JP2015000851A - 体温上昇剤 - Google Patents
体温上昇剤 Download PDFInfo
- Publication number
- JP2015000851A JP2015000851A JP2013124849A JP2013124849A JP2015000851A JP 2015000851 A JP2015000851 A JP 2015000851A JP 2013124849 A JP2013124849 A JP 2013124849A JP 2013124849 A JP2013124849 A JP 2013124849A JP 2015000851 A JP2015000851 A JP 2015000851A
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- Prior art keywords
- body temperature
- increasing agent
- temperature increasing
- strain
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
【解決手段】ラクトバチラス・ブレビス(Lactobacillus brevis)に属するSBC8803(受託番号:FERM BP−10632)菌株の菌体又はその処理物を有効成分として含有する体温上昇剤。
【選択図】なし
Description
(試験方法)
<菌体処理物の調製>
SBL88株を培地(組成:マルトース2質量%、酵母エキス1.4質量%、酢酸ナトリウム0.5質量%、硫酸マンガン0.005質量%、pH6.5〜7.0)に植菌し、30℃で1日間静置培養した。得られた培養液(約8×108cfu/ml)を8,000rpmで10分間遠心分離し、菌体を回収した。回収した菌体を蒸留水に再懸濁し、8,000rpmで10分遠心分離し、菌体を回収した。この操作を2度繰り返した。回収した菌体を蒸留水に懸濁し、105℃で10分間加熱処理した後、凍結乾燥して加熱処理菌体粉末(菌体処理物)を得た。
粉末飼料AIN−93M(オリエンタル酵母工業株式会社製)にSBL88株の菌体処理物を0.5質量%添加した後、ペレット化して菌体処理物を含むマウス飼料(SBL88含有AIN−93M飼料)を調製した。対照として、粉末飼料AIN−93Mをペレット化して菌体処理物を含まないマウス飼料(AIN93M飼料)を調製した。
全期間を通して、マウスを回転かご(SW−15S、有限会社メルクエスト)内で飼育した。マウスの活動量は、クロノバイオロジーキット(Stanford Software Systems,CA)を用いて測定した。
AIN−93M飼料又はSBL88含有AIN−93M飼料を与え始めて1日後から、データロガーを用いて体温の測定を開始した。測定は15分毎に行い、1日(24時間)の平均体温を求めた。各群の平均体温は、各群のマウスの体温の平均値として求めた。有意差の有無は、多重比較検定の後にTukeyの方法により群間比較を行った。
SBL88群及び対照群において、体温の測定開始日(0日目)から26日目までを非ストレス飼育期間とし、27日目からストレス飼育期間を開始した。ストレス負荷方法としては、物理的に遮蔽してマウスが回転輪から降りられないように制限することにより、ストレス性睡眠障害を2週間連続的に誘発した。
図1は、非ストレス飼育期間及びストレス飼育期間におけるSBL88群と対照群のマウスの平均体温の推移を示すグラフである。図1中、*を付したデータはp<0.05であり、**を付したデータはp<0.01であることを示す。非ストレス飼育期間(0〜26日目)では、SBL88群は対照群と比較して平均体温が統計的に有意差を持って高い値を示した。
Claims (6)
- ラクトバチラス・ブレビス(Lactobacillus brevis)に属するSBC8803(受託番号:FERM BP−10632)菌株の菌体又はその処理物を有効成分として含有する体温上昇剤。
- 冷え改善剤である、請求項1に記載の体温上昇剤。
- 体温低下抑制剤である、請求項1に記載の体温上昇剤。
- 請求項1に記載の体温上昇剤を含有する医薬品。
- 請求項1に記載の体温上昇剤を含有する飲食品。
- 請求項1に記載の体温上昇剤を含有する飲食品添加物。
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JP2013124849A JP6671652B2 (ja) | 2013-06-13 | 2013-06-13 | 体温上昇剤 |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008023663A1 (fr) * | 2006-08-21 | 2008-02-28 | Sapporo Breweries Limited | Souche bactérienne possédant une activité anti-allergique, et boisson, aliment et agent anti-allergique comprenant une cellule de la souche bactérienne |
JP2013224287A (ja) * | 2012-03-19 | 2013-10-31 | Sapporo Breweries Ltd | セロトニン分泌促進剤 |
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Publication number | Priority date | Publication date | Assignee | Title |
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WO2008023663A1 (fr) * | 2006-08-21 | 2008-02-28 | Sapporo Breweries Limited | Souche bactérienne possédant une activité anti-allergique, et boisson, aliment et agent anti-allergique comprenant une cellule de la souche bactérienne |
JP2013224287A (ja) * | 2012-03-19 | 2013-10-31 | Sapporo Breweries Ltd | セロトニン分泌促進剤 |
Non-Patent Citations (3)
Title |
---|
"体温を上げて免疫力アップ", [ONLINE], vol. [検索日:2014年4月17日], JPN6014018869, 2009, pages インターネット, ISSN: 0003826805 * |
日本看護医療学会雑誌, vol. 13, no. 2, JPN6018024279, 2011, pages 26 - 35, ISSN: 0003826807 * |
矢羽田歩 外: "果たしてGABAにはストレス緩和の効果はあるか:ヒトクロモグラニンAとアミラーゼ活性を中心とした検討", 中村学園大学・中村学園大学短期大学部研究紀要, vol. 第44号, JPN6014018871, 2012, pages 261 - 268, ISSN: 0003826806 * |
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