JP2014531452A5 - - Google Patents
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- Publication number
- JP2014531452A5 JP2014531452A5 JP2014531303A JP2014531303A JP2014531452A5 JP 2014531452 A5 JP2014531452 A5 JP 2014531452A5 JP 2014531303 A JP2014531303 A JP 2014531303A JP 2014531303 A JP2014531303 A JP 2014531303A JP 2014531452 A5 JP2014531452 A5 JP 2014531452A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- light chain
- vertebrate
- gene segments
- lambda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1116122.1 | 2011-09-19 | ||
| GB201116120A GB201116120D0 (en) | 2011-09-19 | 2011-09-19 | Manipulation of immunoglobulin gene diversity and multi antibody therapeutics, especially for infectious diseases |
| GB1116120.5 | 2011-09-19 | ||
| GB201116122A GB201116122D0 (en) | 2011-09-19 | 2011-09-19 | Synthetically-extended & ethnically diverse superhuman immunoglobulin gene repertoires |
| GB1203257.9 | 2012-02-24 | ||
| GBGB1203257.9A GB201203257D0 (en) | 2012-02-24 | 2012-02-24 | Animals, repertoires & methods |
| GBGB1204592.8A GB201204592D0 (en) | 2012-03-15 | 2012-03-15 | Animals, repertoires & methods |
| GB1204592.8 | 2012-03-15 | ||
| GB1205702.2 | 2012-03-29 | ||
| GBGB1205702.2A GB201205702D0 (en) | 2012-03-29 | 2012-03-29 | Animals,repertoires & methods |
| GB1207814.3A GB2501753A (en) | 2012-05-04 | 2012-05-04 | Human antibodies |
| GB1207814.3 | 2012-05-04 | ||
| GB1208749.0 | 2012-05-18 | ||
| GBGB1208749.0A GB201208749D0 (en) | 2012-05-18 | 2012-05-18 | Synthetically-extended & ethnically-diverse superhuman immunoglobulin gene repertoires |
| GB201211692A GB201211692D0 (en) | 2012-07-02 | 2012-07-02 | Animals, repertories & methods |
| GB1211692.7 | 2012-07-02 | ||
| PCT/GB2012/052297 WO2013041845A2 (en) | 2011-09-19 | 2012-09-18 | Animals, repertoires & methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017177720A Division JP2017213005A (ja) | 2011-09-19 | 2017-09-15 | 動物、レパートリーおよび方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014531452A JP2014531452A (ja) | 2014-11-27 |
| JP2014531452A5 true JP2014531452A5 (https=) | 2015-11-12 |
Family
ID=46889369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531303A Pending JP2014531452A (ja) | 2011-09-19 | 2012-09-18 | 動物、レパートリーおよび方法 |
| JP2017177720A Pending JP2017213005A (ja) | 2011-09-19 | 2017-09-15 | 動物、レパートリーおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017177720A Pending JP2017213005A (ja) | 2011-09-19 | 2017-09-15 | 動物、レパートリーおよび方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20140323327A1 (https=) |
| EP (2) | EP3741862A1 (https=) |
| JP (2) | JP2014531452A (https=) |
| WO (1) | WO2013041845A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| BR112012000536A2 (pt) | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| SG10201912639SA (en) | 2010-08-02 | 2020-02-27 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
| RS59728B1 (sr) | 2011-08-05 | 2020-02-28 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lanca |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| WO2013041845A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Animals, repertoires & methods |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| KR20160098514A (ko) | 2011-10-17 | 2016-08-18 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| RU2664181C2 (ru) | 2011-12-20 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Мыши с гуманизированной легкой цепью |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| PT3597037T (pt) | 2012-06-12 | 2021-06-01 | Regeneron Pharma | Animais não humanos humanizados com lócus de cadeia pesada de imunoglobulina restrito |
| EP2840892B1 (en) | 2013-02-20 | 2018-04-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modified immunoglobulin heavy chain sequences |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| DE112014004537T5 (de) | 2013-10-01 | 2016-07-21 | Kymab Limited | Tiermodelle und therapeutische Moleküle |
| WO2015143406A2 (en) | 2014-03-21 | 2015-09-24 | Regeneron Pharmaceuticals, Inc. | Vl antigen binding proteins exhibiting distinct binding characteristics |
| KR102276752B1 (ko) | 2014-03-21 | 2021-07-13 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| EP3927832A4 (en) | 2019-02-18 | 2022-11-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMANIZED IMMUNOGLOBULIN LOCUS |
| KR20230018439A (ko) | 2020-06-02 | 2023-02-07 | 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 | 공동 경쇄 면역글로불린 좌위를 갖는 유전자 변형 비인간 동물 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1690934A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| BE1007904A3 (nl) | 1993-12-23 | 1995-11-14 | Dsm Nv | Werkwijze voor de bereiding van een alkanol en/of een alkanon. |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| GB9823930D0 (en) * | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| US7435871B2 (en) * | 2001-11-30 | 2008-10-14 | Amgen Fremont Inc. | Transgenic animals bearing human Igλ light chain genes |
| WO2009013620A2 (en) | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
| CA2708776A1 (en) | 2007-12-10 | 2009-06-18 | Aliva Biopharmaceuticals, Inc. | Methods for sequential replacement of targeted region by homologous recombination |
| ES2436044T3 (es) | 2008-05-23 | 2013-12-26 | Ablexis, Llc | Procedimiento de generación de anticuerpos de dominio VL individual en animales transgénicos |
| EP2346994B1 (en) | 2008-09-30 | 2022-02-16 | Ablexis, LLC | Knock-in mice for the production of chimeric antibodies |
| JP5827127B2 (ja) | 2008-12-18 | 2015-12-02 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用 |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| BR112012000536A2 (pt) | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| SI2501817T2 (sl) * | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| AU2011266843C9 (en) | 2010-06-17 | 2018-03-01 | Kymab Limited | Animal models and therapeutic molecules |
| US9012717B2 (en) | 2010-06-22 | 2015-04-21 | Regeneron Pharmaceuticals, Inc. | Human lambda light chain mice |
| SG10201912639SA (en) | 2010-08-02 | 2020-02-27 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
| RU2722373C2 (ru) | 2011-02-25 | 2020-05-29 | Редженерон Фармасьютикалс, Инк. | Мыши adam6 |
| WO2013041845A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Animals, repertoires & methods |
| RU2664181C2 (ru) | 2011-12-20 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Мыши с гуманизированной легкой цепью |
-
2012
- 2012-09-18 WO PCT/GB2012/052297 patent/WO2013041845A2/en not_active Ceased
- 2012-09-18 EP EP20171931.7A patent/EP3741862A1/en not_active Withdrawn
- 2012-09-18 EP EP12762377.5A patent/EP2758534B1/en active Active
- 2012-09-18 JP JP2014531303A patent/JP2014531452A/ja active Pending
-
2014
- 2014-03-19 US US14/220,099 patent/US20140323327A1/en not_active Abandoned
-
2017
- 2017-09-15 JP JP2017177720A patent/JP2017213005A/ja active Pending
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