JP2015017067A - Food products, cosmetics, pharmaceuticals, and animal feed for promoting hair growth or preventing and improving hair loss - Google Patents
Food products, cosmetics, pharmaceuticals, and animal feed for promoting hair growth or preventing and improving hair loss Download PDFInfo
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Abstract
Description
本発明は、有効成分として、バナナ果皮又はバナナ果皮抽出物を含有した育毛促進剤に関する。 The present invention relates to a hair growth-promoting agent containing banana peel or banana peel extract as an active ingredient.
毛髪は毛根部に毛乳頭細胞、毛母細胞が存在する。発毛は毛乳頭細胞の活性化によって毛母細胞の分化が誘導される他、内毛根鞘細胞、外毛根鞘細胞、メラノサイト等の様々な細胞が密接に関与している。毛髪は発毛期、成長期、退行期、休止期、脱毛を繰り返すヘアサイクルによって制御されており、脱毛はヘアサイクルの期間の短縮が原因である。加齢、食生活や生活環境、精神的ストレス等を起因とした毛母細胞の不活性化並びに代謝異常が主たる要因である。よって、育毛促進又は脱毛予防は毛母細胞の活性化及び代謝改善が重要である。 Hair has dermal papilla cells and hair matrix cells at the root of the hair. Hair growth is induced by the activation of dermal papilla cells, in addition to the differentiation of hair matrix cells, and various cells such as inner root sheath cells, outer root sheath cells, and melanocytes are closely involved. Hair is controlled by a hair cycle that repeats the hair growth phase, the growth phase, the regression phase, the resting phase, and hair loss. Hair loss is caused by shortening the period of the hair cycle. The main factors are inactivation of hair matrix cells and abnormal metabolism due to aging, dietary life, living environment, mental stress, and the like. Therefore, activation of hair matrix cells and improvement of metabolism are important for promoting hair growth or preventing hair loss.
脱毛症は、加齢や生活環境要因によるストレス、ホルモンバランスの崩壊、薬剤の副作用等が原因とされ、美容的観点において日常生活の質を低下させる。様々な原因により毛乳頭細胞の代謝が低下すると、毛母細胞の活性化及び分化が抑制され、ヘアサイクルの乱れに繋がる。その結果、異常な抜毛や薄毛等の脱毛症を発症する。育毛剤に含有される有効成分は、血行促進成分としてミノキシジル、塩化カルプロニウム、トウガラシチンキ、ビタミンE誘導体、イチョウエキス、センブリエキス等が使用され、毛母細胞活性化成分としてペンタデカン酸グリセリド、ニコチン酸アミド等が使用されている（特許文献１：特開２０１３−１１９５３５）。 Alopecia is caused by stress due to aging and living environment factors, disruption of hormone balance, side effects of drugs, and the like, and reduces the quality of daily life from a cosmetic viewpoint. When the metabolism of hair papilla cells decreases due to various causes, activation and differentiation of hair matrix cells are suppressed, leading to disturbance of the hair cycle. As a result, alopecia such as abnormal hair loss and thinning hair develops. Active ingredients contained in hair restorers include minoxidil, carpronium chloride, red pepper tincture, vitamin E derivatives, ginkgo biloba extract, assembly extract, etc. as blood circulation promoting ingredients, and pentadecanoic acid glycerides, nicotinic acid amides as hair matrix activation components Etc. are used (Patent Document 1: JP 2013-119535 A).
しかしながら、臨床上薬効や副作用の点において十分に満足できる薬剤は未だなく、効果が高く副作用の少ない育毛促進剤が望まれている。また、食品成分は消化管から体内へ吸収・代謝されるため、毛乳頭細胞への作用は限定的と考えられ、育毛促進に十分な効果を得られない場合がある。従って、毛乳頭細胞に対して生体内から直接働きかけることが可能な脱毛症を予防する食品成分が望まれる。 However, there are no drugs that are sufficiently satisfactory in terms of clinical efficacy and side effects, and a hair growth promoter that is highly effective and has few side effects is desired. In addition, since food components are absorbed and metabolized from the gastrointestinal tract to the body, the action on hair papilla cells is considered to be limited, and a sufficient effect for promoting hair growth may not be obtained. Therefore, a food ingredient that prevents alopecia that can directly act on hair papilla cells from the living body is desired.
本発明者等は、食習慣があり安全であるバナナ、とりわけ、バナナ果皮及びバナナ果皮抽出物に着目し、これらがヘアサイクル延長に有用であり、その結果、毛髪存在箇所に付与し又は体内摂取により、育毛促進及び脱毛予防に効果的である、との知見を得た。本発明は、係る知見に基づいてなされたものである。 The present inventors focused on bananas that are eating habits and are safe, especially banana peels and banana peel extracts, which are useful for hair cycle extension, and as a result, applied to the hair location or taken into the body. Thus, it was found that it is effective for promoting hair growth and preventing hair loss. The present invention has been made based on such knowledge.
よって、本発明によれば、有効成分として、バナナ果皮又はバナナ果皮抽出物を含有してなる、育毛促進剤を提案することができる。 Therefore, according to this invention, the hair growth promoter which contains a banana peel or a banana peel extract as an active ingredient can be proposed.
本発明によれば、食習慣があり安全であるバナナ果皮又はバナナ果皮抽出物を有効成分として包含することにより、極めて高い次元において、人間を包含する動物の育毛促進及び脱毛予防を達成することが可能となる。その結果、加齢及び男性型脱毛をはじめとする毛母細胞の不活性化若しくは代謝異常を伴う、脱毛症の治療、改善及び予防に有用である。とりわけ、本発明によれば、バナナ果皮又はバナナ果皮抽出物を有効成分として、体内において摂取することにより、体内から育毛促進及び脱毛予防を達成することができたことは極めて特異的な効果であったということができる。また、食習慣があり安全であるバナナ果皮又はバナナ果皮抽出物を有効成分とすることから、本発明による促進剤、組成物は、そのまま経口摂取することができ、又は毛髪部位に直接塗布しても安全である。 According to the present invention, it is possible to achieve hair growth promotion and hair loss prevention of animals including humans in a very high dimension by including banana peel or banana peel extract, which is safe and eating habits, as an active ingredient. It becomes possible. As a result, it is useful for the treatment, improvement and prevention of alopecia accompanied by inactivation or metabolic abnormality of hair matrix cells including aging and male pattern hair loss. In particular, according to the present invention, it was a very specific effect that hair growth promotion and hair loss prevention could be achieved from the body by ingesting banana peel or banana peel extract as an active ingredient in the body. It can be said that. In addition, since the banana peel or banana peel extract, which is safe and has eating habits, is used as an active ingredient, the promoter and composition according to the present invention can be taken orally as it is or applied directly to the hair site. Is also safe.
＜Ｉ．定義＞
１）育毛促進剤
「育毛促進剤」とは、脱毛症の予防、脱毛症の進行・進展の防止、及び／又は脱毛症患者における毛髪の状態の改善のため、更には毛髪の健康状態を維持するため、ヒト若しくはヒト以外の動物に与えられる、医薬品（動物用治療薬も含む）用、飲食品用、化粧品用及び飼料用又はペットフード等を意味する。
<I. Definition>
1) Hair growth promoter “Hair growth promoter” refers to the prevention of alopecia, the prevention and progression of alopecia, and / or the improvement of hair condition in alopecia patients, and the maintenance of hair health. Therefore, it means for pharmaceuticals (including animal therapeutics), foods and drinks, cosmetics and feeds, pet foods, etc. given to humans or non-human animals.
２）育毛促進作用
「育毛促進作用」とは、生体内で毛母細胞の活性化を促進、並びに毛鞘の伸長促進作用のことをいい、脱毛症をはじめとする毛髪の減少を伴う疾患の予防をも包含するものである。従って、「育毛促進作用」は、毛母細胞の活性化を介して毛鞘伸長を促進し、加えて生体内のヘアサイクルを改善することも包含される。
2) Hair growth promoting action “Hair growth promoting action” refers to the action of promoting the activation of hair matrix cells and the promotion of hair sheath elongation in vivo, and is a disease associated with hair loss such as alopecia. It also encompasses prevention. Therefore, the “hair growth promoting effect” includes promoting hair sheath elongation through activation of hair matrix cells and improving the hair cycle in vivo.
３）育毛促進作用評価
「育毛促進作用」は、評価物質を培養細胞に添加し増殖促進する作用により評価することができるが、生体内の毛母細胞活性化による育毛作用を動物実験により評価する方法もある。
具体的には、背部を剃毛したマウスにサンプルを経口投与し、経時的変化を比較することによりサンプルの育毛効果の有無及び促進効果を評価することができる。
育毛状態の評価には育毛スコアをもとに数値化する。この測定評価において、サンプルの活性が一般に溶媒対照と比較し、高い値を示す場合、そのサンプルを「育毛促進活性あり」と評価する。
3) Evaluation of hair growth promoting action “Hair growth promoting action” can be evaluated by the action of promoting growth by adding an evaluation substance to cultured cells. The hair growth action by in vivo hair matrix activation is evaluated by animal experiments. There is also a method.
Specifically, the sample can be orally administered to a mouse shaved at the back, and the presence or absence and the promoting effect of the sample can be evaluated by comparing changes over time.
The hair growth state is evaluated based on the hair growth score. In this measurement evaluation, when the activity of the sample generally shows a high value compared to the solvent control, the sample is evaluated as “with hair growth promoting activity”.
４）脱毛症及び毛髪疾患
「脱毛症及び毛髪疾患」としては、一般的なものが包含され、例えば、男性型脱毛症、女性型脱毛症、円形脱毛症、脂漏性脱毛症、粃糠性脱毛症、加齢性脱毛症などが挙げられる。
4) Alopecia and hair diseases "Alopecia and hair diseases" include general ones such as male pattern alopecia, female pattern alopecia, alopecia areata, seborrheic alopecia, fertility Examples include alopecia and age-related alopecia.
＜ＩＩ．育毛促進剤又は毛髪細胞活性剤＞
（バナナ果皮）
本発明の原料は、バナナ（Musa spp.）であり、バショウ科バショウ属のうち、果実を食用とするものを対象とする。食用のバナナであれば、具体的な種類を問わず、例えば、生食用又は料理用として、キャベンディッシュ、ラカタン、レディ、シマバナナ、プランテーン、グロスミッチェル等があげられる。本発明にあっては、バナナ果皮を対象とするが、むろん、少量の果肉が含まれてもよいものである。また、バナナ果実は、未熟、成熟、過成熟のいずれの段階のものでもよく、生又は乾燥であってもよい。そして、バナナ果皮もバナナ果実の生長段階に拘わらず、採取してよく、生又は乾燥したものとして使用することができる。本発明にあっては、有効成分として、バナナ果皮を使用する場合には、保存安定性、製造容易性等の見地から、乾燥させたものが好ましい。乾燥したバナナ果皮は、そのもの自体、破砕又は粉砕したものとして使用することが可能である。
<II. Hair growth promoter or hair cell activator>
(Banana peel)
The raw material of the present invention is a banana (Musa spp.), Which is intended for edible fruits among the genus Bacolaceae. In the case of edible bananas, regardless of specific types, for example, for edible or cooked foods, there are cavendish, lacatan, lady, striped banana, plantain, gross mitchell and the like. In the present invention, banana peels are targeted, but, of course, a small amount of pulp may be included. The banana fruit may be in any stage of immaturity, maturation, and overmaturity, and may be raw or dried. And a banana peel may be extract | collected irrespective of the growth stage of a banana fruit, and can be used as a raw or dry thing. In the present invention, when banana peel is used as an active ingredient, it is preferably dried from the viewpoint of storage stability, ease of production, and the like. The dried banana peel itself can be used as crushed or crushed.
（バナナ果皮抽出物）
バナナ果皮抽出物は、バナナ果皮（上記したもの）を原料とし、食品又は医薬分野において安全とされる方法で抽出されてよい。例えば、バナナ果皮を水性（極性）溶媒等によって、抽出し、濾過、乾燥することで得ることができる。
(Banana peel extract)
The banana peel extract may be extracted by a method that uses banana peel (as described above) as a raw material and is safe in the food or pharmaceutical field. For example, the banana peel can be obtained by extraction with an aqueous (polar) solvent, filtration, and drying.
本発明にあっては、溶媒を用いて抽出することが好ましく、溶媒は水溶性または非水溶性のものであってよく、好ましくは水溶性溶媒（より好ましくは水）を用いる。溶媒抽出の際に用いる原料は、そのままであっても、また乾燥したものであってもよいが、抽出率の向上、抽出手続等の利便性等の理由から乾燥させた原料を用いることが好ましい。
溶媒抽出の場合、例えば、水、低級アルコール及び／又はポリオール、こられの混合溶液を用いることができる。低級アルコールとしては、エタノール、プロパノール、ブタノール等が、ポリオールとしては、プロピレングリコール、1,3-ブチレングリコール、グリセリン等が挙げられる。抽出に際しては、ｐＨ調整剤等の化学的処理を施してもよい。
In the present invention, it is preferable to perform extraction using a solvent. The solvent may be water-soluble or water-insoluble, and preferably a water-soluble solvent (more preferably water) is used. The raw material used in the solvent extraction may be as it is or may be dried, but it is preferable to use a dried raw material for reasons such as improvement in extraction rate, convenience of extraction procedures, and the like. .
In the case of solvent extraction, for example, water, lower alcohol and / or polyol, and a mixed solution thereof can be used. Examples of the lower alcohol include ethanol, propanol, and butanol, and examples of the polyol include propylene glycol, 1,3-butylene glycol, and glycerin. In the extraction, chemical treatment such as a pH adjusting agent may be performed.
バナナ果皮抽出は、バナナ果皮を上記抽出溶媒に浸漬し、又は浸漬して攪拌又は加熱還流した後、ろ過することにより行ってよい。バナナ果皮抽出物としては、濾過した粗液状態のままのものであってもよく、必要に応じて濃縮、精製、乾燥等したものを使用してもよい。 The banana peel extraction may be performed by immersing the banana peel in the above extraction solvent, or by immersing and stirring or heating under reflux, followed by filtration. The banana peel extract may be in a filtered crude liquid state, or may be concentrated, purified, dried, etc., if necessary.
本発明の好ましい別の方法によれば、抽出物はそれから水を除去した抽出物であって良い。溶媒を除去する方法としては、一般的には、減圧濃縮、加熱濃縮、通風濃縮、冷凍濃縮、噴霧濃縮、およびその他の濃縮方法、またはこれらの混合方法を用いることができる。濃縮の際の、圧力、温度、風力、噴霧等は、得られる抽出物の量に併せて適宜設定することができる。 According to another preferred method of the invention, the extract may be an extract from which water has been removed. As a method for removing the solvent, generally, vacuum concentration, heat concentration, ventilation concentration, freeze concentration, spray concentration, and other concentration methods, or a mixing method thereof can be used. The pressure, temperature, wind force, spraying and the like at the time of concentration can be appropriately set according to the amount of the extract to be obtained.
本発明の好ましい別の方法によれば、得られた抽出物から水を除去したもの、または得られた抽出物を乾燥し、得られた乾燥物を含んでなるものであってもよい。本発明において、乾燥方法は、天日乾燥、（熱）風乾燥、真空乾燥、通気乾燥、流動乾燥、噴霧乾燥、凍結乾燥、減圧乾燥、赤外線乾燥、高周波乾燥、およびその他の乾燥法、またはこれらの混合方法が用いられるが、本発明においては、好ましくは凍結乾燥が利用される。この凍結乾燥を行う場合、凍結温度、乾燥（湿度）は得られる凍結乾燥物の量に併せて適宜設定することができる。 According to another preferred method of the present invention, water obtained by removing water from the obtained extract, or obtained by drying the obtained extract, may be obtained. In the present invention, the drying method includes sun drying, (hot) air drying, vacuum drying, aeration drying, fluidized drying, spray drying, freeze drying, vacuum drying, infrared drying, high frequency drying, and other drying methods, or these In the present invention, lyophilization is preferably used. When performing this lyophilization, the freezing temperature and drying (humidity) can be appropriately set according to the amount of the lyophilized product to be obtained.
（含有量）
本発明による育毛促進剤又は毛髪細胞活性剤は、有効成分としてバナナ果皮又はバナナ果皮抽出物を含有すればよく、また、食品安全性の見地から、薬理効果が十分達成されるように、高濃度に添加されてよいものである。従って、本発明による育毛促進剤又は毛髪細胞活性剤は、バナナ果皮又はバナナ果皮抽出物の含有量を特定する必要性がないが、育毛促進剤又は毛髪細胞活性剤全量に対して、バナナ果皮又はバナナ果皮抽出物が２０重量％以上、好ましくは、４０重量％以上、より好ましくは、６０重量％以上程度含有してなるものであってよい。
(Content)
The hair growth promoter or hair cell activator according to the present invention may contain banana peel or banana peel extract as an active ingredient, and from a food safety standpoint, a high concentration so that the pharmacological effect is sufficiently achieved. It may be added to. Therefore, the hair growth-promoting agent or hair cell active agent according to the present invention does not need to specify the content of banana peel or banana peel extract, but banana peel or The banana peel extract may contain 20% by weight or more, preferably 40% by weight or more, and more preferably about 60% by weight or more.
（調剤）
本発明による育毛促進剤又は毛髪細胞活性剤は、必須成分として、バナナ果皮又はバナナ果皮抽出物を添加することで調剤されるが、必要に応じて、界面活性剤、油性成分、ビタミン類及び色素、保湿剤、高分子化合物、紫外線吸収剤、抗炎症剤、殺菌剤、酸化防止剤、防腐剤、香料等を配合し、常法に従って製造することができる。その場合の製剤化処理は限定されないが、例えば食用油脂や乳化剤などの助剤を用いた乳化処理、粉末化、増粒などが挙げられる。そのようにして得られた製剤は、吸収性や、摂取の容易さ、取り扱いの容易さの観点から有利である。
(Dispensing)
The hair growth-promoting agent or hair cell active agent according to the present invention is prepared by adding banana peel or banana peel extract as an essential component, but if necessary, surfactant, oily component, vitamins and pigments , Moisturizers, polymer compounds, ultraviolet absorbers, anti-inflammatory agents, bactericides, antioxidants, preservatives, fragrances, and the like, and can be produced according to conventional methods. In this case, the formulation treatment is not limited, and examples thereof include emulsification treatment using auxiliaries such as edible oils and fats and emulsifiers, powderization, and granulation. The preparation thus obtained is advantageous from the viewpoints of absorbability, ease of intake, and ease of handling.
＜ＩＩＩ．医薬用組成物＞
本発明にあっては、有効成分として、バナナ果皮又はバナナ果皮抽出物を含有してなる、育毛促進又は脱毛予防の為の医薬用組成物が提案される。とりわけ、本発明にあっては、脱毛症の治療及び予防の為の、医薬組成物が提案される。
バナナ果皮又はバナナ果皮抽出物、添加剤、調剤等については、「ＩＩ．育毛促進剤又は毛髪細胞活性剤」の項で説明したのと同様であってよい。
<III. Pharmaceutical composition>
In the present invention, a pharmaceutical composition for promoting hair growth or preventing hair loss comprising banana peel or banana peel extract as an active ingredient is proposed. In particular, in the present invention, a pharmaceutical composition for the treatment and prevention of alopecia is proposed.
The banana peel or banana peel extract, additive, preparation and the like may be the same as those described in the section “II. Hair growth promoter or hair cell activator”.
本発明による医薬用組成物は、動物(人間包含)の毛髪成長部位に直接投与することができる。また、本発明の好ましい態様によれば、経口および非経口（例えば、直腸投与、経皮投与）のいずれかの投与経路で、人を含む動物に投与することもできる。本発明による医薬用組成物は、投与経路に応じた適切な剤形として提供されることが好ましい。例えば、液剤、ローション剤、ゲル剤、カプセル剤、錠剤、顆粒剤、散剤、丸剤、細粒剤、トローチ錠等の経口剤、直腸投与剤等の種々に調製して使用することが可能である。本発明による医薬用組成物は、その用途は限定されず、例えば一般用医薬品（ＯＴＣ）など容易に入手可能な医薬品又は医薬部外品などとして製剤されてよいものである。 The pharmaceutical composition according to the present invention can be administered directly to the hair growth site of animals (including humans). Moreover, according to the preferable aspect of this invention, it can also administer to the animal including a human by any oral and parenteral (for example, rectal administration, transdermal administration) administration route. The pharmaceutical composition according to the present invention is preferably provided as an appropriate dosage form according to the administration route. For example, various preparations such as liquids, lotions, gels, capsules, tablets, granules, powders, pills, fine granules, lozenges and other oral preparations, rectal administration agents and the like can be used. is there. The use of the pharmaceutical composition according to the present invention is not limited. For example, the pharmaceutical composition may be formulated as a readily available medicine such as an over-the-counter medicine (OTC) or a quasi-drug.
本発明による医薬用組成物としての効果をより確実なものとするために、例えば、賦形剤、増量剤、結合剤、湿潤化剤、崩壊剤、表面活性剤、滑沢剤、分散剤、緩衝剤、保存剤、溶解補助剤、矯味矯臭剤、無痛化剤、安定化剤等、薬学上許容される担体または添加剤を適宜選択し、組み合わせたものを添加してよい。使用可能な無毒性の上記添加剤は、例えば乳糖、果糖、ブドウ糖、でん粉、ゼラチン、炭酸マグネシウム、合成ケイ酸マグネシウム、タルク、ステアリン酸マグネシウム、メチルセルロース、カルボキシメチルセルロースまたはその塩、アラビアゴム、ポリエチレングリコール、シロップワセリン、グリセリン、エタノール、プロピレングリコール、クエン酸、塩化ナトリウム、亜硫酸ソーダ、リン酸ナトリウム等が挙げられる。 In order to ensure the effect as the pharmaceutical composition according to the present invention, for example, an excipient, a bulking agent, a binder, a wetting agent, a disintegrant, a surfactant, a lubricant, a dispersant, A combination of a pharmaceutically acceptable carrier or additive such as a buffer, a preservative, a solubilizing agent, a flavoring agent, a soothing agent, and a stabilizer may be appropriately selected and added. Non-toxic additives that can be used include, for example, lactose, fructose, glucose, starch, gelatin, magnesium carbonate, synthetic magnesium silicate, talc, magnesium stearate, methylcellulose, carboxymethylcellulose or salts thereof, gum arabic, polyethylene glycol, Examples include syrup petrolatum, glycerin, ethanol, propylene glycol, citric acid, sodium chloride, sodium sulfite, and sodium phosphate.
本発明による医薬用組成物には、脱毛症をはじめとする毛髪疾患に対して育毛促進効果のある物質をさらに含有させても良い。育毛促進効果のある物質としては、今まで公知の物質を用いることができ、単独又は複数を組み合わせることが好ましい。これらの含有量は限定されないが、育毛に対して効果が発揮できる範囲で含まれていれば良い。 The pharmaceutical composition according to the present invention may further contain a substance having a hair growth promoting effect against hair diseases such as alopecia. As the substance having an effect of promoting hair growth, conventionally known substances can be used, and it is preferable to use a single substance or a combination of plural substances. Although content of these is not limited, it should just be contained in the range which can exhibit an effect with respect to hair growth.
本発明による医薬用組成物によれば、動物（人間包含する哺乳動物）に投与することにより、脱毛症をはじめとする毛髪疾患を処置、改善又は予防することができる。具体的には、男性型脱毛症、女性型脱毛症、円形脱毛症、脂漏性脱毛症、粃糠性脱毛症、加齢性脱毛症等を治療し、又は予防することが可能となる。 According to the pharmaceutical composition of the present invention, hair diseases such as alopecia can be treated, ameliorated, or prevented by administration to animals (mammals including humans). Specifically, male pattern alopecia, female pattern alopecia, alopecia areata, seborrheic alopecia, erosive alopecia, age-related alopecia and the like can be treated or prevented.
＜ＩＶ．飲食用組成物＞
本発明にあっては、有効成分として、バナナ果皮又はバナナ果皮抽出物を含有してなる、育毛促進又は脱毛予防の為の飲食用組成物が提案される。とりわけ、本発明にあっては、脱毛症の治療及び予防に有効な、飲食用組成物が提案される。
バナナ果皮又はバナナ果皮抽出物、添加剤、調剤等については、「ＩＩ．育毛促進剤又は毛髪細胞活性剤」の項で説明したのと同様であってよい。また、本発明による飲食用組成物は、飲食物、健康（補助）食品又は、飼料（ペットフード）として利用されてよい。
<IV. Eating and drinking composition>
In this invention, the composition for eating and drinking for hair growth promotion or hair loss prevention which contains a banana peel or a banana peel extract as an active ingredient is proposed. In particular, in the present invention, a composition for eating and drinking that is effective for the treatment and prevention of alopecia is proposed.
The banana peel or banana peel extract, additive, preparation and the like may be the same as those described in the section “II. Hair growth promoter or hair cell activator”. Moreover, the composition for eating and drinking according to the present invention may be used as food and drink, health (auxiliary) food, or feed (pet food).
本発明にあっては、「飲食用」とは、例えば、一般食品、保健機能食品（特定保健用食品、栄養機能食品）、健康食品、栄養補助食品、ペットフードなどである。「一般食品」とは、飲料、乳製品、発酵乳、乳酸菌飲料、加工乳、コーヒー飲料、ジュース、アイスクリーム、飴、ビスケット、ウェハース、ゼリー、スープ、麺類、を含むがそれに限定されるものではない。好ましくは飲料、乳製品、加工乳、発酵乳、乳酸菌飲料、ウェハース、ゼリーがあげられる。 In the present invention, “for food and drink” includes, for example, general foods, health functional foods (specific health foods, nutritional functional foods), health foods, nutritional supplements, pet foods, and the like. “General food” includes but is not limited to beverages, dairy products, fermented milk, lactic acid bacteria beverages, processed milk, coffee beverages, juices, ice creams, strawberries, biscuits, wafers, jelly, soups, noodles Absent. Preferred examples include beverages, dairy products, processed milk, fermented milk, lactic acid bacteria beverages, wafers, and jelly.
（飲食物）
本発明の好ましい態様によれば、本発明による飲食用組成物を含んでなる飲食物が提案される。本発明による飲食用組成物を含んでなる飲料物の形態は、液体、固形、半固形、グミ、ゼリー等の形態を問わないものである。本発明による飲食用組成物を含んでなる飲食物の具体例としては、液体飲料、果汁飲料、清涼飲料、スポーツ飲料、アルコール飲料、茶、栄養補助飲料等の飲料食品；パン、めん類、ごはん、菓子類（ビスケット、ケーキ、キャンデー、チョコレート、和菓子）、豆腐およびその他の加工食品；清酒、焼酎、リキュール、薬用酒、みりん、食酢、醤油、味噌などの発酵食品；食用油脂などの油脂食品；ヨーグルト、ハム、ベーコン、ソーセージなどの畜産加工食品；かまぼこ、さつま揚げ、はんぺん等の練り製品、干物等の水産加工食品等が挙げられる。
(Food)
According to a preferred aspect of the present invention, a food or drink comprising the food or drink composition according to the present invention is proposed. The form of the beverage comprising the composition for eating and drinking according to the present invention is not limited to liquid, solid, semi-solid, gummy, jelly and the like. Specific examples of foods and drinks comprising the food and drink composition according to the present invention include beverages such as liquid drinks, fruit juice drinks, soft drinks, sports drinks, alcoholic drinks, tea, and nutritional supplement drinks; bread, noodles, rice, Confectionery (biscuits, cakes, candy, chocolate, Japanese confectionery), tofu and other processed foods; fermented foods such as sake, shochu, liqueur, medicinal liquor, mirin, vinegar, soy sauce, miso; Processed livestock foods such as ham, bacon and sausage; kamaboko, deep-fried sweet potato, kneaded products such as hampen, and processed fishery products such as dried fish.
（健康（補助）食品）
本発明の好ましい態様によれば、本発明による飲食用組成物を含んでなる健康（補助）食品が提案される。本発明による健康（補助）食品は、本発明による飲食用組成物を含んでなる食材であってよい。食材の具体例は先の飲食物において説明したのと同様であってよい。また、本発明による健康（補助）食品は、本発明による飲食用組成物に、食品安全のある、賦形剤、増量剤、結合剤、増粘剤、乳化剤、香料、酸味料、防腐剤、酸化防止剤、増粘剤、着色料、食品添加物、調味料等と混合したものであってもよい。また、健康補助食品とする場合、栄養補助剤として、ローヤルゼリー、ビタミン類、アミノ酸類、プロテイン、キトサン、レシチン等と配合され、さらに糖液等を加えたものであってよい。
(Health (subsidiary) food)
According to a preferred embodiment of the present invention, a healthy (auxiliary) food comprising the food and drink composition according to the present invention is proposed. The health (auxiliary) food according to the present invention may be a food material comprising the composition for eating and drinking according to the present invention. The specific example of a foodstuff may be the same as having demonstrated in the previous food and drink. In addition, the health (auxiliary) food according to the present invention includes food and drink composition according to the present invention, food-safe excipients, extenders, binders, thickeners, emulsifiers, fragrances, acidulants, preservatives, What mixed with antioxidant, a thickener, a coloring agent, a food additive, a seasoning, etc. may be used. In addition, when it is used as a health supplement, it may be blended with royal jelly, vitamins, amino acids, protein, chitosan, lecithin or the like as a nutritional supplement, and further added with a sugar solution or the like.
本発明による健康（補助）食品は、通常の方法により、例えば錠剤、ソフトカプセル剤、ハードカプセル剤、顆粒剤、固形剤、散剤、粉末剤、丸剤、溶剤、チュアブル剤、ドリンク剤、ドレッシング類、菓子類等の形態に製造することができる。 The health (supplementary) food according to the present invention can be obtained by conventional methods, for example, tablets, soft capsules, hard capsules, granules, solids, powders, powders, pills, solvents, chewables, drinks, dressings, confectionery. It can be manufactured in the form of a kind.
本発明の別の態様によれば、本発明による健康（補助）食品は、その包装容器又は包装紙等において、育毛促進又は脱毛予防のための表示を伴った形態で提供される。 According to another aspect of the present invention, the health (auxiliary) food according to the present invention is provided in a form with a label for promoting hair growth or preventing hair loss in the packaging container or the wrapping paper.
（飼料）
本発明の好ましい態様によれば、本発明による飲食用組成物を含んでなる（動物用）飼料が提案される。本発明による飼料は、本発明による飲食用組成物に、飼料安全のある、賦形剤、増量剤、結合剤、増粘剤、乳化剤、香料、酵素、微生物製剤、酸化防止剤、増粘剤、着色料、飼料添加物、調味料等と混合したものであってもよい。本発明による飼料は、通常の方法により、例えば、固体、半固体、液体等の形態に製造することができる。本発明による飼料は、動物、特に家畜、ペットに使用することができる。
(feed)
According to a preferred embodiment of the present invention, an (animal) feed comprising the food and drink composition according to the present invention is proposed. The feed according to the present invention comprises a feed safety, excipient, extender, binder, thickener, emulsifier, fragrance, enzyme, microbial preparation, antioxidant, thickener, which is a feed-safety composition according to the present invention. , A colorant, a feed additive, a seasoning and the like may be mixed. The feed according to the present invention can be produced, for example, in the form of a solid, semi-solid, liquid or the like by a usual method. The feed according to the invention can be used for animals, in particular livestock, pets.
本発明の別の態様によれば、本発明による飼料は、その包装容器又は包装紙等において、脂質代謝改善のための表示を伴った形態で提供される。 According to another aspect of the present invention, the feed according to the present invention is provided in a form accompanied by a display for improving lipid metabolism in the packaging container or the wrapping paper.
以下の実施例により、本発明の内容をより詳細に説明するが、本発明の範囲は実施例によって限定して解釈されるものではない。 The contents of the present invention will be described in more detail with reference to the following examples, but the scope of the present invention should not be construed as being limited by the examples.
（実施例）
バナナ果皮乾燥物を用意し、バナナ果皮乾燥微粉末を蒸留水に懸濁したものをバナナ果皮サンプルとした。
（比較例）
対照群として、実施例におけるサンプルと同量の蒸留水をサンプルとした。
(Example)
A dried banana peel was prepared, and the banana peel dry powder suspended in distilled water was used as a banana peel sample.
(Comparative example)
As a control group, the same amount of distilled water as the sample in the example was used as a sample.
（評価試験）
実施例と比較例のサンプルを、背部を動物用バリカンで剃毛したC３Hマウスに経口投与した。実施例のサンプルは１）２５０ｍｇ／ｋｇ、及び２）５００ｍｇ／ｋｇの濃度で投与した。
剃毛翌日から投与を開始し、０、４、７、１０、１２、１３、１４、１５、１６、１７、２０、２１、２３、２８、３０、３４、３６の各日の写真を撮影した。撮影画像より剃毛面積と育毛面積の概算比率を育毛スコア表（表１）に照会し数値化した。
（評価結果）
実施例のサンプル投与群は、比較例のサンプル投与群と比較して、育毛スコアが高く、経口摂取による育毛促進効果が優位に認められた。
(Evaluation test)
The samples of Examples and Comparative Examples were orally administered to C3H mice whose backs were shaved with animal clippers. The example samples were administered at concentrations of 1) 250 mg / kg, and 2) 500 mg / kg.
The administration was started from the day after shaving, and photographs of each day of 0, 4, 7, 10, 12, 13, 14, 15, 16, 17, 20, 21, 23, 28, 30, 34, 36 were taken. . From the photographed image, the approximate ratio between the shaved area and the hair growth area was referred to the hair growth score table (Table 1) and digitized.
(Evaluation results)
The sample administration group of the example had a higher hair growth score than the sample administration group of the comparative example, and the effect of promoting hair growth by oral intake was recognized.
本発明によれば、食品、医薬組成物、化粧品などの組成物として様々な形態で提供することが可能である。 According to the present invention, it can be provided in various forms as a composition for foods, pharmaceutical compositions, cosmetics and the like.
Claims (6)
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| JP2013146314A JP2015017067A (en) | 2013-07-12 | 2013-07-12 | Food products, cosmetics, pharmaceuticals, and animal feed for promoting hair growth or preventing and improving hair loss |
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| CN109287880A (en) * | 2018-09-18 | 2019-02-01 | 广西壮族自治区农业科学院农产品加工研究所 | A kind of banana skin nursing period peg dog food and preparation method thereof |
| CN110354051A (en) * | 2018-08-03 | 2019-10-22 | 丁海椿 | Anticreep hair composition |
| US10588932B2 (en) * | 2018-05-25 | 2020-03-17 | Tci Co., Ltd. | Method for promoting hair growth using banana stamen extract |
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| KR101827655B1 (en) | 2016-12-22 | 2018-02-08 | 동의대학교 산학협력단 | A composition comprising banana having inhibitory effect on induction of grey hair and positive effect on induction of black hair |
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| CN110354051A (en) * | 2018-08-03 | 2019-10-22 | 丁海椿 | Anticreep hair composition |
| CN109287880A (en) * | 2018-09-18 | 2019-02-01 | 广西壮族自治区农业科学院农产品加工研究所 | A kind of banana skin nursing period peg dog food and preparation method thereof |
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