JP6040600B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a dentifrice composition in which colored granules are dispersed and blended, which has an excellent cleaning effect and can give the user a high cleaning feeling that the teeth have been cleaned cleanly by brushing.

  Having the user feel the cleaning of toothpaste, especially the feeling of removing the dirt on the teeth, is effective for making the toothpaste habits and expressing its effects. As one of means for making the user feel the cleaning feeling of toothpaste, in particular, the feeling of removing dirt on teeth, there is a method of blending and dispersing granules in a dentifrice composition to remove colored stains and plaque on teeth.

  Techniques for blending granules into a dentifrice composition are proposed in Patent Documents 1 to 3. In Patent Document 1, both zeolite particles and granules having specific particle sizes and strengths are blended, zeolite granules are used as zeolite particles, and Patent Document 2 may contain a mixture of granules. And it is known to incorporate two or more types of granules in a dentifrice composition. Furthermore, in order to give an aesthetic effect to the granule, it is generally performed to disperse and disperse a granule carrying a colorant. Patent Document 2 describes a granule in which Gunjo or titanium oxide is blended as a colorant. Yes.

  On the other hand, the feeling that the user feels while brushing teeth using the dentifrice composition varies depending on the size, hardness, blending amount, etc. of the blended granules. Regarding the feeling of use, Patent Document 2 discloses that the use of granules having an appropriate apparent density and disintegration strength makes it possible to reduce tactile sensation in the mouth, and Patent Document 3 discloses a synthetic amorphous aluminum-bonded silica. It has been disclosed that by blending an acid salt with granular zeolite having an appropriate particle size and disintegration strength, the brushing feeling is excellent.

  However, it is difficult to say that a sufficient cleaning feeling can be imparted even if granules are added to the dentifrice composition, and a technique capable of imparting a higher cleaning feeling has been desired.

JP 2004-123684 A JP-A-4-243815 JP 2010-275273 A

Therefore, it has been a technical problem to improve the cleaning feeling of the dentifrice composition.
The present invention has been made in view of the above circumstances, and provides a dentifrice composition capable of imparting a high cleaning feeling that the cleaning effect is excellent and the teeth are cleanly cleaned and the stains are removed by brushing. With the goal.

  As a result of intensive studies to achieve the above object, the present inventor has found that the dentifrice composition has granules (A) colored with a cold color pigment and granules (B) not colored with a cold color pigment. It has been found that mixing and dispersing the composition enhances the cleaning effect and increases the cleaning effect imparting effect of toothpaste. In addition, it is possible to visually recognize that granules (A) colored with a cold-colored pigment are dispersed, and the color appearance of the granules (A) is stably maintained over time, and the appearance stability of the preparation is excellent. I found out.

In more detail, the compounding of the granules in the dentifrice composition is effective in improving the cleaning action such as the removal of colored stains on the teeth and the removal of plaque, but the sense of effectiveness, that is, the tooth stains are removed cleanly by brushing. Although it was difficult to say that the cleaning feeling that it was cleaned was sufficient, the above-mentioned granule (A) and granule (B) were used in combination, and in particular, granule (A) / granule (B) was 1/40 as a mass ratio. When blended at a ratio of ~ 2.5 / 1, surprisingly, the user can dramatically improve the cleaning feeling while brushing their teeth. Can give a high feeling of cleaning. In addition, the color of the granules (A) blended and dispersed in the preparation does not fade over time, and the appearance of the preparation discharged from a container such as a tube can be kept stable.
In addition, the cleaning feeling in this invention cannot be realized only by the effective feeling by the granule felt in an oral cavity, or visual recognition of the external appearance of a formulation, but it is a special thing which it shows by using together a granule (A) and a granule (B). .

Therefore, in the present invention, a white dentifrice base is prepared by dispersing and blending granules (A) colored with a cool color pigment and white granules (B) not colored with a cool color pigment. ) Is dissolved in a water-insoluble material selected from zeolite, silica, calcium carbonate and aluminum oxide, and chloroform or 1-chloronaphthalene, and a visible absorption spectrum in the range of 400 to 800 nm is measured, the range is 560 to 730 nm. the cold color dye having an absorption maximum, water contain 0.01 to 0.5 wt% based on the total granules (a), the granules (B) is selected zeolite, silica, calcium carbonate and aluminum oxide A dentifrice composition containing an insoluble material and having a blending mass ratio (A) / (B) of granules (A) to granules (B) of 1/20 to 2/1 is provided.

  ADVANTAGE OF THE INVENTION According to this invention, while providing the cleaning effect which was excellent, the dentifrice composition by which the coloring granule was disperse-blended which can provide the high cleaning feeling that the tooth | gear was cleanly cleaned by toothpaste and the stain | pollution | contamination fell. can do.

  Hereinafter, the present invention will be described in more detail. In the dentifrice composition of the present invention, a granule (A) colored with a cool color pigment and a granule (B) not colored with a cool color pigment are dispersed and blended. It is characterized by becoming.

The granule (A) is a granulated product colored with a cold-colored pigment, and is composed of the granulated product and a cold-colored pigment coloring the granulated product.
Here, the granulated product of the granules (A) may be any material that can be blended in the dentifrice composition, and an appropriate water-insoluble material can be used, and one or more of them can be used. However, a water-insoluble material selected from zeolite, silica, calcium carbonate and aluminum oxide is particularly suitable for imparting a cleaning feeling, more preferably zeolite, silica and calcium carbonate. In particular, a granulated product containing zeolite and silica as constituent components is preferable.

Furthermore, in addition to the above materials, the granulated product may be added with known components that can be usually blended into the granule, and specific examples include a fragrance component, other excipients, and medicinal components. These optional components can be added as long as the effects of the present invention are not impaired.
In addition, the said granulated material can be prepared by granulating the component of a raw material by a normal method.

  In the granule (A), the cold color pigment for coloring the granulated material may be organic or inorganic as long as it can be blended in the dentifrice composition, but a cold color organic pigment that does not dissolve in water is particularly preferable. .

  As a cold color pigment, a pigment having an absorption maximum value in the range of 560 to 730 nm when dissolved in a solvent, particularly chloroform or 1-chloronaphthalene and measuring a visible absorption spectrum in the range of 400 to 800 nm, is preferably used. A preferable cold color pigment is an organic pigment selected from blue, green and purple, and blue organic pigments are particularly suitable.

Specific examples of such a cold color pigment include blue 201, blue 204, green 202, purple 201 and the like. Of these, blue 201 and blue 204 are preferable. The above pigments may be used alone or in combination of two or more in terms of effect expression.
In addition, if the granule (A) shows a cold color, a yellow or red colorant may be added in addition to the cold colorant.

If the granule (A) is colored in the above-mentioned cold-colored dye, preferably in the cold-colored system having an absorption maximum in the above-mentioned range, the color appearance can be appropriately adjusted. The color of the granule (A) is, for example, blue, green, grass color, light green, dark green, blue green, light blue, light blue green, light blue, purple, light blue purple, etc. Among them, blue, green, especially blue It is preferable from the viewpoint of imparting a cleaning feeling.
In addition, in the case of granules colored with a dye other than the cold-colored dye and exhibiting a warm-colored color such as red or yellow, the effect of imparting cleaning feeling cannot be improved even when used in combination with the granule (B). The object of the invention is not achieved.

  The amount of the cold color pigment used is preferably 0.01 to 0.5% (mass%, the same shall apply hereinafter), more preferably 0.02 to 0.1, based on the whole granulated product of the granules (A). %. A content of 0.01% or more is effective for manifesting the effects of the present invention, and 0.5% or less is preferable to give a good appearance of the preparation.

In addition, it is preferable that a granule (A) is a disintegrating granule, The average disintegration strength becomes like this. Preferably it is 10-100 g / piece, More preferably, it is 15-50 g / piece. The higher the average disintegration strength, the more the cleaning feeling can be imparted during tooth brushing, but it is preferably 100 g / piece or less because no discomfort due to granules is imparted during tooth brushing.
The average disintegration strength of the granules is determined by measuring automatically breaking strength for each of 30 granules by using a rheometer (Sun Rheometer CR-200D manufactured by Sun Science Co., Ltd.). It is the average value of the values measured for the load when the granules disintegrate.

Moreover, it is preferable that the average particle diameter of a granule (A) is 150-800 micrometers, More preferably, it is 200-500 micrometers. The larger the average particle size, the better the cleaning feeling can be imparted during tooth brushing, and it is suitable for visualizing the granules. However, it is preferred that the average particle size is 800 μm or less because it can be brushed while suppressing the uncomfortable feeling caused by the granules.
The average particle diameter of the granules is a value obtained by measuring the mass of the granules remaining on each sieve after sieving with a JIS sieve and calculating the 50% particle diameter from this mass distribution.

  In the dentifrice composition of the present invention, the compounding amount of the granules (A) is preferably 0.3 to 3%, more preferably 0.5 to 2% of the entire composition. Mixing 0.3% or more is suitable for enhancing the cleaning feeling imparting effect. Moreover, 3% or less is preferable for giving a good formulation appearance, and if too much is added, a problem may occur in the formulation appearance.

Granule (B) is a granulated product that is not colored with a cold-colored pigment.
Here, the granulated product of the granules (B) may be any material that can be blended in the dentifrice composition, and an appropriate water-insoluble material can be used. Specifically, one or more of the same water-insoluble materials as mentioned in the granule (A) can be used, and the preferred water-insoluble materials are also the same.
Further, as in the case of the granule (B), in addition to the above materials, components that can be usually blended in the granule may be added within a range that does not impede the effects of the present invention. ).

The granule (B) may be a granulated product that is not colored with a cold-colored pigment, and may be an uncolored granule that is used as it is without being colored, or a pigment other than a cold-colored pigment, Although it may be a granule colored with other components, the color of the granule (B) is preferably a color that is difficult to visually recognize when dispersed in the dentifrice base, and should be the same color as the dentifrice base. More preferred. In particular, it is preferable that the same granule (B) as the base color is dispersed and blended in a white dentifrice base. As the granules (B), those having such colors are suitable.
For coloring the granules (B), for example, powders of titanium oxide, aluminum oxide, calcium carbonate and the like can be used.

  In addition, it is preferable that a granule (B) is a disintegrating granule, and average disintegration strength becomes like this. Preferably it is 10-100 g / piece, More preferably, it is 15-50 g / piece. The greater the average disintegration strength, the more the cleaning feeling can be imparted during brushing. However, it is preferable that the average disintegration strength is 50 g / piece or less because it does not give a sense of discomfort due to granules during brushing. The average disintegration strength was measured with a rheometer in the same manner as the granules (A).

  Further, the average particle diameter of the granules (B) is preferably in the same range as the granules (A), and the measurement method is also the same. As the average particle size is larger, a cleaning feeling can be imparted during tooth brushing, but it is preferable that the average particle size is not too large because tooth brushing can be performed without giving a sense of incongruity due to granules.

  The granule (B) and the granule (A) may have the same or different constituents and compositions of the granulated product, but it is a cleaning feeling that the same average disintegration strength and / or average particle size are used. It is suitable at the point which provides.

  1-20% of the whole composition is preferable, and, as for the compounding quantity of the granule (B) to a dentifrice composition, More preferably, it is 3-15%. Mixing in this range is suitable for improving the cleaning feeling imparting effect, and is desirable for providing a cleaning action. 20% or less is desirable from the point of view of use.

  Moreover, 1.5-20% of the whole composition is preferable, and, as for the total compounding quantity of a granule (A) and a granule (B), More preferably, it is 2-15%. If it is 1.5% or more, it is suitable for improving the cleaning feeling imparting effect, and if it exceeds 20%, the feeling of use may be affected.

  In the present invention, the combination of the granule (A) and the granule (B) improves the cleaning effect and improves the cleaning feeling imparting effect. If the granule (A) or the granule (B) is absent, the cleaning feeling It is inferior to the grant effect. In this case, it is particularly suitable for the expression of the cleaning effect and the cleaning feeling imparting effect that the mixing ratio of the granule (A) and the granule (B) is appropriate. The mixing ratio of the granules (A) and the granules (B) is preferably (A) / (B) of 1/40 to 2.5 / 1, more preferably 1/20 to 2/1 as a mass ratio. . Even if the granule (A) is too much or too little, the cleaning feeling imparting effect may be reduced, and it is preferable from the above-mentioned ratio range to blend the cleaning feeling. If it is less than 1/40, the cleaning feeling imparting effect may be low, and if it exceeds 2.5 / 1, the appearance of the preparation may be affected.

The dentifrice composition of the present invention can be prepared in the form of a paste, gel, etc., and can be prepared as a dosage form such as a toothpaste, a liquid dentifrice, a moisturizing dentifrice, particularly a toothpaste. As the production method, a conventional method corresponding to the dosage form can be adopted. In this case, appropriate known components can be blended in addition to the granules (A) and granules (B) according to the purpose of the composition, dosage form, and the like. For example, in the case of toothpastes, abrasives, binders, thickeners such as polyhydric alcohols, surfactants such as sodium lauryl sulfate, preservatives, sweeteners such as sodium saccharin, colorants, fragrances, fluorides An active ingredient such as can be blended, and these ingredients and water can be mixed to produce. In addition, what is necessary is just to mix | blend these arbitrary components in a normal quantity as needed.
Moreover, the preparation method of a dentifrice composition will not be restrict | limited especially if a granule (A) and a granule (B) can be disperse | distributed, A well-known method is employable.

Here, as the abrasive, silica-based abrasive such as silica gel, precipitated silica, zirconosilicate, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, phosphoric acid abrasive such as calcium pyrophosphate, water Examples thereof include aluminum oxide, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tertiary magnesium phosphate, zirconium silicate, hydroxyapatite, and synthetic resin abrasive. The average particle diameter of the abrasive is usually 30 μm or less, preferably 3 to 20 μm, as measured by the microtrack method.
The compounding quantity of an abrasive | polishing agent can be 3 to 60%.

  In the dentifrice composition of the present invention, the dentifrice base color is, for example, white, pale yellow to yellow, pale blue to blue, pale green to green, pale red to red, pale orange to orange, pale pink to pink. However, as described above, the dispersion of the granules (A) can be visually recognized, and the dispersion of the granules (B) is difficult to visually recognize, particularly the dentifrice-based color and the granules (B). Are preferably the same, and the dentifrice base color is more preferably white.

  In the present invention, in particular, a white toothpaste base is dispersed and blended with 0.5 to 3% of granules (A) and 1 to 20% of granules (B) having the same color as the base. The average particle size of the abrasive used for the base is 3 to 20 μm, the granules (A) and granules (B) are each 200 to 500 μm in average particle size, and the granules (A) and granules (B) are respectively A dentifrice composition having an average disintegration strength of 15 to 50 g / piece is desirable for providing a cleaning feeling together with a high cleaning effect and for providing the effects of the present invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Granules (A) shown in Table 1 were prepared by coloring the granulated material prepared by the following method, and granules (B) were prepared by the following method.
Using the prepared granule, a dentifrice having the composition shown in Table 2 was prepared by a conventional method and evaluated by the following method. The results are shown in Table 2. The dentifrice base color obtained was white.
In addition, as for other used raw materials, those conforming to the quasi-drug raw material standard 2006 were used.

Preparation of granules (A):
Granules were prepared by the production method (sintering method) shown below using the raw materials shown in Table 1.
Each raw material shown in Table 1 was mixed in the granulation vessel, granulated and dried for 30 minutes, and baked at 100 ° C. for 20 minutes. Thereafter, those passing through a sieve having an aperture of 106 μm (140 mesh) and those not passing through an aperture of 850 μm (18 mesh) are excluded by screening with a JIS sieve to produce granules (A) -1 to (A) -4. did.

Preparation of granules (B):
Granules (B) were prepared by granulating in the same manner as the above granules (A) using 16 kg of zeolite (Cosmo), 3 kg of anhydrous silicic acid (TIXOSIL43, Rhodia) and 1 kg of titanium oxide (Ishihara Sangyo). . Granule (B) was white and the same color as the base color of the dentifrice.

  The obtained granules (A) were measured for an absorption spectrum in the range of 400 to 800 nm using the following solvent, and the absorption maximum wavelength was a value shown in Table 1. The average particle size and average disintegration strength of the granules (A) and granules (B) were the same, and both were within the range of an average particle size of 150 to 800 μm and an average disintegration strength of 10 to 100 g / piece (respectively above and (Measured in the same way).

＊１：ゼオライト（コスモ社製）
＊２：無水ケイ酸（ローディア社製 ＴＩＸＯＳＩＬ４３）
＊３：青色２０１号（癸巳化成社製）
＊４：緑色２０２号（癸巳化成社製）

* 1: Zeolite (Cosmo)
* 2: Silica anhydride (TIXOSIL43, Rhodia)
* 3: Blue No. 201 (Made by Kasei Kasei)
* 4: Green No. 202 (Made by Kasei Kasei)

Evaluation Method-1: Formulation Appearance The test was conducted on 20 general panelists. The prepared dentifrice is extruded from a tube container and placed on a toothbrush about 1 cm. The appearance of the formulation is as follows. The appearance when placed on the toothbrush and the feeling of cleaning effect when the paste of the dentifrice is seen are as follows: Judgment was made according to the criteria. An average score of 20 judgment points was calculated and evaluated according to the following evaluation criteria.
<Good looking>
Judgment criteria 5: Colored granules are uniformly dispersed in the dentifrice placed on the toothbrush, and the appearance is good 4: Colored granules are dispersed almost uniformly in the dentifrice placed on the toothbrush, and the appearance is somewhat good 3: Neither can be said 2: Colored granules disperse slightly unevenly in the dentifrice placed on the toothbrush and look a little bad 1: Colored granules disperse unevenly in the dentifrice placed on the toothbrush, and agglomeration was observed, and the look was poor ◎: Average point is 4.5 points or more ○: Average point is 3.5 points or more and less than 4.5 points △: Average point is 2.5 points or more and less than 3.5 points ×: Average point is less than 2.5 points

<Feeling for cleaning effect>
Judgment criteria 5: The feeling of removing dirt in the mouth is very 4: 4: The feeling of removing dirt in the mouth is a little 3: 3: Neither can be said 2: The feeling of removing dirt in the mouth is not so much 1: The feeling of removing dirt in the mouth Not evaluated at all ◎: Average point is 4.0 points or more ○: Average point is 3.0 points or more and less than 4.0 points △: Average point is 2.0 points or more and less than 3.0 points ×: Average point is 2 Less than 0 points

Evaluation method-2: Feeling of granule at the time of toothbrushing It was carried out on 20 general panelists. When the prepared dentifrice was extruded from a tube container and placed on a toothbrush about 1 cm and brushed for 3 minutes as usual, the brushing comfort of the dentifrice was determined based on the following criteria. An average score of 20 judgment points was calculated and evaluated according to the following evaluation criteria.
Criterion 5: Feeling of granule is very comfortable when brushing 4: Feeling of granule is comfortable when brushing 3: Feeling of no problem, but feel of no problem 2: Feeling of granule is not very comfortable when brushing 1: Feeling of granule is not comfortable when brushing teeth Evaluation standard ◎: Average point is 4.0 points or more ○: Average point is 3.0 points or more and less than 4.0 points △: Average point is 2.0 points or more Less than 0 x: Average score is less than 2.0

Evaluation method-3: Feeling of cleaning The test was conducted on 20 general panelists. The prepared dentifrice was extruded from a tube container and placed on a toothbrush about 1 cm, and the actual cleaning feeling when brushed for 3 minutes as usual was determined based on the following criteria. An average score of 20 judgment points was calculated and evaluated according to the following evaluation criteria.
Here, the cleaning feeling is an effective feeling that can be felt that the blended granules have removed the dirt on the teeth (for example, the gap between the teeth and the gap between the teeth). It is to perceive that the roughness and stickiness in the mouth after brushing are gone.
Judgment criteria 5: Feeling that the granule has removed dirt 4: Feeling that the granule has removed dirt 3: Feeling that the granules have removed dirt 2: Feeling that the granules have removed dirt 1: Not feel that the granules have become dirty 1: The granules are dirty Evaluation criteria ◎: Average score is 4.5 or more ○: Average score is 3.5 or more and less than 4.5 △: Average score is 2.5 or more and less than 3.5 ×: Average score less than 2.5

Evaluation Method-4: Cleanability The color of the surface of the untreated hydroxyapatite pellet was measured with a color difference meter as the reference color, and the value was defined as L0. The pellet was immersed in saliva at 37 ° C. for 30 minutes, and then washed with ion-exchanged water to remove surface moisture. The following three types of immersion liquids are prepared with a remineralization liquid in which 0.74 mM calcium ion, 2.59 mM phosphate ion, and 50 mM NaCl are mixed, and 0.5% albumin relime is added to the previous pellet. After repetitively soaking for 1 hour in a recalcification solution → 3% Japanese tea + 1% coffee + 1% black tea remineralization solution → 0.6% ammonium iron citrate re-mineralization solution after air drying at room temperature for 1 day After washing with running water and air drying again, the color of the finished colored pellet surface was measured, and the value was defined as L1. The surface of this colored pellet was brushed 1,000 times with a toothbrush on which 1 g of the prepared dentifrice was placed, then washed lightly with running water and dried, and the color was measured again. The value was L2.
The colored stain removal rate was calculated by the following formula, and the cleaning property was judged according to the following evaluation criteria for the average value of 10 times.
Colored stain removal rate (%) = [(L1-L2) / (L1-L0)] × 100
Evaluation criteria ◎: Average value 80% or more ○: Average value 70% or more and less than 80% △: Average value 60% or more and less than 70% ×: Average value less than 60%

Evaluation method-5: Appearance stability After the prepared dentifrice was stored in a tube container and stored at 5 ° C for 1 month and after stored at 50 ° C for 1 month, it was placed on a toothbrush in the same manner as described above. The appearance of the formulation was determined. The appearance stability was evaluated by comparing the appearance of the cold-colored granules with the one stored at 5 ° C. as a control.
Evaluation criteria A: Not changed from those stored at −5 ° C. ○: Almost the same as those stored at −5 ° C. Δ: Although it is understood that there are cold-colored granules, it is difficult to see compared with those stored at −5 ° C. ×: I do not know that there are cold-colored granules

＊：研磨剤（炭酸カルシウム）の平均粒径は３〜２０μｍの範囲（マイクロトラック法
にて測定。）。

*: The average particle diameter of the abrasive (calcium carbonate) is in the range of 3 to 20 μm (measured by the microtrack method).

From the results shown in Table 2, when the granule (B) is contained but the cold-colored granule (A) is not contained, the appearance and the cleaning effect when placed on the toothbrush are inferior, and the cleaning feeling is not excellent (Comparative Example) 1). Moreover, even if it contained the granule (A), if it did not contain the granule (B), the feel and cleanability of the granule or the appearance were inferior, and the cleaning feeling was not excellent (Comparative Examples 2 and 3).
Surprisingly, when cold-colored granules are found in the dentifrice when placed on a toothbrush, it seems to have a cleaning effect when the dentifrice is seen before brushing, and the appearance of the dentifrice and the granules in the dentifrice It was found that the touch was good, the cleaning property was excellent, and the cleaning feeling after brushing was high (Examples 1 to 6).
From the above results, the cleaning property is excellent by blending and dispersing granules (A) colored with a cold color pigment and granules (B) not colored with a cold color pigment in the dentifrice composition. At the same time, it was found that the effect of imparting a cleaning feeling by brushing was dramatically increased. In addition, the color of the granules (A) blended and dispersed in the preparation does not fade over time, and the appearance of the preparation discharged from a container such as a tube can be kept stable, that is, the granules (A) It has been found that the color is stably maintained over time and the appearance stability of the preparation is excellent.

Claims (8)

In a white dentifrice base, a granule (A) colored with a cool color pigment and a white granule (B) not colored with a cool color pigment are dispersed and blended. , A water-insoluble material selected from calcium carbonate and aluminum oxide, and a cold color having an absorption maximum value in the range of 560 to 730 nm when dissolved in chloroform or 1-chloronaphthalene and measuring a visible absorption spectrum in the range of 400 to 800 nm the system dye, containing 0.01 to 0.5 wt% based on the total granules (a), the granules (B) is contained zeolite, silica, water-insoluble material selected from calcium carbonate and aluminum oxide, A dentifrice composition having a blending mass ratio (A) / (B) of granules (A) and granules (B) of 1/20 to 2/1.   The dentifrice composition according to claim 1, wherein the cold color pigment of the granule (A) is at least one selected from blue 201, blue 204, green 202 and purple 201.   The granule (A) is colored in a color selected from blue, green, grass, light green, dark green, blue green, light blue, light blue green, light blue, purple and light blue purple. 2. The dentifrice composition according to 2.   The dentifrice composition according to any one of claims 1 to 3, wherein the granules (B) are uncolored granules or white granules colored with a white pigment. The dentifrice composition according to claim 4, wherein the granules (B) are white granules colored with titanium oxide.   The dentifrice composition according to any one of claims 1 to 5, wherein the blending amount of the granules (A) is 0.3 to 3% by mass.   The dentifrice composition according to any one of claims 1 to 6, wherein the total amount of the granule (A) and the granule (B) is 1.5 to 20% by mass.   The dentifrice according to any one of claims 1 to 7, wherein the mixing ratio of the granules (A) and the granules (B) is such that (A) / (B) is in a range of 1/11 to 1/1 as a mass ratio. Agent composition.