JP2014530191A5 - - Google Patents
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- JP2014530191A5 JP2014530191A5 JP2014530804A JP2014530804A JP2014530191A5 JP 2014530191 A5 JP2014530191 A5 JP 2014530191A5 JP 2014530804 A JP2014530804 A JP 2014530804A JP 2014530804 A JP2014530804 A JP 2014530804A JP 2014530191 A5 JP2014530191 A5 JP 2014530191A5
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- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- alkyl
- group
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000004103 aminoalkyl group Chemical group 0.000 claims 9
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000005123 aminoalkylcarboxy group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 4
- 125000005416 guanidinoalkyloxy group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000005096 aminoalkylaminocarbonyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 239000007943 implant Substances 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000005128 aryl amino alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 claims 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- -1 C-carboxyalkyl Chemical group 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 125000005197 alkyl carbonyloxy alkyl group Chemical group 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000002439 hemostatic effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 235000012431 wafers Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161534185P | 2011-09-13 | 2011-09-13 | |
| US61/534,185 | 2011-09-13 | ||
| PCT/US2012/055244 WO2013040265A1 (en) | 2011-09-13 | 2012-09-13 | Compositions for treating bone diseases and broken bones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530191A JP2014530191A (ja) | 2014-11-17 |
| JP2014530191A5 true JP2014530191A5 (https=) | 2015-07-23 |
| JP6038154B2 JP6038154B2 (ja) | 2016-12-07 |
Family
ID=49157862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530804A Active JP6038154B2 (ja) | 2011-09-13 | 2012-09-13 | 骨疾患および破断骨治療のための組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9155746B2 (https=) |
| EP (1) | EP2755661A1 (https=) |
| JP (1) | JP6038154B2 (https=) |
| CN (1) | CN104080459B (https=) |
| CA (1) | CA2852989C (https=) |
| IL (1) | IL231510B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104053458B (zh) | 2011-07-20 | 2016-07-20 | 布莱阿姆青年大学 | 包含洗脱塞拉集宁化合物的水凝胶材料 |
| US9603859B2 (en) | 2011-09-13 | 2017-03-28 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
| US9694019B2 (en) | 2011-09-13 | 2017-07-04 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
| US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
| EP2908826A1 (en) | 2012-10-17 | 2015-08-26 | Brigham Young University | Treatment and prevention of mastitis |
| JP6294352B2 (ja) | 2013-01-07 | 2018-03-14 | ブリガム・ヤング・ユニバーシティＢｒｉｇｈａｍ Ｙｏｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ | 細胞増殖を減少させ、ある特定の疾患を治療する方法 |
| US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| WO2014151411A1 (en) | 2013-03-15 | 2014-09-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
| US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
| US20150203527A1 (en) | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
| US9931350B2 (en) * | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
| US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
| US10441595B2 (en) | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
| US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
| US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
| US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
| DE102015100806A1 (de) * | 2015-01-20 | 2016-07-21 | Antonis Alexakis | Biokompatibles Formteil |
| US9527883B2 (en) | 2015-04-22 | 2016-12-27 | Brigham Young University | Methods for the synthesis of ceragenins |
| US10370403B2 (en) | 2015-04-22 | 2019-08-06 | Brigham Young University | Methods for the synthesis of ceragenins |
| US9434759B1 (en) * | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
| US20170080128A1 (en) * | 2015-09-21 | 2017-03-23 | Brigham Young University | Novel endotracheal tube for the reduction of intubation-related complication in neonates and babies |
| US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
| US12186328B2 (en) | 2019-05-23 | 2025-01-07 | Brigham Young University | Use of CSA compounds to stimulate stem cells and hair growth |
| CN114585316A (zh) * | 2019-07-24 | 2022-06-03 | 布莱阿姆青年大学 | 骨结合化合物 |
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| US4990338A (en) | 1988-05-09 | 1991-02-05 | Dow Corning Corporation | Antimicrobial superabsorbent compositions and methods |
| US5356630A (en) | 1989-02-22 | 1994-10-18 | Massachusetts Institute Of Technology | Delivery system for controlled release of bioactive factors |
| US4972848A (en) | 1989-08-23 | 1990-11-27 | Medtronic, Inc. | Medical electrical lead with polymeric monolithic controlled release device and method of manufacture |
| GB9020075D0 (en) | 1990-09-14 | 1990-10-24 | Filler Aaron G | Contrast agents for magnetic resonance imaging of axonal transport |
| US5286479A (en) | 1991-12-10 | 1994-02-15 | The Dow Chemical Company | Oral compositions for suppressing mouth odors |
| KR100296810B1 (ko) | 1993-03-12 | 2001-10-24 | 로렌스 티. 마이젠헬더 | 결정성세프티오퍼유리산 |
| ES2164110T3 (es) | 1994-03-10 | 2002-02-16 | Magainin Pharma | Usos farmaceuticos de derivados de esteroides. |
| US6132765A (en) | 1996-04-12 | 2000-10-17 | Uroteq Inc. | Drug delivery via therapeutic hydrogels |
| US6767904B2 (en) | 1998-03-06 | 2004-07-27 | Bringham Young University | Steroid derived antibiotics |
| CN100398109C (zh) | 1998-03-06 | 2008-07-02 | 杨伯翰大学 | 甾族化合物衍生的抗生素 |
| US6350738B1 (en) | 1998-03-06 | 2002-02-26 | Brigham Young University | Steroid derived antibiotics |
| US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
| US6673771B1 (en) * | 1999-07-28 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
| US6551608B2 (en) | 2000-03-06 | 2003-04-22 | Porex Technologies Corporation | Porous plastic media with antiviral or antimicrobial properties and processes for making the same |
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| US6514556B2 (en) | 2000-12-15 | 2003-02-04 | Ecolab Inc. | Method and composition for washing poultry during processing |
| JP5170934B2 (ja) | 2001-08-16 | 2013-03-27 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 改良ｄｎａリポフェクションならびに／または徐放性プロドラッグおよび薬物療法のための試薬の合成と使用 |
| US9056048B2 (en) * | 2001-08-16 | 2015-06-16 | The Trustees Of The University Of Pennsylvania | Synthesis and use of cationic steroids for anti-inflammatory drug therapy |
| US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
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| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
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| KR101303299B1 (ko) | 2010-10-08 | 2013-09-03 | 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 | 항균 펩타이드의 피부 세포 재생 촉진제로서의 신규한 용도 |
| RU2576459C2 (ru) | 2010-11-03 | 2016-03-10 | Брайем Янг Юниверсити | Устойчивые при хранении антимикробные композиции, включающие церагениновые соединения, и способы их применения |
| CN102172356B (zh) * | 2011-03-03 | 2013-04-03 | 山东农业大学 | 牛磺鹅去氧胆酸在制备防治骨质疏松的药物中的应用 |
| CN104053458B (zh) | 2011-07-20 | 2016-07-20 | 布莱阿姆青年大学 | 包含洗脱塞拉集宁化合物的水凝胶材料 |
| WO2013029059A1 (en) | 2011-08-25 | 2013-02-28 | Brigham Young University | Medical devices incorporating ceragenin-containing composites |
| WO2013029055A1 (en) | 2011-08-25 | 2013-02-28 | Brigham Young University | Incorporation of particulate ceragenins in polymers |
| US8945217B2 (en) | 2011-08-25 | 2015-02-03 | Brigham Young University | Medical devices incorporating ceragenin-containing composites |
| MX369385B (es) | 2011-09-13 | 2019-11-07 | Univ Brigham Young | Productos para cicatrizar heridas tisulares. |
| KR20140116111A (ko) | 2011-12-21 | 2014-10-01 | 브라이엄 영 유니버시티 | 구강 관리 조성물 |
| EP2819531B1 (en) | 2012-03-01 | 2016-01-20 | Brigham Young University | Anti-microbial food processing compositions including ceragenin compounds and methods of use |
| US20130280391A1 (en) | 2012-04-24 | 2013-10-24 | Brigham Young University | Anti-microbial wash compositions including ceragenin compounds and methods of use for treating non-meat food products |
| EP2908826A1 (en) | 2012-10-17 | 2015-08-26 | Brigham Young University | Treatment and prevention of mastitis |
| JP6294352B2 (ja) | 2013-01-07 | 2018-03-14 | ブリガム・ヤング・ユニバーシティＢｒｉｇｈａｍ Ｙｏｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ | 細胞増殖を減少させ、ある特定の疾患を治療する方法 |
| WO2014151411A1 (en) | 2013-03-15 | 2014-09-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
-
2012
- 2012-09-13 EP EP12775878.7A patent/EP2755661A1/en active Pending
- 2012-09-13 JP JP2014530804A patent/JP6038154B2/ja active Active
- 2012-09-13 US US13/615,244 patent/US9155746B2/en active Active
- 2012-09-13 CA CA2852989A patent/CA2852989C/en active Active
- 2012-09-13 CN CN201280055680.6A patent/CN104080459B/zh active Active
-
2014
- 2014-03-13 IL IL231510A patent/IL231510B/en active IP Right Grant
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