CN104010652A - 超浓缩的速效胰岛素类似物制剂 - Google Patents

超浓缩的速效胰岛素类似物制剂 Download PDF

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Publication number
CN104010652A
CN104010652A CN201280064561.7A CN201280064561A CN104010652A CN 104010652 A CN104010652 A CN 104010652A CN 201280064561 A CN201280064561 A CN 201280064561A CN 104010652 A CN104010652 A CN 104010652A
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CN
China
Prior art keywords
insulin
substitution
sequence
chain
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280064561.7A
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English (en)
Chinese (zh)
Inventor
M.魏斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of CN104010652A publication Critical patent/CN104010652A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201280064561.7A 2011-10-27 2012-10-29 超浓缩的速效胰岛素类似物制剂 Pending CN104010652A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161552246P 2011-10-27 2011-10-27
US61/552246 2011-10-27
PCT/US2012/062423 WO2013063572A1 (en) 2011-10-27 2012-10-29 Ultra-concentrated rapid-acting insulin analogue formulations

Publications (1)

Publication Number Publication Date
CN104010652A true CN104010652A (zh) 2014-08-27

Family

ID=48168643

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280064561.7A Pending CN104010652A (zh) 2011-10-27 2012-10-29 超浓缩的速效胰岛素类似物制剂

Country Status (10)

Country Link
US (1) US9908925B2 (enExample)
EP (1) EP2771026A4 (enExample)
JP (1) JP2014533241A (enExample)
KR (1) KR20150021011A (enExample)
CN (1) CN104010652A (enExample)
AU (1) AU2012328407A1 (enExample)
BR (1) BR112014010139A2 (enExample)
IN (1) IN2014CN03888A (enExample)
SG (1) SG11201401835VA (enExample)
WO (1) WO2013063572A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108430493A (zh) * 2015-12-23 2018-08-21 卡斯西部储备大学 超稳胰岛素类似物在聚合物熔体中的包囊

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2694418T3 (es) * 2012-11-05 2018-12-20 Case Western Reserve University Análogos de insulina de cadena sencilla de acción prolongada
BR112016016290A2 (pt) 2014-01-13 2017-10-03 Thermalin Diabetes Llc Composições farmacêuticas de insulina de ação rápida, conjunto de infusão, sistema de conjunto de infusão e usos de análogos monoméricos ou diméricos de insulina
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
EP3223844A4 (en) * 2014-10-20 2018-08-15 Case Western Reserve University Halogenated insulin analogues of enhanced biological potency
SG10201809428UA (en) * 2014-11-21 2018-11-29 Merck Sharp & Dohme Insulin receptor partial agonists
WO2016105545A2 (en) * 2014-12-24 2016-06-30 Case Western Reserve University Insulin analogues with enhanced stabilized and reduced mitogenicity
JP2018531901A (ja) 2015-08-25 2018-11-01 ノヴォ ノルディスク アー／エス 新規インスリン誘導体及びその医学的使用
US11352406B2 (en) 2015-08-25 2022-06-07 Novo Nordisk A/S Insulin derivatives and the medical uses hereof
EP3341402A1 (en) 2015-08-25 2018-07-04 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
WO2017070617A1 (en) * 2015-10-21 2017-04-27 Case Western Reserve University Diol-modified insulin analogues containing a glucose-regulated conformational switch
SG11202106167XA (en) * 2018-12-11 2021-07-29 Sanofi Sa Insulin conjugates
CA3159114A1 (en) 2019-12-11 2021-06-17 Frantisek Hubalek Novel insulin analogues and uses thereof
WO2024194897A1 (en) * 2023-03-22 2024-09-26 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) A glycation resistant insulin polypeptide and a method of preparing the same thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
US20100099601A1 (en) * 2006-10-04 2010-04-22 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US20110166064A1 (en) * 2008-07-31 2011-07-07 Case Western Reserve University Halogen-stabilized insulin
US20110257091A1 (en) * 2008-12-19 2011-10-20 Dimarchi Richard D Insulin analogs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03506023A (ja) 1988-07-20 1991-12-26 ノボ　ノルデイスク　アクツイエセルスカプ ポリペプチド
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US20030104981A1 (en) * 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
EP1453860A2 (en) 2001-12-02 2004-09-08 Novo Nordisk A/S Novel glucose-dependant insulins
US7317000B2 (en) * 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
CA2522818A1 (en) * 2003-03-11 2004-09-23 Soren Ostergaard Pharmaceutical preparations comprising acid-stabilised insulin
SE0401942D0 (sv) * 2004-07-28 2004-07-28 Lipopeptide Ab New antimicrobial peptide complexes
WO2006018450A2 (en) 2004-08-20 2006-02-23 Novo Nordisk A/S Pharmaceutically active insulin receptor-modulating molecules
CA2703830A1 (en) * 2007-11-20 2009-05-28 Ambrx, Inc. Modified insulin polypeptides and their uses
EP2318432B1 (en) * 2008-07-31 2015-09-02 Case Western Reserve University Halogen-stabilized insulin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
US20100099601A1 (en) * 2006-10-04 2010-04-22 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US20110166064A1 (en) * 2008-07-31 2011-07-07 Case Western Reserve University Halogen-stabilized insulin
US20110257091A1 (en) * 2008-12-19 2011-10-20 Dimarchi Richard D Insulin analogs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108430493A (zh) * 2015-12-23 2018-08-21 卡斯西部储备大学 超稳胰岛素类似物在聚合物熔体中的包囊

Also Published As

Publication number Publication date
WO2013063572A1 (en) 2013-05-02
NZ624493A (en) 2016-02-26
EP2771026A4 (en) 2015-08-05
SG11201401835VA (en) 2014-09-26
AU2012328407A1 (en) 2014-05-22
KR20150021011A (ko) 2015-02-27
US20140323398A1 (en) 2014-10-30
JP2014533241A (ja) 2014-12-11
EP2771026A1 (en) 2014-09-03
BR112014010139A2 (pt) 2017-04-25
IN2014CN03888A (enExample) 2015-10-16
US9908925B2 (en) 2018-03-06

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Legal Events

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20140827