JP2015119705A5 - - Google Patents
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- JP2015119705A5 JP2015119705A5 JP2014263739A JP2014263739A JP2015119705A5 JP 2015119705 A5 JP2015119705 A5 JP 2015119705A5 JP 2014263739 A JP2014263739 A JP 2014263739A JP 2014263739 A JP2014263739 A JP 2014263739A JP 2015119705 A5 JP2015119705 A5 JP 2015119705A5
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- Prior art keywords
- cancer
- antibody
- dual target
- target antibody
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- Prior art date
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- 108090001123 antibodies Proteins 0.000 claims 18
- 102000004965 antibodies Human genes 0.000 claims 18
- 230000027455 binding Effects 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 210000004027 cells Anatomy 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102100013180 KDR Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 3
- 238000003259 recombinant expression Methods 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 206010064930 Age-related macular degeneration Diseases 0.000 claims 1
- 102000009075 Angiopoietin-2 Human genes 0.000 claims 1
- 108010048036 Angiopoietin-2 Proteins 0.000 claims 1
- 101710042656 BQ2027_MB1231C Proteins 0.000 claims 1
- 210000000988 Bone and Bones Anatomy 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 102100005175 CSF1R Human genes 0.000 claims 1
- 101700063802 CSF1R Proteins 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 102100010813 EGF Human genes 0.000 claims 1
- 101700033006 EGF Proteins 0.000 claims 1
- 101700041204 ERBB3 Proteins 0.000 claims 1
- 102000027776 ERBB3 Human genes 0.000 claims 1
- 101700023619 ERBB4 Proteins 0.000 claims 1
- 102100009851 ERBB4 Human genes 0.000 claims 1
- 210000002889 Endothelial Cells Anatomy 0.000 claims 1
- 101710003421 FGF Proteins 0.000 claims 1
- 108091008101 FGF receptors Proteins 0.000 claims 1
- 102100006565 FLT1 Human genes 0.000 claims 1
- 102100004573 FLT3 Human genes 0.000 claims 1
- 101710009074 FLT3 Proteins 0.000 claims 1
- 102100013182 FLT4 Human genes 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 102100014263 IGF1R Human genes 0.000 claims 1
- 101700025802 IGF1R Proteins 0.000 claims 1
- 108060003940 IL6 Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000009029 Macular Degeneration, Age-Related, 2 Diseases 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 206010027476 Metastasis Diseases 0.000 claims 1
- 108010061543 Neutralizing Antibodies Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 102100004939 PDGFRB Human genes 0.000 claims 1
- 101710018346 PDGFRB Proteins 0.000 claims 1
- 102100012897 PGF Human genes 0.000 claims 1
- 101710014083 PGF Proteins 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 1
- 206010038038 Rectal cancer Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 229920002684 Sepharose Polymers 0.000 claims 1
- 210000002536 Stromal Cells Anatomy 0.000 claims 1
- 101710037124 TEK Proteins 0.000 claims 1
- 102100015249 VEGFA Human genes 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 claims 1
- 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 claims 1
- -1 c-Met Proteins 0.000 claims 1
- 101710014509 celF Proteins 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 210000002358 circulating endothelial cell Anatomy 0.000 claims 1
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- 201000011231 colorectal cancer Diseases 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 230000003511 endothelial Effects 0.000 claims 1
- 102000017256 epidermal growth factor-activated receptor activity proteins Human genes 0.000 claims 1
- 108040009258 epidermal growth factor-activated receptor activity proteins Proteins 0.000 claims 1
- 102000017175 fibroblast growth factor-activated receptor activity proteins Human genes 0.000 claims 1
- 230000002489 hematologic Effects 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 201000001514 prostate carcinoma Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000004881 tumor cells Anatomy 0.000 claims 1
Claims (18)
- 抗体の重鎖または軽鎖のＮ−末端に水溶性リガンドが融合された、二重標的抗体。
- 前記抗体が、腫瘍細胞、癌間質細胞、腫瘍関連内皮細胞、腫瘍関連内皮前駆細胞、腫瘍関連循環内皮細胞、循環腫瘍細胞および癌幹細胞からなる群より選ばれた細胞で特異的に発現する抗原に対する抗体である、請求項１に記載の二重標的抗体。
- 前記抗原が、ＶＥＧＦＲ−１、ＶＥＧＦＲ−２、ＶＥＧＦＲ−３、ＦＬＴ３、ｃ−ＦＭＳ／ＣＳＦ１Ｒ、ＲＥＴ、ｃ−Ｍｅｔ、ＥＧＦＲ、Ｈｅｒ２／ｎｅｕ、ＨＥＲ３、ＨＥＲ４、ＦＧＦＲ、ＩＧＦＲ、ＰＤＧＦＲ、ｃ−ＫＩＴ、ＢＣＲ、インテグリンおよびＭＭＰからなる群より選択される、請求項２に記載の二重標的抗体。
- 前記抗体が、ＶＥＧＦＲ−２／ＫＤＲに対する中和抗体ＴＴＡＣ０００１である、請求項１に記載の二重標的抗体。
- 前記水溶性リガンドが、ＶＥＧＦ、ＥＧＦ、ＰｌＧＦ、ＦＧＦ、ＰＤＧＦ、ＨＧＦおよびアンジオポエチンからなる群より選択される、請求項１に記載の二重標的抗体。
- 前記水溶性リガンドが、アンジオポエチン２のＴｉｅ−２に対する結合ドメインである、請求項１に記載の二重標的抗体。
- 前記水溶性リガンドが、リンカーを介して前記抗体の重鎖または軽鎖のＮ−末端に融合される、請求項１に記載の二重標的抗体。
- 請求項１から請求項７のいずれか一項に記載の二重標的抗体をコードする、ＤＮＡ。
- 前記抗体の軽鎖および水溶性リガンドが、配列番号：６に示す塩基配列からなる、請求項８に記載のＤＮＡ。
- 請求項８に記載のＤＮＡを含む、組換え発現ベクター。
- 図２に示す切断地図を有するｐＩｇＧＬＤ−ｍＡｎｇ２−ＴＴＡＣ０００１ Ｌｇｔを含む、請求項１０に記載の組換え発現ベクター。
- 請求項１０に記載の組換え発現ベクターで形質転換された、宿主細胞。
- 請求項１２に記載の宿主細胞を培養する段階；および
前記宿主細胞の培養液から二重標的抗体を単離する段階
を含む、二重標的抗体を製造する方法。 - 二重標的抗体が、プロテインＡ親和性カラム、ＳＰ−セファロースカラム、およびサイズ排除クロマトグラフィによる高速液体クロマトグラフィ（ＦＰＬＣ）を用いてさらに精製される、請求項１３に記載の方法。
- 請求項１から請求項７のいずれか一項に記載の二重標的抗体を含む、薬学的組成物。
- 血管新生関連疾患の治療に用いられる、請求項１５に記載の薬学的組成物。
- 血管新生関連疾患が、癌、老人性黄斑変性、関節リウマチ、糖尿病性網膜症、乾癬および慢性炎症からなる群より選択される、請求項１６に記載の薬学的組成物。
- 癌が、胃癌、肝癌、肺癌、甲状腺癌、乳癌、子宮頸部癌、大腸癌、膵臓癌、直腸癌、結腸直腸癌、前立腺癌、腎臓癌、黒色腫、前立腺癌の骨転移癌、卵巣癌および血液癌からなる群より選択される、請求項１７に記載の薬学的組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020090044032A KR101224468B1 (ko) | 2009-05-20 | 2009-05-20 | 신규한 형태의 이중표적항체 및 그 용도 |
| KR10-2009-0044032 | 2009-05-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511742A Division JP5744012B2 (ja) | 2009-05-20 | 2009-07-22 | 新規な形態の二重標的抗体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015119705A JP2015119705A (ja) | 2015-07-02 |
| JP2015119705A5 true JP2015119705A5 (ja) | 2015-11-12 |
Family
ID=43126324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511742A Active JP5744012B2 (ja) | 2009-05-20 | 2009-07-22 | 新規な形態の二重標的抗体およびその使用 |
| JP2014263739A Pending JP2015119705A (ja) | 2009-05-20 | 2014-12-26 | 新規な形態の二重標的抗体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511742A Active JP5744012B2 (ja) | 2009-05-20 | 2009-07-22 | 新規な形態の二重標的抗体およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10125194B2 (ja) |
| EP (1) | EP2433968B1 (ja) |
| JP (2) | JP5744012B2 (ja) |
| KR (1) | KR101224468B1 (ja) |
| CN (1) | CN102428104B (ja) |
| AU (1) | AU2009346447B2 (ja) |
| BR (1) | BRPI0924535B1 (ja) |
| CA (1) | CA2762555C (ja) |
| DK (1) | DK2433968T3 (ja) |
| ES (1) | ES2605604T3 (ja) |
| RU (1) | RU2520824C2 (ja) |
| SG (1) | SG175971A1 (ja) |
| WO (1) | WO2010134666A1 (ja) |
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| CA2892193C (en) * | 2012-11-21 | 2018-06-19 | Pharmabcine Inc. | Dual-target antibody targeting vegfr-2 and dll4, and pharmaceutical composition including the same |
| WO2014108854A1 (en) | 2013-01-09 | 2014-07-17 | Fusimab Ltd. | Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies |
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