JP2014533241A - 超濃縮速効型インスリン類似体製剤 - Google Patents

超濃縮速効型インスリン類似体製剤 Download PDF

Info

Publication number
JP2014533241A
JP2014533241A JP2014539111A JP2014539111A JP2014533241A JP 2014533241 A JP2014533241 A JP 2014533241A JP 2014539111 A JP2014539111 A JP 2014539111A JP 2014539111 A JP2014539111 A JP 2014539111A JP 2014533241 A JP2014533241 A JP 2014533241A
Authority
JP
Japan
Prior art keywords
insulin
substitution
sequence
chain
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014539111A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014533241A5 (enExample
Inventor
ワイス、マイケル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of JP2014533241A publication Critical patent/JP2014533241A/ja
Publication of JP2014533241A5 publication Critical patent/JP2014533241A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2014539111A 2011-10-27 2012-10-29 超濃縮速効型インスリン類似体製剤 Pending JP2014533241A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161552246P 2011-10-27 2011-10-27
US61/552,246 2011-10-27
PCT/US2012/062423 WO2013063572A1 (en) 2011-10-27 2012-10-29 Ultra-concentrated rapid-acting insulin analogue formulations

Publications (2)

Publication Number Publication Date
JP2014533241A true JP2014533241A (ja) 2014-12-11
JP2014533241A5 JP2014533241A5 (enExample) 2015-12-17

Family

ID=48168643

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014539111A Pending JP2014533241A (ja) 2011-10-27 2012-10-29 超濃縮速効型インスリン類似体製剤

Country Status (10)

Country Link
US (1) US9908925B2 (enExample)
EP (1) EP2771026A4 (enExample)
JP (1) JP2014533241A (enExample)
KR (1) KR20150021011A (enExample)
CN (1) CN104010652A (enExample)
AU (1) AU2012328407A1 (enExample)
BR (1) BR112014010139A2 (enExample)
IN (1) IN2014CN03888A (enExample)
SG (1) SG11201401835VA (enExample)
WO (1) WO2013063572A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016506366A (ja) * 2012-11-05 2016-03-03 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 長時間作用型単鎖インスリン類似体
JP2022513776A (ja) * 2018-12-11 2022-02-09 サノフイ インスリン受容体結合親和性が低下したインスリンアナログ

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
US20170304361A1 (en) * 2014-10-20 2017-10-26 Case Western Reserve University Halogenated insulin analogues of enhanced biological potency
TW201625673A (zh) * 2014-11-21 2016-07-16 默沙東藥廠 胰島素受體部分促效劑
US10822386B2 (en) * 2014-12-24 2020-11-03 Case Western Reserve University Insulin analogues with enhanced stability and reduced mitogenicity
CN108026157B (zh) 2015-08-25 2022-11-25 诺和诺德股份有限公司 新型胰岛素衍生物及其医学用途
WO2017032795A1 (en) 2015-08-25 2017-03-02 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
EP3341402A1 (en) 2015-08-25 2018-07-04 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
WO2017070617A1 (en) * 2015-10-21 2017-04-27 Case Western Reserve University Diol-modified insulin analogues containing a glucose-regulated conformational switch
CN108430493A (zh) 2015-12-23 2018-08-21 卡斯西部储备大学 超稳胰岛素类似物在聚合物熔体中的包囊
MY208364A (en) 2019-12-11 2025-05-01 Novo Nordisk As Novel insulin analogues and uses thereof
WO2024194897A1 (en) * 2023-03-22 2024-09-26 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) A glycation resistant insulin polypeptide and a method of preparing the same thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104981A1 (en) * 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
JP2005526009A (ja) * 2001-12-02 2005-09-02 ノボ　ノルディスク　アクティーゼルスカブ 新規グルコース依存性インスリン
JP2007523211A (ja) * 2004-02-24 2007-08-16 リポペプチド・アクチエボラーグ 新規な複合体
JP2008510692A (ja) * 2004-08-20 2008-04-10 ノボ ノルディスク アクティーゼルスカブ 薬学的に活性なインスリン受容体調節分子
WO2010014946A2 (en) * 2008-07-31 2010-02-04 Case Western Reserve University Halogen-stabilized insulin
WO2010080606A1 (en) * 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Insulin analogs

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
KR900701842A (ko) 1988-07-20 1990-12-04 헨리 브뢰늄 인간 인슐린 동족체와 그를 포함하는 제제
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
US7317000B2 (en) * 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
CA2522818A1 (en) * 2003-03-11 2004-09-23 Soren Ostergaard Pharmaceutical preparations comprising acid-stabilised insulin
ES2554773T3 (es) * 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
KR101656107B1 (ko) 2007-11-20 2016-09-08 암브룩스, 인코포레이티드 변형된 인슐린 폴리펩티드 및 이의 용도
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104981A1 (en) * 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
JP2005526009A (ja) * 2001-12-02 2005-09-02 ノボ　ノルディスク　アクティーゼルスカブ 新規グルコース依存性インスリン
JP2007523211A (ja) * 2004-02-24 2007-08-16 リポペプチド・アクチエボラーグ 新規な複合体
JP2008510692A (ja) * 2004-08-20 2008-04-10 ノボ ノルディスク アクティーゼルスカブ 薬学的に活性なインスリン受容体調節分子
WO2010014946A2 (en) * 2008-07-31 2010-02-04 Case Western Reserve University Halogen-stabilized insulin
WO2010080606A1 (en) * 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Insulin analogs

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016506366A (ja) * 2012-11-05 2016-03-03 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 長時間作用型単鎖インスリン類似体
JP2022513776A (ja) * 2018-12-11 2022-02-09 サノフイ インスリン受容体結合親和性が低下したインスリンアナログ

Also Published As

Publication number Publication date
BR112014010139A2 (pt) 2017-04-25
AU2012328407A1 (en) 2014-05-22
US20140323398A1 (en) 2014-10-30
NZ624493A (en) 2016-02-26
IN2014CN03888A (enExample) 2015-10-16
EP2771026A4 (en) 2015-08-05
EP2771026A1 (en) 2014-09-03
WO2013063572A1 (en) 2013-05-02
CN104010652A (zh) 2014-08-27
KR20150021011A (ko) 2015-02-27
SG11201401835VA (en) 2014-09-26
US9908925B2 (en) 2018-03-06

Similar Documents

Publication Publication Date Title
US9908925B2 (en) Ultra-concentrated rapid-acting insulin analogue formulations
US8343914B2 (en) Fibrillation resistant proteins
US9079975B2 (en) Insulin analogues with chlorinated amino acids
US9388228B2 (en) Halogen-stabilized insulin
US20150299286A1 (en) Glutamic acid-stabilized insulin analogues
US10745458B2 (en) Non-standard insulin analogues
US9200053B2 (en) Insulin analogues containing penta-fluoro-Phenylalanine at position B24
EP2948166B1 (en) N-terminal truncated insulin analogues
AU2013237740B2 (en) Insulin analogues containing penta-fluora-phenyalanine at position B24
NZ624493B2 (en) Ultra-concentrated rapid-acting insulin analogue formulations

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151026

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151026

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160719

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170307