JP2014530837A5 - - Google Patents
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- Publication number
- JP2014530837A5 JP2014530837A5 JP2014536252A JP2014536252A JP2014530837A5 JP 2014530837 A5 JP2014530837 A5 JP 2014530837A5 JP 2014536252 A JP2014536252 A JP 2014536252A JP 2014536252 A JP2014536252 A JP 2014536252A JP 2014530837 A5 JP2014530837 A5 JP 2014530837A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- optionally substituted
- general formula
- hal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000003612 virological effect Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 206010022000 influenza Diseases 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 241000712892 Arenaviridae Species 0.000 claims 2
- 241000711573 Coronaviridae Species 0.000 claims 2
- 241000711950 Filoviridae Species 0.000 claims 2
- 241000710781 Flaviviridae Species 0.000 claims 2
- 241000700586 Herpesviridae Species 0.000 claims 2
- 241000712464 Orthomyxoviridae Species 0.000 claims 2
- 241000711504 Paramyxoviridae Species 0.000 claims 2
- 241000150350 Peribunyaviridae Species 0.000 claims 2
- 241000709664 Picornaviridae Species 0.000 claims 2
- 241000712907 Retroviridae Species 0.000 claims 2
- 241000711931 Rhabdoviridae Species 0.000 claims 2
- 241000710924 Togaviridae Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 claims 1
- 101800004538 Bradykinin Proteins 0.000 claims 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 1
- 102100035792 Kininogen-1 Human genes 0.000 claims 1
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 claims 1
- 229940123424 Neuraminidase inhibitor Drugs 0.000 claims 1
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 claims 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 1
- 229930003827 cannabinoid Natural products 0.000 claims 1
- 239000003557 cannabinoid Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229940125400 channel inhibitor Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002911 sialidase inhibitor Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550045P | 2011-10-21 | 2011-10-21 | |
| US61/550,045 | 2011-10-21 | ||
| PCT/EP2012/070757 WO2013057251A2 (en) | 2011-10-21 | 2012-10-19 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530837A JP2014530837A (ja) | 2014-11-20 |
| JP2014530837A5 true JP2014530837A5 (cg-RX-API-DMAC7.html) | 2015-12-03 |
| JP6047168B2 JP6047168B2 (ja) | 2016-12-21 |
Family
ID=47178587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014536252A Expired - Fee Related JP6047168B2 (ja) | 2011-10-21 | 2012-10-19 | ヘテロアリールヒドロキサム酸誘導体及びウイルス性疾患の治療、改善又は予防におけるその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130102600A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2776396A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6047168B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140100476A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103958475B (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014001369A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2852750A1 (cg-RX-API-DMAC7.html) |
| HK (2) | HK1199640A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2014003803A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2014120421A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013057251A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014177514A1 (en) | 2013-04-30 | 2014-11-06 | Bayer Cropscience Ag | Nematicidal n-substituted phenethylcarboxamides |
| CA2953862A1 (en) | 2014-07-07 | 2016-01-14 | F. Hoffmann-La Roche Ag | Dihydropyridopyrazine-1,8-diones and their use in the treatment, amelioration or prevention of viral diseases |
| JP2017525777A (ja) * | 2014-08-28 | 2017-09-07 | エックス−ケム，インコーポレーテッド | 可溶性エポキシドヒドロラーゼ阻害剤及びこれらの使用 |
| US10392406B2 (en) | 2015-04-28 | 2019-08-27 | Shionogi & Co., Ltd. | Substituted polycyclic pyridone derivatives and prodrugs thereof |
| HRP20230215T1 (hr) | 2015-04-28 | 2023-04-14 | Shionogi & Co., Ltd. | Supstituirani policiklički derivati piridona i njihov predlijek |
| US20170081331A1 (en) | 2015-09-18 | 2017-03-23 | F. Hoffmann-La Roche Ag | Pyrazolopyrazines and their use in the treatment, amelioration or prevention of a viral disease |
| KR102084109B1 (ko) | 2015-12-15 | 2020-03-03 | 시오노기세야쿠 가부시키가이샤 | 캡 의존적 엔도뉴클레아제 저해제 및 항인플루엔자 약을 조합하는 것을 특징으로 하는 인플루엔자 치료용 의약 |
| JP6957535B2 (ja) | 2016-06-29 | 2021-11-02 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピリダジノンベースの広域スペクトル抗インフルエンザ阻害剤 |
| JP6249434B1 (ja) | 2016-08-10 | 2017-12-20 | 塩野義製薬株式会社 | 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物 |
| MX394277B (es) * | 2016-09-05 | 2025-03-24 | Guangdong Raynovent Biotech Co Ltd | Derivados de pirimidina contra virus de la influenza |
| EP4271383A4 (en) * | 2020-12-29 | 2024-10-23 | Merck Sharp & Dohme LLC | Amido-substituted pyridyl compounds and methods of use thereof for the treatment of herpesviruses |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
| US6680385B2 (en) * | 2002-01-25 | 2004-01-20 | The Hong Kong Polytechnic University | Catalytic preparation of aryl methyl ketones using a molecular oxygen-containing gas as the oxidant |
| JP4953297B2 (ja) | 2004-09-15 | 2012-06-13 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体 |
| WO2010100475A1 (en) * | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| JP5697163B2 (ja) | 2009-03-26 | 2015-04-08 | 塩野義製薬株式会社 | 置換された３−ヒドロキシ−４−ピリドン誘導体 |
| WO2011000566A2 (en) * | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
-
2012
- 2012-10-18 US US13/655,394 patent/US20130102600A1/en not_active Abandoned
- 2012-10-19 CN CN201280051750.0A patent/CN103958475B/zh not_active Expired - Fee Related
- 2012-10-19 KR KR1020147013723A patent/KR20140100476A/ko not_active Withdrawn
- 2012-10-19 BR BR112014001369A patent/BR112014001369A2/pt not_active IP Right Cessation
- 2012-10-19 HK HK14113138.0A patent/HK1199640A1/xx unknown
- 2012-10-19 RU RU2014120421/04A patent/RU2014120421A/ru not_active Application Discontinuation
- 2012-10-19 WO PCT/EP2012/070757 patent/WO2013057251A2/en not_active Ceased
- 2012-10-19 MX MX2014003803A patent/MX2014003803A/es unknown
- 2012-10-19 JP JP2014536252A patent/JP6047168B2/ja not_active Expired - Fee Related
- 2012-10-19 CA CA2852750A patent/CA2852750A1/en not_active Abandoned
- 2012-10-19 HK HK14110437.4A patent/HK1197059A1/xx unknown
- 2012-10-19 EP EP12786860.2A patent/EP2776396A2/en not_active Withdrawn
-
2016
- 2016-04-06 US US15/091,632 patent/US20160297763A1/en not_active Abandoned