JP2014530369A - 分子検知デバイス - Google Patents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4412—Scattering spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
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- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
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Abstract
Description
Claims (15)
- 分子検知デバイスであって、
基板と、
i)前記基板の表面上に配置された材料に形成されるか、又はii)前記基板の表面に形成されるウェルと、
前記ウェル内に配置された信号増幅構造体と、
前記ウェル内に堆積されて前記信号増幅構造体を取り囲む浸漬流体と、
を備える、分子検知デバイス。 - 前記浸漬流体は、不活性ガス、液体、又は液体及び該液体に溶解された機能性化学種を含む、請求項1に記載の分子検知デバイス。
- 閉鎖位置にあるときに前記ウェル内の前記浸漬流体を密封する取り外し可能カバーを更に備える、請求項1に記載の分子検知デバイス。
- i)前記基板の前記表面上に配置された前記材料に形成されるか、又はii)前記基板の前記表面に形成される個別のウェルのアレイと、
前記個別のウェル内のそれぞれにおけるそれぞれの信号増幅構造体と、
を備える、請求項1に記載の分子検知デバイス。 - 前記浸漬流体は、前記個別のウェルのそれぞれにおいて同じであるか、又は
前記浸漬流体は、前記個別のウェルのそれぞれにおいて異なるか、又は
前記個別のウェルのうちの幾つかは、前記浸漬流体を有し、前記個別のウェルのうちの他の幾つかは、前記浸漬流体と異なる1つ又は複数の他の浸漬流体を有する、請求項4に記載の分子検知デバイス。 - 前記アレイにおける前記個別のウェルのうちの少なくとも2つを流体分離する隔壁を更に備える、請求項4に記載の分子検知デバイス。
- 前記それぞれの信号増幅構造体のうちの少なくとも2つは、異なる化学種を受容するように機能化される、請求項4に記載の分子検知デバイス。
- 前記それぞれの信号増幅構造体は、前記個別のウェル内のそれぞれにおいて同じである、請求項4に記載の分子検知デバイス。
- 前記信号増幅構造体は、ラマン分光増強構造体である、請求項1に記載の分子検知デバイス。
- 請求項1に記載の分子検知デバイスを用いる方法であって、前記基板の前記表面上の前記材料又は前記基板の表面に取り外し可能カバーを取り付けることによって、前記ウェル内の前記浸漬流体を密封することを含む、請求項1に記載の分子検知デバイスを用いる方法。
- 表面増強ラマン分光システムであって、
請求項1に記載の分子検知デバイスと、
前記分子検知デバイスの前記ウェル内に導入される、化学種を含有する溶液と、
或る波長又は波長のスペクトル内の光を前記分子検知デバイスの前記ウェルに向けて放出するレーザー源と、
前記レーザー源からの前記光が前記ウェル内の前記化学種と相互作用した後に散乱した光を検出し、該散乱した光を検出したことに応答して信号を出力する光検出器と、
前記分子検知デバイスと前記光検出器との間に配置された光フィルタリング素子と、
前記分子検知デバイスと前記光検出器との間に配置された光分散素子と、
を備える、表面増強ラマン分光システム。 - 分子検知デバイスを作製する方法であって、
i)前記基板の表面上に配置された材料に、又はii)前記基板の表面に、ウェルを形成することと、
前記ウェル内に信号増幅構造体を形成することと、
前記信号増幅構造体が浸漬流体によって取り囲まれるように、該浸漬流体を前記ウェル内に導入することと、
を含む、分子検知デバイスを作製する方法。 - 前記ウェルを形成すること及び前記信号増幅構造体を形成することは、同時に行われ、前記ウェル及び前記信号増幅構造体を形成するステップは、
前記基板上に配置されたレジスト材料内にモールドをプレス加工することであって、該モールドは、前記ウェルと該ウェル内の前記信号増幅構造体とを形成するパターンを有することと、
前記モールドが前記レジスト材料内にプレス加工されている間、前記レジスト材料を少なくとも部分的に硬化させることと、
前記モールドを除去することと、
少なくとも前記信号増幅構造体の基部の表面上に信号増強材料を堆積させることと、
によって達成される、請求項12に記載の方法。 - 前記浸漬流体を導入する前に、所定の化学種に対して選択的である所定の機能性リガンドを含むように前記浸漬流体を選択することを更に含む、請求項12に記載の方法。
- 前記基板の前記表面上の前記材料又は前記基板の表面に取り外し可能カバーを付着させることによって、前記浸漬流体を前記ウェルに密封することを更に含む、請求項12に記載の方法。
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PCT/US2011/056699 WO2013058739A1 (en) | 2011-10-18 | 2011-10-18 | Molecular sensing device |
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JP6022585B2 JP6022585B2 (ja) | 2016-11-09 |
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US (1) | US20140198314A1 (ja) |
EP (1) | EP2769214B1 (ja) |
JP (1) | JP6022585B2 (ja) |
CN (1) | CN103930780B (ja) |
TW (1) | TW201319566A (ja) |
WO (1) | WO2013058739A1 (ja) |
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US9267894B2 (en) | 2012-08-10 | 2016-02-23 | Hamamatsu Photonics K.K. | Method for making surface enhanced Raman scattering device |
JP5923992B2 (ja) * | 2012-01-18 | 2016-05-25 | セイコーエプソン株式会社 | 試料分析素子および検出装置 |
JP2013221883A (ja) | 2012-04-18 | 2013-10-28 | Seiko Epson Corp | 試料分析素子および検出装置 |
JP2013234977A (ja) | 2012-05-11 | 2013-11-21 | Seiko Epson Corp | 試料分析素子並びに検査装置およびセンサーカートリッジ |
JP5921381B2 (ja) | 2012-08-10 | 2016-05-24 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
EP2884264B1 (en) | 2012-08-10 | 2019-11-20 | Hamamatsu Photonics K.K. | Surface-enhanced raman scattering element, and method for producing same |
EP2889606A4 (en) * | 2012-08-10 | 2016-04-20 | Hamamatsu Photonics Kk | SURFACE-REINFORCED RAM APPLICATION UNIT AND USE METHOD THEREFOR |
JP5921380B2 (ja) | 2012-08-10 | 2016-05-24 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
US10551322B2 (en) | 2012-08-10 | 2020-02-04 | Hamamatsu Photonics K.K. | Surface-enhanced Raman scattering unit including integrally formed handling board |
CN104508466B (zh) | 2012-08-10 | 2018-07-17 | 浜松光子学株式会社 | 表面增强拉曼散射元件 |
JP5908370B2 (ja) | 2012-08-10 | 2016-04-26 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
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WO2017095383A1 (en) * | 2015-11-30 | 2017-06-08 | Hewlett-Packard Development Company, L.P. | Substance detection device |
CN112590221B (zh) | 2015-12-18 | 2022-07-29 | 惠普发展公司,有限责任合伙企业 | 三维打印的方法、三维打印机以及计算机可读存储介质 |
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CN103930780B (zh) | 2016-01-20 |
EP2769214B1 (en) | 2019-05-22 |
EP2769214A1 (en) | 2014-08-27 |
CN103930780A (zh) | 2014-07-16 |
EP2769214A4 (en) | 2015-04-08 |
WO2013058739A1 (en) | 2013-04-25 |
JP6022585B2 (ja) | 2016-11-09 |
US20140198314A1 (en) | 2014-07-17 |
TW201319566A (zh) | 2013-05-16 |
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