JP2015013863A5 - - Google Patents
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- Publication number
- JP2015013863A5 JP2015013863A5 JP2014156852A JP2014156852A JP2015013863A5 JP 2015013863 A5 JP2015013863 A5 JP 2015013863A5 JP 2014156852 A JP2014156852 A JP 2014156852A JP 2014156852 A JP2014156852 A JP 2014156852A JP 2015013863 A5 JP2015013863 A5 JP 2015013863A5
- Authority
- JP
- Japan
- Prior art keywords
- ophthalmic
- ophthalmic composition
- composition according
- brimonidine
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 29
- 229960003679 brimonidine Drugs 0.000 claims 12
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 11
- 239000007943 implant Substances 0.000 claims 11
- 239000000126 substance Substances 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 229920002988 biodegradable polymer Polymers 0.000 claims 5
- 239000004621 biodegradable polymer Substances 0.000 claims 5
- 239000007788 liquid Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 210000002159 anterior chamber Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 229920000954 Polyglycolide Polymers 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000012377 drug delivery Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000011859 microparticle Substances 0.000 claims 2
- 230000004112 neuroprotection Effects 0.000 claims 2
- 239000004633 polyglycolic acid Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000004406 elevated intraocular pressure Effects 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- -1 poly (phosphate ester Chemical class 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 230000004304 visual acuity Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67977105P | 2005-05-10 | 2005-05-10 | |
| US60/679,771 | 2005-05-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011209152A Division JP2012046530A (ja) | 2005-05-10 | 2011-09-26 | 増大した前眼部クリアランス速度を有するα−２アドレナリン受容体アゴニストを用いる眼科治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015013863A JP2015013863A (ja) | 2015-01-22 |
| JP2015013863A5 true JP2015013863A5 (enExample) | 2015-03-12 |
Family
ID=37397258
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008511301A Pending JP2008540552A (ja) | 2005-05-10 | 2006-05-09 | 増大した前部クリアランス速度を有するα−２アドレナリン受容体アゴニストを用いる眼科治療 |
| JP2011209152A Pending JP2012046530A (ja) | 2005-05-10 | 2011-09-26 | 増大した前眼部クリアランス速度を有するα−２アドレナリン受容体アゴニストを用いる眼科治療 |
| JP2014156852A Pending JP2015013863A (ja) | 2005-05-10 | 2014-07-31 | 増大した前眼部クリアランス速度を有するα−２アドレナリン受容体アゴニストを用いる眼科治療 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008511301A Pending JP2008540552A (ja) | 2005-05-10 | 2006-05-09 | 増大した前部クリアランス速度を有するα−２アドレナリン受容体アゴニストを用いる眼科治療 |
| JP2011209152A Pending JP2012046530A (ja) | 2005-05-10 | 2011-09-26 | 増大した前眼部クリアランス速度を有するα−２アドレナリン受容体アゴニストを用いる眼科治療 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7931909B2 (enExample) |
| EP (2) | EP1879553B1 (enExample) |
| JP (3) | JP2008540552A (enExample) |
| AU (1) | AU2006244083A1 (enExample) |
| BR (1) | BRPI0608978A2 (enExample) |
| CA (1) | CA2603069C (enExample) |
| ES (1) | ES2798259T3 (enExample) |
| WO (1) | WO2006122165A2 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| ES2384641T3 (es) | 2005-07-14 | 2012-07-10 | Lithera, Inc. | Formulación lipolítica que potencia la liberación mantenida para el tratamiento localizado del tejido adiposo |
| CA2850858A1 (en) * | 2005-09-16 | 2007-04-05 | Allergan, Inc. | Compositions and methods for the intraocular transport of therapeutic agents |
| US20070203144A1 (en) * | 2006-01-17 | 2007-08-30 | Allergan, Inc. | Use of Memantine and Brimonidine to Attenuate Vitreoretinal Vascular Endothelial Growth Factor (VEGF) Protein Levels in Animals |
| PL2077830T3 (pl) * | 2006-10-17 | 2013-04-30 | Lithera Inc | Sposoby, kompozycje i formulacje do leczenia orbitopatii tarczycowej |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| EP2178502A2 (en) * | 2007-06-21 | 2010-04-28 | Yale University | Sustained delivery of drugs from biodegradable polymeric microparticles |
| US20090081277A1 (en) * | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Pharmaceutical formulations and methods for treating ocular conditions |
| GB0724558D0 (en) | 2007-12-15 | 2008-01-30 | Sharma Anant | Optical correction |
| WO2009140246A2 (en) | 2008-05-12 | 2009-11-19 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US8034813B2 (en) * | 2008-11-18 | 2011-10-11 | Bausch & Lomb Incorporated | Polymorphs of brimonidine pamoate |
| WO2010093945A2 (en) | 2009-02-13 | 2010-08-19 | Glaukos Corporation | Uveoscleral drug delivery implant and methods for implanting the same |
| US8633181B2 (en) | 2009-04-09 | 2014-01-21 | Rutgers, The State University Of New Jersey | Treatment of cutaneous hemangioma |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
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| US9370444B2 (en) | 2010-10-12 | 2016-06-21 | Emmett T. Cunningham, JR. | Subconjunctival conformer device and uses thereof |
| US8915877B2 (en) | 2010-10-12 | 2014-12-23 | Emmett T. Cunningham, JR. | Glaucoma drainage device and uses thereof |
| EP2654715B1 (en) | 2010-11-24 | 2017-01-25 | Dose Medical Corporation | Drug eluting ocular implant |
| GEP201606551B (en) | 2010-11-24 | 2016-10-10 | Novamedica Llc | Selective, lipophilic, and long-acting beta agonists monotherapeutic formulations tions and methods for cosmetic treatment of adiposity and contour bulging |
| ES2655090T3 (es) | 2010-12-16 | 2018-02-16 | Allergan, Inc. | Derivados de 1,2-bis-sulfonamida como moduladores de receptores de quimiocinas |
| RU2013132650A (ru) | 2010-12-16 | 2015-01-27 | Аллерган, Инк. | Серные производные в качестве модуляторов хемокиновых рецепторов |
| US8349005B2 (en) | 2011-01-03 | 2013-01-08 | Masatoshi Murata | Method for burying implant to choroid |
| CA2827005A1 (en) | 2011-02-11 | 2012-08-16 | Allergan, Inc. | Novel 1-(1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)urea derivatives as n-formyl peptide receptor like-1 (fprl-1) receptor modulators |
| US8653299B2 (en) | 2011-03-17 | 2014-02-18 | Allergan, Inc. | Dihydronaphthalene and naphthalene derivatives as N-formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| EP2782569A1 (en) | 2011-11-21 | 2014-10-01 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| US20130190324A1 (en) * | 2011-12-23 | 2013-07-25 | The Regents Of The University Of Colorado, A Body Corporate | Topical ocular drug delivery |
| WO2013116186A1 (en) | 2012-01-30 | 2013-08-08 | Allergan, Inc. | Brimonidine for treating visual disorders mediated by central visual projections from the eye |
| SI2820010T1 (sl) | 2012-03-01 | 2018-11-30 | Allergan, Inc. | Derivati benzofuran-2-sulfonamida kot modulatorji kemokinskih receptorjev |
| CN104812397A (zh) | 2012-09-27 | 2015-07-29 | 阿勒根公司 | 用于持续释放蛋白质的生物可降解的药物递送系统 |
| EP2945686B1 (en) | 2013-01-15 | 2024-11-20 | The Regents of The University of Colorado, A Body Corporate | Lacrimal system drug delivery device |
| AU2014216112B2 (en) | 2013-02-15 | 2019-02-21 | Allergan, Inc. | Sustained drug delivery implant |
| US9670190B2 (en) | 2013-03-12 | 2017-06-06 | Allergan, Inc. | Pyridinyl and pyrimidinyl sulfonamide derivatives as chemokine receptor modulators |
| AU2014240139A1 (en) | 2013-03-15 | 2015-09-17 | Acadia Pharmaceuticals Inc. | Muscarinic agonists |
| US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
| AR098583A1 (es) | 2013-12-02 | 2016-06-01 | Allergan Inc | Compuesto de sulfonamida de benzotiofeno, composición farmacéutica que lo comprende y su uso para la preparación de dicha composición |
| KR101587483B1 (ko) * | 2014-03-28 | 2016-01-21 | 동아대학교 산학협력단 | 미토콘드리아성 복합체 ⅰ 저해제를 유효성분으로 함유하는 증식성 유리체망막병증의 예방 또는 치료용 약학적 조성물 |
| US20150342875A1 (en) | 2014-05-29 | 2015-12-03 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| LT3177612T (lt) | 2014-08-04 | 2022-06-10 | Nuevolution A/S | Pirimidino dariniai, pakeisti pasirinktinai kondensuotu heterociklilu, tinkami uždegiminių, metabolinių, onkologinių ir autoimuninių ligų gydymui |
| WO2017040853A1 (en) | 2015-09-02 | 2017-03-09 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| US11857461B2 (en) | 2015-11-23 | 2024-01-02 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal system for drug delivery |
| JP7003110B2 (ja) | 2016-04-20 | 2022-01-20 | ドーズ メディカル コーポレーション | 生体吸収性眼球薬物送達デバイス |
| US11207211B2 (en) | 2016-05-20 | 2021-12-28 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal drug delivery device |
| WO2018093797A1 (en) | 2016-11-15 | 2018-05-24 | The Schepens Eye Research Institute, Inc. | Compositions and methods for the treatment of aberrant angiogenesis |
| CN110337296A (zh) * | 2016-12-27 | 2019-10-15 | 犹他大学研究基金会 | 眼内药物递送装置和相关方法 |
| EP3710008A4 (en) * | 2017-11-14 | 2021-08-25 | The Schepens Eye Research Institute, Inc. | RUNX1 INHIBITION FOR THE TREATMENT OF PROLIFERATIVE VITREORETINOPATHY AND DISEASES ASSOCIATED WITH EPITHELIAL-MESENCHYMAL TRANSITION |
| JP2021534217A (ja) * | 2018-08-21 | 2021-12-09 | アラーガン、インコーポレイテッドAllergan, Incorporated | 視力を改善するためのａ−２−アドレナリン受容体アゴニストの使用 |
| GB2601922B (en) | 2019-06-27 | 2024-04-24 | Layerbio Inc | Ocular device drub delivery systems |
| TWI872177B (zh) | 2019-12-20 | 2025-02-11 | 丹麥商紐韋盧森公司 | 對核受體具有活性之化合物 |
| MX2022007265A (es) | 2019-12-20 | 2022-09-09 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| US11780843B2 (en) | 2020-03-31 | 2023-10-10 | Nuevolution A/S | Compounds active towards nuclear receptors |
| US11613532B2 (en) | 2020-03-31 | 2023-03-28 | Nuevolution A/S | Compounds active towards nuclear receptors |
| US20230301993A1 (en) * | 2020-08-21 | 2023-09-28 | Vyluma Inc. | Low-Dose Ophthalmic Compositions and Methods |
| AU2021329413A1 (en) * | 2020-08-21 | 2023-03-16 | University Of Tennessee Research Foundation | Methods of neuroprotection and uses thereof |
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| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| JPS58126435U (ja) | 1982-02-19 | 1983-08-27 | オリンパス光学工業株式会社 | Ｔｔｌオ−トストロボ用絞り制御回路 |
| US4521210A (en) | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
| US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
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| US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| KR0185215B1 (ko) | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| WO1995003009A1 (en) * | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6369116B1 (en) | 1995-06-02 | 2002-04-09 | Oculex Pharmaceuticals, Inc. | Composition and method for treating glaucoma |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| AU738338B2 (en) | 1997-08-11 | 2001-09-13 | Allergan, Inc. | Sterile bioerodible implant device with improved biocompatability and method |
| US6242442B1 (en) * | 1998-12-17 | 2001-06-05 | Alcon Laboratories, Inc. | Brinzolamide and brimonidine for treating ocular conditions |
| US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| AUPQ496500A0 (en) | 2000-01-06 | 2000-02-03 | University Of Sydney, The | Kit |
| WO2002058730A2 (en) * | 2000-11-01 | 2002-08-01 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
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| US20030114460A1 (en) * | 2001-12-14 | 2003-06-19 | Allergan Sales, Inc. | Pharmaceutical conjugates with enhanced pharmacokinetic characteristics |
| ATE431749T1 (de) | 2002-03-18 | 2009-06-15 | Novartis Pharma Gmbh | Topische zusammensetzung enthaltend ein cyclofructan, einen träger und einen arzneistoff |
| US20070042951A1 (en) * | 2003-10-08 | 2007-02-22 | Allergan, Inc. | Pharmaceutical compositions comprising alpha-2-adrenergics and trefoil factor family peptides |
| US8425929B2 (en) | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
-
2006
- 2006-05-02 US US11/416,929 patent/US7931909B2/en active Active
- 2006-05-09 EP EP06752463.7A patent/EP1879553B1/en active Active
- 2006-05-09 JP JP2008511301A patent/JP2008540552A/ja active Pending
- 2006-05-09 CA CA2603069A patent/CA2603069C/en active Active
- 2006-05-09 ES ES06752463T patent/ES2798259T3/es active Active
- 2006-05-09 WO PCT/US2006/018019 patent/WO2006122165A2/en not_active Ceased
- 2006-05-09 EP EP20150705.0A patent/EP3656374A1/en not_active Withdrawn
- 2006-05-09 AU AU2006244083A patent/AU2006244083A1/en not_active Abandoned
- 2006-05-09 BR BRPI0608978-0A patent/BRPI0608978A2/pt not_active IP Right Cessation
-
2007
- 2007-12-03 US US11/949,751 patent/US20080112923A1/en not_active Abandoned
- 2007-12-03 US US11/949,750 patent/US20080112922A1/en not_active Abandoned
-
2011
- 2011-09-26 JP JP2011209152A patent/JP2012046530A/ja active Pending
-
2014
- 2014-07-31 JP JP2014156852A patent/JP2015013863A/ja active Pending
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