JP2014529621A - 抗炎症性の置換シクロブテンジオン化合物のコリン塩 - Google Patents

抗炎症性の置換シクロブテンジオン化合物のコリン塩 Download PDF

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Publication number
JP2014529621A
JP2014529621A JP2014527801A JP2014527801A JP2014529621A JP 2014529621 A JP2014529621 A JP 2014529621A JP 2014527801 A JP2014527801 A JP 2014527801A JP 2014527801 A JP2014527801 A JP 2014527801A JP 2014529621 A JP2014529621 A JP 2014529621A
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dosage form
enylamino
cyclobut
propylamino
dioxo
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JP2014527801A
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Japanese (ja)
Inventor
アミート・ビジャイ・アンバーケイン
アルノー・モレー
カルステン・ティンペ
ウルス・ベティッヒ
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ノバルティスアーゲー
ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2014527801A 2011-09-02 2012-08-31 抗炎症性の置換シクロブテンジオン化合物のコリン塩 Pending JP2014529621A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161530516P 2011-09-02 2011-09-02
US61/530,516 2011-09-02

Related Child Applications (1)

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JP2016175348A Division JP6612200B2 (ja) 2011-09-02 2016-09-08 抗炎症性の置換シクロブテンジオン化合物のコリン塩

Publications (1)

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JP2014529621A true JP2014529621A (ja) 2014-11-13

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JP2014527801A Pending JP2014529621A (ja) 2011-09-02 2012-08-31 抗炎症性の置換シクロブテンジオン化合物のコリン塩
JP2016175348A Expired - Fee Related JP6612200B2 (ja) 2011-09-02 2016-09-08 抗炎症性の置換シクロブテンジオン化合物のコリン塩
JP2018135448A Pending JP2019001787A (ja) 2011-09-02 2018-07-19 抗炎症性の置換シクロブテンジオン化合物のコリン塩

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JP2016175348A Expired - Fee Related JP6612200B2 (ja) 2011-09-02 2016-09-08 抗炎症性の置換シクロブテンジオン化合物のコリン塩
JP2018135448A Pending JP2019001787A (ja) 2011-09-02 2018-07-19 抗炎症性の置換シクロブテンジオン化合物のコリン塩

Country Status (17)

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US (1) US9018261B2 (enExample)
EP (2) EP3287438A1 (enExample)
JP (3) JP2014529621A (enExample)
KR (1) KR102024955B1 (enExample)
CN (1) CN103842330B (enExample)
BR (1) BR112014004963A2 (enExample)
CA (1) CA2846510C (enExample)
EA (1) EA201490552A1 (enExample)
ES (1) ES2655942T3 (enExample)
HU (1) HUE035751T2 (enExample)
IN (1) IN2014DN02346A (enExample)
MX (1) MX359259B (enExample)
NO (1) NO2679622T3 (enExample)
PL (1) PL2760821T3 (enExample)
PT (1) PT2760821T (enExample)
SI (1) SI2760821T1 (enExample)
WO (1) WO2013030803A1 (enExample)

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UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
KR20200089286A (ko) 2017-11-16 2020-07-24 노파르티스 아게 조합 요법
CN111867579B (zh) 2018-01-08 2023-11-24 凯莫森特里克斯股份有限公司 Ccr6或cxcr2拮抗剂治疗泛发性脓疱型银屑病的方法
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
JP2022514315A (ja) 2018-12-20 2022-02-10 ノバルティス アーゲー ３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体を含む投与計画及び薬剤組み合わせ
AU2020222346B2 (en) 2019-02-15 2021-12-09 Novartis Ag Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
EP3924054B1 (en) 2019-02-15 2025-04-02 Novartis AG 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
US20230057071A1 (en) 2019-12-20 2023-02-23 Novartis Ag Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome
CN118806759A (zh) * 2020-04-24 2024-10-22 福尔克博士药物有限责任公司 用于tg2相关疾病的吡啶酮衍生物的全身性制剂
JP2023531676A (ja) 2020-06-23 2023-07-25 ノバルティス アーゲー ３－（１－オキソイソインドリン－２－イル）ピぺリジン－２，６－ジオン誘導体を含む投与レジメン
CN116134027B (zh) 2020-08-03 2025-01-24 诺华股份有限公司 杂芳基取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途
TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
AR125874A1 (es) 2021-05-18 2023-08-23 Novartis Ag Terapias de combinación

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EP2760821A1 (en) 2014-08-06
JP6612200B2 (ja) 2019-11-27
EP2760821B1 (en) 2017-10-11
BR112014004963A2 (pt) 2017-03-21
IN2014DN02346A (enExample) 2015-05-15
NO2679622T3 (enExample) 2018-01-20
KR102024955B1 (ko) 2019-09-24
US20140206768A1 (en) 2014-07-24
PT2760821T (pt) 2018-01-11
HUE035751T2 (hu) 2018-08-28
PL2760821T3 (pl) 2018-04-30
EP3287438A1 (en) 2018-02-28
CN103842330A (zh) 2014-06-04
CA2846510A1 (en) 2013-03-07
JP2019001787A (ja) 2019-01-10
MX2014002492A (es) 2014-05-28
CN103842330B (zh) 2016-10-19
KR20140059264A (ko) 2014-05-15
MX359259B (es) 2018-09-20
EA201490552A1 (ru) 2014-11-28
JP2017025081A (ja) 2017-02-02
WO2013030803A1 (en) 2013-03-07
SI2760821T1 (en) 2018-02-28
ES2655942T3 (es) 2018-02-22
CA2846510C (en) 2019-10-22
US9018261B2 (en) 2015-04-28

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