JP2015117185A5 - - Google Patents
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- Publication number
- JP2015117185A5 JP2015117185A5 JP2013259713A JP2013259713A JP2015117185A5 JP 2015117185 A5 JP2015117185 A5 JP 2015117185A5 JP 2013259713 A JP2013259713 A JP 2013259713A JP 2013259713 A JP2013259713 A JP 2013259713A JP 2015117185 A5 JP2015117185 A5 JP 2015117185A5
- Authority
- JP
- Japan
- Prior art keywords
- deuterium
- hydrogen
- compound
- compound according
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 229910052805 deuterium Inorganic materials 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- 206010028537 myelofibrosis Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- 230000000155 isotopic effect Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 2
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 229960004117 capecitabine Drugs 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229960000255 exemestane Drugs 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 2
- 229960005184 panobinostat Drugs 0.000 claims 2
- 208000003476 primary myelofibrosis Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000017733 acquired polycythemia vera Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000037244 polycythemia vera Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013259713A JP6367545B2 (ja) | 2013-12-17 | 2013-12-17 | ルキソリチニブの重水素化誘導体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013259713A JP6367545B2 (ja) | 2013-12-17 | 2013-12-17 | ルキソリチニブの重水素化誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018128417A Division JP6830460B2 (ja) | 2018-07-05 | 2018-07-05 | ルキソリチニブの重水素化誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015117185A JP2015117185A (ja) | 2015-06-25 |
| JP2015117185A5 true JP2015117185A5 (enExample) | 2017-02-09 |
| JP6367545B2 JP6367545B2 (ja) | 2018-08-01 |
Family
ID=53530252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013259713A Active JP6367545B2 (ja) | 2013-12-17 | 2013-12-17 | ルキソリチニブの重水素化誘導体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6367545B2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3294570A1 (en) * | 2015-06-30 | 2026-03-02 | Eiger Group International, Inc. | Use of r-chloroquine or metabolites, r-rhydroxychloroquine or metabolites, or deuterated analogs of r-chloroquine or rhydroxychloroquine, in treatment of liver inflammation |
| CA3000547C (en) * | 2015-09-29 | 2021-03-23 | Kangpu Biopharmaceuticals, Ltd. | Pharmaceutical composition comprising benzoheterocyclic compound and androgen receptor pathway modulator for prevention or treatment of prostate cancer |
| US10561659B2 (en) * | 2016-05-04 | 2020-02-18 | Concert Pharmaceuticals, Inc. | Treatment of hair loss disorders with deuterated JAK inhibitors |
| JP6802899B2 (ja) * | 2016-07-25 | 2020-12-23 | 深▲セン▼市塔吉瑞生物医▲薬▼有限公司Ｓｈｅｎｚｈｅｎ ＴａｒｇｅｔＲｘ，Ｉｎｃ． | 置換ボロン酸化合物、該化合物を含む医薬組成物およびその使用 |
| JP6830460B2 (ja) * | 2018-07-05 | 2021-02-17 | コンサート ファーマシューティカルズ インコーポレイテッド | ルキソリチニブの重水素化誘導体 |
| GB201907871D0 (en) * | 2019-06-03 | 2019-07-17 | Small Pharma Ltd | Therapeutic compositions |
| AU2021206286A1 (en) * | 2020-01-10 | 2024-08-08 | Consynance Therapeutics, Inc. | Therapeutic combinations of drugs and methods of using them |
| WO2021116503A2 (en) * | 2020-06-02 | 2021-06-17 | Small Pharma Ltd | Deuterated compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE028588T2 (hu) * | 2005-12-13 | 2016-12-28 | Incyte Holdings Corp | Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok |
| CA2792508C (en) * | 2010-03-10 | 2018-01-16 | Incyte Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
-
2013
- 2013-12-17 JP JP2013259713A patent/JP6367545B2/ja active Active
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