JP2015010059A - 医薬組成物 - Google Patents
医薬組成物 Download PDFInfo
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- JP2015010059A JP2015010059A JP2013136616A JP2013136616A JP2015010059A JP 2015010059 A JP2015010059 A JP 2015010059A JP 2013136616 A JP2013136616 A JP 2013136616A JP 2013136616 A JP2013136616 A JP 2013136616A JP 2015010059 A JP2015010059 A JP 2015010059A
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Abstract
【解決手段】(A)イブプロフェンピコノール及びその塩からなる群より選択される少なくとも1種、並びに(B)イソプロピルメチルフェノール及びその塩からなる群より選択される少なくとも1種を含有する医薬組成物であって、前記(B)成分の含有量が、医薬組成物100重量%中、0.7〜1.5重量%である、医薬組成物。
【選択図】なし
Description
[医薬組成物]
本発明の医薬組成物は、(A)成分及び(B)成分を含有し、(B)成分の含有量が特定の範囲にある。当該医薬組成物においては、(B)成分を特定の含有量で含むことで、(A)成分の製剤安定性が高まっている。また、当該医薬組成物は特定の態様では、(A)成分及び(B)成分を特定の比率で併用することで、メラニン生成の抑制作用も発揮する。とりわけ当該医薬組成物は、更なる成分として、(C)成分を併用することによって、(A)成分の製剤安定性がより高められる。さらに、当該医薬組成物は、本発明の効果を損なわない限り、その他の成分等を含有してもよい。以下、当該医薬組成物の必須成分である(A)成分及び(B)成分、並びに(C)成分及びその他の成分等について詳述する。
(A)成分は、イブプロフェンピコノール及びその塩からなる群より選択される少なくとも1種である。(A)成分は従来使用されている通り、急性湿疹やニキビなど各種の皮膚疾患に有効な成分である。
(B)成分は、イソプロピルメチルフェノール及びその塩からなる群より選択される少なくとも1種である。イソプロピルメチルフェノール及びその塩は従来抗菌作用を有する物質として広く使用されている物質である。イソプロピルメチルフェノールには種々の位置異性体が知られており、本発明にはそのいずれを用いてもよい。具体的に、イソプロピルメチルフェノールの位置異性体としては、3−メチル−4−イソプロピルフェノール〔ビオゾールとも呼ばれる〕、2−イソプロピル−5−メチルフェノール〔チモールとも呼ばれる〕、又は2−メチル−5−イソプロピルフェノール〔カルバクロールとも呼ばれる〕等が挙げられるが、これらに限定されない。本発明の効果発現の観点から、好ましくは3−メチル−4−イソプロピルフェノールである。
本発明の医薬組成物は、更なる成分として、(C)有機酸及びその塩からなる群より選択される少なくとも1種を含有することが好ましい。本発明の医薬組成物に(C)成分を更に配合することにより、(A)成分の製剤安定性をより高めることができる。
本発明の医薬組成物は、以上説明した(A)成分及び(B)成分を含有し、更に必要に応じて(C)成分を含有し、その他、種々の目的に応じて、保湿成分、多価アルコール、スクラブ剤、紫外線吸収成分、紫外線散乱成分、(A)成分以外の抗炎症剤、収斂成分、ビタミン類、ペプチド又はその誘導体、アミノ酸又はその誘導体、洗浄成分、(B)成分以外の抗菌成分、角質柔軟成分、細胞賦活化成分、老化防止成分、血行促進作用成分、美白成分等のその他の成分を、本発明の効果を損なわない範囲で含んでいてもよい。なかでも、多価アルコール、ビタミン類、(A)成分以外の抗炎症剤を含有することが好ましい。なお、これらのその他の成分は、1種単独で使用してもよいし、2種以上を併用してもよい。また、その他の成分であって上記(C)成分としても挙げられているものは、本発明において(C)成分としての機能も果たす。
本発明の医薬組成物のpHは特に制限されるものではないが、本発明の効果を損なわず、また後述する各種の疾患に適用する観点からは、通常pH3.0〜10.0、好ましくはpH3.0〜8.0の範囲である。
本発明の医薬組成物の製造方法は特に制限されず、必須成分である(A)成分及び(B)成分、並びに必要に応じて(C)成分の他、通常の、医薬組成物を製造するのに必要な各種成分(上記その他の成分、後述する基剤又は担体、添加剤等)を適宜選択、配合して、常法により、製造することができる。
本発明の医薬組成物においては、以上説明したとおり、(A)成分及び(B)成分を含有し、(B)成分を特定の量で含有しているため、(A)成分の製剤安定性が向上している。(A)成分は従来、急性湿疹、接触性皮膚炎、アトピー性皮膚炎、慢性湿疹、酒さ様皮膚炎、口囲皮膚炎、帯状疱疹、ニキビなどの各種皮膚疾患に利用されている成分であるので、当該医薬組成物はこれらの治療・予防等のための医薬組成物として使用することができ、とりわけ皮膚外用剤として好適に使用することができる。そして(A)成分の製剤安定性が向上しているので、当該医薬組成物は長期間これらに対して有効に使用できるものと期待される。
本発明の医薬組成物は、その必須成分及び上記で説明したその他の成分等を、医薬品に通常使用される基剤又は担体、及び必要に応じて、後述する添加剤と共に常法に従い混合して、必要に応じて乳化又は可溶化を行い、各種の製剤形態の医薬組成物とすることができる。
本発明の医薬組成物の製剤形態は特に限定されず、例えば、軟膏剤、液剤、懸濁剤、乳化剤(乳液及びクリーム)、ゲル剤、リニメント剤、ローション剤、パップ剤、エアゾール剤、固形剤等が挙げられる。これらのうち、液状〜半固体状の製剤形態が好ましく、特に、液剤、ローション剤、軟膏剤、ゲル剤、乳化剤に適用すると有用である。これらの製剤は、常法、例えば第16改正日本薬局方製剤総則に記載の方法等に従い製造することができる。
本発明の医薬組成物には、本発明の効果を損なわない範囲で、医薬品に添加される公知の添加剤、例えば、界面活性剤、安定化剤、酸化防止剤、着色剤、パール光沢付与剤、分散剤、キレート剤、pH調整剤、清涼化剤、保存剤、増粘剤、刺激低減剤等を添加することができる。なかでも、清涼化剤、増粘剤を添加することが好ましい。これらの添加剤は、1種単独で用いてもよいし、2種以上を併用することもできる。また、添加剤であって上記(C)成分としても挙げられているものは、本発明において(C)成分としての機能も果たす。
下記の表1〜3に記載の処方に従い、常法にて、各実施例及び比較例の水中油型組成物(表1に示す各製剤は透明の可溶化ゲル;表2〜3に示す各製剤は水中油型乳化剤)を調製した。具体的には、先ず、油溶性成分と水溶性成分をそれぞれ別々に70〜80℃で混合溶解し、油相及び水相を調製した。次いで、用意した水相をディスパー(ロボミックス、プライミクス(株)製)で十分に攪拌しながら、そこに予め調製した油相を徐々に添加し、均一になるように十分に混合させながら、室温まで冷却した。水酸化カリウム及び/又はトリエタノールアミンを適量添加することによりpHの調整を行い、各実施例及び比較例の組成物を得た。なお、下記表1〜4において、「残量」とは組成物全体の量を100重量%とする量である。
・検出器:紫外吸光光度計(測定波長:254nm)
・カラム:内径4.6mm,長さ15cmのステンレス管に5μmの液体クロマトグラフ用オクタデシルシリル化シリカゲルを充てんしたカラム(Inertsil ODS2、GLサイエンス社製)を使用した。
・カラム温度:40℃付近の一定温度
・移動相:メタノール/pH4.0の酢酸・酢酸ナトリウム緩衝液混液(4:1)
今回の試験では種々の試験条件下で熱安定性評価を行ったが、上記表1〜3に示される通り、いずれの場合でも組成物中にイソプロピルメチルフェノールを1.0重量%含有させることにより、イソプロピルメチルフェノールを含有させない場合(比較例1,3及び5)、2.0重量%含有させた場合(比較例2及び4)及び0.5重量%含有させた場合(比較例6)に対し、高度にイブプロフェンピコノールの含量低下が抑制されることが判明した。また、一部の態様では、残存率がほぼ100%のレベルに保たれていた。
上記試験例1と同様の手順で、下記表4に示す各水中油型乳化組成物を調製した。調製した各組成物をそれぞれ容量10mLのガラス製ねじ口ビンに5g充填し、それらを50℃遮光下にて2週間保存した。その後、試験例1と同様の定量条件下でイブプロフェンピコノールの定量を行い、各組成物中における、前記保存前の初期含量を100%としたときのイブプロフェンピコノールの残存率(%)を算出した。
試験結果を上記表4に併せて示す。表4の結果から明らかなように、有機酸(グルコン酸)と共に1.0重量%のイソプロピルメチルフェノールを配合した場合に、イブプロフェンピコノールの含量低下抑制効果が特に優れることが明らかとなった。
マウス由来メラノーマ細胞を、10%FBS含有DMEM培地を用いて、1.0×104cells/mLの密度で6ウェルプレートに播種し、37℃、5%炭酸ガス及び95%空気の環境下で1日間培養後、同培地で培地交換を行うと共に、下記表5に示す各被験薬(表5に示した成分をエタノールに溶解したもの)を5/10,000,000に希釈した終濃度となるように培地に添加し、さらに3日間にわたり37℃、5%炭酸ガス及び95%空気の環境下で培養した。
マウス由来メラノーマ細胞を、10%FBS含有DMEM培地を用いて、1.0×104cells/mLの密度で6ウェルプレートに播種し、37℃、5%炭酸ガス及び95%空気の環境下で1日間培養後、同培地で培地交換を行うと共に、下記表6に示す各被験薬(表6に示した成分をエタノールに溶解したもの)を5/1,000,000に希釈した終濃度となるように培地に添加し、さらに4日間にわたり37℃、5%炭酸ガス及び95%空気の環境下で培養した。4日間の培養後、上記試験例3と同様の手順でメラニン量と生存細胞数の測定を行い、コントロール及び各実施例・比較例の被験薬で処理した場合で、生存細胞数に大きな差は無いことを確認し、さらにコントロールに対するメラニン生成率(%)を算出した。
Claims (8)
- (A)イブプロフェンピコノール及びその塩からなる群より選択される少なくとも1種、並びに
(B)イソプロピルメチルフェノール及びその塩からなる群より選択される少なくとも1種
を含有する医薬組成物であって、前記(B)成分の含有量が、医薬組成物100重量%中、0.7〜1.5重量%である、医薬組成物。 - (A)成分の含有量が、医薬組成物100重量%中、0.1〜10.0重量%である、請求項1に記載の医薬組成物。
- (A)成分1重量部に対して、(B)成分を0.2〜5重量部の割合で含有する、請求項1又は2に記載の医薬組成物。
- 水中油型組成物である、請求項1〜3のいずれかに記載の医薬組成物。
- 更に、(C)有機酸及びその塩からなる群より選択される少なくとも1種を含有する、請求項1〜4のいずれかに記載の医薬組成物。
- メラニン生成を抑制するために使用され得る、請求項1〜5のいずれかに記載の医薬組成物。
- ニキビの治療及び/又は予防のために使用され得る、請求項1〜6のいずれかに記載の医薬組成物。
- 外用組成物である、請求項1〜7のいずれかに記載の医薬組成物。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020050679A (ja) * | 2015-06-12 | 2020-04-02 | ロート製薬株式会社 | アクネ菌バイオフィルム破壊組成物 |
WO2023120583A1 (ja) * | 2021-12-22 | 2023-06-29 | ライオン株式会社 | にきび用外用組成物及びアクネ菌選択的抗菌・殺菌用外用組成物 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007308430A (ja) * | 2006-05-19 | 2007-11-29 | Zeria Pharmaceut Co Ltd | ニキビ治療剤 |
JP2009149568A (ja) * | 2007-12-21 | 2009-07-09 | Lion Corp | 皮膚外用剤組成物 |
JP2011011993A (ja) * | 2009-06-30 | 2011-01-20 | Lion Corp | ニキビ治療薬 |
WO2011086891A1 (ja) * | 2010-01-12 | 2011-07-21 | 株式会社ナノエッグ | 非侵襲的に皮膚の色素の除去を促進するための組成物 |
JP2013227230A (ja) * | 2012-04-24 | 2013-11-07 | Kao Corp | チロシナーゼ阻害剤 |
-
2013
- 2013-06-28 JP JP2013136616A patent/JP6185773B2/ja active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007308430A (ja) * | 2006-05-19 | 2007-11-29 | Zeria Pharmaceut Co Ltd | ニキビ治療剤 |
JP2009149568A (ja) * | 2007-12-21 | 2009-07-09 | Lion Corp | 皮膚外用剤組成物 |
JP2011011993A (ja) * | 2009-06-30 | 2011-01-20 | Lion Corp | ニキビ治療薬 |
WO2011086891A1 (ja) * | 2010-01-12 | 2011-07-21 | 株式会社ナノエッグ | 非侵襲的に皮膚の色素の除去を促進するための組成物 |
JP2013227230A (ja) * | 2012-04-24 | 2013-11-07 | Kao Corp | チロシナーゼ阻害剤 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020050679A (ja) * | 2015-06-12 | 2020-04-02 | ロート製薬株式会社 | アクネ菌バイオフィルム破壊組成物 |
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