JP2014530181A5 - - Google Patents
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- Publication number
- JP2014530181A5 JP2014530181A5 JP2014530237A JP2014530237A JP2014530181A5 JP 2014530181 A5 JP2014530181 A5 JP 2014530181A5 JP 2014530237 A JP2014530237 A JP 2014530237A JP 2014530237 A JP2014530237 A JP 2014530237A JP 2014530181 A5 JP2014530181 A5 JP 2014530181A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- cancer
- formula
- combination
- pathway inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims 39
- 239000003112 inhibitor Substances 0.000 claims 21
- 102000043136 MAP kinase family Human genes 0.000 claims 19
- 108091054455 MAP kinase family Proteins 0.000 claims 19
- 230000037361 pathway Effects 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 16
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 6
- 201000002528 pancreatic cancer Diseases 0.000 claims 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
- 206010014733 Endometrial cancer Diseases 0.000 claims 4
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 4
- 206010066476 Haematological malignancy Diseases 0.000 claims 4
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 201000002510 thyroid cancer Diseases 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000002231 Muscle Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 230000002301 combined effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000002077 muscle cancer Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 230000002195 synergetic effect Effects 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 102000001291 MAP Kinase Kinase Kinase Human genes 0.000 claims 1
- 108060006687 MAP kinase kinase kinase Proteins 0.000 claims 1
- 229940124647 MEK inhibitor Drugs 0.000 claims 1
- 102100025093 Zinc fingers and homeoboxes protein 2 Human genes 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000009929 raf Kinases Human genes 0.000 claims 1
- 108010077182 raf Kinases Proteins 0.000 claims 1
- GPXBXXGIAQBQNI-UHFFFAOYSA-N CCCS(Nc(ccc(F)c1C(c(c2c3)c[nH]c2ncc3-c(cc2)ccc2Cl)=O)c1F)(=O)=O Chemical compound CCCS(Nc(ccc(F)c1C(c(c2c3)c[nH]c2ncc3-c(cc2)ccc2Cl)=O)c1F)(=O)=O GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 description 1
- 0 C[n]1c(cc(C(NOCCO)=O)c(Nc2ccc(*)cc2Cl)c2F)c2nc1 Chemical compound C[n]1c(cc(C(NOCCO)=O)c(Nc2ccc(*)cc2Cl)c2F)c2nc1 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11306172.5 | 2011-09-16 | ||
| EP11306172A EP2570127A1 (en) | 2011-09-16 | 2011-09-16 | Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014530181A JP2014530181A (ja) | 2014-11-17 |
| JP2014530181A5 true JP2014530181A5 (https=) | 2015-10-01 |
Family
ID=46851503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530237A Abandoned JP2014530181A (ja) | 2011-09-16 | 2012-09-14 | ＰＩ３Ｋβ阻害剤ならびにＭＥＫおよびＲＡＦ阻害剤を含むＭＡＰＫ経路阻害剤を使用する、癌を処置するための組成物および方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20140275078A1 (https=) |
| EP (2) | EP2570127A1 (https=) |
| JP (1) | JP2014530181A (https=) |
| KR (1) | KR20140062143A (https=) |
| CN (1) | CN103889418A (https=) |
| AR (1) | AR087902A1 (https=) |
| AU (1) | AU2012307309A1 (https=) |
| BR (1) | BR112014005839A2 (https=) |
| CA (1) | CA2847091A1 (https=) |
| CL (1) | CL2014000606A1 (https=) |
| CO (1) | CO6910192A2 (https=) |
| CR (1) | CR20140102A (https=) |
| DO (1) | DOP2014000046A (https=) |
| EA (1) | EA201490638A1 (https=) |
| EC (1) | ECSP14013244A (https=) |
| GT (1) | GT201400038A (https=) |
| IL (1) | IL231212A0 (https=) |
| MA (1) | MA35615B1 (https=) |
| MX (1) | MX2014003223A (https=) |
| NI (1) | NI201400020A (https=) |
| PE (1) | PE20141035A1 (https=) |
| PH (1) | PH12014500536A1 (https=) |
| SG (1) | SG11201400380XA (https=) |
| TN (1) | TN2014000086A1 (https=) |
| UY (1) | UY34341A (https=) |
| WO (1) | WO2013037943A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA38522A1 (fr) * | 2013-03-21 | 2017-10-31 | Novartis Ag | Thérapie de combinaison comprenant un inhibiteur de b-raf et un second inhibiteur. |
| CN105163736A (zh) * | 2013-04-05 | 2015-12-16 | 赛诺菲 | 包含PI3Kβ选择性抑制剂和PI3Kα选择性抑制剂的抗肿瘤组合物 |
| WO2015051252A1 (en) * | 2013-10-03 | 2015-04-09 | Duke University | Compositions and methods for treating cancer with jak2 activity |
| US10028958B2 (en) | 2014-04-19 | 2018-07-24 | Massachusetts Institute Of Technology | Methods of treating cancer with a combination of selected MEK1/2 and AXL inhibitors |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| KR101950094B1 (ko) | 2017-07-28 | 2019-02-19 | 이성재 | 보릿대 공예품 제작방법 |
| CN113440616A (zh) * | 2020-03-25 | 2021-09-28 | 上海科州药物研发有限公司 | Ras或raf突变型癌症的联合疗法 |
| CN120204228B (zh) * | 2025-04-17 | 2026-01-30 | 重庆医科大学附属第一医院 | 化合物或其盐在制备癌症治疗药物中的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100984595B1 (ko) | 2002-03-13 | 2010-09-30 | 어레이 바이오파마 인크. | Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체 |
| UA95244C2 (ru) | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
| SG10201402867TA (en) | 2009-07-02 | 2014-08-28 | Sanofi Sa | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
| FR2951169B1 (fr) * | 2009-10-09 | 2011-12-02 | Sanofi Aventis | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
-
2011
- 2011-09-16 EP EP11306172A patent/EP2570127A1/en not_active Ceased
-
2012
- 2012-09-14 MX MX2014003223A patent/MX2014003223A/es not_active Application Discontinuation
- 2012-09-14 PH PH1/2014/500536A patent/PH12014500536A1/en unknown
- 2012-09-14 CN CN201280051036.1A patent/CN103889418A/zh active Pending
- 2012-09-14 SG SG11201400380XA patent/SG11201400380XA/en unknown
- 2012-09-14 BR BR112014005839A patent/BR112014005839A2/pt not_active IP Right Cessation
- 2012-09-14 CA CA2847091A patent/CA2847091A1/en not_active Abandoned
- 2012-09-14 PE PE2014000346A patent/PE20141035A1/es not_active Application Discontinuation
- 2012-09-14 US US14/343,935 patent/US20140275078A1/en not_active Abandoned
- 2012-09-14 WO PCT/EP2012/068072 patent/WO2013037943A1/en not_active Ceased
- 2012-09-14 EP EP12759137.8A patent/EP2755653A1/en not_active Withdrawn
- 2012-09-14 JP JP2014530237A patent/JP2014530181A/ja not_active Abandoned
- 2012-09-14 EA EA201490638A patent/EA201490638A1/ru unknown
- 2012-09-14 AU AU2012307309A patent/AU2012307309A1/en not_active Abandoned
- 2012-09-14 KR KR1020147009655A patent/KR20140062143A/ko not_active Withdrawn
- 2012-09-17 UY UY0001034341A patent/UY34341A/es not_active Application Discontinuation
- 2012-09-17 AR ARP120103421A patent/AR087902A1/es unknown
-
2014
- 2014-02-27 IL IL231212A patent/IL231212A0/en unknown
- 2014-02-27 CR CR20140102A patent/CR20140102A/es unknown
- 2014-02-28 TN TNP2014000086A patent/TN2014000086A1/en unknown
- 2014-03-03 GT GT201400038A patent/GT201400038A/es unknown
- 2014-03-04 DO DO2014000046A patent/DOP2014000046A/es unknown
- 2014-03-13 CL CL2014000606A patent/CL2014000606A1/es unknown
- 2014-03-14 NI NI201400020A patent/NI201400020A/es unknown
- 2014-03-14 EC ECSP14013244 patent/ECSP14013244A/es unknown
- 2014-03-14 CO CO14055689A patent/CO6910192A2/es unknown
- 2014-04-10 MA MA36908A patent/MA35615B1/fr unknown
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