishing agent is 3 to 60% normally.

  In the dentifrice composition of the present invention, the color of the dentifrice base is not particularly limited, but it is preferable that the dispersion of the colored granules can be visually recognized. More preferably, the dentifrice base color is white.

  In the present invention, in particular, white dentifrice base is dispersed and blended with 0.3 to 3% of colored granules (A) and 0.003 to 0.5% of the above ingredients as warming agents (B). More preferably, the abrasive compounded in the dentifrice base is calcium carbonate, the colored granules (A) have an average particle size of 150 to 800 μm, and an average disintegration strength of 10 to 100 g / piece, In particular, a toothpaste composition having an abrasive having an average particle size of 3 to 20 μm provides an effect of imparting a massage effect and a warm feeling, and is suitable for imparting the effect of the present invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Granules having the composition shown in Table 1 were prepared by the preparation method shown below.
Using the prepared granules, dentifrice compositions (toothpastes) having the compositions shown in Tables 2 and 3 were prepared by conventional methods and evaluated by the following methods. The results are shown in Tables 2 and 3. In addition, the base color of the obtained dentifrice composition was white.

<Preparation method of granule>
Granules were prepared by the production method (sintering method) shown below using the raw materials shown in Table 1.
Each raw material shown in Table 1 was mixed in a granulation container, granulated for 30 minutes, and baked at 100 ° C. for 20 minutes. Thereafter, those passing through a sieve having an aperture of 106 μm (140 mesh) and those not passing through an aperture of 850 μm (18 mesh) were screened out using a JIS sieve to prepare granules.
As shown in Table 1, white granules were prepared in the same manner as described above except that 16 kg of zeolite, 3 kg of anhydrous silicic acid, and 1 kg of titanium oxide were used as raw materials.

In addition, the average particle diameter and the average disintegration strength of the obtained granules were the same, and both were within the range of an average particle diameter of 200 to 500 μm and an average disintegration strength of 15 to 50 g / piece (same as described above). To measure).
Moreover, the absorption maximum value of the pigment | dye (red 226, orange color 203, yellow 205) used as a raw material exists in the range of 400-559 nm (the absorption spectrum of 400-800 nm was measured similarly by the said method). ), The absorption maximum wavelength of the obtained red granule, orange granule and yellow granule was the same as the pigment used. The absorption maximum values of Blue No. 201 and titanium oxide were outside the above range, and the absorption maximum values of blue granules and white granules were outside the above range.

* 1: Zeolite (Cosmo)
* 2: Silicic acid anhydride (TIXOSIL43 manufactured by Rhodia)
* 3: Red No. 226 (manufactured by Kasei Chemical Co., Ltd .: absorption maximum value 543 nm (measuring solvent: 1-chloronaphthalene))
* 4: Daidai-color No. 203 (manufactured by Kasei Chemical Co., Ltd .: absorption maximum value 480 nm (measuring solvent: chloroform))
* 5: Yellow No. 205 (manufactured by Hatake Kasei Co., Ltd .: Absorption maximum value 424 nm (measuring solvent: chloroform))
* 6: Blue 201 (Made by Kasei Chemical Co., Ltd .: Absorption maximum value 603 nm (measurement solvent: chloroform))
* 7: Titanium oxide (made by Ishihara Sangyo Co., Ltd.)

Moreover, the detail of the used warming agent is shown below.
<Warm sensation agent (B)>
Spirantol (manufactured by Takasago International Corporation)
Pepper extract (manufactured by Eisei Main Store)
Ginger oil (manufactured by Taiyo Fragrance Co., Ltd.)
In addition, about the other use raw material, the thing corresponding to the quasi-drug raw material specification 2006 was used. Moreover, in the used fragrance | flavor, none of the compound of a warming agent (B) is contained.

<Evaluation method>
Evaluation method-1: Evaluation of massage effect feeling (massage effect imparting effect) at the time of brushing teeth The test was conducted on 20 general panelists. The prepared dentifrice composition was extruded from a tube container, placed on a toothbrush about 1 cm (about 1 g), and massaged when brushed for 3 minutes in the same manner as usual, was judged based on the following criteria. An average score of 20 judgment points was calculated and evaluated according to the following evaluation criteria.
Here, the massage effect feeling is a pleasant stimulation feeling felt by the gums.

Judgment criteria 5: Feeling the massage effect very much when brushing teeth 4: Feeling the massage effect when brushing teeth 3: Feeling the massage effect slightly when brushing teeth 2: Feeling the massage effect a little when brushing teeth 1: Massage effect when brushing teeth The average score of the scores evaluated based on the above judgment criteria was calculated and evaluated according to the following criteria: A: The average score is 4.0 or higher and 5.0 or lower ○: The average score is 3.0 or higher Less than 0 △: Average score is 2.0 or more and less than 3.0 ×: Average score is less than 2.0

Evaluation method-2: Evaluation of warm feeling effect (warming feeling imparting effect) at the time of brushing tooth It carried out for 20 general panelists. The prepared dentifrice composition was extruded from a tube container, placed on a toothbrush about 1 cm (about 1 g), and the warming effect when brushed for 3 minutes as usual was determined based on the following criteria. An average score of 20 judgment points was calculated and evaluated according to the following evaluation criteria.

Criteria 5: Feeling the warmth effect when brushing teeth 4: Feeling the warmth effect when brushing teeth 3: Feeling the warmth effect slightly when brushing teeth 2: Not feeling the warmth effect when brushing teeth 1: Toothpaste When the temperature does not feel warm, the average score of the scores evaluated based on the above criteria was calculated and evaluated according to the following criteria: A: The average score is 4.0 or higher and 5.0 or lower ○: The average score is 3. 0 point or more and less than 4.0 point Δ: Average point is 2.0 point or more and less than 3.0 point ×: Average point is less than 2.0 point

Claims (6)

  A colored granule (A) containing a pigment and an excipient having an absorption maximum in the range of 400 to 559 nm when dissolved in a solvent and measuring an absorption spectrum of 400 to 800 nm, a warming agent (B), A dentifrice composition comprising:   The dentifrice composition according to claim 1, wherein the pigment contained in the colored granule (A) is one or two or more pigments selected from red, orange and yellow.   The dentifrice composition according to claim 1 or 2, wherein the excipient contained in the colored granules (A) is one or more water-insoluble materials selected from zeolite, silica, calcium carbonate and aluminum oxide.   The colored granule (A) is a granulated product colored with a pigment obtained by heating a raw material containing a pigment and an excipient at 90 to 150 ° C after granulation. Dentifrice composition.   The dentifrice composition according to any one of claims 1 to 4, wherein the warming agent (B) is one or more selected from spirantol, chili extract, and ginger oil.   In a white dentifrice base, 0.3 to 3% by mass of colored granules (A) and 0.003 to 0.5% by mass of warming agent (B) are dispersed and blended. The dentifrice composition according to any one of claims 1 to 5, which is a dentifrice composition having an average particle size of 150 to 800 µm and an average disintegration strength of 10 to 100 g / piece.